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30 条记录 (耗时 0.024 秒)

    Method of preparing sodium salts of imidazoledicarboxylic acid substituted cephalosporin derivatives
    1.
    发明授权
    Method of preparing sodium salts of imidazoledicarboxylic acid substituted cephalosporin derivatives 失效
    制备咪唑二羧酸取代头孢菌素衍生物的钠盐的方法

    公开(公告)号：US4423215A

    公开(公告)日：1983-12-27

    申请号：US353809

    申请日：1982-03-02

    申请人： Naohiko Yasuda ,  Hisao Iwagami ,  Yasuo Irie ,  Eiji Nakanishi ,  Hideomi Saito

    发明人： Naohiko Yasuda ,  Hisao Iwagami ,  Yasuo Irie ,  Eiji Nakanishi ,  Hideomi Saito

    IPC分类号： C07D501/04 ,  C07D501/38 ,  C07D501/46

    CPC分类号： C07D501/46

    摘要： A method of preparing sodium salts of an imidazoledicarboxylic acid derivative of a substituted cephalosporin represented by the general formula of ##STR1## where X is a radical selected from the group consisting of hydrogen, halogen, hydroxyl, alkyl, aryl, aralkyl, alkoxy, aryloxy, aralkyloxy, mercapto, alkylthio, arylthio, aralkylthio, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, alkylsulfinyl, arylsulfinyl, aralkylsulfinyl, amino, mono- or dialkylamino, mono- or diarylamino, mono- or diaralkylamino, acylamino, sulfonic acid, nitro or heterocyclic group;and where R is a radical selected from hydrogen, an organic radical such as alkyl, aryl or aralkyl or a heterocyclic group, said organic radical and heterocyclic group being optionally substituted;said method comprising reacting a compound represented by the following formula: ##STR2## with 4-pyridineethanesulfonic acid in an aqueous solution of sodium iodide and subsequently recovering the salt.The compounds are useful in the treatment of bacterial infections, particularly Pseudomonas aeruginosa, in man and other animals.

    摘要翻译： 一种制备由通式（I）＆lt; IMAGE＆gt;表示的取代头孢菌素的咪唑二羧酸衍生物的钠盐的方法，其中X是选自氢，卤素，羟基，烷基，芳基 芳烷氧基，烷氧基，芳氧基，芳烷硫基，芳烷硫基，烷基磺酰基，芳基磺酰基，芳烷基磺酰基，烷基亚磺酰基，芳基亚磺酰基，芳烷基亚磺酰基，氨基，一烷基氨基或二芳基氨基，单或二芳基氨基， ，硝基或杂环基; 并且其中R是选自氢，有机基团如烷基，芳基或芳烷基或杂环基的基团，所述有机基团和杂环基团任选被取代; 所述方法包括将由下式表示的化合物与4-吡啶乙磺酸在碘化钠水溶液中反应，随后回收盐。 这些化合物可用于治疗人和其他动物中细菌感染，特别是铜绿假单胞菌（Pseudomonas aeruginosa）。

    Method and Composition to Evaluate Cytochrome P450 2D6 Isoenzyme Activity Using a Breath Test
    7.
    发明申请
    Method and Composition to Evaluate Cytochrome P450 2D6 Isoenzyme Activity Using a Breath Test 审中-公开
    使用呼吸试验评估细胞色素P450 2D6同工酶活性的方法和组成

    公开(公告)号：US20100329979A1

    公开(公告)日：2010-12-30

    申请号：US12874350

    申请日：2010-09-02

    申请人： Anil S. Modak ,  Yasuo Irie ,  Yasuhisa Kurogi

    发明人： Anil S. Modak ,  Yasuo Irie ,  Yasuhisa Kurogi

    IPC分类号： A61K51/08

    CPC分类号： C12Q1/26 ,  A61K51/1206

    摘要： The present invention relates, generally to a method of determining and assessing cytochrome P450 2D6 isoenzyme (CYP2D6)-related metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of 13CO2 exhaled by a the subject upon intravenous or oral administration of a 13C-labeled CYP2D6 substrate compound. The present invention is useful as an in vivo phenotype assay for evaluating CYP2D6-related activity using the metabolite 13CO2 in expired breath and to determine the optimal dosage and timing of administration of CYP2D6 substrate compound.

