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1.发明申请公开(公告)号：US20050058800A1
公开(公告)日：2005-03-17
申请号：US10877812
申请日：2004-06-25
CPC分类号： G11B7/26 , G11B7/005 , G11B7/252 , G11B20/00086 , G11B20/00608 , G11B20/00695 , G11B20/0084 , G11B23/281 , Y10S430/146
摘要： Methods and apparatus are provided for making an optically readable media unreadable and tamper-resistant. A method is disclosed for making an optically readable media unreadable, as is a media that operates in accordance with the method. The method has steps of (a) providing the media with a readout surface layer that is non-flat (i.e., textured in some way, such as by embossing, scratching, depositing a non-planar layer or regions, such as droplets) and that inhibits optical readout of the media; (b) applying a coating layer to the non-flat surface layer to smooth the non-flat surface and to enable optical readout of the media; and, after an initiation of a readout period, (c) removing the coating layer so as to expose the non-flat readout surface layer, thereby inhibiting optical readout of the media. Preferably, the coating layer is substantially index matched to the readout surface layer. In one embodiment the step of removing includes a step of evaporating at least one component material of the coating layer, while in another embodiment the step of removing includes a step of subliming at least one component material of the coating layer. A method is also disclosed for discouraging tampering with a readout-limiting mechanism of an optically readable media, as is a media that is constructed so as to operate in accordance with the method. In this embodiment the method has steps of: (a) providing the media with at least one layer that embodies the readout-limiting mechanism; (b) providing a textured surface that forms part of a layer that underlies the at least one layer, where the textured surface inhibits optical readout of the media; and (c) applying a coating layer over the textured surface to smooth the textured surface and to enable optical readout of the media, wherein removal of the coating layer exposes the textured surface thereby inhibiting optical readout of the media. The disk can be packaged in a sealed container with a source of an agent that inhibits transport of a volatile species from the color forming layer or from a layer that sublimates, wherein the onset of the limited play period coincides with the opening of the container.
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2.发明授权Methods and apparatus for rendering an optically encoded medium unreadable and tamper-resistant 失效用于使光学编码介质呈现不可读和防篡改的方法和装置公开(公告)号：US06780564B2
公开(公告)日：2004-08-24
申请号：US10209376
申请日：2002-07-30
IPC分类号： G11B724
CPC分类号： G11B7/26 , G11B7/005 , G11B7/252 , G11B20/00086 , G11B20/00608 , G11B20/00695 , G11B20/0084 , G11B23/281 , Y10S430/146
摘要： “Methods and apparatus are provided for making an optically readable media unreadable and tamper-resistant. A method has steps of (a)providing the media with a readout surface layer that is non-flat (i.e., texture in some way, such as by embossing, scratching, depositing a non-flat layer or regions, such as droplets) and that inhibits optical readout of the media; (b) applying a coating layer to the non-flat surface layer to smooth the non-flat surface and to enable optical readout of the media; and, after an initiation of a readout period, (c) removing the coating layer so as to expose the non-flat readout surface layer, thereby inhibiting optical readout of the media. Preferably, the coating layer is substantially index matched to the readout surface layer. The step of removing includes at least one of evaporating or subliming a component material of the coating layer A method is also disclosed for discouraging tampering with a readout-limiting mechanism by (a) providing the media with at least one layer that embodies the readout-limiting mechanism; (b) providing a textured surface that forms part of a layer that underlies the at least one layer, where the textured surface inhibits optical readout of the media; and (c) applying a coating layer over the textured surface to smooth the textured surface and to enable optical readout of the media, wherein removal of the coating layer exposes the textured surface thereby inhibiting optical readout of the media.”
