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    3′-ethynylcytidine derivative
    1.
    发明授权
    3′-ethynylcytidine derivative 失效
    3'-乙炔基胞苷衍生物

    公开(公告)号：US08058261B2

    公开(公告)日：2011-11-15

    申请号：US12375077

    申请日：2007-07-23

    申请人： Motoaki Tanaka ,  Masakazu Fukushima

    发明人： Motoaki Tanaka ,  Masakazu Fukushima

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： C07H19/06

    摘要： To provide a compound which exhibits excellent anti-tumor activity and excellent oral absorption and which is a useful anti-tumor drug.The invention provides a 3′-ethynylcytidine derivative represented by formula (1): (wherein X represents a (substituted) alkylcarbonyl group, a (substituted) alkoxycarbonyl group, or a hydrogen atom; one of Y and Z represents a hydrogen atom or a group represented by (R1)(R2)(R3)Si— and the other represents a group represented by (R4)(R5)(R6)Si—; and R1, R2, R3, R4, R5, and R6 each represent a (substituted) alkyl group, a (substituted) cyclic alkyl group, or a (substituted) aryl group) or a salt thereof.

    摘要翻译： 提供表现出优异的抗肿瘤活性和优异的口服吸收并且是有用的抗肿瘤药物的化合物。 本发明提供由式（1）表示的3'-乙炔基胞苷衍生物：其中X表示（取代）烷基羰基，（取代）烷氧基羰基或氢原子; Y和Z之一表示氢原子或 （R 1）（R 2）（R 3）Si表示的基团，另一个表示由（R 4）（R 5）（R 6）Si - 表示的基团，R 1，R 2，R 3，R 4，R 5和R 6各自表示 （取代的）烷基，（取代的）环烷基或（取代的）芳基）或其盐。

    3'-ETHYNYLCYTIDINE DERIVATIVE
    2.
    发明申请
    3'-ETHYNYLCYTIDINE DERIVATIVE 失效
    3'-乙酰基衍生物

    公开(公告)号：US20090306008A1

    公开(公告)日：2009-12-10

    申请号：US12375077

    申请日：2007-07-23

    申请人： Motoaki Tanaka ,  Masakazu Fukushima

    发明人： Motoaki Tanaka ,  Masakazu Fukushima

    IPC分类号： A61K31/7068 ,  C07H19/067 ,  A61P35/00

    CPC分类号： C07H19/06

    摘要： To provide a compound which exhibits excellent anti-tumor activity and excellent oral absorption and which is a useful anti-tumor drug.The invention provides a 3′-ethynylcytidine derivative represented by formula (1): (wherein X represents a (substituted) alkylcarbonyl group, a (substituted) alkoxycarbonyl group, or a hydrogen atom; one of Y and Z represents a hydrogen atom or a group represented by (R1)(R2)(R3)Si— and the other represents a group represented by (R4)(R5)(R6)Si—; and R1, R2, R3, R4, R5, and R6 each represent a (substituted) alkyl group, a (substituted) cyclic alkyl group, or a (substituted) aryl group) or a salt thereof.

    摘要翻译： 提供表现出优异的抗肿瘤活性和优异的口服吸收并且是有用的抗肿瘤药物的化合物。 本发明提供由式（1）表示的3'-乙炔基胞苷衍生物：其中X表示（取代）烷基羰基，（取代）烷氧基羰基或氢原子; Y和Z之一表示氢原子或 （R 1）（R 2）（R 3）Si表示的基团，另一个表示由（R 4）（R 5）（R 6）Si - 表示的基团，R 1，R 2，R 3，R 4，R 5和R 6各自表示 （取代的）烷基，（取代的）环烷基或（取代的）芳基）或其盐。

    Potentiator for radiation therapy comprising pyridine derivative as active ingredient
    3.
    发明授权
    Potentiator for radiation therapy comprising pyridine derivative as active ingredient 有权
    包括吡啶衍生物作为活性成分的放射治疗剂

    公开(公告)号：US08569324B2

    公开(公告)日：2013-10-29

    申请号：US12978743

    申请日：2010-12-27

    申请人： Masakazu Fukushima

    发明人： Masakazu Fukushima

    IPC分类号： A61K31/435

    CPC分类号： C07D213/69 ,  A61K41/0038

    摘要： The present invention relates to a radiotherapy enhancer that can reduce the radiation dose and adverse drug reactions when used in combination with a cancer radiotherapy. There is provided a radiotherapy enhancer comprising, as an active ingredient, a pyridine derivative represented by general formula (1): wherein R1, R2, and R4 may be the same or different from one another and represent a hydrogen atom, hydroxy group, or protected hydroxy group, excluding the case where R1, R2, and R4 are all a hydrogen atom, and R3 represents a halogen atom, amino group, carboxyl group, carbamoyl group, cyano group, nitro group, alkyl group having 1 to 6 carbon atoms, alkenyl group having 2 to 6 carbon atoms, or carbonyl group containing an alkoxy group having 1 to 6 carbon atoms).

