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1.发明授权公开(公告)号：US07060847B2
公开(公告)日：2006-06-13
申请号：US10622254
申请日：2003-07-18
申请人： Mitali Ghoshal , Gerald F. Sigler , Richard Terry Root , Anlonga Ouyang , Salvatore J. Salamone
发明人： Mitali Ghoshal , Gerald F. Sigler , Richard Terry Root , Anlonga Ouyang , Salvatore J. Salamone
IPC分类号： C07D317/46
CPC分类号： C07D317/46 , A61K39/0005 , C07K16/44 , G01N33/946 , Y02P20/55 , Y10S530/809
摘要： The present invention comprises novel analogs of ecstasy-class compounds and novel ecstasy-class immunogens leashed out of, i.e., derived from, the methylenedioxy position. The invention also comprises unique monoclonal antibodies generated using MDO-leashed MDMA immunogens as well as unique conjugates and tracers. These antibodies, conjugates, and tracers are useful in immunoassays for the detection of ecstasy-class compounds in biological fluids.
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2.发明授权Ecstasy-class derivatives, immunogens, and antibodies and their use in detecting ecstasy-class drugs 失效迷魂药类衍生物，免疫原和抗体及其在检测狂喜药物中的应用公开(公告)号：US07569676B2
公开(公告)日：2009-08-04
申请号：US11076569
申请日：2005-03-09
申请人： Mitali Ghoshal , Gerald F. Sigler , Richard Terry Root , Anlonga Ouyang , Salvatore J. Salamone
发明人： Mitali Ghoshal , Gerald F. Sigler , Richard Terry Root , Anlonga Ouyang , Salvatore J. Salamone
CPC分类号： C07D317/46 , A61K39/0005 , C07K16/44 , G01N33/946 , Y02P20/55 , Y10S530/809
摘要： The present invention comprises novel analogs of ecstasy-class compounds and novel ecstasy-class immunogens leashed out of, i.e., derived from, the methylenedioxy position. The invention also comprises unique monoclonal antibodies generated using MDO-leashed MDMA immunogens as well as unique conjugates and tracers. These antibodies, conjugates, and tracers are useful in immunoassays for the detection of ecstasy-class compounds in biological fluids.
摘要翻译： 本发明包括狂喜类化合物的新类似物和从亚甲二氧基位置衍生出的新的狂喜类免疫原。 本发明还包括使用MDO引发的MDMA免疫原产生的独特的单克隆抗体以及独特的缀合物和示踪物。 这些抗体，缀合物和示踪剂可用于免疫测定中用于检测生物液体中摇头丸类化合物。
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公开(公告)号：US07482437B2
公开(公告)日：2009-01-27
申请号：US11670467
申请日：2007-02-02
申请人： Gerald F. Sigler , Raymond A. Hui , Ina Deras , Richard Terry Root , Mitali Ghoshal , Erasmus Huber , Herbert W. Von Der Eltz , Sigrun Metz , Peter Kern
发明人： Gerald F. Sigler , Raymond A. Hui , Ina Deras , Richard Terry Root , Mitali Ghoshal , Erasmus Huber , Herbert W. Von Der Eltz , Sigrun Metz , Peter Kern
IPC分类号： C07K17/06 , C07K1/10 , C07K16/00 , C07D403/02 , C07D241/04
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
摘要翻译： 可用于产生HIV蛋白酶抑制剂的免疫原的活化的半抗原，可用于产生HIV蛋白酶抑制剂的抗体的免疫原，以及可用于HIV蛋白酶抑制剂沙奎那韦的免疫测定的抗体和标记的缀合物。 新型半抗原在中心非末端羟基处具有活化的功能。 还描述了与洛匹那韦，奈非那韦，安仁那韦，利托那韦和茚地那韦具有小于10％交叉反应性的沙奎那韦特异性单克隆抗体，以及产生所述抗体的鼠杂交瘤。
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公开(公告)号：US07465797B2
公开(公告)日：2008-12-16
申请号：US11683496
申请日：2007-03-08
IPC分类号： C07D489/00 , C07K1/00
CPC分类号： C07D489/02 , A61K47/542 , A61K47/646 , C07K16/44 , Y10S530/807
摘要： Analogs of 6-monoacetyl morphine (6-MAM) are described. These include analogs derivatized at either the C-3 position, the C-6 position, or the nor position of the molecule. These analogs allow for elaboration with linkers terminated by a functional group such as an activated ester, the functional groups being useful for attaching the molecule to other entities such as proteins, polysaccharides, and reporter groups.
