公开(公告)号：US5496561A

公开(公告)日：1996-03-05

申请号：US294052

申请日：1994-08-24

申请人： Minoru Okada ,  Kenji Ono ,  Shuichi Kasai ,  Akira Iwasa

发明人： Minoru Okada ,  Kenji Ono ,  Shuichi Kasai ,  Akira Iwasa

IPC分类号： A61K9/32 ,  A61K9/28 ,  A61K9/50 ,  A61K9/52 ,  A61K9/54 ,  A61K47/32 ,  A61K47/38 ,  A61K9/24

CPC分类号： A61K9/5078 ,  A61K9/2846 ,  A61K9/2853

摘要： A controlled release-initiation and controlled release-rate pharmaceutical composition in which a drug-containing composition is coated with a membrane layer comprising a water insoluble high polymer and silicone. The starting time for the release of drugs from the controlled release-initiation and controlled release-rate pharmaceutical composition of this invention and the drug-releasing rate thereafter can be controlled at will.

摘要翻译： 一种控制释放引发和控制释放速率的药物组合物，其中药物组合物涂覆有包含水不溶性高分子聚合物和硅氧烷的膜层。 从本发明的控制释放引发和控制释放速率的药物组合物释放药物的起始时间和其后的药物释放速率可以随意控制。

公开(公告)号：US06197326B1

公开(公告)日：2001-03-06

申请号：US09172271

申请日：1998-10-14

申请人： Makoto Suzuki ,  Kenji Ishigaki ,  Minoru Okada ,  Kenji Ono ,  Shuichi Kasai ,  Katsumi Imamori

发明人： Makoto Suzuki ,  Kenji Ishigaki ,  Minoru Okada ,  Kenji Ono ,  Shuichi Kasai ,  Katsumi Imamori

IPC分类号： A61F200

CPC分类号： A61K9/5031 ,  Y10S514/825

摘要： This invention relates to an intra-articular preparation for the treatment of arthropathy, which comprises microcapsules of (a) a high-molecular substance, which has biodegradability and biocompatibility, and (b) a drug. When applied directly to a joint area, this preparation can achieve a high drug concentration at the target area, can inhibit occurrence of general side effect, and can maintain drug efficacy over a long term. The preparation can therefore alleviate the burden on the patient.

摘要翻译： 本发明涉及用于治疗关节病的关节内制剂，其包含（a）具有生物降解性和生物相容性的高分子物质的微胶囊和（b）药物。 当直接用于接合部位时，该制剂可以在目标区域达到高药物浓度，可以抑制一般副作用的发生，并能长期保持药效。 因此，该制剂可以减轻患者的负担。

公开(公告)号：US06428804B1

公开(公告)日：2002-08-06

申请号：US09706762

申请日：2000-11-07

申请人： Makoto Suzuki ,  Kenji Ishigaki ,  Minoru Okada ,  Kenji Ono ,  Shuichi Kasai ,  Katsumi Imamori

发明人： Makoto Suzuki ,  Kenji Ishigaki ,  Minoru Okada ,  Kenji Ono ,  Shuichi Kasai ,  Katsumi Imamori

IPC分类号： A61F200

CPC分类号： A61K9/5031 ,  Y10S514/825

摘要： This invention relates to an intra-articular preparation for the treatment of arthropathy, which comprises microcapsules of (a) a high-molecular substance, which has biodegradability and biocompatibility, and (b) a drug. When applied directly to a joint area, this preparation can achieve a high drug concentration at the target area, can inhibit occurrence of general side effect, and can maintain drug efficacy over a long term. The preparation can therefore alleviate the burden on the patient.

摘要翻译： 本发明涉及用于治疗关节病的关节内制剂，其包含（a）具有生物降解性和生物相容性的高分子物质的微胶囊和（b）药物。 当直接用于接合部位时，该制剂可以在目标区域达到高药物浓度，可以抑制一般副作用的发生，并能长期保持药效。 因此，该制剂可以减轻患者的负担。

公开(公告)号：US06375988B1

公开(公告)日：2002-04-23

申请号：US09172270

申请日：1998-10-14

申请人： Makoto Suzuki ,  Kenji Ishigaki ,  Minoru Okada ,  Kenji Ono ,  Shuichi Kasai ,  Katsumi Imamori

发明人： Makoto Suzuki ,  Kenji Ishigaki ,  Minoru Okada ,  Kenji Ono ,  Shuichi Kasai ,  Katsumi Imamori

IPC分类号： A61K950

CPC分类号： A61K9/205 ,  A61K9/1652 ,  Y10S514/952

摘要： This invention relates to a drug composition with a controlled drug release rate. The drug composition comprises: a matrix formed of the following ingredients (a) and (b): (a) a biodegradable, biocompatible high-molecular substance and/or polyvalent metal ions or polyvalent metal ion source, and (b) hyaluronic acid or a salt thereof; and a drug incorporated as an ingredient (c) in said matrix. The drug composition has biodegradability and biocompatibility, permits easy control of a release rate of the drug, and can persistently exhibit its pharmacological effect over a long time.

