公开(公告)号：US11744250B2

公开(公告)日：2023-09-05

申请号：US17559857

申请日：2021-12-22

Applicant: Monsanto Technology LLC

Inventor： David J. Bowen ,  Catherine A. Chay ,  Arlene R. Howe ,  Jason S. Milligan ,  Christina M. Taylor ,  Monika R. VanGordon ,  Kimberly M. Wegener ,  Brian E. Weiner

IPC: A01N63/50 ,  A01P7/04 ,  C07K14/32 ,  C12N15/82 ,  C12Q1/6895 ,  G01N33/68

CPC classification number: A01N63/50 ,  A01P7/04 ,  C07K14/32 ,  C12N15/8286 ,  C12Q1/6895 ,  G01N33/68 ,  C12Q2600/13

Abstract: Pesticidal proteins exhibiting inhibitory, suppressive, and toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC4064 and TIC4064 amino acid sequence variants. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC4064 and TIC4064 amino acid sequence variant pesticidal proteins are also provided.

公开(公告)号：US20170029844A1

公开(公告)日：2017-02-02

申请号：US15217695

申请日：2016-07-22

Applicant: Monsanto Technology LLC

Inventor： Timothy K. Ball ,  Artem G. Evdokimov ,  Larry A. Gilbertson ,  Victor M. Guzov ,  Jeffrey A. Haas ,  Qing Huai ,  Sergey Ivashuta ,  Melissa M. Kemp ,  Yifei Kong ,  Thomas M. Malvar ,  Byron V. Olsen ,  Parthasarathy Ramaseshadri ,  Brian E. Weiner

IPC: C12N15/82 ,  A01N37/44

CPC classification number: C12N15/8286 ,  A01N37/44 ,  A01N37/46 ,  C07K14/325 ,  Y02A40/162

Abstract: Pesticidal proteins are provided that combine two or more modes of action into a single molecule. These pesticidal proteins therefor exhibit greater efficacy and/or durability of resistance, for the purposes of pest control, and can be utilized for pest control by provision in the diet of a pest organism, or by topical application to crop plants and/or pests. Methods and compositions for producing and using such proteins are also provided.

Abstract translation: 提供了将两种或多种作用模式组合成单个分子的杀虫蛋白质。 这些杀虫蛋白为了有害生物控制的目的而具有较高的抗性和/或耐久性，并且可以通过在有害生物的饮食中提供病虫害防治，或通过局部应用于作物植物和/或害虫来利用。 还提供了用于生产和使用这些蛋白质的方法和组合物。

公开(公告)号：US20240117374A1

公开(公告)日：2024-04-11

申请号：US18497825

申请日：2023-10-30

Applicant: Monsanto Technology LLC

Inventor： Timothy K. Ball ,  Artem G. Evdokimov ,  Larry A. Gilbertson ,  Victor M. Guzov ,  Jeffrey A. Haas ,  Qing Huai ,  Sergey Ivashuta ,  Melissa M. Kemp ,  Yifei Kong ,  Thomas M. Malvar ,  Byron V. Olsen ,  Parthasarathy Ramaseshadri ,  Brian E. Weiner

IPC: C12N15/82 ,  A01N37/44 ,  A01N37/46 ,  C07K14/325

CPC classification number: C12N15/8286 ,  A01N37/44 ,  A01N37/46 ,  C07K14/325 ,  Y02A40/146

Abstract: Pesticidal proteins are provided that combine two or more modes of action into a single molecule. These pesticidal proteins therefor exhibit greater efficacy and/or durability of resistance, for the purposes of pest control, and can be utilized for pest control by provision in the diet of a pest organism, or by topical application to crop plants and/or pests. Methods and compositions for producing and using such proteins are also provided.

公开(公告)号：US11825850B2

公开(公告)日：2023-11-28

申请号：US17556428

申请日：2021-12-20

Applicant: Monsanto Technology LLC

Inventor： David J. Bowen ,  Catherine A. Chay ,  Arlene R. Howe ,  Matthew S. Marengo ,  Jason Meyer ,  Jason S Milligan ,  Brian E. Weiner

IPC: A01N63/50 ,  C07K14/32 ,  C12N15/82 ,  C12Q1/68 ,  C07K14/325 ,  C12Q1/6895

CPC classification number: A01N63/50 ,  C07K14/325 ,  C12N15/8286 ,  C12Q1/6895

Abstract: Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC4029, TIC4029_1, and TIC4029_8. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding pesticidal proteins of the TIC4029 class. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the TIC4029 class in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC4029, TIC4029_1, and TIC4029_8 pesticidal proteins are also provided.