    摘要翻译： 本发明一般涉及通过呼吸测定法确定和评估个体哺乳动物受试者中的细胞色素P450 2D6同工酶（CYP2D6）相关代谢能力的方法，通过确定受试者在静脉内或口服时呼出的13CO2的相对量 施用13C标记的CYP2D6底物化合物。 本发明可用作体内表型测定法，用于使用呼气中的代谢物13CO2评估CYP2D6相关活性，并确定CYP2D6底物化合物的最佳剂量和给药时间。

    Propeller for ship
    8.
    发明授权
    Propeller for ship 失效
    船用螺旋桨

    公开(公告)号：US4514146A

    公开(公告)日：1985-04-30

    申请号：US436988

    申请日：1982-10-22

    申请人： Takeo Nojiri ,  Yasuo Irie

    发明人： Takeo Nojiri ,  Yasuo Irie

    IPC分类号： B63H1/14 ,  B63H1/28 ,  B63H1/20

    CPC分类号： B63H1/28 ,  B63H1/14 ,  B63H2001/145

    摘要： In a propeller for use in a ship of the type comprising 4 or more even number blades, at least one of two adjacent blades is inclined forwardly or rearwardly or one inclined forwardly and the other rearwardly so as to make different the rake angles of the two blades. The pitch angle of the rearwardly inclined blade is made larger than that of the forwardly inclined blade. With this construction the mutual interference between adjacent blades is efficiently utilized to prevent decrease in the efficiency even when operating conditions and the diameter of the propeller vary.

    摘要翻译： 在用于包括4个或更多个偶数叶片的类型的船舶的螺旋桨中，两个相邻叶片中的至少一个叶片向前或向后倾斜，或者向前倾斜并且向后倾斜，以使两者的前角不同 刀片。 使向后倾斜的叶片的俯仰角比前倾叶片的俯仰角大。 利用这种结构，即使在螺旋桨的操作条件和直径变化的情况下，相邻叶片之间的相互干扰也被有效地利用以防止效率降低。

    Coin dispensing apparatus
    9.
    发明授权
    Coin dispensing apparatus 有权
    硬币分配装置

    公开(公告)号：US07445545B2

    公开(公告)日：2008-11-04

    申请号：US11006191

    申请日：2004-12-07

    申请人： Hiroshi Abe ,  Yasuo Irie

    发明人： Hiroshi Abe ,  Yasuo Irie

    IPC分类号： G07D1/00

    CPC分类号： G07D9/008

    摘要： A coin dispensing apparatus is provided that has features to easily adjust the distance between the base plate and the rotating disk and to adapt to the thickness of the coins. The coin dispensing apparatus includes a disk (102) which separates coins one by one. A coin base (104) supports the coins which are moved by the disk. A body (100) includes the base and a step section (149) which provides different distances to the base to adapt to the thickness of the coins. A rotating shaft member (160) is selectively attached to the step section and can be adjusted to the body. The rotating shaft member for rotating the disk is selectively attached at the step section in stages. Therefore the distance between the disk and the base is adjusted to adapt the thickness of coin.

    摘要翻译： 提供了一种硬币分配装置，其具有容易地调整基板和旋转盘之间的距离并适应硬币的厚度的特征。 硬币分配装置包括一个一个地分离硬币的盘（102）。 硬币基座（104）支撑由盘移动的硬币。 主体（100）包括基座和台阶部分（149），其向基座提供不同距离以适应硬币的厚度。 旋转轴构件（160）选择性地附接到台阶部并且可以调节到身体。 用于旋转盘的旋转轴构件分阶段地选择性地附接在台阶部分。 因此，调整盘和基座之间的距离以适应硬币的厚度。

    Method and composition to evaluate cytochrome P450 2D6 isoenzyme activity using a breath test
    10.
    发明申请
    Method and composition to evaluate cytochrome P450 2D6 isoenzyme activity using a breath test 审中-公开
    使用呼吸试验评估细胞色素P450 2D6同工酶活性的方法和组成

    公开(公告)号：US20070026480A1

    公开(公告)日：2007-02-01

    申请号：US11404965

    申请日：2006-04-14

    申请人： Anil Modak ,  Yasuo Irie ,  Yasuhisa Kurogi

    发明人： Anil Modak ,  Yasuo Irie ,  Yasuhisa Kurogi

    IPC分类号： C12Q1/26

    CPC分类号： C12Q1/26 ,  A61K51/1206

    摘要： The present invention relates, generally to a method of determining and assessing cytochrome P450 2D6 isoenzyme (CYP2D6)-related metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of 13CO2 exhaled by a the subject upon intravenous or oral administration of a 13C-labeled CYP2D6 substrate compound. The present invention is useful as an in vivo phenotype assay for evaluating CYP2D6-related activity using the metabolite 13CO2 in expired breath and to determine the optimal dosage and timing of administration of CYP2D6 substrate compound.

    摘要翻译： 本发明一般涉及通过呼吸测定法确定和评估个体哺乳动物受试者中的细胞色素P450 2D6同工酶（CYP2D6）相关代谢能力的方法，通过测定相对量的< 在静脉内或口服给予13 C-标记的CYP2D6底物化合物时，由受试者呼出的SUB> 2 。 本发明可用作体内表型测定法，用于使用呼吸道呼吸中的代谢物13评估CYP2D6相关活性，并确定最佳剂量和施用时间 的CYP2D6底物化合物。