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公开(公告)号：US06514990B2
公开(公告)日：2003-02-04
申请号：US10038178
申请日：2001-11-09
IPC分类号： A61K3147
CPC分类号： C07D209/08 , C07D209/90 , C07D209/92 , C07D215/08 , C07D215/12 , C07D221/12 , C07D223/22 , C07D225/08 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/36 , C07D277/62 , C07D279/16 , C07D281/10 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indolinyl and 5,6-dihydrophenanthridinyl compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.
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2.发明授权公开(公告)号：US06358993B1
公开(公告)日：2002-03-19
申请号：US09425582
申请日：1999-10-22
IPC分类号： A61K31405
CPC分类号： C07D209/08 , C07D209/90 , C07D209/92 , C07D215/08 , C07D215/12 , C07D221/12 , C07D223/22 , C07D225/08 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/36 , C07D277/62 , C07D279/16 , C07D281/10 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indolinyl and 5,6-dihydrophenanthridinyl compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.
摘要翻译： 本发明涉及药学上可接受的化合物，包括某些取代的二氢吲哚基及其衍生物，1,2,3,4-四氢喹啉基及其衍生物，1,2,3,4-四氢异喹啉基，苯并[cd] 二氢吩芬丁基化合物，以及使用或包含一种或多种这样的化合物的治疗方法和药物组合物。 本发明的化合物特别可用于治疗或预防神经损伤和神经变性疾病。
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公开(公告)号：US06770668B2
公开(公告)日：2004-08-03
申请号：US10321402
申请日：2002-12-17
IPC分类号： A61K3140
CPC分类号： C07D209/08 , C07D209/90 , C07D209/92 , C07D215/08 , C07D215/12 , C07D221/12 , C07D223/22 , C07D225/08 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/36 , C07D277/62 , C07D279/16 , C07D281/10 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indolinyl and 5,6-dihydrophenanthridinyl compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.
摘要翻译： 本发明涉及药学上可接受的化合物，包括某些取代的二氢吲哚基及其衍生物，1,2,3,4-四氢喹啉基及其衍生物，1,2,3,4-四氢异喹啉基，苯并[cd] 二氢吩芬丁基化合物，以及使用或包含一种或多种这样的化合物的治疗方法和药物组合物。 本发明的化合物特别可用于治疗或预防神经损伤和神经变性疾病。
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公开(公告)号：US06025355A
公开(公告)日：2000-02-15
申请号：US858399
申请日：1997-05-19
IPC分类号： C07D209/08 , C07D209/90 , C07D209/92 , C07D215/08 , C07D215/12 , C07D221/12 , C07D223/22 , C07D225/08 , C07D265/36 , C07D277/62 , C07D279/16 , C07D281/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D521/00 , A61K31/495 , A61K31/535 , A61K31/54
CPC分类号： C07D209/08 , C07D209/90 , C07D209/92 , C07D215/08 , C07D215/12 , C07D221/12 , C07D223/22 , C07D225/08 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/36 , C07D277/62 , C07D279/16 , C07D281/10 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indolinyl and 5,6-dihydrophenanthridinyl compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.
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公开(公告)号：US06787569B1
公开(公告)日：2004-09-07
申请号：US09637512
申请日：2000-08-11
申请人： Stanley M. Goldin , James B. Fischer , Andrew Gannett Knapp , N. Laxma Reddy , David Berlove , Graham J. Durant , Subbarao Katragadda , Lain-Yen Hu , Sharad Magar , Wenhong Fan , Elizabeth Yost , Jun Qing Guo
发明人： Stanley M. Goldin , James B. Fischer , Andrew Gannett Knapp , N. Laxma Reddy , David Berlove , Graham J. Durant , Subbarao Katragadda , Lain-Yen Hu , Sharad Magar , Wenhong Fan , Elizabeth Yost , Jun Qing Guo
IPC分类号： A61K31155
CPC分类号： C07D277/62 , A61K31/155 , A61K31/405 , A61K31/445 , A61K31/50 , C07C279/18 , C07C2602/08 , C07C2602/10 , C07C2603/12 , C07C2603/18 , C07C2603/20 , C07C2603/74 , C07D209/08 , C07D209/90 , C07D209/92 , C07D217/06 , C07D285/10 , C07D295/215 , C07D317/58 , C07D471/04
摘要： The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.
摘要翻译： 本发明提供治疗上有用的取代胍，以及使用或包含一种或多种此类胍的治疗方法和药物组合物。
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公开(公告)号：US07351743B1
公开(公告)日：2008-04-01
申请号：US09637774
申请日：2000-08-11
申请人： Stanley M. Goldin , James B. Fischer , Andrew Gannett Knapp , N. Laxma Reddy , David Berlove , Graham J. Durant , Subbarao Katragadda , Lain-Yen Hu , Sharad Magar , Wenhong Fan , Elizabeth Yost , Juo Qing Guo
发明人： Stanley M. Goldin , James B. Fischer , Andrew Gannett Knapp , N. Laxma Reddy , David Berlove , Graham J. Durant , Subbarao Katragadda , Lain-Yen Hu , Sharad Magar , Wenhong Fan , Elizabeth Yost , Juo Qing Guo
IPC分类号： A61K31/155 , C07C279/18
CPC分类号： A61K31/155 , C07C279/18
摘要： The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.
