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公开(公告)号：US10517918B2
公开(公告)日：2019-12-31
申请号：US15103521
申请日：2014-12-12
申请人： NESTEC S.A.
发明人： Magali Faure
IPC分类号： A61K38/40 , A61K38/01 , A61K35/20 , A23L33/00 , A23L33/19 , A61K35/745 , A61K35/747 , A61K9/00 , A61K35/741
摘要： The invention relates to modified sweet whey protein (MSWP) for promoting the establishment of healthy and normal cognitive function in young mammals. In particular, the invention relates to the use of MSWP for promoting development of the brain structures responsible for cognitive functions (e.g. cortex and its associated neural pathways) and/or to reverse retardation and/or to prevent retardation of the establishment of cognitive functions. Humans or animals and, in particular, a foetus, pre-term or term born infant, toddler or child or a young adult may benefit from the invention.
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公开(公告)号：US10137108B2
公开(公告)日：2018-11-27
申请号：US15544088
申请日：2016-01-22
申请人： NESTEC S.A.
IPC分类号： A01N47/00 , A61K31/21 , A61K31/26 , A61K31/401 , A23L2/00 , A61K31/198 , A61K31/20 , A61K31/202 , A61K31/70 , A61K31/715 , A61K31/718 , A61K35/20 , A61K38/18 , A61K31/201
摘要： Compositions and methods are provided that are useful in the treatment of inflammatory bowel disease (IBD) patients. The Compositions and methods are suitable in the prevention or postponement of a relapse in inflammatory bowel disease patients.
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公开(公告)号：US20170370910A1
公开(公告)日：2017-12-28
申请号：US15544307
申请日：2016-01-22
申请人： NESTEC S.A.
摘要： The present invention relates to a method for determining the distinctive nutritional requirements of a patient with specific nutritional needs and providing a composition meeting the distinctive nutritional requirements of said patient.
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公开(公告)号：US20160128960A1
公开(公告)日：2016-05-12
申请号：US14995847
申请日：2016-01-14
申请人： NESTEC S.A.
IPC分类号： A61K31/198 , A61K9/00 , A61K31/401
CPC分类号： A61K31/198 , A23K20/142 , A23K20/147 , A23K50/40 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K9/0095 , A61K31/195 , A61K31/401 , A23V2250/0642 , A23V2250/064 , A23V2250/0648 , A23V2250/0616 , A23V2250/0612 , A23V2250/16 , A23V2250/1578 , A23V2250/161 , A23V2250/1612 , A23V2250/1592 , A23V2250/1588 , A23V2250/1642 , A23V2250/06 , A23V2250/156 , A23V2250/702 , A23V2250/704 , A23V2250/641 , A23V2250/0644
摘要： A nutritional composition is used to reconstitute an optimal healthy microbiota ecosystem in humans or animals. In particular, an ingestible carrier contains specific amino acids designed to favor the growth of bacteria favorable to individuals health or for reducing the risk of developing deleterious events. In another aspect, specific amino acids are used to reconstitute an optimal healthy microbiota ecosystem in humans or animals, in particular in infants, critically ill patients, in the case of chronic diseases or any stresses impacting the gut and in elderly people.
摘要翻译： 营养组合物用于重建人或动物中最佳的健康微生物群落生态系统。 特别地，可摄取的载体含有特定的氨基酸，其设计有利于有利于个体健康的细菌的生长或用于降低发生有害事件的风险。 另一方面，特定的氨基酸用于重建人或动物中的最佳健康微生物群落生态系统，特别是在婴儿，危重病人，慢性疾病或任何影响肠道和老年人的压力的情况下。
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公开(公告)号：US09095570B2
公开(公告)日：2015-08-04
申请号：US14073522
申请日：2013-11-06
申请人： NESTEC S.A.
发明人： Magali Faure , Bing Wang , Jeroen Schmitt
CPC分类号： A61K38/40 , A23L2/66 , A23L33/19 , A23L33/40 , A23V2002/00 , A61K35/20 , A23V2250/54248 , A23V2200/322 , A23V2200/32
摘要： The present invention relates generally to the field of neuronal health and neuronal protection. One embodiment of the present invention relates to a composition that can be used for the protection of the enteric nervous system from neurodegeneration. Disorders linked to an impaired enteric nervous system can be treated or prevented by the administration of lactoferrin containing compositions according to the present invention.
