-
1.发明申请Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof 审中-公开氨基苯氧基乙酰胺衍生物和含有它们的药物组合物公开(公告)号：US20060178401A1
公开(公告)日：2006-08-10
申请号：US11337664
申请日：2006-01-24
IPC分类号： A61K31/454 , A61K31/445 , C07D211/56 , C07D401/02
CPC分类号： C07D417/04 , C07D211/58
摘要： The present invention relates to an amiophenoxyacetamide derivative of the formula (I): wherein R1 to R4 are, independent from each other, a hydrogen atom or an optionally substituted alkyl group; E1 is —NR4—; and E2 is an oxygen atom or —NR10—; Q is the group —X—Y-Q′, wherein X and Y are connecting bonds or X is an alkylene or alkenylene group and Y is selected from a group comprising C═O, NHC(═O), and C(═O)NH, and Q′ is a hydrogen atom or a phenyl or pyridyl group which may be substituted; and pharmaceutically acceptable salts thereof. The present invention further relates to compositions comprising compounds of the formula (I) and methods of using said compounds for treating cerebral functional disorders and cerebral organic disorders.
摘要翻译： 本发明涉及式（I）的氨基苯氧基乙酰胺衍生物：其中R 1至R 4彼此独立地为氢原子或任选取代的烷基 组; E 1是-NR 4 - ; 并且E 2是氧原子或-NR 10 - ; Q是-XY-Q'基团，其中X和Y是连接键或X是亚烷基或亚烯基，Y选自CO，NHC（-O）和C（-O）NH的基团，和 Q'是氢原子或可被取代的苯基或吡啶基; 及其药学上可接受的盐。 本发明还涉及包含式（I）化合物和使用所述化合物治疗脑功能障碍和脑部有机疾病的方法的组合物。
-
2.发明授权Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof 失效氨基苯氧基乙酰胺衍生物和含有它们的药物组合物公开(公告)号：US07067533B2
公开(公告)日：2006-06-27
申请号：US10009566
申请日：2001-04-13
IPC分类号： A61K31/4468 , A61K31/4523 , A61K31/454 , A61K31/4545 , C07D211/58 , C07D215/00 , C07D217/00
CPC分类号： C07D417/04 , C07D211/58
摘要： The present invention relates to an aminophenoxyacetamide derivative of the formula (I): wherein R1 to R4 are, independent from each other, a hydrogen atom or an optionally substituted alkyl group; E1 is —NR4—; and E2 is an oxygen atom or —NR10—; Q is the group —X—Y-Q′, wherein X and Y are connecting bonds or X is an alkylene or alkenylene group and Y is selected from a group comprising C═O, NHC(═), and C(═O)NH, and Q′ is a hydrogen atom or a phenyl or pyridyl group which may be substituted; and pharmaceutically acceptable salts thereof. The present invention further relates to compositions comprising compounds of the formula (I) and methods of using said compounds for treating cerebral functional disorders and cerebral organic disorders.
摘要翻译： 本发明涉及式（I）的氨基苯氧基乙酰胺衍生物：其中R 1至R 4彼此独立地为氢原子或任选取代的烷基 组; E 1是-NR 4 - ; 并且E 2是氧原子或-NR 10 - ; Q是-XY-Q'基团，其中X和Y是连接键或X是亚烷基或亚烯基，Y选自CO，NHC（ - ）和C（-O）NH，Q '是氢原子或可被取代的苯基或吡啶基; 及其药学上可接受的盐。 本发明还涉及包含式（I）化合物和使用所述化合物治疗脑功能障碍和脑部有机疾病的方法的组合物。
-
3.发明授权Aminophenoxyacetic acid derivatives and pharmaceutical composition containing thereof 失效氨基苯氧基乙酸衍生物和含有它们的药物组合物公开(公告)号：US06998401B2
公开(公告)日：2006-02-14
申请号：US10394221
申请日：2003-03-24
IPC分类号： A61K31/445 , A61K31/535 , C07D211/80 , C07D401/00 , C07D217/02
CPC分类号： C07D401/06 , A61K31/445 , A61K31/454 , A61K31/4545 , C07D211/58 , C07D401/12
摘要： There is provided an aminophenoxyacetic acid derivative of the following formula (I): wherein, R1, R2, R3 and R4 are, independent from each other, alkoxy group, alkyl group or aryl group, etc.; E1 and E2 are oxygen atom, sulfur atom, etc.; n is 0 to 5; X and Y are alkylene group, cycloalkylen group, or alkenylen group; Q is pheny group which may be substituted or benzoyl group, etc, or a pharmaceutically acceptable salt thereof. These compounds have neuroprotective effects by inducing calbindin D28Kd, one of Ca2+-binding proteins.
