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    Method and device for securing a functional device to a stomach
    2.
    发明授权
    Method and device for securing a functional device to a stomach 有权
    用于将功能装置固定到胃的方法和装置

    公开(公告)号：US07120498B2

    公开(公告)日：2006-10-10

    申请号：US10691880

    申请日：2003-10-23

    申请人： Mir A. Imran ,  Olivier K. Colliou ,  Ted W. Layman ,  Deepak R. Gandhi ,  Sharon L. Lake

    发明人： Mir A. Imran ,  Olivier K. Colliou ,  Ted W. Layman ,  Deepak R. Gandhi ,  Sharon L. Lake

    IPC分类号： A61N1/18

    CPC分类号： A61B5/6882 ,  A61B5/4238 ,  A61B17/3421 ,  A61B17/3478 ,  A61B2017/00004 ,  A61B2017/00017 ,  A61B2017/00026 ,  A61B2017/00084 ,  A61B2017/00477 ,  A61B2017/306 ,  A61B2017/3488 ,  A61F5/0003 ,  A61M25/02 ,  A61M2025/0233 ,  A61M2025/028 ,  A61N1/0509 ,  A61N1/0517 ,  A61N1/36007 ,  A61N1/372 ,  G01N27/126 ,  G06F19/00

    摘要： A device, system and method for diagnosing and treating gastric disorders is provided. A functional device resides within the patient's stomach and is secured to the stomach wall by an attachment device. The functional device may be a sensor for sensing various parameters of the stomach or stomach environment, or may be a therapeutic delivery device. The functional device in one embodiment provides a device, system and method for gastric electrical stimulation where stimulating electrodes are secured to the wall of the stomach by the attachment device or otherwise. A preferred device includes: at least one stimulating electrode in electrical contact with the stomach wall; an electronics unit containing the electronic circuitry of the device; and an attachment mechanism for attaching the device to the stomach wall. The functional devices may be programmed to respond to sensed information or signals. An endoscopic delivery system delivers the functional device through the esophagus and into the stomach where it is attached the stomach wall. The endoscopic instruments attach or remove the attachment devices and functional devices from the stomach and may be used to assist in determining the optimal attachment location.

    摘要翻译： 提供了用于诊断和治疗胃疾病的装置，系统和方法。 功能装置位于患者的胃内，并通过附接装置固定到胃壁。 功能装置可以是用于感测胃或胃环境的各种参数的传感器，或者可以是治疗递送装置。 在一个实施例中的功能装置提供了用于胃电刺激的装置，系统和方法，其中刺激电极通过附接装置或其它方式固定到胃壁。 优选的装置包括：与胃壁电接触的至少一个刺激电极; 包含该装置的电子电路的电子单元; 以及用于将装置附接到胃壁的附接机构。 功能设备可以被编程为响应感测的信息或信号。 内窥镜递送系统通过食管将功能装置输送到胃中，在胃附着胃壁。 内窥镜器械将附接装置和功能装置从胃附接或移除，并且可以用于帮助确定最佳的附接位置。

    Aspiration needle apparatus incorporating its own vacuum and method and adapter for use therewith
    4.
    发明授权
    Aspiration needle apparatus incorporating its own vacuum and method and adapter for use therewith 失效
    吸入针装置结合其自身的真空和方法以及与其一起使用的适配器

    公开(公告)号：US5902280A

    公开(公告)日：1999-05-11

    申请号：US937259

    申请日：1997-09-13

    申请人： Trevor J. Powles ,  Mir A. Imran ,  Baber Syed ,  Deepak R. Gandhi ,  Ami K. Mehta ,  Russell Spreier

    发明人： Trevor J. Powles ,  Mir A. Imran ,  Baber Syed ,  Deepak R. Gandhi ,  Ami K. Mehta ,  Russell Spreier

