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    EARLY BIOMARKERS OF AGE-RELATED LOW-GRADE INFLAMMATION
    2.
    发明申请
    EARLY BIOMARKERS OF AGE-RELATED LOW-GRADE INFLAMMATION 审中-公开
    与年龄相关的低等级炎症的早期生物标志物

    公开(公告)号：US20150011019A1

    公开(公告)日：2015-01-08

    申请号：US14491635

    申请日：2014-09-19

    申请人： NESTEC S.A.

    发明人： Viral Brahmbhatt ,  Denis Breuille ,  Philippe Alexandre Guy ,  Ivan Roura Montoliu ,  Isabelle Papet ,  Karine Vidal

    IPC分类号： G01N33/49

    CPC分类号： G01N33/492 ,  G01N33/6893 ,  G01N2800/7042 ,  G01N2800/7095

    摘要： The present invention relates to a method for predicting the risk of acquiring an age-related low-grade inflammation for a subject, said method comprising a) providing a biological sample from a subject, b) determining in said sample the level of at least one biomarker selected from the group consisting of a compound of molecular weight between 859-863 g/mol and which is an alkylacylphosphatidylcholine, a compound of molecular weight between 861-865 g/mol and which is a diacylphosphatidylcholine, a compound of molecular weight between 791-794 g/mol and which is an alkylacylphosphatidylcholine, a compound of molecular weight between 522-525 g/mol and which is a monoacylphosphatidylcholine, octadecanoylcarnitine (C18), and tryptophan, c) comparing the level of the at least one biomarker to a reference level, and d) determining whether said subject is likely to be at risk of acquiring an age-related low-grade inflammation, when the level of biomarker(s) deviate significantly from the respective reference level.

    摘要翻译： 本发明涉及一种用于预测获得受试者年龄相关的低度炎症的风险的方法，所述方法包括：a）从受试者提供生物样品，b）在所述样品中确定至少一种 选自分子量在859-863g / mol之间的化合物，即烷基酰基磷脂酰胆碱，分子量为861-865g / mol的化合物，其为二酰基磷脂酰胆碱的分子量为791的化合物 -794g / mol，其为烷基酰基磷脂酰胆碱，分子量在522-​​525g / mol之间的化合物，其为单酰基磷脂酰胆碱，十八烷酰基肉碱（C18）和色氨酸，c）将至少一种生物标志物的水平与 参考水平，以及d）确定所述受试者是否有可能获得与年龄有关的低度炎症的风险，当生物标志物的水平显着偏离 ective参考水平。