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    COMPOSITION FOR IMPROVING TLR-MEDIATED CELLULAR IMMUNITY COMPRISING POLY-GAMMA-GLUTAMIC ACID
    1.
    发明申请
    COMPOSITION FOR IMPROVING TLR-MEDIATED CELLULAR IMMUNITY COMPRISING POLY-GAMMA-GLUTAMIC ACID 审中-公开
    用于改善包含多糖 - 谷氨酸的TLR介导的细胞免疫的组合物

    公开(公告)号：US20100255040A1

    公开(公告)日：2010-10-07

    申请号：US12682662

    申请日：2007-10-15

    申请人： Moon-Hee Sung ,  Chul Joong Kim ,  Haryoung Poo ,  Il Han Lee ,  Yang-Hyun Kim

    发明人： Moon-Hee Sung ,  Chul Joong Kim ,  Haryoung Poo ,  Il Han Lee ,  Yang-Hyun Kim

    IPC分类号： A61K39/00 ,  A61P31/12 ,  A61P31/04 ,  A61P35/00

    CPC分类号： A61K31/765

    摘要： The present invention relates to a composition for improving cellular immunity, which comprises an effective dose of poly-gamma-glutamic acid, and more particularly, to a composition for improving cellular immunity comprising poly-gamma-glutamic acid, which has effects of inducing enhancement of TLR-mediated Th1 cellular immunity and improving antigen presenting activity to maintain the improved activity. The inventive composition comprising an effective dose of poly-gamma-glutamic acid has very little toxicity and side effects, and can be added to a vaccine composition for preventing and treating animal viral or bacterial infections and cancer, or a vaccine composition for preventing and treating human viral or bacterial infections and cancer to show cellular immunity-enhancing effects.

    摘要翻译： 本发明涉及一种用于改善细胞免疫的组合物，其包含有效剂量的聚-γ-谷氨酸，更具体地，涉及包含多聚γ-谷氨酸的组合物，所述组合物具有诱导增强的作用 的TLR介导的Th1细胞免疫并改善抗原呈递活性以维持改善的活性。 包含有效剂量的聚-γ-谷氨酸的本发明组合物具有非常少的毒性和副作用，并且可以加入用于预防和治疗动物病毒或细菌感染和癌症的疫苗组合物或用于预防和治疗的疫苗组合物 人类病毒或细菌感染和癌症显示细胞免疫增强作用。

    COMPOSITION FOR PREVENTING VIRUS INFECTION COMPRISING POLY-GAMMA-GLUTAMIC ACID
    2.
    发明申请
    COMPOSITION FOR PREVENTING VIRUS INFECTION COMPRISING POLY-GAMMA-GLUTAMIC ACID 审中-公开
    用于预防包含多糖 - 谷氨酸的病毒感染的组合物

    公开(公告)号：US20100256050A1

    公开(公告)日：2010-10-07

    申请号：US12678027

    申请日：2007-09-13

    申请人： Moon-Hee Sung ,  Chul Joong Kim ,  Haryoung Poo ,  Young-Ki Choi ,  Il Han Lee ,  Dai-Won Yoo

    发明人： Moon-Hee Sung ,  Chul Joong Kim ,  Haryoung Poo ,  Young-Ki Choi ,  Il Han Lee ,  Dai-Won Yoo

    IPC分类号： A61K38/16 ,  A61P31/12

    CPC分类号： A61K31/785 ,  A61K38/164

    摘要： The present invention relates to a pharmaceutical composition for inhibiting or preventing viral infection, which comprises an effective dose of poly-gamma-glutamic acid (γ-PGA), and more particularly, to a pharmaceutical composition, a functional food, and a feedstuff additive capable of inhibiting viral infection and preventing viral diseases, which comprise poly-gamma-glutamic acid having an infection-inhibiting effect against viruses, such as an influenza virus, inducing respiratory infection or systemic infection, as an effective ingredient.The composition containing poly-gamma-glutamic acid as an effective ingredient according to the present invention, is effective for use as an animal feedstuff additive or a pharmaceutical agent for preventing influenza virus infection and various viral diseases as well as a pharmaceutical composition and a functional food to promote human health.

    摘要翻译： 本发明涉及用于抑制或预防病毒感染的药物组合物，其包含有效剂量的聚-γ-谷氨酸（γ-PGA），更具体地，涉及药物组合物，功能性食品和饲料添加剂 能够抑制病毒感染和预防病毒性疾病，其包含对病毒（例如流感病毒）诱导呼吸道感染或全身感染具有感染抑制作用的聚-γ-谷氨酸作为有效成分。 含有根据本发明的有效成分的聚-γ-谷氨酸的组合物可用作动物饲料添加剂或用于预防流感病毒感染和各种病毒性疾病的药剂以及药物组合物和功能性 食物促进人体健康。

    Composition for preventing virus infection comprising poly-gamma-glutamic acid
    3.
    发明授权
    Composition for preventing virus infection comprising poly-gamma-glutamic acid 有权
    用于预防包含聚-γ-谷氨酸的病毒感染的组合物

    公开(公告)号：US09095605B2

    公开(公告)日：2015-08-04

    申请号：US13234670

    申请日：2011-09-16

    申请人： Moon-Hee Sung ,  Chul Joong Kim ,  Haryoung Poo ,  Young-Ki Choi ,  Il Han Lee ,  Dai-Won Yoo

    发明人： Moon-Hee Sung ,  Chul Joong Kim ,  Haryoung Poo ,  Young-Ki Choi ,  Il Han Lee ,  Dai-Won Yoo

    IPC分类号： A61K38/16 ,  A61K31/785

    CPC分类号： A61K31/785 ,  A61K38/164

    摘要： The present invention relates to a pharmaceutical composition for inhibiting or preventing viral infection, which comprises an effective dose of poly-gamma-glutamic acid (γ-PGA), and more particularly, to a pharmaceutical composition, a functional food, and a feedstuff additive capable of inhibiting viral infection and preventing viral diseases, which comprise poly-gamma-glutamic acid having an infection-inhibiting effect against viruses, such as an influenza virus, inducing respiratory infection or systemic infection, as an effective ingredient.The composition containing poly-gamma-glutamic acid as an effective ingredient according to the present invention, is effective for use as an animal feedstuff additive or a pharmaceutical agent for preventing influenza virus infection and various viral diseases as well as a pharmaceutical composition and a functional food to promote human health.

