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    SLIPPERINESS-IMPARTING AGENT AND SLIPPERINESS-IMPARTING METHOD
    1.
    发明申请
    SLIPPERINESS-IMPARTING AGENT AND SLIPPERINESS-IMPARTING METHOD 审中-公开

    公开(公告)号：US20190316054A1

    公开(公告)日：2019-10-17

    申请号：US16313515

    申请日：2017-06-28

    申请人： NOF CORPORATION ,  THE UNIVERSITY OF TOKYO

    发明人： Kazuhiko ISHIHARA ,  Tomozumi NODA ,  Masaru MATSUDA ,  Satoshi YAMADA ,  Nobuyuki SAKAMOTO

    IPC分类号： C10M107/48 ,  C08F230/02

    摘要： Provided is a lubricity-imparting agent that can impart durable lubricity (in particular, lubricity at the time of wetting) to a substrate. It has been found that a lubricity-imparting agent including a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine and a constitutional unit (B) based on a photoreactive functional group-containing monomer, or a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine, a constitutional unit (B) based on a photoreactive functional group-containing monomer, and a constitutional unit (C) based on a hydrophobic group-containing monomer can impart durable lubricity to a substrate surface through a simple approach called photoirradiation.

    PROTEIN ADSORPTION INHIBITOR AND METHOD FOR INHIBITING PROTEIN ADSORPTION
    3.
    发明申请
    PROTEIN ADSORPTION INHIBITOR AND METHOD FOR INHIBITING PROTEIN ADSORPTION 审中-公开

    公开(公告)号：US20170261481A1

    公开(公告)日：2017-09-14

    申请号：US15509617

    申请日：2015-09-08

    申请人： NOF CORPORATION

    发明人： Fumio NAKASHIMA ,  Satoshi YAMADA ,  Tomozumi NODA ,  Masaru MATSUDA

    IPC分类号： G01N33/15 ,  C07F9/10

    CPC分类号： G01N33/15 ,  C07F9/091 ,  C07F9/10

    摘要： A protein adsorption inhibitor includes a compound of Formula (1) as an active ingredient. The protein adsorption inhibitor is capable of highly inhibiting non-specific adsorption of a protein such as an antibody or an enzyme to a surface of a base body such as an immune reaction vessel or an assay instrument. Also provided is a coating layer-formed base body having a coating layer containing the protein adsorption inhibitor on the base body. The coating layer-formed base body has an excellent protein adsorption-inhibiting function. A method for inhibiting the adsorption of the protein to the base body is provided. The method includes forming the coating layer containing the protein adsorption inhibitor on the surface of the base body: wherein, X is a hydrogen atom or a methyl group and n is an integer of 9 to 15.

    REACTION COMPOSITION FOR NUCLEIC ACID AMPLIFICATION AND NUCLEIC ACID AMPLIFICATION METHOD USING SAME
    4.
    发明公开
    REACTION COMPOSITION FOR NUCLEIC ACID AMPLIFICATION AND NUCLEIC ACID AMPLIFICATION METHOD USING SAME 审中-公开

    公开(公告)号：US20240110235A1

    公开(公告)日：2024-04-04

    申请号：US18458354

    申请日：2023-08-30

    申请人： NOF CORPORATION

    发明人： Hirotaka SUZUKI ,  Masaru MATSUDA

    IPC分类号： C12Q1/686 ,  C12Q1/6848

    CPC分类号： C12Q1/686 ,  C12Q1/6848

    摘要： A method for improving repeatability of a nucleic acid amplification method is provided by the present invention, the method including performing a nucleic acid amplification reaction using a reaction composition containing water, an amplification target nucleic acid at a concentration of not more than 10,000 copies/mL, and one or more polymers selected from the following group A at a concentration of 0.005 to 0.5 w/v %:
    [group A]
    (A1) a polymer consisting of a constitutional unit derived from 2-(meth)acryloyloxyethylphosphorylcholine
    (A2) a copolymer containing a constitutional unit derived from 2-(meth)acryloyloxyethylphosphorylcholine and a constitutional unit derived from (meth)acrylic acid.

    COPOLYMER AND APPLICATION THEREFOR
    7.
    发明申请
    COPOLYMER AND APPLICATION THEREFOR 审中-公开

    公开(公告)号：US20190153137A1

    公开(公告)日：2019-05-23

    申请号：US16313292

    申请日：2017-06-28

    申请人： NOF CORPORATION ,  THE UNIVERSITY OF TOKYO

    发明人： Kazuhiko ISHIHARA ,  Masaru MATSUDA ,  Tomozumi NODA ,  Satoshi YAMADA ,  Nobuyuki SAKAMOTO

    IPC分类号： C08F230/02 ,  C08F212/08 ,  C08F220/18 ,  C08J3/28 ,  A61L27/34

    摘要： Provided are a copolymer having biocompatibility sufficient for use in medical material applications, and a method of forming a crosslinked body, the method including imparting biocompatibility to a substrate surface through the use of the copolymer. More specifically, a protein adsorption-suppressing effect and a cell adhesion-suppressing effect, which are features of a phosphorylcholine group, are imparted to the substrate surface. It has been found that a copolymer containing a phosphorylcholine constitutional unit and a photoreactive constitutional unit, or a copolymer containing a phosphorylcholine constitutional unit, a photoreactive constitutional unit, and a hydrophobic constitutional unit can impart a protein adsorption-suppressing effect and a cell adhesion-suppressing effect to a substrate surface through a simple approach called photoirradiation.