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公开(公告)号:US08853234B2
公开(公告)日:2014-10-07
申请号:US13043956
申请日:2011-03-09
申请人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
发明人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
IPC分类号: C07D498/06 , C07D498/16 , C07D471/14 , C07D513/14
CPC分类号: C07D513/14 , C07D471/14 , C07D498/06 , C07D498/16
摘要: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
摘要翻译: 本发明提供可抑制细胞增殖和/或诱导细胞凋亡的新型喹诺酮化合物及其药物组合物。 本发明还提供了制备这种化合物和组合物的方法及其制备和使用方法。
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公开(公告)号:US20110218184A1
公开(公告)日:2011-09-08
申请号:US13043956
申请日:2011-03-09
申请人: Johnny Yasuo NAGASAWA , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
发明人: Johnny Yasuo NAGASAWA , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
IPC分类号: A61K31/497 , C07D513/14 , A61K31/496 , A61K31/5377 , C07D471/14 , A61K31/4375 , A61K31/551 , C07D417/14 , A61K31/541 , A61P35/00 , C12N5/071
CPC分类号: C07D513/14 , C07D471/14 , C07D498/06 , C07D498/16
摘要: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
摘要翻译: 本发明提供可抑制细胞增殖和/或诱导细胞凋亡的新型喹诺酮化合物及其药物组合物。 本发明还提供了制备这种化合物和组合物的方法及其制备和使用方法。
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公开(公告)号:US07928100B2
公开(公告)日:2011-04-19
申请号:US12245619
申请日:2008-10-03
申请人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
发明人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
IPC分类号: A01N43/62 , A61K31/55 , C07D243/08
CPC分类号: C07D513/14 , C07D471/14 , C07D498/06 , C07D498/16
摘要: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
摘要翻译: 本发明提供可抑制细胞增殖和/或诱导细胞凋亡的新型喹诺酮化合物及其药物组合物。 本发明还提供了制备这种化合物和组合物的方法及其制备和使用方法。
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公开(公告)号:US20120208792A1
公开(公告)日:2012-08-16
申请号:US13315103
申请日:2011-12-08
IPC分类号: A61K31/4745 , A61K31/5377 , A61K31/497 , C12N5/09 , A61P35/00 , A61P35/02 , A61P29/00 , A61K31/496 , A61K31/551
CPC分类号: C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译: 本发明部分地涉及具有某些生物活性的分子,包括但不限于抑制细胞增殖,调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶(Flt)活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号:US08168651B2
公开(公告)日:2012-05-01
申请号:US12396084
申请日:2009-03-02
IPC分类号: A61K31/44 , C07D471/02
CPC分类号: C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译: 本发明部分地涉及具有某些生物活性的分子,包括但不限于抑制细胞增殖,调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶(Flt)活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号:US20090239859A1
公开(公告)日:2009-09-24
申请号:US12396084
申请日:2009-03-02
IPC分类号: A61K31/5377 , C07D413/14 , C12N5/00 , A61P35/00
CPC分类号: C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译: 本发明部分地涉及具有某些生物活性的分子,包括但不限于抑制细胞增殖,调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶(Flt)活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号:US07816406B2
公开(公告)日:2010-10-19
申请号:US11228636
申请日:2005-09-16
申请人: Jeffrey P. Whitten , Fabrice Pierre , Collin Regan , Michael Schwaebe , Johnny Y. Nagasawa , Peter Chua
发明人: Jeffrey P. Whitten , Fabrice Pierre , Collin Regan , Michael Schwaebe , Johnny Y. Nagasawa , Peter Chua
IPC分类号: C07D471/22 , A61K31/437 , A61K31/4365
CPC分类号: C07D215/56 , C07D471/14 , C07D513/04 , C07D513/14
摘要: The present invention provides quinolone analogs which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing quinolone analogs, and methods of using the same.
摘要翻译: 本发明提供可抑制细胞增殖和/或诱导细胞凋亡的喹诺酮类似物。 本发明还提供制备喹诺酮类似物的方法及其使用方法。
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公开(公告)号:US07652134B2
公开(公告)日:2010-01-26
申请号:US11149007
申请日:2005-06-09
申请人: Jeffrey P. Whitten , Fabrice Pierre , Collin Regan , Michael Schwaebe , George Petros Yiannikouros , Michael Jung
发明人: Jeffrey P. Whitten , Fabrice Pierre , Collin Regan , Michael Schwaebe , George Petros Yiannikouros , Michael Jung
IPC分类号: C07D413/14 , C07D401/14
CPC分类号: C07D403/12 , C07D403/14 , C07D498/04 , C07D513/04
摘要: The present invention relates to methods of preparing compounds having formula (1), (2), (5), and ((6A)-(6D)) comprising contacting the corresponding ester, an amine with formula NHR1R2, and a Lewis acid having formula MLn, wherein L is a halogen atom or an organic radical, n is 3-5, and M is a group III elemental atom, a group IV elemental atom, As, Sb, V or Fe, wherein A, B, V, X, Z, W, R1, R2, R5, Z1, Z2, Z3, Z4, Z5, Z6, Z7, and Z8 are substituents. Z4, Z5, Z6, Z7, and Z8 are substituents.
摘要翻译: 本发明涉及制备具有式(1),(2),(5)和((6A) - (6D))的化合物的方法,包括使相应的酯与式NHR1R2的胺和具有式 式MLn,其中L是卤素原子或有机基团,n是3-5,M是III族元素原子,IV族元素原子,As,Sb,V或Fe,其中A,B,V, X,Z,W,R 1,R 2,R 5,Z 1,Z 2,Z 3,Z 4,Z 5,Z 6,Z 7和Z 8为取代基。 Z4,Z5,Z6,Z7和Z8是取代基。
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公开(公告)号:US20090215761A1
公开(公告)日:2009-08-27
申请号:US12165476
申请日:2008-06-30
IPC分类号: A61K31/5383 , C07D498/06 , C12N5/06 , G01N33/566
CPC分类号: C07D498/06
摘要: The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, W, X, Z, B, L, R1, R3, R4 and R5 are substituents. The present invention also relates to methods for using such compounds.
摘要翻译: 本发明涉及具有以下通式的醌苯并恶嗪类似物及其药学上可接受的盐,酯和前药; 其中A,U,W,X,Z,B,L,R 1,R 3,R 4和R 5为取代基。 本发明还涉及使用这些化合物的方法。
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公开(公告)号:US07402579B2
公开(公告)日:2008-07-22
申请号:US11404947
申请日:2006-04-14
IPC分类号: A61K31/54 , A61K31/5377 , A61K31/4025 , A61K31/496 , A61K31/4178 , C07D265/38 , C07D273/04 , C07D233/54 , C07D413/02 , C07D413/12 , C07D417/04
CPC分类号: C07D498/06
摘要: The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, W, X, Z, B, L, R1, R3, R4 and R5 are substituents. The present invention also relates to methods for using such compounds.
摘要翻译: 本发明涉及具有以下通式的醌苯并恶嗪类似物及其药学上可接受的盐,酯和前药; 其中A,U,W,X,Z,B,L,R 1,R 3,R 4和R 5 SUP>是取代基。 本发明还涉及使用这些化合物的方法。
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