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公开(公告)号：US08093239B2
公开(公告)日：2012-01-10
申请号：US12128099
申请日：2008-05-28
申请人： Kevin Kuntz , David Edward Uehling , Alex Gregory Waterson , Kyle Allen Emmitte , Kirk Stevens , John Brad Shotwell , Stephon Cornell Smith , Kristen E. Nailor , James M. Salovich , Brian John Wilson , Mui Cheung , Robert Anthony Mook , Erich W. Baum , Ganesh Moorthy
发明人： Kevin Kuntz , David Edward Uehling , Alex Gregory Waterson , Kyle Allen Emmitte , Kirk Stevens , John Brad Shotwell , Stephon Cornell Smith , Kristen E. Nailor , James M. Salovich , Brian John Wilson , Mui Cheung , Robert Anthony Mook , Erich W. Baum , Ganesh Moorthy
IPC分类号： A61K31/55 , A61K31/505 , A61K31/497 , A61K31/535 , C07D243/08 , C07D413/14 , C07D403/14 , C07D239/02
CPC分类号： C07D471/04
摘要： The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译： 本发明提供咪唑并吡啶化合物，含有它们的组合物，以及其制备方法和用作药剂的方法。
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公开(公告)号：US07595330B2
公开(公告)日：2009-09-29
申请号：US11467577
申请日：2006-08-28
IPC分类号： A61K31/454 , C07D409/14 , A61K31/496 , A61K31/4184 , C07D409/04
CPC分类号： C07D409/04 , C07D409/14
摘要： The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译： 本发明提供苯并咪唑噻吩化合物，其含有它们的药物组合物，其制备方法及其作为药剂的用途。
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公开(公告)号：US20080300242A1
公开(公告)日：2008-12-04
申请号：US12128099
申请日：2008-05-28
申请人： Kevin Kuntz , David Edward Uehling , Alex Gregory Waterson , Kyle Allen Emmitte , Kirk Stevens , John Brad Shotwell , Stephon Cornell Smith , Kristen E. Nailor , James M. Salovich , Brian John Wilson , Mui Cheung , Robert Anthony Mook , Erich W. Baum , Ganesh Moorthy
发明人： Kevin Kuntz , David Edward Uehling , Alex Gregory Waterson , Kyle Allen Emmitte , Kirk Stevens , John Brad Shotwell , Stephon Cornell Smith , Kristen E. Nailor , James M. Salovich , Brian John Wilson , Mui Cheung , Robert Anthony Mook , Erich W. Baum , Ganesh Moorthy
IPC分类号： A61K31/496 , C07D401/04 , C07D279/12 , A61P35/00 , A61K31/541 , A61K31/506
CPC分类号： C07D471/04
摘要： The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译： 本发明提供咪唑并吡啶化合物，含有它们的组合物，以及其制备方法和用作药剂的方法。
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4.发明申请Heterocyclic Sulfone MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction 有权杂环砜MGLUR4变构电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20130158078A1
公开(公告)日：2013-06-20
申请号：US13697783
申请日：2011-05-12
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
IPC分类号： A61K31/4439 , A61K45/06 , C07D417/12
CPC分类号： A61K31/4439 , A61K45/06 , C07D401/12 , C07D413/12 , C07D417/12
摘要： Heterocyclic sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的杂环砜化合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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5.发明授权Pyrazolopyridine, pyrarolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权吡唑并吡啶，吡咯并吡嗪，吡唑并嘧啶，吡唑并噻吩和吡唑并噻唑化合物作为MGLUR4变构增效剂，组合物和治疗神经功能障碍的方法公开(公告)号：US09163015B2
公开(公告)日：2015-10-20
申请号：US13578812
申请日：2011-02-11
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
IPC分类号： A61K31/437 , A61K31/506 , C07D487/04 , C07D513/04 , C07D471/04 , A61K31/415 , A61K31/4188 , A61K31/429 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/4985 , A61K31/519 , A61K31/5377 , A61K45/06
CPC分类号： C07D471/04 , A61K31/415 , A61K31/4188 , A61K31/429 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/04 , C07D513/04
摘要： Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的吡唑并吡啶，吡唑并吡嗪，吡唑并嘧啶，吡唑并噻吩和吡唑并噻唑化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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6.发明申请Pyrazolopyridine, Pyrazolopyrazine, Pyrazolopyrimidine, Pyrazolothiophene and Pyrazolothiazole Compounds as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction 有权吡唑并吡啶，吡唑并吡嗪，吡唑并嘧啶，吡唑并噻吩和吡唑并噻唑化合物作为MGLUR4变构电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20130096110A1