摘要翻译： “方法和装置被提供用于制造光学可读介质不可读和防篡改的方法具有以下步骤：（a）向介质提供非平坦的读出表面层（即，以某种方式，例如由 压花，刮擦，沉积非平坦层或诸如液滴的区域），并且阻止介质的光学读出;（b）将涂层施加到非平坦表面层上以平滑非平坦表面并且使能 介质的光学读出;以及在读出周期开始之后，（c）去除涂层以暴露非平面读出表面层，从而抑制介质的光学读出，优选地，涂层基本上 除去步骤包括蒸发或升华涂层的成分材料中的至少一种。还公开了一种方法，用于通过（a）提供介质wi来抑制篡改读出限制机构 至少一层体现读出限制机构; （b）提供纹理表面，其形成位于所述至少一个层下面的层的一部分，其中织构化表面禁止介质的光学读出; 并且（c）在纹理化表面上涂覆涂层以平滑纹理化表面并且使得能够光学读出介质，其中去除涂层暴露纹理表面，从而抑制介质的光学读出。
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3.发明授权Methods and apparatus for rendering an optically encoded medium unreadable and tamper-resistant 失效用于使光学编码介质呈现不可读和防篡改的方法和装置公开(公告)号：US06531262B1
公开(公告)日：2003-03-11
申请号：US09690405
申请日：2000-10-17
IPC分类号： G11B370
CPC分类号： G11B7/26 , G11B7/005 , G11B7/252 , G11B20/00086 , G11B20/00608 , G11B20/00695 , G11B20/0084 , G11B23/281 , Y10S430/146
摘要： Methods and apparatus are provided for making an optically readable media unreadable and tamper-resistant. A method has steps of (a) providing the media with a readout surface layer that is non-flat (i.e., textured in some way, such as by embossing, scratching, depositing a non-planar layer or regions, such as droplets) and that inhibits optical readout of the media; (b) applying a coating layer to the non-flat surface layer to smooth the non-flat surface and to enable optical readout of the media; and, after an initiation of a readout period, (c) removing the coating layer so as to expose the non-flat readout surface layer, thereby inhibiting optical readout of the media. Preferably, the coating layer is substantially index matched to the readout surface layer. The step of removing includes at least one of evaporating or subliming a component material of the coating layer A method is also disclosed for discouraging tampering with a readout-limiting mechanism by (a) providing the media with at least one layer that embodies the readout-limiting mechanism; (b) providing a textured surface that forms part of a layer that underlies the at least one layer, where the textured surface inhibits optical readout of the media; and (c) applying a coating layer over the textured surface to smooth the textured surface and to enable optical readout of the media, wherein removal of the coating layer exposes the textured surface thereby inhibiting optical readout of the media.
摘要翻译： 提供了用于制造光可读介质不可读和防篡改的方法和装置。 一种方法具有以下步骤：（a）向介质提供非平坦的读出表面层（即，以某种方式，例如通过压花，刮擦，沉积非平面层或诸如液滴的区域）和 这抑制了介质的光学读出; （b）将涂层施加到非平坦表面层上以平滑非平坦表面并使光学读出介质; 并且在读出期间开始之后，（c）去除涂层以露出非平面读出表面层，从而抑制介质的光学读出。 优选地，涂层基本上与读出表面层相匹配。 还公开了去除步骤中的至少一种，其中包括使涂层的组分材料蒸发或升华的方法。方法还公开了通过（a）向介质提供体现读出限制机构的至少一层的阻止篡改读出限制机构的方法， 限制机制; （b）提供纹理表面，其形成位于所述至少一个层下面的层的一部分，其中织构化表面禁止介质的光学读出; 并且（c）在纹理化表面上涂覆涂层以平滑纹理化表面并且使得能够光学读出介质，其中去除涂层暴露纹理化表面，从而抑制介质的光学读出。
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公开(公告)号：US07688524B2
公开(公告)日：2010-03-30
申请号：US12108557
申请日：2008-04-24
申请人： Marianne Krieg-Kowald , Mark McLear
发明人： Marianne Krieg-Kowald , Mark McLear
IPC分类号： G02B5/20
摘要： A molded optical filter is provided having effective filtering of energy emissions at an optical density (OD) of greater than 4 in three energy emission bands corresponding to the wavelengths of laser emissions while preserving the wearer's ability to differentiate and recognize colors and having a pleasing overall color. The selective optical filter is a moldable polymer filter that has three dyes therein to produce sharp notch filtering ranges at about 530 nm, 700 nm and 1060 nm and a fourth color balance dye therein to adjust the overall color of the filter making it more pleasing and desirable to the wearer.
摘要翻译： 提供了一种模制的滤光器，其具有在对应于激光发射波长的三个能量发射带中在大于4的光密度（OD）下有效地过滤能量，同时保持佩戴者区分和识别颜色的能力并且具有令人愉快的整体 颜色。 选择性滤光器是一种可模制的聚合物过滤器，其中具有三种染料以在约530nm，700nm和1060nm处产生尖锐的陷波滤波范围，以及其中的第四色平衡染料，以调节滤色片的整体颜色，使其更令人愉快， 对佩戴者而言是理想的。
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公开(公告)号：US20060002263A1
公开(公告)日：2006-01-05
申请号：US11209953
申请日：2005-08-23
IPC分类号： G11B5/09
CPC分类号： G11B7/252 , G11B7/005 , G11B7/244 , G11B7/2542 , G11B23/281 , Y10T428/21
摘要： An optically readable media (10) has an information-encoding layer (16) and at least one color-forming layer (12) that embodies an optical readout-limiting mechanism. In a first embodiment the at least one color-forming layer contains an additive that does not interfere with the optical readability of the media for a duration of a readout period. The additive, upon exposure to a source of optical radiation that is suitable for reversing the color-forming layer from an optical readout inhibiting state to an optical readout enabling state, undergoes a transformation that maintains the color-forming layer in the optical readout inhibiting state. More specifically, exposure to the source causes the color-forming layer to photobleach and the additive to oxidize, where the oxidation of the additive permanently inhibits the optical readability of the media. The additive may be a leuco dye. In one embodiment the color-forming layer is comprised of 3-[2,2-bis(4-diethylaminophenyl)vinyl]-6-dimethylaminophthalide and the additive is comprised of benzoyl leucomethylene blue. In a further embodiment the additive is placed into a protective layer (18) that overlies the color-forming layer.
