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公开(公告)号：US20050009076A1
公开(公告)日：2005-01-13
申请号：US10900447
申请日：2004-07-27
申请人： Mitali Ghoshal , Gerald Sigler , Raymond Hui , Ronald Hawley , Eva Hoess , Erasmus Huber , John Patterson , Salvatore Salamone , Allan Dorn
发明人： Mitali Ghoshal , Gerald Sigler , Raymond Hui , Ronald Hawley , Eva Hoess , Erasmus Huber , John Patterson , Salvatore Salamone , Allan Dorn
IPC分类号： G01N33/531 , C07D307/88 , C07D405/12 , C07D473/08 , C07J19/00 , C07J41/00 , C07J43/00 , G01N33/53 , G01N33/535 , G01N33/573 , G01N33/58 , G01N33/78 , G01N33/94 , C12Q1/68 , C07H15/24 , C07H21/04 , C07J17/00
CPC分类号： C07D405/12 , C07D307/88 , C07D473/08 , C07H15/20 , C07H15/22 , C07H15/24 , C07J17/00 , C07J19/005 , C07J41/0005 , C07J41/0055 , C07J43/003 , G01N33/53 , G01N33/535 , G01N33/5735 , G01N33/581 , G01N33/78 , G01N33/9453 , G01N2333/904
摘要： The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
摘要翻译： 本发明提供了一种用于测量生物样品中分析物的方法，由此使非竞争性抑制剂与配体偶联并用于均匀测定。 分析物可以是药物或药物衍生物，激素，多肽或寡核苷酸。 本发明还提供了可用于进行这种测量的新型化合物，测定试剂和包装的试剂盒。
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公开(公告)号：US20070142631A1
公开(公告)日：2007-06-21
申请号：US11673180
申请日：2007-02-09
申请人： Mitali Ghoshal , Gerald Sigler , Raymond Hui , Ronald Hawley , Eva Hoess , Erasmus Huber , John Patterson , Salvatore Salamone , Allan Dorn
发明人： Mitali Ghoshal , Gerald Sigler , Raymond Hui , Ronald Hawley , Eva Hoess , Erasmus Huber , John Patterson , Salvatore Salamone , Allan Dorn
IPC分类号： C07J17/00 , C07H15/22 , C07D473/04 , C07H15/24 , C07H15/20
CPC分类号： C07D405/12 , C07D307/88 , C07D473/08 , C07H15/20 , C07H15/22 , C07H15/24 , C07J17/00 , C07J19/005 , C07J41/0005 , C07J41/0055 , C07J43/003 , G01N33/53 , G01N33/535 , G01N33/5735 , G01N33/581 , G01N33/78 , G01N33/9453 , G01N2333/904
摘要： The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
摘要翻译： 本发明提供了一种用于测量生物样品中分析物的方法，由此使非竞争性抑制剂与配体偶联并用于均匀测定。 分析物可以是药物或药物衍生物，激素，多肽或寡核苷酸。 本发明还提供了可用于进行这种测量的新型化合物，测定试剂和包装的试剂盒。
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公开(公告)号：US20070155959A1
公开(公告)日：2007-07-05
申请号：US11669397
申请日：2007-01-31
申请人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
发明人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
IPC分类号： C07K16/00
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
摘要翻译： 可用于产生HIV蛋白酶抑制剂的免疫原的活化的半抗原，可用于产生HIV蛋白酶抑制剂的抗体的免疫原，以及可用于HIV蛋白酶抑制剂沙奎那韦的免疫测定的抗体和标记的缀合物。 新型半抗原在中心非末端羟基处具有活化的功能。 还描述了与洛匹那韦，奈非那韦，安仁那韦，利托那韦和茚地那韦具有小于10％交叉反应性的沙奎那韦特异性单克隆抗体，以及产生所述抗体的鼠杂交瘤。
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公开(公告)号：US20070148708A1
公开(公告)日：2007-06-28
申请号：US11669200
申请日：2007-01-31
申请人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
发明人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavor. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
摘要翻译： 用于产生HIV蛋白酶抑制剂的免疫原的活化的半抗原，可用于产生HIV蛋白酶抑制剂的抗体的免疫原，以及可用于HIV蛋白酶抑制剂saquinavor免疫测定的抗体和标记的缀合物。 新型半抗原在中心非末端羟基处具有活化的功能。 还描述了与洛匹那韦，奈非那韦，安仁那韦，利托那韦和茚地那韦具有小于10％交叉反应性的沙奎那韦特异性单克隆抗体，以及产生所述抗体的鼠杂交瘤。
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公开(公告)号：US20070141643A1
公开(公告)日：2007-06-21
申请号：US11670467
申请日：2007-02-02
申请人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
发明人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
IPC分类号： G01N33/53 , C07D403/02 , C12N5/06
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
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6.发明申请公开(公告)号：US20060264618A1
公开(公告)日：2006-11-23
申请号：US11420497
申请日：2006-05-26
申请人： Ina Deras , Gerald Sigler , Raymond Hui , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
发明人： Ina Deras , Gerald Sigler , Raymond Hui , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
摘要： Monoclonal antibodies specific for lopinavir having less than 10% cross-reactivity with saquinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies are described.
