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1.发明授权N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors 有权可用作单胺再摄取抑制剂的N，N-取代的3-氨基吡咯烷化合物公开(公告)号：US08084442B2
公开(公告)日：2011-12-27
申请号：US11914183
申请日：2006-05-12
申请人： Muneaki Kurimura , Shinichi Taira , Takahiro Tomoyasu , Nobuaki Ito , Kuninori Tai , Noriaki Takemura , Takayuki Matsuzaki , Yasuhiro Menjo , Shin Miyamura , Yohji Sakurai , Akihito Watanabe , Yasuyo Sakata , Takumi Masumoto , Kohei Akazawa , Haruhiko Sugino , Naoki Amada , Satoshi Ohashi , Tomoichi Shinohara , Hirofumi Sasaki , Chisako Morita , Junko Yamashita , Satoko Nakajima
发明人： Muneaki Kurimura , Shinichi Taira , Takahiro Tomoyasu , Nobuaki Ito , Kuninori Tai , Noriaki Takemura , Takayuki Matsuzaki , Yasuhiro Menjo , Shin Miyamura , Yohji Sakurai , Akihito Watanabe , Yasuyo Sakata , Takumi Masumoto , Kohei Akazawa , Haruhiko Sugino , Naoki Amada , Satoshi Ohashi , Tomoichi Shinohara , Hirofumi Sasaki , Chisako Morita , Junko Yamashita , Satoko Nakajima
IPC分类号： A61K31/40 , A61K31/497 , A61K31/538 , A61K31/695 , A61K31/501 , C07D207/12 , C07D241/20 , C07D403/12 , C07D498/04 , A61P25/00
CPC分类号： C07D205/04 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04 , C07F7/10
摘要： The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R101 and R102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.
摘要翻译： 本发明提供通式（1）的吡咯烷化合物或其盐，其中R 101和R 102各自独立地为苯基或吡啶基，苯基或吡啶基可以具有一个或多个选自卤素原子的取代基 和任选被一个或多个卤素原子取代的低级烷基等。本发明的吡咯烷化合物或其盐可用于制备具有较宽治疗谱的药物制剂，并能在短期内表现出足够的治疗效果 行政。
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2.发明授权N, N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors 有权可用作单胺再摄取抑制剂的N，N-取代的3-氨基吡咯烷化合物公开(公告)号：US08420623B2
公开(公告)日：2013-04-16
申请号：US13298336
申请日：2011-11-17
申请人： Muneaki Kurimura , Shinichi Taira , Takahiro Tomoyasu , Nobuaki Ito , Kuninori Tai , Noriaki Takemura , Takayuki Matsuzaki , Yasuhiro Menjo , Shin Miyamura , Yohji Sakurai , Akihito Watanabe , Yasuyo Sakata , Takumi Masumoto , Kohei Akazawa , Haruhiko Sugino , Naoki Amada , Satoshi Ohashi , Tomoichi Shinohara , Hirofumi Sasaki , Chisako Morita , Junko Yamashita , Satoko Nakajima
发明人： Muneaki Kurimura , Shinichi Taira , Takahiro Tomoyasu , Nobuaki Ito , Kuninori Tai , Noriaki Takemura , Takayuki Matsuzaki , Yasuhiro Menjo , Shin Miyamura , Yohji Sakurai , Akihito Watanabe , Yasuyo Sakata , Takumi Masumoto , Kohei Akazawa , Haruhiko Sugino , Naoki Amada , Satoshi Ohashi , Tomoichi Shinohara , Hirofumi Sasaki , Chisako Morita , Junko Yamashita , Satoko Nakajima
IPC分类号： A61K31/40 , A61K31/497 , A61K31/538 , A61K31/695 , A61K31/501 , C07D207/12 , C07D241/20 , C07D403/12 , C07D498/04
CPC分类号： C07D205/04 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04 , C07F7/10
摘要： The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R101 and R102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.
