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公开(公告)号:US08853234B2
公开(公告)日:2014-10-07
申请号:US13043956
申请日:2011-03-09
申请人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
发明人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
IPC分类号: C07D498/06 , C07D498/16 , C07D471/14 , C07D513/14
CPC分类号: C07D513/14 , C07D471/14 , C07D498/06 , C07D498/16
摘要: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
摘要翻译: 本发明提供可抑制细胞增殖和/或诱导细胞凋亡的新型喹诺酮化合物及其药物组合物。 本发明还提供了制备这种化合物和组合物的方法及其制备和使用方法。
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公开(公告)号:US20110218184A1
公开(公告)日:2011-09-08
申请号:US13043956
申请日:2011-03-09
申请人: Johnny Yasuo NAGASAWA , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
发明人: Johnny Yasuo NAGASAWA , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
IPC分类号: A61K31/497 , C07D513/14 , A61K31/496 , A61K31/5377 , C07D471/14 , A61K31/4375 , A61K31/551 , C07D417/14 , A61K31/541 , A61P35/00 , C12N5/071
CPC分类号: C07D513/14 , C07D471/14 , C07D498/06 , C07D498/16
摘要: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
摘要翻译: 本发明提供可抑制细胞增殖和/或诱导细胞凋亡的新型喹诺酮化合物及其药物组合物。 本发明还提供了制备这种化合物和组合物的方法及其制备和使用方法。
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公开(公告)号:US07928100B2
公开(公告)日:2011-04-19
申请号:US12245619
申请日:2008-10-03
申请人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
发明人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
IPC分类号: A01N43/62 , A61K31/55 , C07D243/08
CPC分类号: C07D513/14 , C07D471/14 , C07D498/06 , C07D498/16
摘要: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
摘要翻译: 本发明提供可抑制细胞增殖和/或诱导细胞凋亡的新型喹诺酮化合物及其药物组合物。 本发明还提供了制备这种化合物和组合物的方法及其制备和使用方法。
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公开(公告)号:US20080318938A1
公开(公告)日:2008-12-25
申请号:US12143223
申请日:2008-06-20
申请人: David M. RYCKMAN , Denis Drygin , Jeffrey P. Whitten , Kenna Anderes , Katy Trent , Levan Darjania , Mustapha Haddach , Sean O'Brien , William G. Rice
发明人: David M. RYCKMAN , Denis Drygin , Jeffrey P. Whitten , Kenna Anderes , Katy Trent , Levan Darjania , Mustapha Haddach , Sean O'Brien , William G. Rice
IPC分类号: A61K31/5383 , A61P35/02 , A61P35/00
CPC分类号: A61K31/5383
摘要: The invention relates in part to methods for inhibiting proliferation of cancer cells and treating one or more cell proliferative conditions using compounds described herein.
摘要翻译: 本发明部分地涉及使用本文所述化合物抑制癌细胞增殖和治疗一种或多种细胞增殖性病症的方法。
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公开(公告)号:US20110065687A1
公开(公告)日:2011-03-17
申请号:US12596240
申请日:2008-04-17
IPC分类号: A61K31/5377 , C07D513/14 , A61K31/497 , A61K31/496 , A61K31/551 , C07D498/04 , C07D471/04 , C07D513/04 , C07D498/14 , A61K31/5383 , A61K31/4985 , A61K31/542 , A61P35/00 , A61P31/12 , A61P31/04 , A61P31/10
CPC分类号: C07D498/06 , C07D471/06 , C07D471/14 , C07D498/16 , C07D513/06 , C07D513/14
摘要: This application relates to certain novel polycyclic compounds that interact with quadruplex-forming regions of polynucleotides and thereby inhibit translation of genetic information into polypeptides. These compounds can thus provide anticancer and antibacterial and antiviral effects. The invention includes novel compounds and pharmaceutical compositions, and methods of using them to treat cancer and other conditions.
摘要翻译: 本申请涉及与多核苷酸的四连体形成区相互作用并从而抑制遗传信息转化为多肽的某些新型多环化合物。 因此,这些化合物可提供抗癌和抗细菌和抗病毒作用。 本发明包括新型化合物和药物组合物,以及使用它们治疗癌症和其它病症的方法。
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公开(公告)号:US20120208792A1
公开(公告)日:2012-08-16
申请号:US13315103
申请日:2011-12-08
IPC分类号: A61K31/4745 , A61K31/5377 , A61K31/497 , C12N5/09 , A61P35/00 , A61P35/02 , A61P29/00 , A61K31/496 , A61K31/551
CPC分类号: C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译: 本发明部分地涉及具有某些生物活性的分子,包括但不限于抑制细胞增殖,调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶(Flt)活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号:US08168651B2
公开(公告)日:2012-05-01
申请号:US12396084
申请日:2009-03-02
IPC分类号: A61K31/44 , C07D471/02
CPC分类号: C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译: 本发明部分地涉及具有某些生物活性的分子,包括但不限于抑制细胞增殖,调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶(Flt)活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号:US20090239859A1
公开(公告)日:2009-09-24
申请号:US12396084
申请日:2009-03-02
IPC分类号: A61K31/5377 , C07D413/14 , C12N5/00 , A61P35/00
CPC分类号: C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译: 本发明部分地涉及具有某些生物活性的分子,包括但不限于抑制细胞增殖,调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶(Flt)活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号:US08124649B2
公开(公告)日:2012-02-28
申请号:US12495666
申请日:2009-06-30
IPC分类号: A61K31/195 , A61K31/341 , C07D307/32 , C07D409/04
CPC分类号: C07D405/06 , C07D405/14 , C07D417/14
摘要: The invention provides compounds that inhibit PIM kinases and Flt3 kinase, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation.
摘要翻译: 本发明提供抑制PIM激酶和Flt3激酶的化合物,以及含有这些化合物的组合物。 这些化合物和组合物可用于治疗增殖性疾病如癌症,以及其它激酶相关病症,包括炎症。
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公开(公告)号:US20120190669A1
公开(公告)日:2012-07-26
申请号:US13354563
申请日:2012-01-20
IPC分类号: A61K31/404 , C07D405/14 , A61K31/551 , A61P29/00 , A61K31/496 , A61P35/00 , A61P35/02 , C07D405/06 , A61K31/4439
CPC分类号: C07D405/06 , C07D405/14 , C07D417/14
摘要: The invention provides compounds that inhibit PIM kinases and Flt3 kinase, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation.
摘要翻译: 本发明提供抑制PIM激酶和Flt3激酶的化合物,以及含有这些化合物的组合物。 这些化合物和组合物可用于治疗增殖性疾病如癌症,以及其它激酶相关病症,包括炎症。
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