摘要翻译： 描述了6-单乙酰吗啡（6-MAM）的类似物。 这些包括在分子的C-3位，C-6位或非位置衍生的类似物。 这些类似物允许用官能团如活化酯终止的接头进行阐述，所述官能团可用于将分子连接到其它实体如蛋白质，多糖和报告基团。
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公开(公告)号：US07193065B2
公开(公告)日：2007-03-20
申请号：US10669831
申请日：2003-09-24
申请人： Gerald F. Sigler , Raymond A. Hui , Ina Deras , Richard Terry Root , Mitali Ghoshal , Erasmus Huber , Herbert W. Von Der Eltz , Sigrun Metz , Peter Kern
发明人： Gerald F. Sigler , Raymond A. Hui , Ina Deras , Richard Terry Root , Mitali Ghoshal , Erasmus Huber , Herbert W. Von Der Eltz , Sigrun Metz , Peter Kern
IPC分类号： C07K16/44 , C07K17/06 , C07D239/10 , G01N33/532 , G01N33/533
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for HIV protease inhibitors. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group common to all HIV protease inhibitors, e.g., saquinavir, nelfinavir, indinavir, amprenavir, ritonavir, lopinavir, and atazanavir.
摘要翻译： 可用于产生HIV蛋白酶抑制剂免疫原的活化半抗原，可用于产生HIV蛋白酶抑制剂抗体的免疫原，以及可用于HIV蛋白酶抑制剂免疫测定的抗体和标记的缀合物。 所述新型半抗原在所有HIV蛋白酶抑制剂（例如沙奎那韦，奈非那韦，茚地那韦，安格那韦，利托那韦，洛匹那韦和阿扎那韦）共同的中心非末端羟基上具有活化的功能。
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公开(公告)号：US07238791B1
公开(公告)日：2007-07-03
申请号：US11303903
申请日：2005-12-16
申请人： Mitali Ghoshal , Gerald F. Sigler
发明人： Mitali Ghoshal , Gerald F. Sigler
IPC分类号： C07K1/00
CPC分类号： C07D489/02 , A61K47/542 , A61K47/646 , C07K16/44 , Y10S530/807
摘要： Analogs of 6-monoacetyl morphine (6-MAM) are described. These include analogs derivatized at either the C-3 position, the C-6 position, or the nor position of the molecule. These analogs allow for elaboration with linkers terminated by a functional group such as an activated ester, the functional groups being useful for attaching the molecule to other entities such as proteins, polysaccharides, and reporter groups.
摘要翻译： 描述了6-单乙酰吗啡（6-MAM）的类似物。 这些包括在分子的C-3位，C-6位或非位置衍生的类似物。 这些类似物允许用官能团如活化酯终止的接头进行阐述，所述官能团可用于将分子连接到其它实体如蛋白质，多糖和报告基团。
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公开(公告)号：US07157560B2
公开(公告)日：2007-01-02
申请号：US10197721
申请日：2002-07-18
CPC分类号： C07D457/06 , C07K16/44 , G01N33/946 , Y10S436/815 , Y10S436/901 , Y10T436/13
摘要： The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the present invention, the 2-oxy LSD nucleus is derivatized out of the indole nitrogen to form an aminoalkyl derivative. The resulting haptens can then be further modified at this functionalized position for linking to appropriate immunogenic or labeling groups to provide reagents for immunoassays having substantially equal specificity for both LSD and 2-oxo-3-hydroxy-LSD.