摘要翻译： 本发明提供通式（1）的吡咯烷化合物或其盐，其中R 101和R 102各自独立地为苯基或吡啶基，苯基或吡啶基可以具有一个或多个选自卤素原子的取代基 和任选被一个或多个卤素原子取代的低级烷基等。本发明的吡咯烷化合物或其盐可用于制备具有较宽治疗谱的药物制剂，并能在短期内表现出足够的治疗效果 行政。
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3.发明申请N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS 有权N，N-取代的3-氨基吡咯烷酮化合物作为单体反应抑制剂有用公开(公告)号：US20090088406A1
公开(公告)日：2009-04-02
申请号：US11914183
申请日：2006-05-12
申请人： Muneaki Kurimura , Shinichi Taira , Takahiro Tomoyasu , Nobuaki Ito , Kuninori Tai , Noriaki Takemura , Takayuki Matsuzaki , Yasuhiro Menjo , Shin Miyamura , Yohji Sakurai , Akihito Watanabe , Yasuyo Sakata , Takumi Masumoto , Kohei Akazawa , Haruhiko Sugino , Naoki Amada , Satoshi Ohashi , Tomoichi Shinohara , Hirofumi Sasaki , Chisako Morita , Junko Yamashita , Satoko Nakajima
发明人： Muneaki Kurimura , Shinichi Taira , Takahiro Tomoyasu , Nobuaki Ito , Kuninori Tai , Noriaki Takemura , Takayuki Matsuzaki , Yasuhiro Menjo , Shin Miyamura , Yohji Sakurai , Akihito Watanabe , Yasuyo Sakata , Takumi Masumoto , Kohei Akazawa , Haruhiko Sugino , Naoki Amada , Satoshi Ohashi , Tomoichi Shinohara , Hirofumi Sasaki , Chisako Morita , Junko Yamashita , Satoko Nakajima
IPC分类号： A61K31/40 , C07D207/12 , C07D241/20 , A61K31/497 , A61K31/538 , A61P25/00 , A61K31/695 , A61K31/501 , C07D403/12 , C07D498/04
CPC分类号： C07D205/04 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04 , C07F7/10
摘要： The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R101 and R102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.
摘要翻译： 本发明提供通式（1）的吡咯烷化合物或其盐，其中R 101和R 102各自独立地为苯基或吡啶基，苯基或吡啶基可以具有一个或多个选自卤素原子的取代基 和任选被一个或多个卤素原子取代的低级烷基等。本发明的吡咯烷化合物或其盐可用于制备具有较宽治疗谱的药物制剂，并能在短期内表现出足够的治疗效果 行政。
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公开(公告)号：US09611214B2
公开(公告)日：2017-04-04
申请号：US14300619
申请日：2014-06-10
申请人： Muneaki Kurimura , Shinichi Taira , Takahiro Tomoyasu , Nobuaki Ito , Kuninori Tai , Noriaki Takemura , Takayuki Matsuzaki , Yasuhiro Menjo , Shin Miyamura , Yohji Sakurai , Akihito Watanabe , Yasuyo Sakata , Takumi Masumoto , Kohei Akazawa , Haruhiko Sugino , Naoki Amada , Satoshi Ohashi , Tomoichi Shinohara , Hirofumi Sasaki , Chisako Morita , Junko Yamashita , Satoko Nakajima
发明人： Muneaki Kurimura , Shinichi Taira , Takahiro Tomoyasu , Nobuaki Ito , Kuninori Tai , Noriaki Takemura , Takayuki Matsuzaki , Yasuhiro Menjo , Shin Miyamura , Yohji Sakurai , Akihito Watanabe , Yasuyo Sakata , Takumi Masumoto , Kohei Akazawa , Haruhiko Sugino , Naoki Amada , Satoshi Ohashi , Tomoichi Shinohara , Hirofumi Sasaki , Chisako Morita , Junko Yamashita , Satoko Nakajima
IPC分类号： C07D207/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D401/14 , C07D471/04 , C07D495/04 , C07D413/14 , C07F7/10
CPC分类号： C07D205/04 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04 , C07F7/10
摘要： The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R101 and R102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.
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5.发明授权Image processing method, image processing device and recording medium on which image processing program is recorded 失效图像处理方法，图像处理装置和记录有图像处理程序的记录介质公开(公告)号：US07760963B2
公开(公告)日：2010-07-20
申请号：US11569866
申请日：2005-12-07
IPC分类号： G06K9/40
CPC分类号： G06T5/002 , G06T5/20 , G06T2207/10064 , G06T2207/20192
摘要： A method employing a statistic means to test whether or not luminance signals around a point of interest are distributed according to the same probability distribution with respect to luminance signals of respective pixels constituting the image; determining a range where the same probability distribution can be regarded as being satisfied, estimating the true luminance value of the point of interest by using the luminance data of the range. Especially when the image signals are faint to such an extent that the intensity of the luminance signal is based on the Poisson distribution, it is effective to perform a smoothing processing for each of the probability distributions of the signals and the noises by a test of a uniformity of the Poisson distribution, enabling a clear and denoised image to be obtained.