摘要翻译： 描述了与沙奎那韦，奈非那韦，安仁那韦，利托那韦和茚地那韦具有小于10％交叉反应性的洛匹那韦特异性单克隆抗体，以及产生所述抗体的鼠杂交瘤。
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公开(公告)号：US20070149565A1
公开(公告)日：2007-06-28
申请号：US11627572
申请日：2007-01-26
申请人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
发明人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
IPC分类号： A61K31/47
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
摘要翻译： 可用于产生HIV蛋白酶抑制剂的免疫原的活化的半抗原，可用于产生HIV蛋白酶抑制剂的抗体的免疫原，以及可用于HIV蛋白酶抑制剂沙奎那韦的免疫测定的抗体和标记的缀合物。 新型半抗原在中心非末端羟基处具有活化的功能。 还描述了与洛匹那韦，奈非那韦，安仁那韦，利托那韦和茚地那韦具有小于10％交叉反应性的沙奎那韦特异性单克隆抗体，以及产生所述抗体的鼠杂交瘤。
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8.发明申请公开(公告)号：US20080021201A1
公开(公告)日：2008-01-24
申请号：US11670005
申请日：2007-02-01
申请人： Gerald Sigler , Raymond Hui , Ina Deras , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
发明人： Gerald Sigler , Raymond Hui , Ina Deras , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
IPC分类号： C07K16/44 , C07D235/02 , C07D307/12 , C07D405/02 , C12N5/18 , C08B37/02 , C07K14/47 , C07K14/765
摘要： Activated haptens useful for generating immunogen to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
摘要翻译： 可用于产生HIV蛋白酶抑制剂免疫原的活化半抗原，可用于产生HIV蛋白酶抑制剂抗体的免疫原，以及可用于HIV蛋白酶抑制剂沙奎那韦免疫测定的抗体和标记共轭物。 新型半抗原在中心非末端羟基处具有活化的功能。 还描述了与洛匹那韦，奈非那韦，安仁那韦，利托那韦和茚地那韦具有小于10％交叉反应性的沙奎那韦特异性单克隆抗体，以及产生所述抗体的鼠杂交瘤。
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公开(公告)号：US20060211107A1
公开(公告)日：2006-09-21
申请号：US11420502
申请日：2006-05-26
申请人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Erasmus Huber , Herbert Von Der Eltz
发明人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Erasmus Huber , Herbert Von Der Eltz
IPC分类号： C12N5/06 , C07K16/18 , C07D417/02
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
摘要翻译： 可用于产生HIV蛋白酶抑制剂免疫原的活化的半抗原，可用于产生HIV蛋白酶抑制剂的抗体的免疫原，以及可用于HIV蛋白酶抑制剂沙奎那韦免疫测定的抗体和标记的缀合物。 新型半抗原在中心非末端羟基处具有活化的功能。 还描述了与洛匹那韦，奈非那韦，安仁那韦，利托那韦和茚地那韦具有小于10％交叉反应性的沙奎那韦特异性单克隆抗体，以及产生所述抗体的鼠杂交瘤。
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公开(公告)号：US20090215993A1
公开(公告)日：2009-08-27
申请号：US12257704
申请日：2008-10-24
申请人： Mitali Ghoshal , Raymond Hui , Shaker Rashid
发明人： Mitali Ghoshal , Raymond Hui , Shaker Rashid
IPC分类号： C07K16/44 , C07K14/765 , C07D405/12 , C07K14/47
CPC分类号： C07D307/88
摘要： Described are immunogenic compounds useful for generation of antibodies which are highly specific for mycophenolic acid which do not react or have substantially no cross-reactivity with the glucuronide metabolites of mycophenolic acid, especially the acyl-glucuronide metabolite.
摘要翻译： 描述了可用于产生对麦考酚酸具有高度特异性的抗体的免疫原性化合物，其不与麦考酚酸，特别是酰基 - 葡糖苷酸代谢物的葡糖苷酸代谢物反应或基本上不具有交叉反应性。
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