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公开(公告)号：US20220397511A1
公开(公告)日：2022-12-15
申请号：US17772219
申请日：2020-10-01
发明人： Takayuki KOMORI , Keiichi MIYAJIMA , SooHyeon KIM , Teruo FUJII , Shinji OKAWA
摘要： An extracellular potential measurement device includes multiple insulating films each of which is made from an electric insulating material, the insulating films being stacked and bonded to each other; and multiple electrode wires each of which is made from an electroconductive material, the electrode wires being arranged in multiple heights. Each of the electrode wires is interposed between an upper insulating film and a lower insulating film. Each of the insulating films, except for a lowermost insulating film, has an opening penetrating the insulating film. The opening in a lower insulating film has a size that is less than that of the opening in an upper insulating film, the openings in the insulating films being overlapped to form a recess having a size reducing downward, the recess being adapted to store a collection of cells. Each of the electrode wires has an end that is located near an opening in an insulating film that is immediately below the electrode wire, the ends being exposed in the recess.
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公开(公告)号：US20200283722A1
公开(公告)日：2020-09-10
申请号：US16753207
申请日：2018-10-02
发明人： Takayuki KOMORI , SooHyeon KIM , Teruo FUJII
摘要： A cell capture apparatus includes a cell separation unit having a flat plate shape and a cell capture unit having a flat plate shape located therebelow. A liquid sample and a carrier liquid flow in a cell-separation flow passage of the cell separation unit. The liquid sample contains multiple large cells, multiple small cells, and a sample liquid component. The cell-separation flow passage separates a set of large cells and the carrier liquid from a set of small cells and the sample liquid component. The cell capture unit includes a large-cell flow passage in which the set of large cells and the carrier liquid flows, and multiple electrode wires for attracting the large cells by means of dielectrophoresis. Multiple cell capturing wells are formed in the large-cell flow passage. Each of the multiple cell capturing wells has a size that can capture one of the large cells attracted by the electrode wires.
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公开(公告)号：US20230364612A1
公开(公告)日：2023-11-16
申请号：US18029019
申请日：2021-09-03
申请人： NOK CORPORATION
发明人： Takayuki KOMORI
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2300/0816 , B01L2300/0851 , B01L2300/0864 , B01L2300/0877 , B01L2400/086
摘要： A fine particle capture device, having a chip that has a plane part and projection parts, and is configured such that fine particle-containing liquid entering from an inlet port passes on the surface of the plane part in the chip and between a projection part and another projection part adjacent thereto and the liquid is discharged from an outlet port. The projection parts are disposed on the plane part in the form of layers. The layers each has a plurality of projection parts, and are configured such that the fine particle-containing liquid having passed through a layer on the inlet port side passes through a layer on the outlet port side adjacent thereto. Each layer has a capture part and a bypass part. The capture part is disposed on the outlet port side of the bypass part in a specific layer as a portion of another layer adjacent thereto.
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公开(公告)号：US20230364613A1
公开(公告)日：2023-11-16
申请号：US18029034
申请日：2021-09-10
发明人： Asako NAKAMURA , Kenta TAKAHASHI , Takayuki KOMORI
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L2200/0647 , B01L2300/0809
摘要： A leukocyte trapping apparatus configured so: a chip having protruding parts arranged on a flat part, a blood-containing solution that enters through an inlet port is allowed to pass through the surface of the flat part and through spaces between two adjacent protruding parts in the chip and is discharged through a discharge port; the protruding parts are arranged in layers on the flat part, layer containing a plurality of the protruding parts, and the blood-containing solution that has passed through a layer located on the inlet port side passes through another layer that is adjacent to the layer on the discharge port side; a trapping part and a bypass part are between two adjacent protruding parts in each layer; and the trapping part is on the discharge port side of the bypass part in a specific layer as a portion of another layer adjacent to the specific layer.
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公开(公告)号：US20200279669A1
公开(公告)日：2020-09-03
申请号：US16877529
申请日：2020-05-19
申请人： NOK CORPORATION
发明人： Takayuki KOMORI , Ryo FUTASHIMA , Toru UDA , Yasushi SUGIYAMA
IPC分类号： H01B1/22 , A61B5/0402 , C08K3/04 , C09D183/06
摘要： A bioelectrode includes a conductive rubber electrode and a silver coating layer provided on the conductive rubber electrode and containing a silicone rubber and silver particles. The silver coating layer further contains a modified silicone.
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公开(公告)号：US20200061614A1
公开(公告)日：2020-02-27
申请号：US16609258
申请日：2018-09-19
申请人： NOK CORPORATION
发明人： Takayuki KOMORI , Takahiro HAYASHI
摘要： A microfluidic chip includes a flow passage plate, a flat plate, and an annular seal. In the flow passage plate, a recess forming a flow passage for liquid and a communication hole communicating with the recess are formed. The flat plate is stacked on or under the flow passage plate to close the recess for defining the flow passage. In the flat plate, a communication through-hole communicating with the recess is formed. The annular seal is located on, or formed on, an outer surface of at least one of the flow passage plate and the flat plate, the annular seal surrounding at least one of the communication hole and the communication through-hole. The annular seal is made of an elastomer.
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公开(公告)号：US20230285959A1
公开(公告)日：2023-09-14
申请号：US18010290
申请日：2021-04-13
申请人： NOK CORPORATION
发明人： Takayuki KOMORI
CPC分类号： B01L3/502707 , B81B1/00 , B01J19/0093 , B81C3/00 , C12M1/34 , B03C5/02 , B01J2219/00783
摘要： A method of manufacturing a micro flow path device includes: arranging a cover film on a surface of a base film on which an electrode pattern made of a metallic thin film has been formed and obtaining a flow path forming laminate; punching the obtained flow path forming laminate along a shape of a flow path so as to cut a part of the electrode pattern and forming a punched portion in which at least a pair of opposite electrodes are exposed to a part of the punched cut surface; and disposing a first planar member, defining a bottom surface of the flow paths on a back surface side of the flow path forming laminate on which the punched portion has been formed and disposing a second planar member defining a top surface of the flow path on a front surface side of the flow path forming laminate.
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