公开(公告)号：US20180037635A1

公开(公告)日：2018-02-08

申请号：US15678965

申请日：2017-08-16

申请人： Neurimmune Holding AG ,  University of Zurich

发明人： Jan GRIMM ,  Roland MARTIN ,  Benoit COMBALUZIER ,  Ivan JELCIC

IPC分类号： C07K16/08 ,  C07K14/005 ,  G01N33/569 ,  C12N7/00 ,  A61K39/42 ,  A61K45/06 ,  G01N33/68

CPC分类号： C07K16/084 ,  A61K39/42 ,  A61K45/06 ,  C07K14/005 ,  C07K16/081 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/22022 ,  G01N33/56983 ,  G01N33/6893 ,  G01N2333/025

摘要： Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of JC virus (JCV) and/or BK virus (BKV) as well as methods related thereto. Furthermore, assays and kits related to antibodies specific for polyomaviruses, polyomavirus VP1 and or polyomavirus VP1 Virus-Like Particles (VLPs), preferably of the type of JCV and/or BKV, are disclosed. The human-derived antibodies as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for polyomavirus targeted immunotherapy and diagnostics.

公开(公告)号：US20160052996A1

公开(公告)日：2016-02-25

申请号：US14758615

申请日：2014-01-02

申请人： NEURIMMUNE HOLDING AG ,  UNIVERSITY OF ZURICH

发明人： Jan GRIMM ,  Roland MARTIN ,  Benoit COMBALUZIER ,  Ivan JELCIC

IPC分类号： C07K16/08 ,  C12N7/00 ,  C07K14/005 ,  A61K39/42 ,  A61K45/06

CPC分类号： C07K16/084 ,  A61K39/42 ,  A61K45/06 ,  C07K14/005 ,  C07K16/081 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/22022 ,  G01N33/56983 ,  G01N33/6893 ,  G01N2333/025

摘要： Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of JC virus (JCV) and/or BK virus (BKV) as well as methods related thereto. Furthermore, assays and kits related to antibodies specific for polyomaviruses, polyomavirus VP1 and or polyomavirus VP1 Virus-Like Particles (VLPs), preferably of the type of JCV and/or BKV, are disclosed. The human-derived antibodies as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for polyomavirus targeted immunotherapy and diagnostics.

摘要翻译： 提供了特异性识别多瘤病毒多肽的新型人源性抗体，优选能够结合JC病毒（JCV）和/或BK病毒（BKV）类型的多瘤病毒以及与之相关的方法。 此外，公开了与针对多瘤病毒，多瘤病毒VP1和/或多瘤病毒VP1病毒样颗粒（VLP），特别是JCV和/或BKV类型的抗体相关的测定和试剂盒。 人源抗体以及其结合片段，衍生物和变体可以用于用于多瘤病毒靶向免疫治疗和诊断的药物和诊断组合物中。