公开(公告)号：US20170223937A1

公开(公告)日：2017-08-10

申请号：US15519030

申请日：2015-10-13

申请人： NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY

发明人： Masato ASAI ,  Masahide TAKAHASHI ,  Naoya ASAI ,  Atsushi ENOMOTO ,  Kozo UCHIYAMA

IPC分类号： A01K67/027

CPC分类号： A01K67/0276 ,  A01K2207/25 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0356 ,  C12N15/09 ,  G01N33/5088 ,  G01N2800/2857

摘要： Provided are a knockout mouse, a method for screening a substance for suppressing mesial temporal lobe epilepsy, and a method for selecting a technique for suppressing mesial temporal lobe epilepsy. A knockout mouse 30 or more days of age that has lost the function of the Girdin gene in at least the nervous tissues and exhibits the phenotypes of (1), (2), and (3) below. (1) hippocampal sclerosis should be present, (2) extrahippocampal brain damage should be limited, and (3) spontaneous epilepsy that can be said to be of hippocampal origin should be present.

公开(公告)号：US20160360735A1

公开(公告)日：2016-12-15

申请号：US15178935

申请日：2016-06-10

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Michael Karin ,  Atsushi Umemura ,  Hayato Nakagawa

IPC分类号： A01K67/027 ,  G01N33/50 ,  C12Q1/68

CPC分类号： A01K67/0271 ,  A01K2207/12 ,  A01K2207/25 ,  A01K2227/105 ,  A01K2267/0331 ,  G01N33/5011 ,  G01N33/5088

摘要： The invention provides a non-human animal model for non-alcoholic steatohepatitis (NASH)-induced heptocellular carcinoma, methods of screening for agents for treating heptocellular carcinoma, methods of screening for targets useful in suppressing NASH progression to heptocellular carcinoma, methods of treating heptocellular carcinoma, and compositions for treating the same.

摘要翻译： 本发明提供非酒精性脂肪性肝炎（NASH）诱导的肝细胞癌的非人动物模型，筛选用于治疗肝细胞癌的药物的方法，筛选用于抑制NASH进展为肝细胞癌的靶标的方法，治疗肝细胞癌的方法 癌和用于治疗癌症的组合物。

公开(公告)号：US09034859B2

公开(公告)日：2015-05-19

申请号：US13441241

申请日：2012-04-06

申请人： Shunlin Ren

发明人： Shunlin Ren

IPC分类号： A61K31/575 ,  A61P3/06 ,  A61P1/16 ,  C07J31/00 ,  A01K67/027 ,  C12N9/10 ,  A61K48/00

CPC分类号： A61K31/575 ,  A01K67/027 ,  A01K2207/25 ,  A01K2227/105 ,  A01K2267/0362 ,  A61K48/005 ,  C12N9/13 ,  C12N2799/022 ,  Y10S514/893

摘要： Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25HC3S) to the subject e.g. by 1) administering 25HC3S to the subject; or 2) overexpressing, in the subject, the hydroxysterol sulfotransferase enzyme SULT2B1b, which catalyzes the sulfation of 25-hydroxycholesterol (25HC) to form 25HC3S.

摘要翻译： 提供了在有需要的受试者中预防和治疗肝损伤或疾病的方法和组合物。 所述方法包括向受试者提供硫酸化氧固醇25-羟基胆固醇-3-硫酸酯（25HC 3 S）。 通过1）向受试者施用25HC3S; 或2）在受试者中过表达了羟基甾醇磺基转移酶SULT2B1b，其催化25-羟基胆固醇（25HC）的硫酸化形成25HC3S。

