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公开(公告)号:US20110152240A1
公开(公告)日:2011-06-23
申请号:US12946759
申请日:2010-11-15
申请人: Mustapha Haddach , Joe A. Tran , Fabrice Pierre , Collin F. Regan , Nicholas B. Raffaele , Suchitra Ravula , David M. Ryckman
发明人: Mustapha Haddach , Joe A. Tran , Fabrice Pierre , Collin F. Regan , Nicholas B. Raffaele , Suchitra Ravula , David M. Ryckman
IPC分类号: A61K31/519 , C12N9/12 , C12N5/09 , A61K31/553 , A61K31/551 , A61K31/5377 , A61K31/53 , A61K31/5025 , A61K31/4985 , C07D487/04 , A61P35/00 , A61P29/00 , A61P31/00 , A61P9/00 , A61P37/02 , A61P25/28
CPC分类号: C07D487/04 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/551 , A61K31/553 , A61K45/06
摘要: The invention provides compounds that inhibit protein kinase CK2 activity (CK2 activity), and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, and certain immunological disorders, and have the following general formula:
摘要翻译: 本发明提供抑制蛋白激酶CK2活性的化合物(CK2活性)以及含有这些化合物的组合物。 这些化合物和组合物可用于治疗增殖性疾病如癌症,以及其它激酶相关病症,包括炎症,疼痛和某些免疫学疾病,并具有以下通式:
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公开(公告)号:US08575177B2
公开(公告)日:2013-11-05
申请号:US12946759
申请日:2010-11-15
申请人: Mustapha Haddach , Joe A. Tran , Fabrice Pierre , Collin F. Regan , Nicholas B. Raffaele , Suchitra Ravula , David M. Ryckman
发明人: Mustapha Haddach , Joe A. Tran , Fabrice Pierre , Collin F. Regan , Nicholas B. Raffaele , Suchitra Ravula , David M. Ryckman
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00
CPC分类号: C07D487/04 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/551 , A61K31/553 , A61K45/06
摘要: The invention provides compounds that inhibit protein kinase CK2 activity (CK2 activity), and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, and certain immunological disorders, and have the following general formula:
摘要翻译: 本发明提供抑制蛋白激酶CK2活性的化合物(CK2活性)以及含有这些化合物的组合物。 这些化合物和组合物可用于治疗增殖性疾病如癌症,以及其它激酶相关病症,包括炎症,疼痛和某些免疫学疾病,并具有以下通式:
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公开(公告)号:US20120208792A1
公开(公告)日:2012-08-16
申请号:US13315103
申请日:2011-12-08
IPC分类号: A61K31/4745 , A61K31/5377 , A61K31/497 , C12N5/09 , A61P35/00 , A61P35/02 , A61P29/00 , A61K31/496 , A61K31/551
CPC分类号: C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译: 本发明部分地涉及具有某些生物活性的分子,包括但不限于抑制细胞增殖,调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶(Flt)活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号:US08168651B2
公开(公告)日:2012-05-01
申请号:US12396084
申请日:2009-03-02
IPC分类号: A61K31/44 , C07D471/02
CPC分类号: C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译: 本发明部分地涉及具有某些生物活性的分子,包括但不限于抑制细胞增殖,调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶(Flt)活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号:US20090239859A1
公开(公告)日:2009-09-24
申请号:US12396084
申请日:2009-03-02
IPC分类号: A61K31/5377 , C07D413/14 , C12N5/00 , A61P35/00
CPC分类号: C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译: 本发明部分地涉及具有某些生物活性的分子,包括但不限于抑制细胞增殖,调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶(Flt)活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号:US08853234B2
公开(公告)日:2014-10-07
申请号:US13043956
申请日:2011-03-09
申请人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
发明人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
IPC分类号: C07D498/06 , C07D498/16 , C07D471/14 , C07D513/14
CPC分类号: C07D513/14 , C07D471/14 , C07D498/06 , C07D498/16
摘要: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
摘要翻译: 本发明提供可抑制细胞增殖和/或诱导细胞凋亡的新型喹诺酮化合物及其药物组合物。 本发明还提供了制备这种化合物和组合物的方法及其制备和使用方法。
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公开(公告)号:US20110218184A1
公开(公告)日:2011-09-08
申请号:US13043956
申请日:2011-03-09
申请人: Johnny Yasuo NAGASAWA , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
发明人: Johnny Yasuo NAGASAWA , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
IPC分类号: A61K31/497 , C07D513/14 , A61K31/496 , A61K31/5377 , C07D471/14 , A61K31/4375 , A61K31/551 , C07D417/14 , A61K31/541 , A61P35/00 , C12N5/071
CPC分类号: C07D513/14 , C07D471/14 , C07D498/06 , C07D498/16
摘要: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
摘要翻译: 本发明提供可抑制细胞增殖和/或诱导细胞凋亡的新型喹诺酮化合物及其药物组合物。 本发明还提供了制备这种化合物和组合物的方法及其制备和使用方法。
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公开(公告)号:US07928100B2
公开(公告)日:2011-04-19
申请号:US12245619
申请日:2008-10-03
申请人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
发明人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
IPC分类号: A01N43/62 , A61K31/55 , C07D243/08
CPC分类号: C07D513/14 , C07D471/14 , C07D498/06 , C07D498/16
摘要: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
摘要翻译: 本发明提供可抑制细胞增殖和/或诱导细胞凋亡的新型喹诺酮化合物及其药物组合物。 本发明还提供了制备这种化合物和组合物的方法及其制备和使用方法。
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公开(公告)号:US07910600B2
公开(公告)日:2011-03-22
申请号:US12201892
申请日:2008-08-29
申请人: Fabrice Pierre , Mustapha Haddach
发明人: Fabrice Pierre , Mustapha Haddach
IPC分类号: A01N43/42 , A61K31/44 , C07D471/04
CPC分类号: C12Q1/485 , C07D471/04 , C07D513/04 , G01N2333/91215 , G01N2500/04
摘要: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, and modulating protein kinase activity. Molecules of the invention can modulate casein kinase (CK) activity. The invention also relates in part to methods for using such molecules.
摘要翻译: 本发明部分地涉及具有某些生物活性的分子,包括但不限于抑制细胞增殖和调节蛋白激酶活性。 本发明的分子可以调节酪蛋白激酶(CK)活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号:US20110065712A1
公开(公告)日:2011-03-17
申请号:US12883703
申请日:2010-09-16
申请人: Mustapha HADDACH , Fabrice Pierre
发明人: Mustapha HADDACH , Fabrice Pierre
IPC分类号: A61K31/5025 , C07D487/04 , C07D471/14 , C07D487/14 , C12N9/12 , A61K31/519 , C12N5/09 , A61P35/00 , A61P29/00 , A61P9/00 , A61P31/00 , A61P37/02
CPC分类号: A61K31/5025 , A61K31/519 , C07D471/14 , C07D487/04 , C07D487/14
摘要: The invention provides compounds that inhibit CK2 and/or Pim kinases and compositions containing such compounds. These tricyclic compounds and compositions containing them are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, pathogenic infections, and certain immunological disorders.
摘要翻译: 本发明提供抑制CK2和/或Pim激酶的化合物和含有这些化合物的组合物。 这些三环化合物和含有它们的组合物可用于治疗增殖性疾病如癌症,以及其它激酶相关病症,包括炎症,疼痛,致病性感染和某些免疫学疾病。
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