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公开(公告)号：US10047126B2
公开(公告)日：2018-08-14
申请号：US15301310
申请日：2015-04-01
Applicant: Monash University
Inventor： Jian Li , Roger Nation , Tony Velkov , Philip Thompson , Kade D. Roberts
Abstract: The present invention relates to antimicrobial compounds and their uses, and in particular to peptide antibiotics which may be used in the treatment of bacterial infections such as Gram-negative bacterial infections, particularly those caused by multidrug-resistant (MDR) pathogens.
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公开(公告)号：US11306066B2
公开(公告)日：2022-04-19
申请号：US15572554
申请日：2016-05-06
Applicant: Monash University , The Florey Institute of Neuroscience and Mental Health , St. Vincent's Institute of Medical Research
Inventor： Siew Yeen Chai , Philip Thompson , Simon Mountford , Michael W. Parker
IPC: A61K31/351 , A61K31/352 , A61K31/35 , C07D309/32 , C07D311/74 , C07D311/02 , C07D311/00 , A61P25/28 , C07D405/04 , C07D405/10 , C07D493/04 , C07D407/10 , C07D409/10
Abstract: The present disclosure relates generally, but not exclusively, to compounds and their use in therapy, to compositions and agents comprising said compounds, to methods of treatment using said compounds, and their use in the manufacture of medicaments. The disclosure further relates to inhibitors of IRAP and their use in the treatment or prevention of Alzheimer's disease and the treatment and prevention of memory and cognitive disorders.
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公开(公告)号：USRE48335E1
公开(公告)日：2020-12-01
申请号：US16144967
申请日：2018-09-27
Applicant: Monash University
Inventor： Jian Li , Roger Nation , Tony Velkov , Philip Thompson , Kade D. Roberts
Abstract: The present invention relates to antimicrobial compounds and their uses, and in particular to peptide antibiotics which may be used in the treatment of bacterial infections such as Gram-negative bacterial infections, particularly those caused by multidrug-resistant (MDR) pathogens.
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