公开(公告)号：US07794743B2

公开(公告)日：2010-09-14

申请号：US11218654

申请日：2005-09-02

Applicant: Murthy V. Simhambhatla ,  Ni Ding ,  Stephen D. Pacetti

Inventor： Murthy V. Simhambhatla ,  Ni Ding ,  Stephen D. Pacetti

IPC: A61F2/04 ,  A61K9/50

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/606 ,  A61L2300/622 ,  A61L2300/626 ,  C08L77/04

Abstract: Polycationic peptide coatings for implantable medical devices and methods of making the same are described. The methods include applying an emulsion on the device, the emulsion including a polymer and a polycationic peptide. Other methods include incorporation of the polycationic peptide in microspheres and liposomes.

Abstract translation: 描述了用于可植入医疗装置的聚阳离子肽涂层及其制造方法。 所述方法包括在所述装置上施加乳液，所述乳液包括聚合物和聚阳离子肽。 其他方法包括将聚阳离子肽掺入微球和脂质体中。

公开(公告)号：US07011842B1

公开(公告)日：2006-03-14

申请号：US10177114

申请日：2002-06-21

Applicant: Murthy V Simhambhatla ,  Ni Ding ,  Stephen D. Pacetti

Inventor： Murthy V Simhambhatla ,  Ni Ding ,  Stephen D. Pacetti

IPC: A61F2/02

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/114 ,  A61L2300/606 ,  A61L2300/622 ,  A61L2300/626 ,  C08L77/04

Abstract: Polycationic peptide coatings for implantable medical devices and methods of making the same are described. The methods include applying an emulsion on the device, the emulsion including a polymer and a polycationic peptide. Other methods include incorporation of the polycationic peptide in microspheres and liposomes.

Abstract translation: 描述了用于可植入医疗装置的聚阳离子肽涂层及其制造方法。 所述方法包括在所述装置上施加乳液，所述乳液包括聚合物和聚阳离子肽。 其他方法包括将聚阳离子肽掺入微球和脂质体中。

公开(公告)号：US08128688B2

公开(公告)日：2012-03-06

申请号：US11820560

申请日：2007-06-19

Applicant: Ni Ding ,  Gene Michal ,  Stephen D. Pacetti

Inventor： Ni Ding ,  Gene Michal ,  Stephen D. Pacetti

IPC: A61F2/01

CPC classification number: A61L31/16 ,  A61L31/084 ,  A61L2300/606

Abstract: A carbon coating on a stent having a bioactive agent covalently attached thereto and methods of making the same are described. The covalent attachment may be achieved via a photo-reactive chemical or a thermo-reactive chemical. In some embodiments, the carbon coating includes a diamond-like material. The bioactive agent may be heparin or superoxide dismutase enzyme or a mimetic thereof.

Abstract translation: 描述了具有共价连接于其上的生物活性剂的支架上的碳涂层及其制备方法。 共价连接可以通过光反应性化学品或热反应性化学品来实现。 在一些实施方案中，碳涂层包括类金刚石材料。 生物活性剂可以是肝素或超氧化物歧化酶或其模拟物。

公开(公告)号：US07875285B1

公开(公告)日：2011-01-25

申请号：US10619727

申请日：2003-07-15

Applicant: Wouter E. Roorda ,  Ni Ding ,  Stephen D. Pacetti

Inventor： Wouter E. Roorda ,  Ni Ding ,  Stephen D. Pacetti

IPC: A61F2/02

CPC classification number: A61L31/10 ,  A61F2/82 ,  A61F2250/0067 ,  A61L31/16

Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polymer having in a dry state a glass transition temperature within a range of between about 20° C. and about 55° C.

Abstract translation: 描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。 涂层可以包括在干燥状态下的玻璃化转变温度在约20℃至约55℃的范围内的聚合物。

公开(公告)号：US07622146B2

公开(公告)日：2009-11-24

申请号：US11592632

申请日：2006-11-02

Applicant: Wouter E. Roorda ,  Syed F. A. Hossainy ,  Ni Ding ,  Fuh-Wei Tang ,  Stephen D. Pacetti

Inventor： Wouter E. Roorda ,  Syed F. A. Hossainy ,  Ni Ding ,  Fuh-Wei Tang ,  Stephen D. Pacetti

IPC: A61L33/00 ,  A61M25/00 ,  A61F2/06

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  A61L2420/08

Abstract: A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solvent for the drug or the polymer of the first layer. The formulation can have a low surface tension value or a high Weber number value.

Abstract translation: 公开了一种涂覆可植入医疗装置（例如支架）的方法。 该方法包括在含有治疗物质的第一聚合物层上施用制剂以形成第二层。 制剂可以含有高度疏水性的聚合物或作为第一层的药物或聚合物的不良溶剂的溶剂。 制剂可以具有低表面张力值或高Weber数值。

公开(公告)号：US07504125B1

公开(公告)日：2009-03-17

申请号：US10040538

申请日：2001-12-28

Applicant: Stephen D. Pacetti ,  Wouter E. Roorda ,  Ni Ding

Inventor： Stephen D. Pacetti ,  Wouter E. Roorda ,  Ni Ding

IPC: B05D3/04

CPC classification number: B05D3/0466 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2420/02 ,  B05D3/0473 ,  B05D3/048 ,  Y10T428/1393 ,  Y10T428/31507 ,  Y10T428/31551 ,  Y10T428/31725 ,  Y10T428/31786 ,  Y10T428/31855

Abstract: A method and system of coating an implantable device, such as a stent, are provided.