摘要翻译： 本发明一般涉及神经元健康和神经元保护领域。 本发明的一个实施方案涉及可用于保护肠神经系统免于神经变性的组合物。 可以通过施用根据本发明的含有乳铁蛋白的组合物来治疗或预防与受损的肠神经系统相关的疾病。
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6.发明申请公开(公告)号：US20160310533A1
公开(公告)日：2016-10-27
申请号：US15104041
申请日：2014-12-12
申请人： NESTEC S.A.
发明人： Magali Faure
IPC分类号： A61K35/20 , A23L33/00 , A23L33/19 , A61K35/745
CPC分类号： A61K35/20 , A23L33/19 , A23L33/40 , A23V2002/00 , A61K35/745 , A61K35/747 , A61K2300/00 , A23V2200/322 , A23V2250/54252
摘要： The present invention relates to administration of sweet whey protein (SWP) for promoting the enteric neuronal development in infants, especially preterm, low birth, very low and extremely low birth weight infants as well as in young children up until the age of six. Administration of the SWP according to the invention prevents and treats disorders associated with an immature or impaired enteric nervous system. The disorders are, notably, dysfunctional gastrointestinal motility manifested as slow intestinal transit, intestinal discomfort, hard stools, constipation and/or gastrointestinal reflux, gut barrier dysfunction, food intolerance or necrotizing enterocolitis.
摘要翻译： 本发明涉及用于促进婴儿，特别是早产，低出生，非常低和极低出生体重婴儿以及直到六岁的幼儿的肠神经元发育的甜乳清蛋白（SWP）。 根据本发明的施用SWP防止和治疗与未成熟或受损的肠神经系统相关的疾病。 这些疾病尤其是表现为慢肠运输，肠不适，硬便，便秘和/或胃肠反流，肠屏障功能障碍，食物不耐受或坏死性小肠结肠炎的功能障碍性胃肠蠕动。
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公开(公告)号：US20140335130A1
公开(公告)日：2014-11-13
申请号：US14338583
申请日：2014-07-23
申请人： Nestec S.A.
IPC分类号： A61K31/401 , A23L1/305 , A61K31/198
CPC分类号： A61K31/198 , A23K20/142 , A23K20/147 , A23K50/40 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K9/0095 , A61K31/195 , A61K31/401 , A23V2250/0642 , A23V2250/064 , A23V2250/0648 , A23V2250/0616 , A23V2250/0612 , A23V2250/16 , A23V2250/1578 , A23V2250/161 , A23V2250/1612 , A23V2250/1592 , A23V2250/1588 , A23V2250/1642 , A23V2250/06 , A23V2250/156 , A23V2250/702 , A23V2250/704 , A23V2250/641 , A23V2250/0644
摘要： The present invention pertains to a nutritional composition for reconstituting an optimal healthy microbiota ecosystem in humans or animals. In particular, the present invention relates to an ingestible carrier containing specific amino acids designed to favor the growth of bacteria favorable to individuals health or for reducing the risk of developing deleterious events. The invention also pertains to the use of specific amino acids for reconstituting an optimal healthy microbiota ecosystem in humans or animals, in particular in infants, critically ill patients, in the case of chronic diseases or any stresses impacting the gut and in elderly people.
摘要翻译： 本发明涉及用于重建人或动物中最佳健康微生物群落生态系统的营养组合物。 特别地，本发明涉及含有特定氨基酸的可摄入载体，其被设计为有利于有利于个人健康的细菌的生长或用于降低发生有害事件的风险。 本发明还涉及特定氨基酸用于在人或动物，特别是婴儿，危重病患者，慢性疾病或任何影响肠道和老年人的压力的情况下，重建最佳的健康微生物群落生态系统。
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8.发明申请USE OF A MODIFIED SWEET WHEY AND A MODIFIED SWEET WHEY CONTAINING INFANT FORMULA FOR PROMOTING THE POSTNATAL DEVELOPMENT OF THE INFANT CENTRAL NERVOUS SYSTEM AND RELATED COGNITIVE FUNCTIONS 审中-公开使用修改后的甜食和含有婴儿配方的改良食品，用于促进婴幼儿中枢神经系统和相关认知功能的后期发展公开(公告)号：US20160310557A1
公开(公告)日：2016-10-27
申请号：US15103521
申请日：2014-12-12
申请人： NESTEC S.A.