    IPC分类号： A61B10/02 ,  A61B10/00 ,  A61M5/00

    CPC分类号： A61B10/0283

    摘要： An aspiration needle apparatus for collecting cell samples from tissue comprising a vacuum container having an enclosed evacuated space evacuated to a subambient pressure and sealed by a penetrable diaphragm. An adapter has a recess to receive the vacuum container. A needle is carried by the adapter and has a distal extremity serving as an aspiration needle to collect the cell sample and has a proximal extremity disposed in the recess and is capable of penetrating the diaphragm of the vacuum container to couple the evacuated space to the flow passage of the needle to supply a subambient pressure to the distal extremity of the needle. An on-off mechanism carried by the adapter includes yieldable means and a member mounted in the recess actuatable by axial movement of the vacuum container into the recess against the force of the yieldable means disposed within the recess. The on-off mechanism also includes means secured to the member for sequentially retaining the member in a rearwardmost or at rest position and a forwardmost or latched position whereby in the forwardmost or latched position the needle means penetrates the diaphragm to supply the subambient pressure in the vacuum container to the needle means and in the rearwardmost or at rest position the needle means is free of the diaphragm so that the subambient pressure is no longer supplied to the needle means.

    摘要翻译： 一种用于从组织收集细胞样品的抽吸针装置，包括真空容器，该真空容器具有抽空到低于环境压力并被可穿透隔膜密封的封闭抽空空间。 适配器具有用于接收真空容器的凹部。 针由适配器承载，并且具有远端用作抽吸针以收集细胞样品并具有设置在凹部中的近端末端，并且能够穿透真空容器的隔膜以将抽空的空间耦合到流动 针头的通过，以向针的远端提供低于一定的压力。 适配器承载的开 - 关机构包括可屈服装置和安装在凹部中的构件，可通过将真空容器轴向移动到抵抗可设置在凹部内的可屈服装置的力的凹部中而致动。 开关机构还包括固定到构件上的装置，用于将构件顺序地保持在最后或静止​​位置以及最前端或闩锁位置，从而在最前端或闭锁位置，针装置穿透隔膜以将次级压力提供到 真空容器到针装置，并且在最后或静止​​位置，针装置没有隔膜，从而不再向针装置提供低于外部压力。

    Guide wire having distal extremity with adjustable support characteristic and method
    5.
    发明授权
    Guide wire having distal extremity with adjustable support characteristic and method 失效
    导丝具有远端，具有可调支撑特性和方法

    公开(公告)号：US5697380A

    公开(公告)日：1997-12-16

    申请号：US585885

    申请日：1996-01-11

    申请人： Dignah B. Quiachon ,  Deepak R. Gandhi ,  Dennis L. Brooks ,  Mir A. Imran ,  Roger J. Guidi

    发明人： Dignah B. Quiachon ,  Deepak R. Gandhi ,  Dennis L. Brooks ,  Mir A. Imran ,  Roger J. Guidi

    IPC分类号： A61F11/00 ,  A61M25/00 ,  A61M25/09 ,  A61M29/00

    CPC分类号： A61M25/09 ,  A61M2025/09083 ,  A61M2025/0915 ,  A61M2025/09158 ,  A61M2025/09175

    摘要： A guide wire having a distal extremity with an adjustable support characteristic comprising a core wire having proximal and distal extremities. The distal extremity has a reduced cross sectional area which is more flexible than the proximal extremity. A tip secured to the distal extremity of the core wire. A sleeve of superelastic material is disposed coaxially on the distal extremity of the core wire. The sleeve is annealed so that it is relatively flexible at a temperature ranging from 20.degree. to 40.degree. C. and becomes progressively stiffer as temperature increases. The core wire conducts electrical energy to the superelastic sleeve to supply heat to the sleeve and extends from the proximal extremity of the core wire to the sleeve to cause the sleeve to become stiffer to thereby increase the stiffness of the distal extremity of the guide wire. A guide wire is provided having a distal extremity with an adjustable support characteristic which varies from a floppy characteristic to a stiff characteristic.

    摘要翻译： 一种具有远端的引导线，其具有可调节的支撑特征，包括具有近端和远端的芯线。 远端具有减小的横截面积，其比近端更灵活。 尖端固定在芯线的远端。 超弹性材料的套筒同轴地设置在芯线的远端上。 套管退火，使其在20°至40°C的温度范围内具有相对的柔韧性，随着温度升高而逐渐变硬。 芯线将电能传导到超弹性套管以向套管供热并且从芯线的近端延伸到套筒以使套筒变得更硬，从而增加导丝的远端的刚度。 提供导丝，其具有远端，具有可调整的支撑特性，其从软盘特性变为刚性特征。

    Low profile balloon catheter and method
    6.
    发明授权
    Low profile balloon catheter and method 失效
    低调气囊导管及方法