    摘要翻译： 本发明涉及一种放射治疗增强剂，当与癌症放射治疗组合使用时，可以减少放射剂量和不良药物反应。 提供一种放射治疗增强剂，其包含作为活性成分的通式（1）表示的吡啶衍生物：其中R 1，R 2和R 4可以相同或不同，表示氢原子，羟基或 氨基，羧基，氨基甲酰基，氰基，硝基，碳原子数为1〜6的烷基，R 1，R 2，R 4全部为氢原子，R 3表示卤素原子，氨基， 具有2〜6个碳原子的烯基或含有1〜6个碳原子的烷氧基的羰基）。

    Electron gun for television camera tube
    6.
    发明授权
    Electron gun for television camera tube 失效
    电子枪电视摄像机管

    公开(公告)号：US4540916A

    公开(公告)日：1985-09-10

    申请号：US437335

    申请日：1982-10-28

    申请人： Masanori Maruyama ,  Masakazu Fukushima ,  Shinichi Kato ,  Chihaya Ogusu

    发明人： Masanori Maruyama ,  Masakazu Fukushima ,  Shinichi Kato ,  Chihaya Ogusu

    IPC分类号： H01J29/48 ,  H01J29/46 ,  H01J29/56

    CPC分类号： H01J29/488

    摘要： An electron gun for a television camera tube comprises a cathode for emission of electrons, a first grid disposed subsequently to the cathode and having a first aperture supplied with a positive voltage relative to the cathode, a second grid disposed subsequently to the first grid and having a second aperture supplied with a higher positive voltage than that supplied to the first grid, and an intermediate grid interposed between the first and second grids and having a hole. The intermediate grid forms a divergent electron lens near the first aperture between the first and second grids. An electron beam having passed through the first aperture is once diverged by the divergent electron lens to form a crossover at an axial position of the gun which is remote from the first grid and at which the potential on the beam axis is high, whereby broadening of the width of the velocity distribution of extracted electrons can be suppressed to a minimum and the amount of beam current passing through the second aperture can be increased.

    摘要翻译： 一种用于电视摄像机管的电子枪包括用于发射电子的阴极，设置在阴极附近并具有相对于阴极提供正电压的第一孔径的第一栅极，以及随后设置在第一栅极上的第二栅极， 提供具有比提供给第一格栅的正电压高的正电压的第二孔，以及插入在第一栅极和第二栅极之间并具有孔的中间栅格。 中间栅格在第一和第二栅极之间的第一孔附近形成发散电子透镜。 已经通过第一孔的电子束一旦被发散的电子透镜分开，在枪的轴向位置处形成一个与第一格栅远离的轴的交叉点，并且在该轴处的波束轴上的电位高，从而使 提取的电子的速度分布的宽度可以被抑制到最小，并且可以增加通过第二孔径的束流的量。

    POTENTIATOR FOR RADIATION THERAPY COMPRISING PYRIDINE DERIVATIVE AS ACTIVE INGREDIENT
    7.
    发明申请
    POTENTIATOR FOR RADIATION THERAPY COMPRISING PYRIDINE DERIVATIVE AS ACTIVE INGREDIENT 审中-公开
    用于将吡啶衍生物作为活性成分包含的放射治疗的潜在剂

    公开(公告)号：US20090137640A1

    公开(公告)日：2009-05-28

    申请号：US11910150

    申请日：2006-03-31

    申请人： Masakazu Fukushima

    发明人： Masakazu Fukushima

    IPC分类号： A61K31/44 ,  C07D213/69 ,  A61P35/00

    CPC分类号： C07D213/69 ,  A61K41/0038

    摘要： The present invention relates to a radiotherapy enhancer that can reduce the radiation dose and adverse drug reactions when used in combination with a cancer radiotherapy. There is provided a radiotherapy enhancer comprising, as an active ingredient, a pyridine derivative represented by general formula (1): wherein R1, R2, and R4 may be the same or different from one another and represent a hydrogen atom, hydroxy group, or protected hydroxy group, excluding the case where R1, R2, and R4 are all a hydrogen atom, and R3 represents a halogen atom, amino group, carboxyl group, carbamoyl group, cyano group, nitro group, alkyl group having 1 to 6 carbon atoms, alkenyl group having 2 to 6 carbon atoms, or carbonyl group containing an alkoxy group having 1 to 6 carbon atoms).

