公开(公告)号：US12048929B2

公开(公告)日：2024-07-30

申请号：US17393147

申请日：2021-08-03

申请人： NATIONAL TSING HUA UNIVERSITY ,  TAIPEI MEDICAL UNIVERSITY

发明人： Yu-Chen Chen ,  Han-Jung Liao ,  Kang-Yun Lee ,  Shu-Chuan Ho ,  Weilun Sun ,  Cheng-Hsien Liu

IPC分类号： B01L3/00 ,  C12M1/12 ,  C12M1/34 ,  C12M1/36 ,  C12M3/06 ,  C12N5/00

CPC分类号： B01L3/502753 ,  B01L3/502715 ,  C12M23/16 ,  C12M25/14 ,  C12M41/46 ,  C12M41/48 ,  C12N5/0068 ,  B01L2300/0645 ,  B01L2300/0819 ,  B01L2300/0883 ,  B01L2400/0424 ,  C12N2513/00

摘要： An array platform for three-dimensional cell culturing and drug testing and screening is disclosed. In the array platform, a hydrogel-cell mixture injection area is configured to inject a plurality of kinds of hydrogel-cell mixtures. Cell observation areas are connected to the hydrogel-cell mixture injection area. Electrodes are disposed under the cell observation areas and automatic cell quantification and three-dimensional cell co-arrangement of the plurality of kinds of hydrogel-cell mixtures in the cell observation areas through the electrodes to imitate a structure of body's tissues. A drug injection area is configured to inject a plurality of kinds of drugs. Drug combination generators respectively correspond to the cell observation areas and are connected to the drug injection area. Each drug combination generator has a microfluidic channel structure and configured to generate drug combinations according to the plurality of kinds of drugs.