公开(公告)号：US06745960B1

公开(公告)日：2004-06-08

申请号：US10009299

申请日：2001-12-04

申请人： Nagayoshi Myo ,  Akira Iwasaki ,  Hiroshi Okada ,  Kuniaki Yamanaka ,  Koji Nagaoka ,  Mamoru Shiratori

发明人： Nagayoshi Myo ,  Akira Iwasaki ,  Hiroshi Okada ,  Kuniaki Yamanaka ,  Koji Nagaoka ,  Mamoru Shiratori

IPC分类号： B02C2324

CPC分类号： C04B41/009 ,  B01J2/14 ,  C04B41/52 ,  F27D1/0009 ,  F27D1/1652 ,  C04B41/4539 ,  C04B41/5031 ,  C04B41/5035 ,  C04B41/4527 ,  C04B41/5029 ,  C04B41/522 ,  C04B14/4625 ,  C04B30/02 ,  C04B14/4631

摘要： A centrifugal tumbling granulating apparatus 1 comprises a fixed wall 7 having a grain contact portion 7a which is in contact with powder grains 2 and of which a horizontal section is formed in a circular shape, and a rotating disk 5 provided a clearance 12 away from an inner side of the fixed wall 7 and rotating in a horizontal direction by a motor 13, wherein an air supply device 21 for supplying drying air 22 to an upper surface side of the rotating disk 5 is provided above the rotating disk 5. The air supply device 21 has a cylindrical straight tube portion 25, and an air supply port 23 formed in a cone shape, and is disposed in a centrifugal tumbling chamber 6 to be movable in an up-and-down direction. During a granulating step, the air supply device 21 stops to supply the dry air 22 and waits at an upper position H. After the granulation processing, the air supply device is lowered at a lower position L and supplies the dry air 22 onto the rotating disk 5 to dry granulated substances. As a result, the granulating apparatus capable of efficiently obtaining, in a single apparatus, spherical particles of which each particle size is small and which exist within a narrow range of particle size distribution and of which deviation from spherical form is small is provided.

摘要翻译： 离心式翻滚造粒装置1包括固定壁7，该固定壁7具有与粉末颗粒2接触并且水平部分形成为圆形的颗粒接触部分7a，以及设置有远离 固定壁7的内侧并通过马达13在水平方向上旋转，其中，在旋转盘5的上方设置有用于将干燥空气22供给到旋转盘5的上表面侧的供气装置21。 装置21具有圆柱形直管部分25和形成为锥形的空气供给口23，并且设置在离心翻转室6中以能够沿上下方向移动。 在制粒步骤期间，空气供给装置21停止供给干燥空气22并在上部位置H等待。在造粒处理之后，供气装置在下部位置L下降，并将干燥空气22供给到旋转 盘5干燥造粒物质。 结果，能够在单个装置中有效地获得颗粒尺寸小的并且存在于窄的粒度分布范围内并且与球形的偏离小的球形颗粒的造粒装置。

公开(公告)号：US06221638B1

公开(公告)日：2001-04-24

申请号：US09064750

申请日：1998-04-23

申请人： Yukio Yamada ,  Akira Iwasaki ,  Noriyuki Kizaki ,  Yasuhiro Ikenaka ,  Masahiro Ogura ,  Junzo Hasegawa

发明人： Yukio Yamada ,  Akira Iwasaki ,  Noriyuki Kizaki ,  Yasuhiro Ikenaka ,  Masahiro Ogura ,  Junzo Hasegawa

IPC分类号： C12P1300

CPC分类号： C12P13/001 ,  C12N9/1096 ,  C12P13/005 ,  C12P13/008 ,  C12P13/04 ,  C12P41/006 ,  Y10S435/83

摘要： The method for preparing an optically active (R)-amino compound characterized by the method comprising stereoselectively carrying out amino group transfer by action of an (R)-form-specific transaminase in the co-presence of a ketone compound (amino acceptor), and an amino compound (amino donor) of a racemic form or an (R)-form, to give an optically active (R)-amino compound. According to the present invention, it is made possible to easily prepare at a high yield the optically active (R)-amino compounds and the like having an aryl group and the like at their 1-position, which have been conventionally difficult to prepare.