摘要翻译： 本发明提供治疗上有用的取代胍，以及使用或包含一种或多种此类胍的治疗方法和药物组合物。
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公开(公告)号：US06288123B1
公开(公告)日：2001-09-11
申请号：US08464103
申请日：1995-06-05
申请人： Stanley M. Goldin , James B. Fischer , Andrew Gannett Knapp , N. Laxma Reddy , David Berlove , Graham J. Durant , Subbarao Katragadda , Lain-Yen Hu , Sharad Magar , Wenhong Fan , Elizabeth Yost , Jun Qing Guo
发明人： Stanley M. Goldin , James B. Fischer , Andrew Gannett Knapp , N. Laxma Reddy , David Berlove , Graham J. Durant , Subbarao Katragadda , Lain-Yen Hu , Sharad Magar , Wenhong Fan , Elizabeth Yost , Jun Qing Guo
IPC分类号： A61K31155
CPC分类号： C07C323/43 , A61K31/155 , A61K31/405 , A61K31/445 , C07C279/04 , C07C279/18 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/12 , C07C2603/18 , C07C2603/20 , C07C2603/24 , C07C2603/26 , C07C2603/40 , C07C2603/74 , C07D209/08 , C07D209/90 , C07D209/92 , C07D217/06 , C07D277/62 , C07D285/10 , C07D295/215 , C07D317/58 , C07D471/04
摘要： The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.
摘要翻译： 本发明提供治疗上有用的取代胍，以及使用或包含一种或多种此类胍的治疗方法和药物组合物。
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公开(公告)号：US06174924B1
公开(公告)日：2001-01-16
申请号：US08462013
申请日：1995-06-05
申请人： Stanley M. Goldin , James B. Fischer , Andrew Gannett Knapp , N. Laxma Reddy , David Berlove , Graham J. Durant , Subbarao Katragadda , Lain-Yen Hu , Sharad Magar , Wenhong Fan , Elizabeth Yost , Jun Qing Guo
发明人： Stanley M. Goldin , James B. Fischer , Andrew Gannett Knapp , N. Laxma Reddy , David Berlove , Graham J. Durant , Subbarao Katragadda , Lain-Yen Hu , Sharad Magar , Wenhong Fan , Elizabeth Yost , Jun Qing Guo
IPC分类号： A61K31155
CPC分类号： C07C323/43 , A61K31/155 , A61K31/405 , A61K31/445 , C07C279/04 , C07C279/18 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/12 , C07C2603/18 , C07C2603/20 , C07C2603/24 , C07C2603/26 , C07C2603/40 , C07C2603/74 , C07D209/08 , C07D209/90 , C07D209/92 , C07D217/06 , C07D277/62 , C07D285/10 , C07D295/215 , C07D317/58 , C07D471/04
摘要： The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.
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公开(公告)号：US6143791A
公开(公告)日：2000-11-07
申请号：US482984
申请日：1995-06-07
申请人： Stanley M. Goldin , James B. Fischer , Andrew Gannett Knapp , N. Laxma Reddy , David Berlove , Graham J. Durant , Subbarao Katragadda , Lain-Hu Hu , Sharad Magar , Wenhong Fan , Elizabeth Yost , Jun Qing Guo
发明人： Stanley M. Goldin , James B. Fischer , Andrew Gannett Knapp , N. Laxma Reddy , David Berlove , Graham J. Durant , Subbarao Katragadda , Lain-Hu Hu , Sharad Magar , Wenhong Fan , Elizabeth Yost , Jun Qing Guo
IPC分类号： A61K31/155 , A61K31/405 , A61K31/445 , A61K31/50
CPC分类号： A61K31/445 , A61K31/155 , A61K31/405 , A61K31/50
摘要： The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.
摘要翻译： 本发明提供治疗上有用的取代胍，以及使用或包含一种或多种此类胍的治疗方法和药物组合物。
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公开(公告)号：US5847006A
公开(公告)日：1998-12-08
申请号：US454927
申请日：1995-05-31
申请人： Sharad Magar , Graham J. Durant , Lain-Yen Hu , Stanley M. Goldin , N. Laxma Reddy , James B. Fischer , Subbarao Katragadda , Andrew Gannett Knapp , Lee David Margolin
发明人： Sharad Magar , Graham J. Durant , Lain-Yen Hu , Stanley M. Goldin , N. Laxma Reddy , James B. Fischer , Subbarao Katragadda , Andrew Gannett Knapp , Lee David Margolin
IPC分类号： C07C279/18 , A01N37/52 , C07C277/00
CPC分类号： C07C279/18 , C07C2103/20
摘要： The present invention provides N,N'-diaryl substituted guanidines having therapeutic utility. The compounds of the present invention are represented by the formula: ##STR1## wherein R and R.sup.1 represent hydrogen or other group and Ar and Ar.sup.1 represent selected aryl groups, and at least one being acenaphthyl.
摘要翻译： 本发明提供具有治疗效用的N，N'-二芳基取代的胍。 本发明的化合物由下式表示：其中R和R 1表示氢或其它基团，Ar和Ar 1表示选择的芳基，至少一个是苊基。
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