公开(公告)号：US20230301308A1

公开(公告)日：2023-09-28

申请号：US18176410

申请日：2023-02-28

Applicant: Monsanto Technology LLC

Inventor： David J. Bowen ,  Catherine A. Chay ,  Arlene R. Howe ,  Jason S. Milligan ,  Christina M. Taylor ,  Monika R. VanGordon ,  Kimberly M. Wegener ,  Brian E. Weiner

IPC: A01N63/50 ,  C12N15/82 ,  C12Q1/6895 ,  C07K14/32 ,  A01P7/04 ,  G01N33/68

CPC classification number: A01N63/50 ,  C12N15/8286 ,  C12Q1/6895 ,  C07K14/32 ,  A01P7/04 ,  G01N33/68 ,  C12Q2600/13

Abstract: Pesticidal proteins exhibiting inhibitory, suppressive, and toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC4064 and TIC4064 amino acid sequence variants. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC4064 and TIC4064 amino acid sequence variant pesticidal proteins are also provided.

公开(公告)号：US20220256863A1

公开(公告)日：2022-08-18

申请号：US17556428

申请日：2021-12-20

Applicant: Monsanto Technology LLC

Inventor： David J. Bowen ,  Catherine A. Chay ,  Arlene R. Howe ,  Matthew S. Marengo ,  Jason Meyer ,  Jason S. Milligan ,  Brian E. Weiner

IPC: A01N63/50 ,  C07K14/325 ,  C12Q1/6895 ,  C12N15/82

Abstract: Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC4029, TIC4029_1, and TIC4029_8. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding pesticidal proteins of the TIC4029 class. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the TIC4029 class in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC4029, TIC4029_1, and TIC4029_8 pesticidal proteins are also provided.

公开(公告)号：US11840700B2

公开(公告)日：2023-12-12

申请号：US15217695

申请日：2016-07-22

Applicant: Monsanto Technology LLC

Inventor： Timothy K. Ball ,  Artem G. Evdokimov ,  Larry A. Gilbertson ,  Victor M. Guzov ,  Jeffrey A. Haas ,  Qing Huai ,  Sergey Ivashuta ,  Melissa M. Kemp ,  Yifei Kong ,  Thomas M. Malvar ,  Byron V. Olsen ,  Parthasarathy Ramaseshadri ,  Brian E. Weiner

IPC: C12N15/82 ,  A01N37/44 ,  C07K14/325 ,  A01N37/46

CPC classification number: C12N15/8286 ,  A01N37/44 ,  A01N37/46 ,  C07K14/325 ,  Y02A40/146

Abstract: Pesticidal proteins are provided that combine two or more modes of action into a single molecule. These pesticidal proteins therefor exhibit greater efficacy and/or durability of resistance, for the purposes of pest control, and can be utilized for pest control by provision in the diet of a pest organism, or by topical application to crop plants and/or pests. Methods and compositions for producing and using such proteins are also provided.

公开(公告)号：US20220192200A1

公开(公告)日：2022-06-23

申请号：US17559857

申请日：2021-12-22

Applicant: Monsanto Technology LLC

Inventor： David J. Bowen ,  Catherine A. Chay ,  Arlene R. Howe ,  Jason S. Milligan ,  Christina M. Taylor ,  Monika R. VanGordon ,  Kimberly M. Wegener ,  Brian E. Weiner

IPC: A01N63/50 ,  C12N15/82 ,  C12Q1/6895 ,  G01N33/68 ,  C07K14/32 ,  A01P7/04

Abstract: Pesticidal proteins exhibiting inhibitory, suppressive, and toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC4064 and TIC4064 amino acid sequence variants. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC4064 and TIC4064 amino acid sequence variant pesticidal proteins are also provided.