摘要翻译： 制备光学活性（R） - 氨基化合物的方法，其特征在于在酮化合物（氨基受体）的共存下通过（R） - 形式 - 特异性转氨酶的作用立体选择性地进行氨基转移的方法， 和外消旋形式的氨基化合物（氨基供体）或（R） - 形式，得到光学活性（R） - 氨基化合物。 根据本发明，可以容易地容易地制备其1-位上具有芳基等的光学活性（R） - 氨基化合物等，其通常难以制备。

公开(公告)号：US20130030164A1

公开(公告)日：2013-01-31

申请号：US13574458

申请日：2011-01-19

申请人： Shinichi Yoshida ,  Akira Iwasaki ,  Motohisa Washida ,  Tozo Nishiyama ,  Daisuke Moriyama ,  Naoaki Taoka

发明人： Shinichi Yoshida ,  Akira Iwasaki ,  Motohisa Washida ,  Tozo Nishiyama ,  Daisuke Moriyama ,  Naoaki Taoka

IPC分类号： C12N9/02 ,  C12N15/63 ,  C07H21/02 ,  C12N1/19 ,  C12N5/10 ,  C12P19/36 ,  C12N15/53 ,  C12N1/21

CPC分类号： C12N9/0036 ,  C12N9/0065 ,  C12P7/02 ,  C12P7/18 ,  C12P7/42 ,  C12P13/04 ,  C12P19/36 ,  C12Y106/03 ,  C12Y106/03001 ,  C12Y111/01001

摘要： Water-forming NADH oxidase derived from Streptococcus mutans should be further improved in terms of stability for practical use in industrial production. An object of the present invention is to provide an enzyme that is obtained through modification of a water-forming NADH oxidase, which is useful as an NAD+ regeneration system for stereoselective oxidation catalyzed by an oxidoreductase, by protein engineering techniques so that the enzyme can withstand long-term use without exhibiting a reduction of its activity for the regeneration of NAD+, that is, an enzyme having improved stability, and to provide a method for efficiently producing a useful substance such as an optically active alcohol or amino acid. The present invention relates to an enzyme modification method that can improve the stability of water-forming NADH oxidase derived from Streptococcus mutans by appropriately introducing mutation.

摘要翻译： 来自变形链球菌的成水NADH氧化酶在工业生产实际使用的稳定性方面应进一步提高。 本发明的目的是提供通过蛋白质工程技术，通过改性水合NADH氧化酶获得的酶，其可用作由氧化还原酶催化的用于立体选择性氧化的NAD +再生系统，使得酶能够承受 长期使用而不显示其NAD +再生活性的活性降低，即稳定性提高的酶，以及提供有效生产光学活性醇或氨基酸等有用物质的方法。 本发明涉及通过适当地引入突变来提高来自变形链球菌的水形成NADH氧化酶的稳定性的酶修饰方法。

公开(公告)号：US06513424B1

公开(公告)日：2003-02-04

申请号：US09647897

申请日：2000-10-06

申请人： Akira Iwasaki ,  Toshinari Sasaki ,  Shigetoshi Kashiwagi ,  Shigemi Isobe

发明人： Akira Iwasaki ,  Toshinari Sasaki ,  Shigetoshi Kashiwagi ,  Shigemi Isobe

IPC分类号： B30B1116

CPC分类号： B30B11/16 ,  B30B11/006 ,  B30B11/18 ,  B30B15/0017 ,  B30B15/0082 ,  B30B15/308

摘要： A pair of compression rollers 38a and 38b parallel with each other are provided and powder grains are supplied to a powder grain introduction/compression part 50 formed between the rollers 38a and 38b and, thereby, compression moldings of the powder grains are formed. A powder grain press/feed means 20 is provided in a front stage of the rollers 38a and 38b. The press/feed means 20 has a deaerating barrel 24 and previously presses the powder grains supplied between the rollers 38a and 38b. In side surfaces of the rollers 38a and 38b, side seals 37 are arranged with clearances 72 maintained from the rollers 38a and 38b. During pressing the powder moldings, the powder grains enter into the clearances so that closer layers are formed between the side surfaces of the compression rollers 38a and 38b and the side seals 37, thereby sealing the powder grain introduction/compression part 50. In a rear stage of the rollers 38a and 38b, a shearing device 75 is provided and shears the compression moldings formed by the rollers 38a and 38b. Torque of the shearing device 75 is detected by a torque sensor, and the compression rollers 38a and 38b and the powder grain transport means 17 are controlled in accordance with the detected torque.