Abstract translation: 提供涂覆可植入装置（例如支架）的方法和系统。

公开(公告)号：US07285304B1

公开(公告)日：2007-10-23

申请号：US10603889

申请日：2003-06-25

Applicant: Syed F. A. Hossainy ,  Ni Ding ,  Stephen D. Pacetti

Inventor： Syed F. A. Hossainy ,  Ni Ding ,  Stephen D. Pacetti

IPC: A61L33/00

CPC classification number: A61L31/10 ,  A61F2/91 ,  A61F2210/0004 ,  Y10S623/901

Abstract: A method of manufacturing an implantable medical device including applying a composition to an implantable medical device, the composition including a polymer, an active agent and a solvent; allowing the solvent to evaporate to form a dry coating, the dry coating comprising less than about 2% residual fluid content (w/w); applying a fluid to the dry coating, the fluid being substantially free from any polymer; and allowing the fluid to evaporate from the coating.

Abstract translation: 一种制造可植入医疗装置的方法，包括将组合物施用于可植入医疗装置，所述组合物包括聚合物，活性剂和溶剂; 允许溶剂蒸发以形成干燥涂层，干涂层包含小于约2％的残留流体含量（w / w）; 将流体施加到干燥涂层，所述流体基本上不含任何聚合物; 并允许流体从涂层蒸发。

公开(公告)号：US09333099B2

公开(公告)日：2016-05-10

申请号：US13436538

申请日：2012-03-30

Applicant: Stephen D. Pacetti ,  Yunbing Wang ,  Ni Ding

Inventor： Stephen D. Pacetti ,  Yunbing Wang ,  Ni Ding

IPC: A61F2/82 ,  C23C8/00 ,  C23C8/42 ,  C23C8/80 ,  C23C8/10 ,  C23C26/00 ,  C23C28/04 ,  C23C28/00 ,  C23C30/00 ,  A61L31/02 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14 ,  A61F2/915

CPC classification number: A61F2/915 ,  A61F2/82 ,  A61F2210/0004 ,  A61F2210/0009 ,  A61F2240/001 ,  A61F2250/003 ,  A61F2310/00041 ,  A61L31/022 ,  A61L31/086 ,  A61L31/088 ,  A61L31/10 ,  A61L31/124 ,  A61L31/148 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2400/18 ,  B22D21/007 ,  B22D25/02 ,  B22D27/00 ,  B23K26/38 ,  B23K26/40 ,  B23K2103/15 ,  C23C8/00 ,  C23C8/10 ,  C23C8/42 ,  C23C8/80 ,  C23C26/00 ,  C23C28/04 ,  C23C28/30 ,  C23C30/00

Abstract: Stents or scaffolds made from magnesium or magnesium alloys including additives or barrier coatings that modify the corrosion rate of the stent are disclosed. Methods of forming barrier coatings that modify the corrosion rate of the stent are disclosed.

Abstract translation: 公开了由镁或镁合金制成的支架或支架，包括改变支架腐蚀速率的添加剂或阻隔涂层。 公开了形成改变支架腐蚀速率的阻挡涂层的方法。

公开(公告)号：US08841412B2

公开(公告)日：2014-09-23

申请号：US13207656

申请日：2011-08-11

Applicant: Bethany Steichen ,  Stephen D. Pacetti ,  Manish Gada ,  Thierry Glauser ,  Lothar W. Kleiner ,  Yunbing Wang ,  James P. Oberhauser ,  Ni Ding

Inventor： Bethany Steichen ,  Stephen D. Pacetti ,  Manish Gada ,  Thierry Glauser ,  Lothar W. Kleiner ,  Yunbing Wang ,  James P. Oberhauser ,  Ni Ding

IPC: C08F6/00

CPC classification number: B29C47/0078 ,  B29B13/06 ,  B29B13/065 ,  B29C47/0014 ,  B29C47/0021 ,  B29C47/0023 ,  B29C47/1018 ,  B29C47/1072 ,  B29C47/76 ,  B29C47/92 ,  B29C2947/922 ,  B29C2947/92228 ,  B29C2947/92342 ,  B29C2947/92695 ,  B29C2947/92704 ,  B29C2947/92723 ,  B29K2995/006

Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.

Abstract translation: 公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的含水量的方法和系统，其允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失。 进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。

公开(公告)号：US20130261735A1

公开(公告)日：2013-10-03

申请号：US13436538

申请日：2012-03-30

Applicant: Stephen D. Pacetti ,  Yunbing Wang ,  Ni Ding

Inventor： Stephen D. Pacetti ,  Yunbing Wang ,  Ni Ding

IPC: A61F2/82 ,  C23C8/42 ,  C23C8/80 ,  C23C8/00

CPC classification number: A61F2/915 ,  A61F2/82 ,  A61F2210/0004 ,  A61F2210/0009 ,  A61F2240/001 ,  A61F2250/003 ,  A61F2310/00041 ,  A61L31/022 ,  A61L31/086 ,  A61L31/088 ,  A61L31/10 ,  A61L31/124 ,  A61L31/148 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2400/18 ,  B22D21/007 ,  B22D25/02 ,  B22D27/00 ,  B23K26/38 ,  B23K26/40 ,  B23K2103/15 ,  C23C8/00 ,  C23C8/10 ,  C23C8/42 ,  C23C8/80 ,  C23C26/00 ,  C23C28/04 ,  C23C28/30 ,  C23C30/00

Abstract: Stents or scaffolds made from magnesium or magnesium alloys including additives or barrier coatings that modify the corrosion rate of the stent are disclosed. Methods of forming barrier coatings that modify the corrosion rate of the stent are disclosed.

Abstract translation: 公开了由镁或镁合金制成的支架或支架，包括改变支架腐蚀速率的添加剂或阻隔涂层。 公开了形成改变支架腐蚀速率的阻挡涂层的方法。