发明人： Magali Faure
IPC分类号： A61K38/01 , A61K35/741 , A61K9/00 , A23L33/00 , A23L33/19
CPC分类号： A61K38/018 , A23L33/19 , A23L33/40 , A23V2002/00 , A61K9/0053 , A61K35/20 , A61K35/741 , A61K35/745 , A61K35/747 , A23V2200/322 , A23V2250/54252 , A61K2300/00
摘要： The invention relates to modified sweet whey protein (MSWP) for promoting the establishment of healthy and normal cognitive function in young mammals. In particular, the invention relates to the use of MSWP for promoting development of the brain structures responsible for cognitive functions (e.g. cortex and its associated neural pathways) and/or to reverse retardation and/or to prevent retardation of the establishment of cognitive functions. Humans or animals and, in particular, a foetus, pre- term or term born infant, toddler or child or a young adult may benefit from the invention.
摘要翻译： 本发明涉及改良的甜乳清蛋白（MSWP），用于促进年轻哺乳动物健康和正常认知功能的建立。 特别地，本发明涉及MSWP用于促进负责认知功能（例如皮质及其相关神经通路）的脑结构的发展和/或反向阻滞和/或阻止认知功能的建立的延迟。 人类或动物，特别是胎儿，前期或期限出生的婴儿，幼儿或儿童或年轻成年人可受益于本发明。
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公开(公告)号：US09271958B2
公开(公告)日：2016-03-01
申请号：US14338583
申请日：2014-07-23
申请人： Nestec S.A.
IPC分类号： A61K31/195 , A61K31/401 , A23K1/16 , A23K1/18 , A23L1/29 , A23L1/305 , A61K31/198
CPC分类号： A61K31/198 , A23K20/142 , A23K20/147 , A23K50/40 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K9/0095 , A61K31/195 , A61K31/401 , A23V2250/0642 , A23V2250/064 , A23V2250/0648 , A23V2250/0616 , A23V2250/0612 , A23V2250/16 , A23V2250/1578 , A23V2250/161 , A23V2250/1612 , A23V2250/1592 , A23V2250/1588 , A23V2250/1642 , A23V2250/06 , A23V2250/156 , A23V2250/702 , A23V2250/704 , A23V2250/641 , A23V2250/0644
摘要： The present invention pertains to a nutritional composition for reconstituting an optimal healthy microbiota ecosystem in humans or animals. In particular, the present invention relates to an ingestible carrier containing specific amino acids designed to favor the growth of bacteria favorable to individuals health or for reducing the risk of developing deleterious events. The invention also pertains to the use of specific amino acids for reconstituting an optimal healthy microbiota ecosystem in humans or animals, in particular in infants, critically ill patients, in the case of chronic diseases or any stresses impacting the gut and in elderly people.
摘要翻译： 本发明涉及用于重建人或动物中最佳健康微生物群落生态系统的营养组合物。 特别地，本发明涉及含有特定氨基酸的可摄入载体，其被设计为有利于有利于个人健康的细菌的生长或用于降低发生有害事件的风险。 本发明还涉及特定氨基酸用于在人或动物，特别是婴儿，危重病患者，慢性疾病或任何影响肠道和老年人的压力的情况下，重建最佳的健康微生物群落生态系统。
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公开(公告)号：US20170368026A1
公开(公告)日：2017-12-28
申请号：US15544066
申请日：2016-01-22
申请人： NESTEC S.A.
发明人： Magali Faure , Stephanie Blum-Sperisen , Mohamed Nabil Bosco , Viral Brahmbhatt , Denis Breuille
IPC分类号： A61K31/401 , A23L33/175 , A61K31/198
CPC分类号： A61K31/401 , A23L33/175 , A23V2002/00 , A61K31/198
摘要： Methods and compositions are provided that use proline, serine and threonine to promote healing of the intestinal mucosa. A therapeutically effective amount of proline, serine and threonine is administered to an individual in need thereof, for example a human or other mammal, such as an individual that has damaged intestinal mucosa. The methods and compositions can promote mucosal healing, restore gut barrier function, repair intestinal epithelial cells, promote protection of the colonic epithelium, and/or promote the replenishment of goblet cells in the intestinal and colonic mucosa.
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