    摘要翻译： 本发明涉及一种放射治疗增强剂，当与癌症放射治疗组合使用时，可以减少放射剂量和不良药物反应。 提供一种放射治疗增强剂，其包含作为活性成分的通式（1）表示的吡啶衍生物：其中R 1，R 2和R 4可以相同或不同，表示氢原子，羟基或 氨基，羧基，氨基甲酰基，氰基，硝基，碳原子数为1〜6的烷基，R 1，R 2，R 4全部为氢原子，R 3表示卤素原子，氨基， 具有2〜6个碳原子的烯基或含有1〜6个碳原子的烷氧基的羰基）。

    Anti-HIV compositions
    8.
    发明授权
    Anti-HIV compositions 失效
    抗HIV组合物

    公开(公告)号：US06596720B1

    公开(公告)日：2003-07-22

    申请号：US10111396

    申请日：2002-05-03

    申请人： Hiroo Hoshino ,  Kenji Kitazato ,  Masakazu Fukushima

    发明人： Hiroo Hoshino ,  Kenji Kitazato ,  Masakazu Fukushima

    IPC分类号： A61K31535

    CPC分类号： A61K31/7072 ,  A61K31/506 ,  A61K31/513 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides: an anti-HIV composition comprising at least one member selected from the group consisting of trifluridine and derivatives thereof, and a pharmaceutically acceptable carrier; an anti-HIV composition comprising (a) at least one member selected from the group consisting of trifluridine and derivatives thereof, (b) a thymidine phosphorylase inhibitor, and a pharmaceutically acceptable carrier; and a composition for potentiating the anti-HIV activity of trifluridine and derivatives thereof, comprising a thymidine phosphorylase inhibitor and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明提供：抗HIV组合物，其包含选自三氟尿苷及其衍生物中的至少一种和药学上可接受的载体;抗HIV组合物，其包含（a）至少一种选自以下的成员： 的三氟尿苷及其衍生物，（b）胸苷磷酸化酶抑制剂和药学上可接受的载体; 以及用于增强三氟尿苷及其衍生物的抗HIV活性的组合物，其包含胸苷磷酸化酶抑制剂和药学上可接受的载体。

    Image pick-up tube with electrostatic deflecting electrode structure
    9.
    发明授权
    Image pick-up tube with electrostatic deflecting electrode structure 失效
    具有静电偏转电极结构的摄像管

    公开(公告)号：US4866337A

    公开(公告)日：1989-09-12

    申请号：US15378

    申请日：1987-02-17

    申请人： Masanori Maruyama ,  Kentaro Oku ,  Masakazu Fukushima ,  Shinichi Kato ,  Mitsuhiro Kurashige

    发明人： Masanori Maruyama ,  Kentaro Oku ,  Masakazu Fukushima ,  Shinichi Kato ,  Mitsuhiro Kurashige

    IPC分类号： H01J29/76 ,  H01J29/74

    CPC分类号： H01J29/74

    摘要： In an electromagnetic focusing electrostatic type image pick-up tube the electrostatic deflecting electrodes formed on the inner surface of the tube consist of 2 pairs of electrodes. Each of these electrostatic deflecting electrodes has a zig-zag shape from the electron gun towards the target. This zig-zag shape is twisted in the circumferential direction around the axis of the tube and variation rates of this twist amount are different, depending on the position in the axial direction.

    摘要翻译： 在电磁聚焦静电型图像拾取管中，形成在管的内表面上的静电偏转电极由2对电极组成。 这些静电偏转电极中的每一个具有从电子枪朝向目标的之字形。 这种锯齿形状围绕管的轴线在圆周方向上扭曲，并且该扭转量的变化率根据轴向方向上的位置而不同。

    Cylindrical image pickup tube having electrostatic deflection electrodes formed of straight line pattern yokes
    10.
    发明授权
    Cylindrical image pickup tube having electrostatic deflection electrodes formed of straight line pattern yokes 失效
    具有由直线图案轭形成的静电偏转电极的圆柱形图像拾取管

    公开(公告)号：US4701668A

    公开(公告)日：1987-10-20

    申请号：US867155

    申请日：1986-05-27

    申请人： Kentaro Oku ,  Masakazu Fukushima ,  Hitomi Suzuki ,  Masanori Maruyama

    发明人： Kentaro Oku ,  Masakazu Fukushima ,  Hitomi Suzuki ,  Masanori Maruyama

    IPC分类号： H01J29/64 ,  H01J29/74 ,  H01J29/70

    CPC分类号： H01J29/74

    摘要： A magnetic focusing and electrostatic deflecting image pickup tube comprises electrostatic deflection electrodes each constituted by a straight arrow pattern yoke composed of straight line segments arrayed in a linear zigzag pattern. The pattern yoke has a twist angle set at a value not greater than 105.degree.. An average value of angles formed by each upper apex and two lower apices adjacent to the upper apex of the zigzag pattern yoke with reference to the axis of the tube lies within a range of 116.degree. to 127.degree..

    摘要翻译： 磁聚焦和静电偏转图像拾取管包括静电偏转电极，每个静电偏转电极由以直线形之字形图案排列的直线段组成的直箭头图案磁轭构成。 图案磁轭的扭转角设定在105度以下。 相对于管的轴线，每个上顶点和相邻于之字形图形磁轭的上顶点的两个下顶点形成的角度的平均值在116°至127°的范围内。