摘要翻译： 设置一对彼此平行的压缩辊38a和38b，并且将粉末颗粒供给到形成在辊38a和38b之间的粉末颗粒引入/压缩部分50，从而形成粉末颗粒的压缩模制品。 在辊38a和38b的前段设置有粉粒挤压/进给装置20。 压榨/进料装置20具有脱气筒24并预先挤压供应在辊38a和38b之间的粉末颗粒。 在辊38a和38b的侧表面中，侧密封件37布置有从辊38a和38b保持的间隙72。 在挤压粉末成型体期间，粉粒进入间隙，使得在压缩辊38a和38b的侧表面与侧密封件37之间形成更近的层，从而密封粉粒引入/压缩部50.在后部 辊38a和38b的阶段，设置有剪切装置75，并且剪切由辊38a和38b形成的压缩模制品。 通过转矩传感器检测剪切装置75的扭矩，根据检测的转矩来控制压缩辊38a，38b和粉粒传送装置17。

公开(公告)号：US06291557B1

公开(公告)日：2001-09-18

申请号：US09695975

申请日：2000-10-26

申请人： Kyoichi Yamamoto ,  Kojun Utaka ,  Hisashi Takada ,  Akira Iwasaki

发明人： Kyoichi Yamamoto ,  Kojun Utaka ,  Hisashi Takada ,  Akira Iwasaki

IPC分类号： C08K310

CPC分类号： C09J163/00 ,  C08G59/4292

摘要： The invention provides an alkali-soluble adhesive agent characterized by comprising an alkali-soluble resin that is a reaction product (C) obtained by allowing a polycarboxylic acid and/or a polycarboxylic anhydride having two or more carboxyl groups to react with a reaction product of a compound (A) having at least one epoxy group with a monocarboxylic acid compound (B). Preferably, the alkali-soluble resin is used in combination with a ketone organic solvent, optionally with at least one member selected from the group consisting of a melt viscosity reducing agent, a surface active agent and a plasticizer. The alkali-soluble adhesive agent can be removed by an alkali aqueous solution without recourse to any organic solvent, and is of an environmental protection-conscious type with improvements in adhesion, adhesion strength, coatability, surface smoothness, softening point controllability, melt viscosity controllability and spread controllability.

摘要翻译： 本发明提供一种碱溶性粘合剂，其特征在于包含碱溶性树脂，其为通过使多羧酸和/或具有两个或更多个羧基的多元羧酸酐与下述反应产物反应获得的反应产物（C） 具有至少一个环氧基的化合物（A）与单羧酸化合物（B）。 优选地，碱溶性树脂与酮有机溶剂组合使用，任选地与选自熔体粘度降低剂，表面活性剂和增塑剂中的至少一种组合使用。 碱溶性粘合剂可以通过碱水溶液除去而不用任何有机溶剂，并且具有环保意识型，其粘合性，粘合强度，可涂布性，表面平滑性，软化点可控性，熔体粘度可控性 并传播可控性。

公开(公告)号：US5906704A

公开(公告)日：1999-05-25

申请号：US937463

申请日：1997-09-25

申请人： Kazushige Matsuura ,  Akira Iwasaki ,  Hideki Ohmori

发明人： Kazushige Matsuura ,  Akira Iwasaki ,  Hideki Ohmori

IPC分类号： A41D27/06 ,  B29C41/18 ,  C08G18/10 ,  C08G18/80 ,  C08K5/16 ,  C08K5/21 ,  C08L75/04 ,  C09J175/04 ,  C09K3/00 ,  C08G18/40 ,  C08G18/66 ,  C08K5/205

CPC分类号： C08G18/10 ,  C09J175/04 ,  C08G2170/20

摘要： The present invention provides a hot-melt resin composition which comprises 1 to 30% by weight of a compound represented by the general formula (1)Q-(X-A)n (1)(wherein X is a urethane or urea group, Q is a group with a valence of n, A is a univalent group, one of Q and A being an isocyanate residue and the other being an amine or alcohol residue, and n is an integer of 1 to 3) and 70 to 99% by weight of a thermoplastic polyurethane resin (B); a method of producing a powder form of said hot-melt resin composition; and a hot-melt resin powder composition which comprises said powder-form hot-melt resin composition.