公开(公告)号：US20110239318A1

公开(公告)日：2011-09-29

申请号：US13128858

申请日：2009-11-17

申请人： David Stephen ,  Gaye Elizabeth Morgenthaler

发明人： David Stephen ,  Gaye Elizabeth Morgenthaler

IPC分类号： A01K67/027 ,  C12N15/00 ,  A61K38/00 ,  C10L1/02 ,  C10L1/04 ,  A61P43/00

CPC分类号： A01K67/0275 ,  A01K67/02 ,  A01K67/027 ,  A01K2207/05 ,  A01K2207/10 ,  A01K2207/25 ,  A01K2217/00 ,  A01K2217/052 ,  A01K2227/40 ,  A01K2267/02 ,  C07K14/47 ,  C10L1/02 ,  C10L2200/0469 ,  C10L2290/28 ,  C10L2290/544 ,  C12N15/8509

摘要： The invention provides methods for producing biofuel from algae, that use fish which have a high capacity of producing and/or accumulating lipids to harvest algae from an algal culture. The invention also provides methods for growing fish that result in a high lipid content. The invention also provides methods for creating fish that have a high capacity of producing and accumulating lipids by breeding and/or recombinant DNA techniques. Also included are transgenic fish that have a higher lipid content than wild-type fish.

摘要翻译： 本发明提供用于从藻类生产生物燃料的方法，其使用具有高生产和/或积累脂质以从藻类培养物中收获藻类的鱼。 本发明还提供了用于生长导致高脂质含量的鱼的方法。 本发明还提供了通过育种和/或重组DNA技术产生具有高产生和积累脂质的鱼的方法。 还包括具有比野生型鱼类更高的脂质含量的转基因鱼。

公开(公告)号：US20190191676A1

公开(公告)日：2019-06-27

申请号：US16307241

申请日：2017-06-08

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Guang William Wong ,  Susana Rodriguez

IPC分类号： A01K67/027 ,  A61K38/17 ,  A61P1/16 ,  A61K31/4402

CPC分类号： A01K67/0276 ,  A01K67/027 ,  A01K2207/25 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0362 ,  A61K31/4402 ,  A61K38/1719 ,  A61P1/16

摘要： Methods for the treatment or prevention of disease, such as fatty liver disease and obesity, are described including the modulation the amount of CTRP1 in a subject. Novel mouse strains are also described.

公开(公告)号：US20180303075A1

公开(公告)日：2018-10-25

申请号：US15767404

申请日：2016-10-12

申请人： VIRGINIA COMMONWEALTH UNIVERSITY

发明人： Arun Sanyal ,  Faridoddin Mirshahi

IPC分类号： A01K67/027

CPC分类号： A01K67/027 ,  A01K2207/25 ,  A01K2227/105 ,  A01K2267/035 ,  A01K2267/0362

摘要： An isogenic murine animal model for liver disease resulting from a Western (high fat, high sugar) diet is provided. This phenotypically and genotypically stable model sequentially develops steatosis (4-8 weeks), steatohepatitis (12-16 weeks), progressive fibrosis (16 week onwards) and spontaneous HCC (32-52 weeks), but only when fed a diet high in fat and sugar. The mice also develop obesity, insulin resistance and dyslipidemia, and the mouse hepatic transcriptome is concordant with the human NASH transcriptome at early and late time points, including activation of lipogenic, inflammatory and apoptotic signaling. The mouse HCC gene signature resembles S1 and S2 human HCC subclasses. This simple model of NASH and HCC that mirrors the development of human disease in terms of its triggers, serology, phenotype, histology, transcriptome and outcomes has utility in new target discovery, biomarker discovery, diagnostic test development, and screening and development of drugs for the corresponding liver conditions.

公开(公告)号：US20160377598A1

公开(公告)日：2016-12-29

申请号：US14697562

申请日：2015-04-27

申请人： Bellamkonda K. Kishore ,  Yue Zhang ,  Carolyn M. Ecelbarger

发明人： Bellamkonda K. Kishore ,  Yue Zhang ,  Carolyn M. Ecelbarger

IPC分类号： G01N33/50 ,  A61K47/26 ,  A61K38/46 ,  C07K16/28 ,  C12N15/113

CPC分类号： G01N33/5044 ,  A01K67/0276 ,  A01K2207/25 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0362 ,  A61K38/465 ,  A61K47/26 ,  C07K16/28 ,  C07K2317/76 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/30 ,  C12Y301/00

摘要： The invention provides a method for treating or preventing diet-induced obesity in a subject comprising administering an agent in an effective amount so that expression or activity of the P2Y2 receptor is decreased or inhibited in the subject thereby treating or preventing diet-induced obesity in the subject.