公开(公告)日：2013-04-18
申请号：US13578812
申请日：2011-02-11
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
IPC分类号： C07D471/04 , A61K31/506 , A61K31/444 , C07D487/04 , A61K31/519 , A61K45/06 , A61K31/5377 , A61K31/497 , C07D513/04 , A61K31/429 , A61K31/4709 , A61K31/437 , A61K31/4985
CPC分类号： C07D471/04 , A61K31/415 , A61K31/4188 , A61K31/429 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/04 , C07D513/04
摘要： Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的吡唑并吡啶，吡唑并吡嗪，吡唑并嘧啶，吡唑并噻吩和吡唑并噻唑化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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公开(公告)号：US20130065895A1
公开(公告)日：2013-03-14
申请号：US13584735
申请日：2012-08-13
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
IPC分类号： A61K31/437 , A61K31/506 , C07D487/04 , A61K31/519 , A61K31/4985 , A61K31/5377 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/22 , A61P25/00 , A61P3/04 , A61P25/08 , A61P35/00 , A61P29/00 , A61P3/00 , C07D471/04
CPC分类号： C07D471/04 , A61K31/415 , A61K31/4188 , A61K31/429 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/04 , C07D513/04
摘要： Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
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8.发明申请MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 失效MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20120245153A1
公开(公告)日：2012-09-27
申请号：US13394309
申请日：2010-09-07
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers , Patrick R. Gentry , Yiu-Yin Cheung , James M. Salovich , Rocco D. Gogliotti
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers , Patrick R. Gentry , Yiu-Yin Cheung , James M. Salovich , Rocco D. Gogliotti
IPC分类号： A61K31/542 , A61K31/4985 , A61K31/506 , A61K31/437 , A61K31/4439 , C07D513/04 , C07D498/04 , C07D487/04 , C07D471/04 , C07D401/12 , A61P25/18 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/16 , A61P25/28 , A61K31/5377
CPC分类号： C07D487/04 , C07D401/10 , C07D471/04 , C07D498/04 , C07D513/04
摘要： Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的化合物及其用途。
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9.发明授权
公开(公告)号：US5326760A
公开(公告)日：1994-07-05
申请号：US31439
申请日：1993-03-15
IPC分类号： C07C237/06 , C07D209/48 , C07D209/66 , C07D213/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D453/02 , C07D487/04 , C07F7/18 , A61K31/395 , A61K31/40
CPC分类号： C07D209/48 , C07C237/06 , C07D209/66 , C07D213/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D453/02 , C07D487/04 , C07F7/1852 , C07F7/1856
摘要： Aminobutanoic acids of the following formula (I): ##STR1## where R.sup.1 -R.sup.5 are a variety of substituents, novel intermediates, a pharmaceutical composition for treating inflammatory diseases, demyelinating diseases, and tumor metastasis, methods for such treatment and processes for preparing compounds of formula (I).
摘要翻译： 下式（I）的氨基丁酸：其中R1-R5是多种取代基，新型中间体，用于治疗炎性疾病，脱髓鞘疾病和肿瘤转移的药物组合物，其用于治疗和治疗的方法 用于制备式（I）的化合物。
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10.发明授权Heterocyclic sulfone mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权杂环砜mGluR4变构增效剂，组合物和治疗神经功能障碍的方法公开(公告)号：US09192603B2
公开(公告)日：2015-11-24
申请号：US13697783
申请日：2011-05-12
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
IPC分类号： A61K31/4439 , C07D417/12 , A61K45/06 , C07D401/12 , C07D413/12
CPC分类号： A61K31/4439 , A61K45/06 , C07D401/12 , C07D413/12 , C07D417/12
摘要： Heterocyclic sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的杂环砜化合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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