摘要翻译： 本发明提供了可用于制备用于免疫测定用于检测LSD和2-氧代-3-羟基LSD的抗原，抗体和试剂的半抗原衍生物。 在本发明中，将2-氧基LSD核从吲哚氮中衍生出氨基烷基衍生物。 然后可以在该官能化位置进一步修饰所得的半抗原，以连接到合适的免疫原性或标记基团，以提供对LSD和2-氧代-3-羟基-LDD具有基本相同特异性的免疫测定试剂。
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公开(公告)号：US06794496B2
公开(公告)日：2004-09-21
申请号：US09733534
申请日：2000-12-08
IPC分类号： C07K1706
CPC分类号： C07D457/06 , C07K16/44 , G01N33/946 , Y10S436/815 , Y10S436/901 , Y10T436/13
摘要： The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the present invention, the 2-oxy LSD nucleus is derivatized out of the indole nitrogen to form an aminoalkyl derivative. The resulting haptens can then be further modified at this functionalized position for linking to appropriate immunogenic or labeling groups to provide reagents for immunoassays having substantially equal specificity for both LSD and 2-oxo-3-hydroxy-LSD.
摘要翻译： 本发明提供了可用于制备用于免疫测定用于检测LSD和2-氧代-3-羟基LSD的抗原，抗体和试剂的半抗原衍生物。 在本发明中，将2-氧基LSD核从吲哚氮中衍生出氨基烷基衍生物。 然后可以在该官能化位置进一步修饰所得的半抗原，以连接到合适的免疫原性或标记基团，以提供对LSD和2-氧代-3-羟基-LDD具有基本相同特异性的免疫测定试剂。
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9.发明申请HOMOGENEOUS DOUBLE RECEPTOR AGGLUTINATION ASSAY FOR IMMUNOSUPPRESSANT DRUGS 审中-公开用于免疫抑制剂的均质双重受体AGAGUTINATION测定公开(公告)号：US20080081379A1
公开(公告)日：2008-04-03
申请号：US11772886
申请日：2007-07-03
申请人： Gerald F. Sigler , Mitali Ghoshal , Shaker Rashid , Yifei Wu , Allan R. Dorn , Jane S.C. Tsai
发明人： Gerald F. Sigler , Mitali Ghoshal , Shaker Rashid , Yifei Wu , Allan R. Dorn , Jane S.C. Tsai
IPC分类号： G01N33/53
CPC分类号： G01N33/9493 , G01N33/54346
摘要： A homogeneous, non-competitive, double receptor agglutination assay for measuring immunosuppressant drugs is described. The assay employs at least two receptors wherein each receptor is specific for a separate binding site on the drug and wherein each receptor is bound to a detection particle. The immunosuppressant drug binds to the receptors and causes particle agglutination, which can be measured and correlated with the presence or amount of immunosuppressant drug in a sample.
摘要翻译： 描述了用于测量免疫抑制剂药物的均匀的，非竞争性的双受体凝集测定法。 该测定使用至少两种受体，其中每种受体对药物上的单独结合位点是特异性的，并且其中每个受体结合到检测颗粒。 免疫抑制剂药物与受体结合并引起颗粒凝集，其可被测量并与样品中免疫抑制剂药物的存在或量相关。
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公开(公告)号：US07566549B2
公开(公告)日：2009-07-28
申请号：US11639707
申请日：2006-12-14
IPC分类号： G01N33/53 , G01N33/532 , G01N33/533 , G01N33/535
CPC分类号： C07D457/06 , C07K16/44 , G01N33/946 , Y10S436/815 , Y10S436/901 , Y10T436/13
摘要： The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the present invention, the 2-oxy LSD nucleus is derivatized out of the indole nitrogen to form an aminoalkyl derivative. The resulting haptens can then be further modified at this functionalized position for linking to appropriate immunogenic or labeling groups to provide reagents for immunoassays having substantially equal specificity for both LSD and 2-oxo-3-hydroxy-LSD.
摘要翻译： 本发明提供了可用于制备用于免疫测定用于检测LSD和2-氧代-3-羟基LSD的抗原，抗体和试剂的半抗原衍生物。 在本发明中，将2-氧基LSD核从吲哚氮中衍生出氨基烷基衍生物。 然后可以在该官能化位置进一步修饰所得的半抗原，以连接到合适的免疫原性或标记基团，以提供对LSD和2-氧代-3-羟基-LDD具有基本相同特异性的免疫测定试剂。
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