摘要翻译： 光学可读介质（10）具有信息编码层（16）和体现光读出限制机构的至少一个成色层（12）。 在第一实施例中，至少一个成色层包含在读出期间内不干扰介质的光学可读性的添加剂。 该添加剂在曝光于适合于使着色形成层从光读出禁止状态反转到光学读出使能状态的光学辐射源时，进行使成色层维持在光读出抑制状态的变换 。 更具体地，暴露于源使得着色层光漂白和添加剂氧化，其中添加剂的氧化永久地抑制介质的光学可读性。 添加剂可以是无色染料。 在一个实施方案中，成色层由3- [2,2-双（4-二乙基氨基苯基）乙烯基] -6-二甲基氨基苯酞所组成，并且添加剂由苯甲酰基十二甲基蓝组成。 在另一个实施方案中，添加剂被放置在覆盖着色层的保护层（18）中。
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公开(公告)号：US20090268157A1
公开(公告)日：2009-10-29
申请号：US12108557
申请日：2008-04-24
申请人： Marianne Krieg-Kowald , Mark McLear
发明人： Marianne Krieg-Kowald , Mark McLear
摘要： A molded optical filter is provided having effective filtering of energy emissions at an optical density (OD) of greater than 4 in three energy emission bands corresponding to the wavelengths of laser emissions while preserving the wearer's ability to differentiate and recognize colors and having a pleasing overall color. The selective optical filter is a moldable polymer filter that has three dyes therein to produce sharp notch filtering ranges at about 530 nm, 700 nm and 1060 nm and a fourth color balance dye therein to adjust the overall color of the filter making it more pleasing and desirable to the wearer.
摘要翻译： 提供了一种模制的滤光器，其具有在对应于激光发射波长的三个能量发射带中在大于4的光密度（OD）下有效地过滤能量，同时保持佩戴者区分和识别颜色的能力并且具有令人愉快的整体 颜色。 选择性滤光器是一种可模制的聚合物过滤器，其中具有三种染料以在约530nm，700nm和1060nm处产生尖锐的陷波滤波范围，以及其中的第四色平衡染料，以调节滤色片的整体颜色，使其更令人愉快， 对佩戴者而言是理想的。
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公开(公告)号：US07374804B2
公开(公告)日：2008-05-20
申请号：US11209953
申请日：2005-08-23
IPC分类号： B32B3/02
CPC分类号： G11B7/252 , G11B7/005 , G11B7/244 , G11B7/2542 , G11B23/281 , Y10T428/21
摘要： An optically readable media (10) has an information-encoding layer (16) and at least one color-forming layer (12) that embodies an optical readout-limiting mechanism. In a first embodiment the at least one color-forming layer contains an additive that does not interfere with the optical readability of the media for a duration of a readout period. The additive, upon exposure to a source of optical radiation that is suitable for reversing the color-forming layer from an optical readout inhibiting state to an optical readout enabling state, undergoes a transformation that maintains the color-forming layer in the optical readout inhibiting state. More specifically, exposure to the source causes the color-forming layer to photobleach and the additive to oxidize, where the oxidation of the additive permanently inhibits the optical readability of the media. The additive may be a leuco dye. In one embodiment the color-forming layer is comprised of 3-[2,2-bis(4-diethylaminophenyl)vinyl]-6-dimethylaminophthalide and the additive is comprised of benzoyl leucomethylene blue. In a further embodiment the additive is placed into a protective layer (18) that overlies the color-forming layer.