摘要翻译： 本发明提供了治疗或预防受试者饮食诱导的肥胖症的方法，其包括施用有效量的药剂，使得受试者的P2Y2受体的表达或活性降低或抑制，从而治疗或预防饮食诱导的肥胖症 学科。

公开(公告)号：US20150272093A1

公开(公告)日：2015-10-01

申请号：US14673334

申请日：2015-03-30

申请人： New York University

发明人： Greg Seong-Bae Suh ,  Monica Dus

IPC分类号： A01K67/033 ,  C07K14/435

CPC分类号： A01K67/0339 ,  A01K2207/15 ,  A01K2207/25 ,  A01K2217/052 ,  A01K2227/706 ,  A01K2267/03 ,  C07K14/43581

摘要： Provided is a gene in drosophila designated as dSLC5A1. This gene is responsible for taste independent nutrient sensing. Activation of neurons expressing this gene results in hunger behavior. Provided are compositions and methods for identifying agents that can interfere with hunger behavior.

摘要翻译： 提供的命名为dSLC5A1的果蝇中的基因。 该基因负责味道独立的营养感知。 激活表达该基因的神经元导致饥饿行为。 提供了用于鉴定可能干扰饥饿行为的药剂的组合物和方法。

公开(公告)号：US20150208620A1

公开(公告)日：2015-07-30

申请号：US14420410

申请日：2013-08-01

申请人： SHANGHAI JIAO TONG UNIVERSITY ,  PERFECT (CHINA) CO., LTD

发明人： Liping Zhao ,  Na Fei

IPC分类号： A01K67/027 ,  A61K49/00

CPC分类号： A01K67/0271 ,  A01K2207/12 ,  A01K2207/25 ,  A01K2227/105 ,  A01K2267/0337 ,  A01K2267/0362 ,  A01K2267/0368 ,  A61K49/0008

摘要： The application provides, among others, methods for constructing animal obesity models, methods for screening microorganism or composition of microorganisms that may cause obesity, methods for screening therapeutic targets for treating metabolic disorders, and methods for screening or evaluating microorganisms, compounds, food, recipes, formulations, drugs, nutritional supplements, healthcare products, beverages and other items for preventing and treating metabolic diseases.

摘要翻译： 该应用提供了构建动物肥胖模型的方法，用于筛选可能导致肥胖的微生物或微生物组合物的方法，用于筛选治疗代谢紊乱的治疗靶标的方法，以及用于筛选或评估微生物，化合物，食物，配方的方法 ，制剂，药物，营养补充剂，保健产品，饮料和其他预防和治疗代谢疾病的物品。

公开(公告)号：US08541387B2

公开(公告)日：2013-09-24

申请号：US12993249

申请日：2009-05-21

申请人： Sanjay K. Pandey ,  Sanjay Bhanot ,  Eric G. Marcusson ,  Susan M. Freier

发明人： Sanjay K. Pandey ,  Sanjay Bhanot ,  Eric G. Marcusson ,  Susan M. Freier

IPC分类号： C12N15/11 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： A01K67/027 ,  A01K2207/20 ,  A01K2207/25 ,  A01K2227/105 ,  A01K2267/035 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： Disclosed herein are compounds and methods for decreasing SMRT and treating metabolic and/or cardiovascular diseases in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to SMRT include obesity, diabetes, dyslipidemia, and hypothyroidism.

摘要翻译： 本文公开了用于在有需要的个体中降低SMRT并治疗代谢和/或心血管疾病的化合物和方法。 通过施用靶向SMRT的反义化合物可以改善的疾病状况的实例包括肥胖，糖尿病，血脂异常和甲状腺功能减退。