摘要翻译： 本发明涉及具有受控药物释放速率的药物组合物。 药物组合物包含：由以下成分（a）和（b）形成的基质：（a）可生物降解的生物相容性高分子物质和/或多价金属离子或多价金属离子源，和（b）透明质酸或 其盐; 和作为成分（c）的药物掺入所述基质中。 药物组合物具有生物降解性和生物相容性，容易控制药物的释放速度，并且可以长时间持续显示其药理作用。

公开(公告)号：US06455053B1

公开(公告)日：2002-09-24

申请号：US09509988

申请日：2000-05-24

申请人： Minoru Okada ,  Yasuo Ikeda ,  Kenji Ono ,  Toshiaki Kurazumi ,  Syuichi Kasai ,  Katsumi Imamori

发明人： Minoru Okada ,  Yasuo Ikeda ,  Kenji Ono ,  Toshiaki Kurazumi ,  Syuichi Kasai ,  Katsumi Imamori

IPC分类号： A61K900

CPC分类号： A61K9/2095 ,  A61K9/0056

摘要： An orally administrable uncompressed rapidly dissolving molded dosage form comprises a drug and either one or more saccharides or one saccharide and polyvinylpyrrolidone. Saccarides are chosen and used in proportion based on their solubilities. Methods for producing uncompressed rapidly dissolving solid preparations comprise mixing a drug and carriers according to the present invention and charging the mixture in a mold. Rapidly dissolving oral dosage forms facilitate administration of drugs to patients having a difficulty in swallowing such as children and the elderly.

摘要翻译： 口服给药的未压缩的快速溶解的模塑剂型包含药物和一种或多种糖或一种糖和聚乙烯吡咯烷酮。 根据其溶解度选择和使用Saccarides成比例地使用。 用于生产未压缩的快速溶解固体制剂的方法包括混合根据本发明的药物和载体，并将混合物装入模具中。 快速溶解的口服剂型有助于向吞咽困难的患者（如儿童和老人）投放药物。

公开(公告)号：US09914341B2

公开(公告)日：2018-03-13

申请号：US13381740

申请日：2010-06-10

申请人： Kenji Ono ,  Yuzuru Yoshinami ,  Ryunosuke Ino ,  Kenichiro Minami

发明人： Kenji Ono ,  Yuzuru Yoshinami ,  Ryunosuke Ino ,  Kenichiro Minami

IPC分类号： B60H3/00

CPC分类号： B60H3/0035 ,  B60H2003/0042

摘要： Provided is a fragrance device for vehicle with an aim to restrain an olfactory adaptation of an occupant, to continuously provide the occupant for a long time with changes in sensory intensity of smell caused by intermittent smell emission, and to provide the occupant for a long time with a relaxation effect due to a smell, the fragrance device for vehicle includes: a fragrance holder holding a fragrance; a blowing means for blowing air to the fragrance holder to blow a smell of the fragrance into a vehicle cabin; and a fragrance blowing control means for sequentially repeating the repeating of a predetermined cycle of blowing a smell of the fragrance and a pause predetermined times by intermittently blowing the smell at each cycle, and then the providing of a stop time for stopping the blowing out of the smell of the fragrance for a predetermined time period.

公开(公告)号：US09500841B2

公开(公告)日：2016-11-22

申请号：US13486926

申请日：2012-06-01

申请人： Keisuke Ichikawa ,  Kenji Ono

发明人： Keisuke Ichikawa ,  Kenji Ono

IPC分类号： G02B15/177

CPC分类号： G02B15/177

摘要： The zoom lens comprises, from an object side, a first lens group, a second lens group that includes an aperture stop moving integrally therewith, a third lens group, and a fourth lens group having, respectively, negative, positive, negative, and positive refracting power, and during zooming from a wide-angle end to a telephoto end, a spacing between the first and second lens groups becomes narrow, between the second and third lens groups changes, and between the third and fourth lens groups grows wide, and the first lens group includes a first lens having negative refracting power, a second lens having a reflective surface for bending a light ray coming out of an object and a third lens having positive refracting power, and in said second lens group, a most image-plane-side surface of a lens having negative refracting power is configured in a concave shape on an image plane side.

