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公开(公告)号：US20150030630A1
公开(公告)日：2015-01-29
申请号：US14382579
申请日：2013-03-07
Applicant: Novartis AG
Inventor： Siddhartha Jain , Derek O'Hagan , Manmohan Singh
IPC: A61K39/39 , A61K39/205
CPC classification number: A61K39/39 , A61K33/06 , A61K39/12 , A61K39/205 , A61K2039/5252 , A61K2039/55505 , A61K2039/55511 , C12N2760/20134
Abstract: The efficacy of rabies vaccines can be enhanced by adjuvanting rabies virus immunogens with a mixture of a TLR agonist (preferably a TLR7 agonist) and an insoluble metal salt (preferably an aluminium salt). The TLR agonist is typically adsorbed to the metal salt. The rabies virus immunogen can also be adsorbed to the metal salt.
Abstract translation: 通过用TLR激动剂（优选TLR7激动剂）和不溶性金属盐（优选铝盐）的混合物佐剂狂犬病毒免疫原可以增强狂犬病疫苗的功效。 TLR激动剂通常被吸附到金属盐上。 狂犬病病毒免疫原也可以被吸附到金属盐上。
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公开(公告)号：US09320748B2
公开(公告)日：2016-04-26
申请号：US14381513
申请日：2013-03-07
Applicant: Novartis AG
Inventor： Stephanie Kay Dodd , Siddhartha Jain
IPC: C07F9/6561 , A61K39/39 , A61K31/675 , A61K39/00
CPC classification number: A61K31/675 , A61K39/39 , A61K2039/55511 , C07F9/6561 , Y02A50/466
Abstract: The invention is in the field of salt forms of an immunopotentiator compound and their formulation for in vivo use. In particular the invention relates to arginine salts.
Abstract translation: 本发明在免疫增强剂化合物的盐形式及其用于体内使用的制剂领域。 特别地，本发明涉及精氨酸盐。
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公开(公告)号：US20160074506A1
公开(公告)日：2016-03-17
申请号：US14948908
申请日：2015-11-23
Applicant: NOVARTIS AG
Inventor： Siddhartha Jain , Manmohan Singh , Derek O'Hagan
IPC: A61K39/385
CPC classification number: A61K39/385 , A61K9/1617 , A61K9/1647 , A61K9/5123 , A61K9/5153 , A61K39/12 , A61K39/155 , A61K2039/5256 , A61K2039/53 , A61K2039/55555 , A61K2039/622 , A61P31/14 , C12N15/86 , C12N15/88 , C12N2760/18534 , C12N2770/36143
Abstract: Particle compositions comprising adsorbed RNA replicons as well as methods of making and using the same are described.
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公开(公告)号：US20150125475A1
公开(公告)日：2015-05-07
申请号：US14381513
申请日：2013-03-07
Applicant: Novartis AG
Inventor： Stephanie Kay Dodd , Siddhartha Jain
IPC: A61K31/675 , A61K39/39 , C07F9/6561
CPC classification number: A61K31/675 , A61K39/39 , A61K2039/55511 , C07F9/6561 , Y02A50/466
Abstract: The invention is in the field of salt forms of an immunopotentiator compound and their formulation for in vivo use. In particular the invention relates to arginine salts.
Abstract translation: 本发明在免疫增强剂化合物的盐形式及其用于体内使用的制剂领域。 特别地，本发明涉及精氨酸盐。
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