公开(公告)号：US20230338506A1

公开(公告)日：2023-10-26

申请号：US17796401

申请日：2021-01-29

Applicant: ModernaTX, Inc.

Inventor： Christine Shaw ,  Guillaume Stewart-Jones ,  Elisabeth Narayanan ,  Vladimir Presnyak ,  Sayda Mahgoub Elbashir

IPC: A61K39/275 ,  A61K9/127 ,  C12N15/86 ,  A61K39/155 ,  A61P31/14 ,  C07K14/005

CPC classification number: A61K39/155 ,  A61K9/1271 ,  A61K39/275 ,  A61P31/14 ,  C07K14/005 ,  C12N15/86 ,  A61K2039/53

Abstract: The disclosure relates to respiratory virus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US11911453B2

公开(公告)日：2024-02-27

申请号：US16965589

申请日：2019-01-28

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Kapil Bahl ,  Amy Espeseth ,  Andrew J. Bett ,  Pedro Cejas ,  Lan Zhang ,  Christine Shaw

IPC: A61K39/12 ,  A61K9/00 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K9/0019 ,  A61K2039/53 ,  A61K2039/55555

Abstract: The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines. The vaccine can be formulated in a lipid nanoparticle.

公开(公告)号：US11351242B1

公开(公告)日：2022-06-07

申请号：US16788182

申请日：2020-02-11

Applicant: ModernaTX, Inc.

Inventor： Lori Panther ,  Christine Shaw ,  Igor Smolenov ,  Michael Watson ,  Tal Zaks

IPC: A61K39/12 ,  A61K9/51 ,  A61K39/00

Abstract: Provided herein are vaccine composition comprising a chemically-modified messenger ribonucleic acid (mRNA) encoding a hMPV fusion (F) glycoprotein and a chemically-modified mRNA encoding a hPIV3 F glycoprotein formulated in a cationic lipid nanoparticle formulation, and related method for inducing an antigen-specific immune response.

公开(公告)号：US20240299525A1

公开(公告)日：2024-09-12

申请号：US18418127

申请日：2024-01-19

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Kapil Bahl ,  Amy Espeseth ,  Andrew J. Bett ,  Pedro Cejas ,  Lan Zhang ,  Christine Shaw

IPC: A61K39/12 ,  A61K9/00 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K9/0019 ,  A61K2039/53 ,  A61K2039/55555

Abstract: The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines. The vaccine can be formulated in a lipid nanoparticle.

公开(公告)号：US20220378904A1

公开(公告)日：2022-12-01

申请号：US17737581

申请日：2022-05-05

Applicant: ModernaTX, Inc.

Inventor： Lori Panther ,  Christine Shaw ,  Igor Smolenov ,  Michael Watson ,  Tal Zaks

IPC: A61K39/12 ,  A61K9/51

Abstract: Provided herein are vaccine composition comprising a chemically-modified messenger ribonucleic acid (mRNA) encoding a hMPV fusion (F) glycoprotein and a chemically-modified mRNA encoding a hPIV3 F glycoprotein formulated in a cationic lipid nanoparticle formulation, and related method for inducing an antigen-specific immune response.

公开(公告)号：US20210046173A1

公开(公告)日：2021-02-18

申请号：US16965589

申请日：2019-01-28

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Kapil Bahl ,  Amy Espeseth ,  Andrew J. Bett ,  Pedro Cejas ,  Lan Zhang ,  Christine Shaw

IPC: A61K39/12

Abstract: The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines. The vaccine can be formulated in a lipid nanoparticle.