    公开(公告)号：US5662608A

    公开(公告)日：1997-09-02

    申请号：US507655

    申请日：1995-07-26

    申请人： Mir A. Imran ,  Deepak R. Gandhi ,  Anant V. Hegde

    发明人： Mir A. Imran ,  Deepak R. Gandhi ,  Anant V. Hegde

    IPC分类号： A61M25/00 ,  A61F2/958 ,  A61M25/01 ,  A61M29/02 ,  A61M29/00

    CPC分类号： A61M25/104 ,  A61M25/1002 ,  A61M25/1011 ,  A61M2025/1013

    摘要： A low profile catheter comprising a flexible elongate tubular member having proximal and distal extremities and having a guide wire lumen and at least one balloon inflation lumen extending from the proximal extremity to the distal extremity, said at least one balloon inflation lumen being offset eccentrically with respect to said guide wire lumen, the distal extremity of said flexible elongate tubular member having at least one inflatable balloon formed thereon and having an interior in communication with said at least one balloon inflation lumen, said guide wire lumen extending through said at least one inflatable balloon and being offset eccentrically with respect to said at least one inflatable balloon.

    摘要翻译： 一种低剖面导管，其包括具有近端和远端的柔性细长管状构件，并且具有导丝腔和至少一个从近端至远端延伸的球囊充气腔，所述至少一个球囊充气腔相对于 所述柔性细长管状构件的远端末端具有形成在其上的至少一个可膨胀气囊，并且具有与所述至少一个球囊膨胀腔连通的内部，所述导丝腔延伸穿过所述至少一个可充气球囊 并且相对于所述至少一个可充气气球偏心偏移。

    Guide wire having distal extremity with adjustable support characteristic and method
    7.
    发明授权
    Guide wire having distal extremity with adjustable support characteristic and method 失效
    导丝具有远端，具有可调支撑特性和方法

    公开(公告)号：US6039743A

    公开(公告)日：2000-03-21

    申请号：US902772

    申请日：1997-07-30

    申请人： Dignah B. Quiachon ,  Deepak R. Gandhi ,  Dennis L. Brooks ,  Mir A. Imran ,  Roger J. Guidi

    发明人： Dignah B. Quiachon ,  Deepak R. Gandhi ,  Dennis L. Brooks ,  Mir A. Imran ,  Roger J. Guidi

    IPC分类号： A61F11/00 ,  A61M25/00 ,  A61M25/09 ,  A61M29/00

    CPC分类号： A61M25/09 ,  A61M2025/09083 ,  A61M2025/0915 ,  A61M2025/09158 ,  A61M2025/09175

    摘要： A guide wire having a distal extremity with an adjustable support characteristic including a core wire having proximal and distal extremities. The distal extremity has a reduced cross sectional area which is more flexible than the proximal extremity. A tip is secured to the distal extremity of the core wire. A sleeve of superelastic material is disposed coaxially on the distal extremity of the core wire. The sleeve is annealed so that it is relatively flexible at a temperature ranging from 20.degree. to 40.degree. C. and becomes progressively stiffer as temperature increases. The core wire conducts electrical energy to the superelastic sleeve to supply heat to the sleeve and extends from the proximal extremity of the core wire to the sleeve to cause the sleeve to become stiffer to thereby increase the stiffness of the distal extremity of the guide wire. A guide wire is provided having a distal extremity with an adjustable support characteristic which varies from a floppy characteristic to a stiff characteristic.

    摘要翻译： 一种具有远端的引导线，其具有可调节的支撑特征，包括具有近端和远端的芯线。 远端具有减小的横截面积，其比近端更灵活。 尖端被固定到芯线的远端。 超弹性材料的套筒同轴地设置在芯线的远端上。 套管退火，使其在20°至40°C的温度范围内具有相对的柔韧性，随着温度升高而逐渐变硬。 芯线将电能传导到超弹性套管以向套管供热并且从芯线的近端延伸到套筒以使套筒变得更硬，从而增加导丝的远端的刚度。 提供导丝，其具有远端，具有可调整的支撑特性，其从软盘特性变为刚性特征。

    Guide wire with deflectable tip and method
    8.
    发明授权
    Guide wire with deflectable tip and method 失效

