公开(公告)号：US12070495B2

公开(公告)日：2024-08-27

申请号：US17439198

申请日：2020-03-13

Applicant: ModernaTX, Inc. ,  The United States of America, as represented by the Department of Health and Human Services

Inventor： Paolo Lusso ,  Peng Zhang ,  Elisabeth Narayanan ,  Sayda Mahgoub Elbashir

IPC: A61K39/21 ,  A61K39/39 ,  A61K39/00

CPC classification number: A61K39/21 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/6018

Abstract: Provided herein are methods and compositions for inducing in a subject abroad neutralizing antibody response to human immunodeficiency virus (HIV) infection.

公开(公告)号：US20230338506A1

公开(公告)日：2023-10-26

申请号：US17796401

申请日：2021-01-29

Applicant: ModernaTX, Inc.

Inventor： Christine Shaw ,  Guillaume Stewart-Jones ,  Elisabeth Narayanan ,  Vladimir Presnyak ,  Sayda Mahgoub Elbashir

IPC: A61K39/275 ,  A61K9/127 ,  C12N15/86 ,  A61K39/155 ,  A61P31/14 ,  C07K14/005

CPC classification number: A61K39/155 ,  A61K9/1271 ,  A61K39/275 ,  A61P31/14 ,  C07K14/005 ,  C12N15/86 ,  A61K2039/53

Abstract: The disclosure relates to respiratory virus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20190192646A1

公开(公告)日：2019-06-27

申请号：US16180076

申请日：2018-11-05

Applicant: ModernaTX, Inc.

Inventor： Nadia Cohen ,  Marie-Angele Andjoua Messou ,  Samantha Calabrese ,  Elisabeth Narayanan

IPC: A61K39/112 ,  A61P31/04 ,  C07K14/255 ,  A61K9/51 ,  A61K9/00

CPC classification number: A61K39/0275 ,  A61K9/0019 ,  A61K9/5123 ,  A61K9/5146 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/575 ,  A61K2039/6018 ,  A61K2039/6093 ,  A61K2039/70 ,  A61P31/04 ,  C07K14/255 ,  C07K2319/02

Abstract: The disclosure relates to Salmonella ribonucleic acid vaccines as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20240181030A1

公开(公告)日：2024-06-06

申请号：US18552346

申请日：2022-03-25

Applicant: ModernaTX, Inc.

Inventor： Sunny Himansu ,  Elisabeth Narayanan ,  Andrea Carfi

IPC: A61K39/02 ,  A61K9/51 ,  A61K39/00 ,  A61K39/116 ,  A61K47/60 ,  A61P37/04

CPC classification number: A61K39/099 ,  A61K9/5123 ,  A61K39/0016 ,  A61K39/116 ,  A61K47/60 ,  A61P37/04 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/575 ,  A61K2039/70

Abstract: The disclosure relates to pertussis nucleic acid vaccines, diphtheria nucleic acid vaccines, tetanus nucleic acid vaccines, and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20250073327A1

公开(公告)日：2025-03-06

申请号：US18771978

申请日：2024-07-12

Applicant: ModernaTX, Inc. ,  The United States of America, as represented by the Department of Health and Human Services

Inventor： Paolo Lusso ,  Peng Zhang ,  Elisabeth Narayanan ,  Sayda Mahgoub Elbashir

IPC: A61K39/21 ,  A61K39/00 ,  A61K39/39

Abstract: Provided herein are methods and compositions for inducing in a subject a broad neutralizing antibody response to human immunodeficiency virus (HIV) infection.

公开(公告)号：US20240216500A1

公开(公告)日：2024-07-04

申请号：US18555087

申请日：2022-04-12

Applicant: ModernaTX, Inc.

Inventor： Raffael Nachbagauer ,  Carole Henry ,  Guillaume Stewart-Jones ,  Elisabeth Narayanan ,  Hamilton Bennett ,  Andrea Carfi

IPC: A61K39/145 ,  A61K39/00 ,  A61K39/155 ,  A61K39/215 ,  A61P31/16 ,  C12N7/00

CPC classification number: A61K39/145 ,  A61K39/155 ,  A61K39/215 ,  A61P31/16 ,  C12N7/00 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/55555 ,  A61K2039/70 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16234 ,  C12N2760/16251 ,  C12N2760/18334 ,  C12N2760/18351 ,  C12N2760/18534 ,  C12N2760/18551 ,  C12N2770/20034 ,  C12N2770/20051

Abstract: The disclosure provides combination mRNA vaccines for respiratory viruses, as well as methods of using the vaccines.

公开(公告)号：US20200282047A1

公开(公告)日：2020-09-10

申请号：US16765285

申请日：2018-11-20

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Shinu John ,  Elisabeth Narayanan ,  Brooke Bollman

IPC: A61K39/245 ,  C12N7/00 ,  A61K9/51 ,  A61K9/00

Abstract: The disclosure relates to EBV ribonucleic acid vaccines as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20200038499A1

公开(公告)日：2020-02-06

申请号：US16496135

申请日：2018-03-22

Applicant: ModernaTX, Inc.

Inventor： Elisabeth Narayanan ,  Nadia Cohen ,  Giuseppe Ciaramella

IPC: A61K39/09

Abstract: The disclosure relates to (i) a bacterial vaccine, comprising: at least one RNA polynucleotide having an open reading frame encoding at least one mutated bacterial antigenic polypeptide, wherein the mutated bacterial antigenic polypeptide comprises at least one asparagine (Asn) amino acid substitution; and (ii) a Streptococcal vaccine, comprising: at least one RNA polynucleotide having an open reading frame encoding at least one Streptococcal antigenic polypeptide, such as pneumolysin. Incorporating the RNA in a cationic lipid nanoparticle and a method of inducing an immune response with said vaccine are also disclosed.