摘要翻译： 本发明提供一种热熔树脂组合物，其包含1至30重量％的由通式（1）表示的化合物Q-（XA）n（1）（其中X为氨基甲酸酯或脲基，Q为 化合价为n的基团，A为一价基团，Q和A之一为异氰酸酯残基，另一个为胺或醇残基，n为1〜3的整数），70〜99重量％ 的热塑性聚氨酯树脂（B）; 一种生产所述热熔树脂组合物的粉末形式的方法; 和包含所述粉末状热熔树脂组合物的热熔树脂粉末组合物。

公开(公告)号：US4706977A

公开(公告)日：1987-11-17

申请号：US922040

申请日：1986-10-21

申请人： Norio Ukai ,  Akira Iwasaki

发明人： Norio Ukai ,  Akira Iwasaki

IPC分类号： B62D7/15 ,  B62D7/00

CPC分类号： B62D7/1527

摘要： A steering device for steering front and rear wheels of a motor vehicle has a steering gear box for the front wheels and a steering gear box for the rear wheels. The front wheel steering gear box includes a first rack shaft operatively coupled to the front wheels, a first input shaft and an output shaft operatively coupled to the first rack shaft. The rear wheel steering gear box includes a second rack shaft operatively coupled to the rear wheels and a second input shaft operatively coupled to the second rack shaft. The output shaft and the second input shaft are interconnected by a linkage shaft. The second input shaft has an end inserted into the rear wheel steering gear box and inclined downwardly. The rear wheel steering gear box is supported on the vehicle frame for tilting movement around the second rack shaft.

摘要翻译： 用于转向机动车辆的前轮和后轮的转向装置具有用于前轮的转向齿轮箱和用于后轮的转向齿轮箱。 前轮舵机箱包括可操作地联接到前轮的第一齿条轴，第一输入轴和可操作地联接到第一齿条轴的输出轴。 后轮舵机包括可操作地联接到后轮的第二齿条轴和可操作地联接到第二齿条轴的第二输入轴。 输出轴和第二输入轴通过联动轴相互连接。 第二输入轴具有插入后轮舵机箱中并向下倾斜的一端。 后轮舵机箱被支撑在车架上用于围绕第二齿条轴倾斜运动。

公开(公告)号：US4369852A

公开(公告)日：1983-01-25

申请号：US226911

申请日：1981-01-21

申请人： Masao Nishikawa ,  Yoshihiko Toshimitsu ,  Akira Iwasaki ,  Katsuhiko Fujimoto

发明人： Masao Nishikawa ,  Yoshihiko Toshimitsu ,  Akira Iwasaki ,  Katsuhiko Fujimoto

IPC分类号： B62D5/12 ,  B62D5/22

CPC分类号： B62D5/22

摘要： Power steering apparatus for a vehicle comprising a rack rod operatively connected to a steering wheel and supported in a steering gear casing, the rack rod being drivable by a power cylinder consisting of an outer cylinder fixed to the steering gear casing, an inner cylinder disposed in the outer cylinder and fitted into the steering gear casing, and a piston mounted on the rack rod to divide the interior of the inner cylinder into first and second oil chambers. A control valve is mounted on the lower surface of the steering gear casing for controlling the operation of the power cylinder. The second oil chamber is in communication with the outer cylinder via the spaces between the coils of a coil spring, the inner cylinder being supported in floating state on the outer cylinder by the coil spring. A pair of parallel, annular or semi-annular oil passages are provided in that portion of the steering gear casing which is engaged with the inner cylinder. The oil passages are respectively in communication with a pair of output ports of the control valve. The oil passages are also in communication at respective upper portions thereof with the outer cylinder and the first oil chamber separately. Due to these internally provided oil passages, the number of parts and assembly steps of the apparatus can be minimized. Because the inner cylinder is supported in floating state by the coil spring on the outer cylinder, it can be kept concentric therewith so that the piston can be operated smoothly at all times. The mounting of the control valve under the gear casing leaves a large space above the gear casing for the installation of the engine.