摘要翻译： 一种使用统计装置来测试关于感兴趣点周围的亮度信号是否根据构成图像的各个像素的亮度信号的相同概率分布来分配的方法; 确定可以认为相同概率分布被满足的范围，通过使用该范围的亮度数据来估计感兴趣点的真实亮度值。 特别是当图像信号微弱到亮度信号的强度基于泊松分布的程度时，通过测试信号和噪声对信号和噪声的每个概率分布执行平滑处理是有效的 泊松分布的均匀性，使得能够获得清晰和去噪的图像。
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公开(公告)号：US07845442B2
公开(公告)日：2010-12-07
申请号：US12274956
申请日：2008-11-20
申请人： Kohei Akazawa , Takayuki Sato , Kazuyoshi Miyahara
发明人： Kohei Akazawa , Takayuki Sato , Kazuyoshi Miyahara
CPC分类号： B62D51/06
摘要： A handle structure of a walk-behind working machine includes: a handle having left and right raised portions extending upward from a handle frame and a cross portion interconnecting the left and right raised portions; and a main clutch lever shiftable from a clutch-OFF position to a clutch-ON position by being pivoted into pressed abutment against the cross portion. The main clutch lever is constructed in such a manner that, when the main clutch lever is in abutment against the cross portion, a space for allowing a human operator to grip the left and right raised portions is secured between the left and right raised portions and the main clutch lever.
摘要翻译： 步行式加工机的手柄结构包括：手柄，其具有从手柄框架向上延伸的左右凸起部分和互连左右凸起部分的横截面; 以及主离合器杆，其通过枢转成抵靠所述十字部分而被从离合器关闭位置移动到离合器接合位置。 主离合杆构造成使得当主离合器杆抵靠十字部分时，允许操作者抓住左右凸起部分的空间被固定在左右凸起部分之间，并且 主离合杆。
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7.发明申请Image Processing Method, Image Processing Device and Recording Medium on Which Image Processing Program is Recorded 失效图像处理方法，图像处理装置和记录图像处理程序的记录介质公开(公告)号：US20080292208A1
公开(公告)日：2008-11-27
申请号：US11569866
申请日：2005-12-07
IPC分类号： G06K9/40
CPC分类号： G06T5/002 , G06T5/20 , G06T2207/10064 , G06T2207/20192
摘要： A method employing a statistic means to test whether or not luminance signals around a point of interest are distributed according to the same probability distribution with respect to luminance signals of respective pixels constituting the image; determining a range where the same probability distribution can be regarded as being satisfied, estimating the true luminance value of the point of interest by using the luminance data of the range. Especially when the image signals are faint to such an extent that the intensity of the luminance signal is based on the Poisson distribution, it is effective to perform a smoothing processing for each of the probability distributions of the signals and the noises by a test of a uniformity of the Poisson distribution, enabling a clear and denoised image to be obtained.
摘要翻译： 一种使用统计装置来测试关于感兴趣点周围的亮度信号是否根据构成图像的各个像素的亮度信号的相同概率分布来分配的方法; 确定可以认为相同概率分布被满足的范围，通过使用该范围的亮度数据来估计感兴趣点的真实亮度值。 特别是当图像信号微弱到亮度信号的强度基于泊松分布的程度时，通过测试信号和噪声对信号和噪声的每个概率分布执行平滑处理是有效的 泊松分布的均匀性，使得能够获得清晰和去噪的图像。
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公开(公告)号：US20090127009A1
公开(公告)日：2009-05-21
申请号：US12274956
申请日：2008-11-20
申请人： Kohei Akazawa , Takayuki Sato , Kazuyoshi Miyahara
发明人： Kohei Akazawa , Takayuki Sato , Kazuyoshi Miyahara
CPC分类号： B62D51/06
摘要： A handle structure of a walk-behind working machine includes: a handle having left and right raised portions extending upward from a handle frame and a cross portion interconnecting the left and right raised portions; and a main clutch lever shiftable from a clutch-OFF position to a clutch-ON position by being pivoted into pressed abutment against the cross portion. The main clutch lever is constructed in such a manner that, when the main clutch lever is in abutment against the cross portion, a space for allowing a human operator to grip the left and right raised portions is secured between the left and right raised portions and the main clutch lever.
摘要翻译： 步行式加工机的手柄结构包括：手柄，其具有从手柄框架向上延伸的左右凸起部分和互连左右凸起部分的横截面; 以及主离合器杆，其通过枢转成抵靠所述十字部分而被从离合器关闭位置移动到离合器接合位置。 主离合杆构造成使得当主离合器杆抵靠十字部分时，允许操作者抓住左右凸起部分的空间被固定在左右凸起部分之间，并且 主离合杆。
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