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公开(公告)号：US20240091771A1
公开(公告)日：2024-03-21
申请号：US18246143
申请日：2021-09-17
发明人： Yusuke FUCHIWAKI , Masato TANAKA , Shohei YAMAMURA , Naoki MORISHITA , Kumiko KAMIYA , Seiichiro MATSUZAKI
IPC分类号： B01L3/00
CPC分类号： B01L3/502723 , B01L2300/048 , B01L2300/069
摘要： An assay device and an assay method are each capable of ensuring the accuracy of a target substance detection section. The assay device includes a plurality of assay units 100, each assay unit 100 including a microfluidic channel configured to allow a liquid to flow; a porous absorbing medium disposed at a distance from one end of the microfluidic channel, the one end being located on one side in a flow direction of the liquid; and a separation space disposed between the one end of the microfluidic channel and the porous absorbing medium, in which the microfluidic channel includes, in the microfluidic channel, a detection section 14 having immobilized thereon a substance capable of specifically reacting with a target substance, and an internal standard section 54 having immobilized thereon an internal standard substance, and each assay unit includes two parallel ventilation passages that are respectively adjacent to both sides of the microfluidic channel in the width direction orthogonal to the flow direction, the two parallel ventilation passages communicating with the microfluidic channel to allow for air circulation.
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公开(公告)号：US20240342705A1
公开(公告)日：2024-10-17
申请号：US18259645
申请日：2021-12-27
CPC分类号： B01L3/502707 , G01N35/08 , B01L2300/048 , B01L2300/069 , B01L2300/0867
摘要： An assay device allows reducing manufacturing variation, maintaining the measurement accuracy of the assay device at a high level, and enhancing the liquid control performance. The assay device of the present invention includes a microfluidic channel 2 allowing liquid to flow, an absorbing porous medium 3 disposed at a distance from one end 2a of the microfluidic channel 2, a separating space 4 disposed between the microfluidic channel 2 and the absorbing porous medium 3, and a housing space 5 housing the absorbing porous medium 3. The assay device further includes a lower member 20 which is an integrally molded article constituting a part of the assay device. The lower member 20 defines a lower portion 2b of the microfluidic channel 2, a lower portion 4a of the separating space 4, and a lower portion 5a of the housing space 5. The lower portions 4a, 5a of the separating space 4 and the housing space 5 are inclined downward toward one side from the other side in a flow direction. The lower member 20 supports the absorbing porous medium 3 at the lower portion 5a of the housing space 5.
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公开(公告)号：US20150337355A1
公开(公告)日：2015-11-26
申请号：US14411191
申请日：2013-07-01
CPC分类号： C12Q1/24 , B01L3/502761 , B01L2200/027 , B01L2200/0652 , C12M25/00 , C12M33/00 , G01N15/1404 , G01N15/1459 , G01N15/1484 , G01N33/574 , G01N2015/1006 , G01N2015/1415
摘要： A cell-spreading device may include a microchamber chip having a microchamber capable of enclosing and retaining a cell, a channel-forming frame united with the microchamber chip to form a channel on the microchamber, an inlet provided in the channel-forming frame to allow a cell suspension to flow into the channel, and an outlet provided in the channel-forming frame to allow the cell suspension, which has been allowed to flow into the channel through the inlet, to flow out from the channel. When an aperture of the microchamber is projected perpendicularly to a longitudinal width of the microchamber chip, the void ratio that is a ratio of the sum total of voids to the longitudinal width is not more than 5%, the void being a length of a portion where the projected aperture of the microchamber is not present against the longitudinal width.
摘要翻译： 细胞扩散装置可以包括具有能够封闭和保持细胞的微型室的微型仓芯片，与微型仓结合在一起的通道形成框架以在微型仓上形成通道，设置在通道形成框架中以允许 流入通道的细胞悬浮液和设置在通道形成框架中的出口，以允许已经允许通过入口流入通道的细胞悬浮液从通道流出。 当微孔的孔径垂直于微孔板的纵向宽度投影时，作为空隙总和与纵向宽度的比率的空隙率不大于5％，空隙是部分的长度 其中微孔板的投影孔径不存在抵靠纵向宽度。
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公开(公告)号：US20220026424A1
公开(公告)日：2022-01-27
申请号：US17431128
申请日：2020-02-26
发明人： Hyonchol KIM , Dai KATO , Naoshi KOJIMA , Shohei YAMAMURA , Tomoyuki KAMATA
IPC分类号： G01N33/543 , G01N21/66 , G01N33/574 , G01N33/553
摘要： In order to provide a specific solution for producing a microstructure equipped with a mechanism for selectively detecting a marker molecule expressed by a target cell, or a specific biomolecule, and for detecting and identifying a molecule to be detected using the microstructure, the present invention provides a nearly hemispherical shell-shaped structure made of a first conductive material, and an electrode layer made of a second conductive material disposed on the concave side of the nearly hemispherical shell-shaped structure, wherein the first conductive material includes a magnetic material and the second conductive material includes an electrode material, and the size (diameter) of the cavity surrounded by the electrode layer on the concave side of the nearly hemispherical shell-shaped structure is in the range of about 10 nm to about 50 μm.
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