摘要翻译： 光学可读介质（10）具有信息编码层（16）和体现光读出限制机构的至少一个成色层（12）。 在第一实施例中，至少一个成色层包含在读出期间内不干扰介质的光学可读性的添加剂。 该添加剂在曝光于适合于使着色形成层从光读出禁止状态反转到光学读出使能状态的光学辐射源时，进行使成色层维持在光读出抑制状态的变换 。 更具体地，暴露于源使得着色层光漂白和添加剂氧化，其中添加剂的氧化永久地抑制介质的光学可读性。 添加剂可以是无色染料。 在一个实施方案中，成色层由3- [2,2-双（4-二乙基氨基苯基）乙烯基] -6-二甲基氨基苯酞所组成，并且添加剂由苯甲酰基十二甲基蓝组成。 在另一个实施方案中，添加剂被放置在覆盖着色层的保护层（18）中。
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8.发明申请Method of making, and the use of cytotoxic agents containing elemental selenium 失效制造方法，以及使用含有元素硒的细胞毒素公开(公告)号：US20050053675A1
公开(公告)日：2005-03-10
申请号：US10701870
申请日：2003-11-05
申请人： Fritz Sieber , Wolfgang Gunther , Jean-Pierre Daziano , Marianne Krieg-Kowald , Jamal Bousbaa , Raymond Bula
发明人： Fritz Sieber , Wolfgang Gunther , Jean-Pierre Daziano , Marianne Krieg-Kowald , Jamal Bousbaa , Raymond Bula
CPC分类号： A61K49/0002 , A61K31/28 , A61K33/04 , A61K38/38 , A61K47/62 , A61K2300/00
摘要： Pharmaceutical compositions containing elemental selenium (Se(0)), Se(0)-carrier conjugates, a chromophore photoproduct, fluorescent conjugates of the chromophore photoproduct and carrier molecules, or a mixture thereof are disclosed. Methods of using the pharmaceutical compositions such as inducing cell death are also disclosed. Further disclosed are methods of making the pharmaceutical compositions and components thereof.
摘要翻译： 公开了含有元素硒（Se（0）），Se（0） - 载体共轭物，发色团光产物，发色团光产物和载体分子的荧光共轭物或其混合物的药物组合物。 还公开了使用药物组合物如诱导细胞死亡的方法。 进一步公开了制备药物组合物及其组分的方法。
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公开(公告)号：US20100110370A1
公开(公告)日：2010-05-06
申请号：US12652446
申请日：2010-01-05
申请人： Marianne Krieg-Kowald , Mark McLear
发明人： Marianne Krieg-Kowald , Mark McLear
摘要： A molded optical filter is provided having effective filtering of energy emissions at an optical density (OD) of greater than 4 in three energy emission bands corresponding to the wavelengths of laser emissions while preserving the wearer's ability to differentiate and recognize colors and having a pleasing overall color. The selective optical filter is a moldable polymer filter that has three dyes therein to produce sharp notch filtering ranges at about 530 nm, 700 nm and 1060 nm and a fourth color balance dye therein to adjust the overall color of the filter making it more pleasing and desirable to the wearer.
摘要翻译： 提供了一种模制的滤光器，其具有在对应于激光发射波长的三个能量发射带中在大于4的光密度（OD）下有效地过滤能量，同时保持佩戴者区分和识别颜色的能力并且具有令人愉快的整体 颜色。 选择性滤光器是一种可模制的聚合物过滤器，其中具有三种染料以在约530nm，700nm和1060nm处产生尖锐的陷波滤波范围，以及其中的第四色平衡染料，以调节滤色片的整体颜色，使其更令人愉快， 对佩戴者而言是理想的。
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10.发明授权Method of making, and the use of cytotoxic agents containing elemental selenium 失效制造方法，以及使用含有元素硒的细胞毒素公开(公告)号：US07205002B2
公开(公告)日：2007-04-17
申请号：US10701870
申请日：2003-11-05
申请人： Fritz Sieber , Wolfgang H. H. Günther , Jean-Pierre Daziano , Marianne Krieg-Kowald , Jamal Bousbaa , Raymond J. Bula
发明人： Fritz Sieber , Wolfgang H. H. Günther , Jean-Pierre Daziano , Marianne Krieg-Kowald , Jamal Bousbaa , Raymond J. Bula
CPC分类号： A61K49/0002 , A61K31/28 , A61K33/04 , A61K38/38 , A61K47/62 , A61K2300/00
摘要： Pharmaceutical compositions containing elemental selenium (Se(0)), Se(0)-carrier conjugates, a chromophore photoproduct, fluorescent conjugates of the chromophore photoproduct and carrier molecules, or a mixture thereof are disclosed. Methods of using the pharmaceutical compositions such as inducing cell death are also disclosed. Further disclosed are methods of making the pharmaceutical compositions and components thereof.
摘要翻译： 公开了含有元素硒（Se（0）），Se（0） - 载体共轭物，发色团光产物，发色团光产物和载体分子的荧光共轭物或其混合物的药物组合物。 还公开了使用药物组合物如诱导细胞死亡的方法。 进一步公开了制备药物组合物及其组分的方法。
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