摘要翻译： 变焦透镜从物体侧包括第一透镜组，包括与其一体移动的孔径光阑的第二透镜组，第三透镜​​组和第四透镜组，分别具有负，正，负和正的 折射力，并且在从广角端到望远端的变焦期间，第一和第二透镜组之间的间隔变窄，在第二和第三透镜组之间变化，并且在第三和第四透镜组之间变宽，并且 第一透镜组包括具有负折射力的第一透镜，具有用于弯曲从物体出射的光线的反射表面的第二透镜和具有正折射率的第三透镜，并且在所述第二透镜组中， 具有负折射率的透镜的平面侧表面在像平面侧上被构造成凹形。

公开(公告)号：US08199412B2

公开(公告)日：2012-06-12

申请号：US12927984

申请日：2010-11-30

申请人： Tomoyuki Satori ,  Hideyuki Nagaoka ,  Kenji Ono

发明人： Tomoyuki Satori ,  Hideyuki Nagaoka ,  Kenji Ono

IPC分类号： G02B15/14

CPC分类号： H04N5/2251 ,  G02B5/04 ,  G02B15/177

摘要： A zoom lens includes, in order from the object side, an object side lens group having a negative refracting power at the wide angle end and including at least one negative lens unit, and an image side lens group having a positive refracting power at the wide angle end and including at least one positive lens unit including a cemented doublet lens component. The distance between the two lens groups is smaller at the telephoto end than at the wide angle end. The cemented doublet lens component includes, in order from the object side, a negative object side lens having a concave surface facing the image side, and positive image side lens having a meniscus shape with a concave surface facing the image side. The cemented doublet lens component is located closest to the image side in the positive lens unit. The zoom lens satisfies specific conditions.

摘要翻译： 变焦透镜从对象侧依次包括在广角端具有负折射率并包括至少一个负透镜单元的物体侧透镜组，以及在宽广角处具有正折射光焦度的像侧透镜组 并且包括至少一个包括胶合双透镜部件的正透镜单元。 在远摄端，两个透镜组之间的距离比广角端处的距离小。 胶合双透镜部件从物体侧依次包括具有面向图像侧的凹面的负像侧透镜和具有面向图像侧的凹面的弯月形状的正像侧透镜。 胶合的双透镜组件位于正透镜单元中最靠近图像侧的位置。 变焦镜头满足特定条件。

公开(公告)号：US08181628B2

公开(公告)日：2012-05-22

申请号：US13222051

申请日：2011-08-31

申请人： Yoshihiko Akagi ,  Hidefumi Iwaki ,  Kenji Ono

发明人： Yoshihiko Akagi ,  Hidefumi Iwaki ,  Kenji Ono

IPC分类号： F02D41/00

CPC分类号： F02D11/105 ,  F02D11/107 ,  F02D41/2464 ,  F02D2041/2048 ,  F02D2250/16

摘要： A throttle valve controller for an internal combustion engine has a throttle valve driven by a motor. The target opening of the throttle valve is determined based on the operating state of the vehicle or internal combustion engine. A first lower limit is determined beforehand as the minimum target opening, and a second lower limit is set which is smaller than the first lower limit if the determined target opening is smaller than a predetermined opening and/or if the rotation speed of the internal combustion engine is lower than a predetermined speed.

摘要翻译： 用于内燃机的节气门控制器具有由电动机驱动的节流阀。 基于车辆或内燃机的运行状态来确定节气门的目标开度。 预先确定第一下限为最小目标开度，如果确定的目标开度小于预定开度，则设定小于第一下限的第二下限，和/或如果内燃的转速 发动机低于预定速度。

公开(公告)号：US20120107172A1

公开(公告)日：2012-05-03

申请号：US13381740

申请日：2010-06-10

申请人： Kenji Ono ,  Yuzuru Yoshinami ,  Ryunosuke Ino ,  Kenichiro Minami

发明人： Kenji Ono ,  Yuzuru Yoshinami ,  Ryunosuke Ino ,  Kenichiro Minami

IPC分类号： A61L9/04 ,  A61L9/12

CPC分类号： B60H3/0035 ,  B60H2003/0042

摘要： Provided is a fragrance device for vehicle with an aim to restrain an olfactory adaptation of an occupant, to continuously provide the occupant for a long time with changes in sensory intensity of smell caused by intermittent smell emission, and to provide the occupant for a long time with a relaxation effect due to a smell, the fragrance device for vehicle includes: a fragrance holder holding a fragrance; a blowing means for blowing air to the fragrance holder to blow a smell of the fragrance into a vehicle cabin; and a fragrance blowing control means for sequentially repeating the repeating of a predetermined cycle of blowing a smell of the fragrance and a pause predetermined times by intermittently blowing the smell at each cycle, and then the providing of a stop time for stopping the blowing out of the smell of the fragrance for a predetermined time period.

摘要翻译： 本发明提供一种用于车辆的香味装置，其目的是抑制乘员的嗅觉适应，能够长时间地连续地向乘客提供由间歇性气味发射引起的气味的感觉强度的变化，并且能够长时间地为乘客提供 具有由于气味的松弛效果，车辆用香料装置包括：保持香料的香味保持器; 用于将空气吹送到香料保持器以将香料的气味吹入车厢的吹风装置; 以及香味吹出控制装置，用于通过在每个周期间歇地吹送气味来顺序地重复吹送香味的气味的预定循环和暂停预定次数，然后提供停止时间以停止吹出 香味在预定时间段内的气味。