    摘要翻译： 本发明涉及用于抑制或预防病毒感染的药物组合物，其包含有效剂量的聚-γ-谷氨酸（γ-PGA），更具体地，涉及药物组合物，功能性食品和饲料添加剂 能够抑制病毒感染和预防病毒性疾病，其包含对病毒（例如流感病毒）诱导呼吸道感染或全身感染具有感染抑制作用的聚-γ-谷氨酸作为有效成分。 含有根据本发明的有效成分的聚-γ-谷氨酸的组合物可用作动物饲料添加剂或用于预防流感病毒感染和各种病毒性疾病的药剂以及药物组合物和功能性 食物促进人体健康。

    Constitutive strong promoter and use thereof
    5.
    发明授权
    Constitutive strong promoter and use thereof 有权
    组成型强启动子及其用途

    公开(公告)号：US08236940B2

    公开(公告)日：2012-08-07

    申请号：US12532605

    申请日：2008-03-21

    申请人： Moon Hee Sung ,  Chul Joong Kim ,  Seung-Pyo Hong ,  Haryoung Poo ,  Il Han Lee ,  Ji Yeon Kim ,  Kwang Kim

    发明人： Moon Hee Sung ,  Chul Joong Kim ,  Seung-Pyo Hong ,  Haryoung Poo ,  Il Han Lee ,  Ji Yeon Kim ,  Kwang Kim

    IPC分类号： C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12P21/00

    CPC分类号： C12N15/746 ,  C12N9/1276

    摘要： Disclosed herein are an aldolase gene promoter and the use thereof, more particularly, disclosed are a promoter of aldolase gene derived from Lactobacillus casei, having a base sequence of SEQ ID NO: 1, an expression vector containing said promoter, and a recombinant microorganism transformed with said expression vector. The recombinant microorganism transformed with the expression vector containing the disclosed promoter can effectively express a target protein on the surface thereof, and thus will be useful as vaccine vehicles and the like.

    摘要翻译： 本文公开了醛缩酶基因启动子及其用途，更具体地，公开了源自干酪乳杆菌的醛缩酶基因的启动子，其具有SEQ ID NO：1的碱基序列，含有所述启动子的表达载体和转化的重组微生物 与所述表达载体。 用含有公开的启动子的表达载体转化的重组微生物可以在其表面上有效地表达靶蛋白质，因此可用作疫苗载体等。

    Surface expression vector for fusion protein of Myo-2 peptide multimer and myostatin, and microorganism transformed by thereof
    7.
    发明授权
    Surface expression vector for fusion protein of Myo-2 peptide multimer and myostatin, and microorganism transformed by thereof 有权
    Myo-2肽多聚体和肌生成抑制素融合蛋白的表面表达载体，以及由其转化的微生物

    公开(公告)号：US08470551B2

    公开(公告)日：2013-06-25

    申请号：US12682453

    申请日：2007-11-30

    申请人： Moon-Hee Sung ,  Chul Joong Kim ,  Haryoung Poo ,  Ji Yeon Kim ,  Young Suk Kim ,  Long Chun Xu

    发明人： Moon-Hee Sung ,  Chul Joong Kim ,  Haryoung Poo ,  Ji Yeon Kim ,  Young Suk Kim ,  Long Chun Xu

    IPC分类号： C12N15/09 ,  C12N1/21 ,  C12N15/63 ,  C07K1/00

    CPC分类号： C07K14/475

    摘要： The present invention relates to a fusion protein in which a myostatin mature protein is fused to a multimer of myostatin-derived antigenic peptide Myo-2, a surface expression vector containing a polynucleotide encoding the fusion protein, a recombinant microorganism transformed with the vector, and a feedstuff additive or a pharmaceutical composition containing the microorganism as an effective ingredient. The feedstuff additive or pharmaceutical composition according to the present invention can be used for muscle development and regulation of muscle growth in livestock and poultry, as well as for preventing and treating muscle-wasting diseases and degenerative diseases such as muscular dystrophy, muscular atrophy and the like. In addition, the transformed strain shows the same effect even if the strain itself after culture thereof is directly used, and thus it is very economical.

    摘要翻译： 本发明涉及一种融合蛋白，其中肌生成抑制素成熟蛋白质与产生肌生成抑制素的抗原肽Myo-2的多聚体融合，含有编码融合蛋白的多核苷酸的表面表达载体，用载体转化的重组微生物，以及 饲料添加剂或含有该微生物作为有效成分的药物组合物。 根据本发明的饲料添加剂或药物组合物可用于肌肉发育和调节家畜和家禽中的肌肉生长，以及用于预防和治疗肌肉消瘦疾病和退行性疾病如肌营养不良症，肌肉萎缩症和 喜欢。 此外，即使直接使用其培养后的菌株本身，转化菌株也显示相同的效果，因此是非常经济的。