摘要翻译： 一种用于车辆的动力转向装置，包括操作性地连接到方向盘并被支撑在转向齿轮箱中的齿条杆，所述齿条杆可由由固定到所述舵机壳体的外筒组成的动力缸驱动， 外筒并装配到转向齿轮箱中，以及安装在齿条上的活塞，以将内筒的内部分成第一和第二油室。 控制阀安装在舵机壳体的下表面上，用于控制动力缸的操作。 第二油室经由螺旋弹簧的线圈之间的空间与外筒连通，内筒由螺旋弹簧以浮动状态支撑在外筒上。 在与内筒接合的转向齿轮箱的该部分中设置有一对平行的环形或半环形的油通道。 油路分别与控制阀的一对输出口连通。 油路也分别与外筒和第一油室在其各自的上部连通。 由于这些内部提供的油通道，装置的部件数量和组装步骤可以最小化。 由于内筒通过外筒上的螺旋弹簧以浮动状态支撑，所以可以与内筒保持同心，使得活塞能够始终平稳地操作。 控制阀在齿轮箱下面的安装在齿轮箱上方留出了大的空间，用于安装发动机。

公开(公告)号：US20080038803A1

公开(公告)日：2008-02-14

申请号：US11885056

申请日：2006-02-24

申请人： Akira Iwasaki ,  Motohisa Washida ,  Naoaki Taoka ,  Daisuke Moriyama ,  Junzou Hasegawa

发明人： Akira Iwasaki ,  Motohisa Washida ,  Naoaki Taoka ,  Daisuke Moriyama ,  Junzou Hasegawa

IPC分类号： C12P7/02 ,  C12N1/00

CPC分类号： C12P41/002 ,  C12N9/0008 ,  C12N9/0036 ,  C12P7/02 ,  C12P7/18

摘要： The present invention provides a method enabling convenient production of an optically active secondary alcohol useful as a pharmaceutical intermediate, particularly an optically active 1,2-diol and an optically active 2-alkanol, from an enantiomer mixture thereof. An oxidizing enzyme source having the capability of selectively oxidizing one enantiomer of secondary alcohol is allowed to act on an enantiomer mixture of secondary alcohol in the presence of a reducing enzyme source having the capability of reverse enantio-selectively reducing a ketone derivative, to convert the enantiomer mixture into a substantially single enantiomer at a theoretical percent recovery of 100%, whereby an optically active secondary alcohol is produced.

摘要翻译： 本发明提供了一种能够方便地制备可用作药物中间体，特别是光学活性的1,2-二醇和光学活性2-链烷醇的光学活性仲醇的方法。 在具有反向对映选择性还原酮衍生物的能力的还原酶源的存在下，使具有选择性氧化仲醇的对映异构体的氧化酶源作用于仲醇的对映体混合物， 对映异构体混合物变成基本上单一的对映体，理论回收率为100％，由此产生光学活性的仲醇。

公开(公告)号：US07058183B2

公开(公告)日：2006-06-06

申请号：US10760364

申请日：2004-01-21

申请人： Shin Hasegawa ,  Akira Iwasaki ,  Kensaku Yoshida

发明人： Shin Hasegawa ,  Akira Iwasaki ,  Kensaku Yoshida

IPC分类号： H04B1/00

CPC分类号： H03G3/32 ,  H03G5/22

摘要： The object of this invention is to obtain the optimum music level by separately and independently performing the sound correction for the high-frequency range and low-frequency range according to the noise level. The invention comprises: a memory unit in which high-frequency-correction-level information, corresponding to the vehicle speed and music level, and low-frequency-correction-level information, corresponding to the low-frequency noise/music level ratio, are stored; a high-frequency-correction-level-information-acquisition unit that obtains high-frequency-correction-level information based on the vehicle speed and music level; and a low-frequency-correction-level-information-acquisition unit that obtains low-frequency-correction-level information based on the low-frequency noise/music level ratio; and it corrects the sound by a sound-quality-adjustment unit based on the high-frequency-correction-level information and low-frequency-correction-level information.

摘要翻译： 本发明的目的是通过根据噪声水平独立且独立地执行高频范围和低频范围的声音校正来获得最佳音乐水平。 本发明包括：对应于低频噪声/音乐电平比率的对应于车速和音乐电平的高频校正级信息和低频校正级信息的存储单元是 储存; 高频校正级别信息获取单元，其基于车速和音乐级别获得高频校正级信息; 以及低频校正级别信息获取单元，其基于所述低频噪声/音乐电平比获得低频校正级信息; 并且其基于高频校正级信息和低频校正级信息通过声音质量调整单元来校正声音。