    公开(公告)号：US5813997A

    公开(公告)日：1998-09-29

    申请号：US690749

    申请日：1996-08-01

    申请人： Mir A. Imran ,  Deepak R. Gandhi ,  Henry Bourang ,  Dignah B. Quiachon ,  Andrew Y. Chow

    发明人： Mir A. Imran ,  Deepak R. Gandhi ,  Henry Bourang ,  Dignah B. Quiachon ,  Andrew Y. Chow

    IPC分类号： A61M25/00 ,  A61M25/01 ,  A61M25/09 ,  H04L7/00 ,  A61B5/00

    CPC分类号： A61M25/0144 ,  A61M25/0158 ,  A61M25/09 ,  H04L7/0008 ,  A61M2025/0063 ,  A61M2025/0915 ,  A61M25/0054

    摘要： Guide wire for use in a medical procedure and for use with the power supply comprising a flexible elongate tubular member having proximal and distal extremities and having a bore extending from the proximal extremity to the distal extremity. A core wire extends through the bore of the flexible elongate tubular member. A coil assembly is mounted on the distal extremity of the flexible elongate member and has a distal extremity. A rounded tip is formed on the distal extremity. An actuator member has at least a portion thereof disposed in the coil assembly and has proximal and distal extremities. The proximal extremity of the actuator member is secured to the distal extremity of the flexible elongate tubular member. The distal extremity of the actuator member is secured to the rounded tip. The actuator member has a portion thereof formed of a shape memory material and incorporating a shape member therein. A heater is disposed in the vicinity of said portion of the actuator member for heating said portion to cause it to assume the predetermined shape memory. Electrical conductors are connected to the heater and extending to the proximal extremity of the flexible elongate tubular member and are adapted to be connected to the power supply to supply energy to the heater.

    Low profile balloon-on-a-wire catheter with shapeable and/or deflectable tip and method
    9.
    发明授权
    Low profile balloon-on-a-wire catheter with shapeable and/or deflectable tip and method 失效
    薄型气球在线导管，具有可塑和/或可偏转的尖端和方法

    公开(公告)号：US5779688A

    公开(公告)日：1998-07-14

    申请号：US504927

    申请日：1995-07-20

    申请人： Mir A. Imran ,  Cecily M. Hillsman ,  Deepak R. Gandhi ,  Dennis L. Brooks

    发明人： Mir A. Imran ,  Cecily M. Hillsman ,  Deepak R. Gandhi ,  Dennis L. Brooks

    IPC分类号： A61M25/00 ,  A61M25/01 ,  A61M29/02

    CPC分类号： A61M25/0158 ,  A61M25/0097 ,  A61M25/104 ,  A61M2025/0186 ,  A61M2025/1079 ,  A61M2025/1093

    摘要： A low profile, balloon-on-a-wire catheter comprising a flexible elongate tubular member having proximal and distal extremities. A balloon inflation-deflation lumen extends from the proximal extremity to the distal extremity. An inflatable balloon is carried by the distal extremity of the flexible elongate tubular member. The flexible elongate tubular member carries means which establishes communication between the lumen and the interior of the inflatable balloon. A removable inflation device is removably secured to the proximal extremity of the flexible elongate tubular member for supplying an inflation fluid to the lumen for inflating and deflating the balloon. The removable inflation device forms a high pressure seal with the proximal extremity of the flexible elongate tubular member. The removable inflation device is free of obstructions so that another balloon catheter can be advanced over the proximal extremity of the flexible elongate tubular member which serves as a stand-alone guide wire. The distal extremity of the catheter is formed so that it is mechanically shapeable or can be electrically deflectable to facilitate steering of the distal extremity.

    摘要翻译： 一种薄型气球在线导管，其包括具有近端和远端的柔性细长管状构件。 气球充气 - 通气腔从近端延伸到远端。 可膨胀气囊由柔性细长管状构件的远端承载。 柔性细长管状构件承载建立管腔和可充气气囊内部之间的连通的装置。 可移除的充气装置可移除地固定到柔性细长管状构件的近端，用于向腔内供应充气流体以使气囊膨胀和放气。 可移除的充气装置与柔性细长管状构件的近端形成高压密封。 可移除的充气装置没有障碍物，使得另一个气囊导管可以在用作独立导丝的柔性细长管状构件的近端上前进。 导管的远端被形成为使得其可机械地成形或可以电可偏转以便于远端的转向。