公开(公告)号：US20170160174A1

公开(公告)日：2017-06-08

申请号：US15321486

申请日：2015-06-25

申请人： National University Corporation Nagoya University

发明人： Kaori USHIDA ,  Naoya ASAI ,  Masahide TAKAHASHI

IPC分类号： G01N1/36 ,  C08K5/09 ,  C08L89/06 ,  G01N1/30

CPC分类号： G01N1/36 ,  C08K5/09 ,  C08L89/06 ,  C08L2201/54 ,  G01N1/28 ,  G01N1/30

摘要： Provided is an embedding medium for specimen preparation that, when preparing a curable base material nonpenetrating specimen, involves no thermal invasion of the tissue, minimizes wrinkling and tearing during thin slicing, and makes it possible to confirm the position of the tissue in the embedding medium, and also for preparing a curable base material penetrating specimen on the same plane as a curable base material nonpenetrating specimen.The problem can be solved by using an embedding medium for specimen preparation that includes gelatin that is in a liquid state at 15° C.-25° C. and assumes a solid state at 4° C. when made into an aqueous solution.

公开(公告)号：US20170223937A1

公开(公告)日：2017-08-10

申请号：US15519030

申请日：2015-10-13

申请人： NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY

发明人： Masato ASAI ,  Masahide TAKAHASHI ,  Naoya ASAI ,  Atsushi ENOMOTO ,  Kozo UCHIYAMA

IPC分类号： A01K67/027

CPC分类号： A01K67/0276 ,  A01K2207/25 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0356 ,  C12N15/09 ,  G01N33/5088 ,  G01N2800/2857

摘要： Provided are a knockout mouse, a method for screening a substance for suppressing mesial temporal lobe epilepsy, and a method for selecting a technique for suppressing mesial temporal lobe epilepsy. A knockout mouse 30 or more days of age that has lost the function of the Girdin gene in at least the nervous tissues and exhibits the phenotypes of (1), (2), and (3) below. (1) hippocampal sclerosis should be present, (2) extrahippocampal brain damage should be limited, and (3) spontaneous epilepsy that can be said to be of hippocampal origin should be present.