摘要翻译： 提供下式（I）的氨基苯氧基乙酸衍生物：化学式id =“CHEM-US-00001”num =“000
-
公开(公告)号：US06559146B1
公开(公告)日：2003-05-06
申请号：US09581756
申请日：2000-11-01
IPC分类号： A61K31535
CPC分类号： C07D401/06 , A61K31/445 , A61K31/454 , A61K31/4545 , C07D211/58 , C07D401/12
摘要： There is provided an aminophenoxyacetic acid derivative of the following formula (I): wherein, R1, R2, R3 and R4 are, independent from each other, alkoxy group, alkyl group or aryl group, etc.; E1 and E2 are oxygen atom, sulfur atom, etc.; n is 0 to 5; X and Y are alkylene group, cycloalkylen group, or alkenylen group; Q is phenyl group which may be substituted or benzoyl group, etc, or a pharmaceutically acceptable salt thereof. These compounds have neuroprotective effects by inducing calbindin D28Kd, one of Ca2+-binding proteins.
摘要翻译： 提供下式（I）的氨基苯氧基乙酸衍生物：其中，R1，R2，R3和R4彼此独立地为烷氧基，烷基或芳基等; E1和E2是氧原子，硫原子等; n为0〜5; X和Y是亚烷基，环烷基或链烯基; Q是可以被取代的苯基或苯甲酰基等，或其药学上可接受的盐。这些化合物通过诱导钙结合蛋白D28Kd，Ca2 +结合蛋白之一具有神经保护作用。
-
5.发明授权Aminophenoxyacetic acid derivatives and pharmaceutical composition containing thereof 失效氨基苯氧基乙酸衍生物和含有它们的药物组合物公开(公告)号：US07488738B2
公开(公告)日：2009-02-10
申请号：US11174575
申请日：2005-07-06
IPC分类号： A61K31/47 , A61K31/445
CPC分类号： C07D401/06 , A61K31/445 , A61K31/454 , A61K31/4545 , C07D211/58 , C07D401/12
摘要： There is provided an aminophenoxyacetic acid derivative of the following formula (I): wherein, R1, R2, R3 and R4 are, independent from each other, alkoxy group, alkyl group or aryl group, etc.; E1 and E2 are oxygen atom, sulfur atom, etc.; n is 0 to 5; X and Y are alkylene group, cycloalkylen group, or alkenylen group; Q is phenyl group which may be substituted or benzoyl group, etc, or a pharmaceutically acceptable salt thereof. These compounds have neuroprotective effects by inducing calbindin D28Kd, one of Ca2+-binding proteins.
摘要翻译： 提供下式（I）的氨基苯氧基乙酸衍生物：其中，R1，R2，R3和R4彼此独立地为烷氧基，烷基或芳基等; E1和E2是氧原子，硫原子等; n为0〜5; X和Y是亚烷基，环烷基或链烯基; Q是可以被取代的苯基或苯甲酰基等，或其药学上可接受的盐。 这些化合物通过诱导钙结合蛋白D28Kd，Ca2 +结合蛋白之一具有神经保护作用。
-
6.发明申请Aminophenoxyacetic acid derivatives and pharmaceutical composition containing thereof 失效氨基苯氧基乙酸衍生物和含有它们的药物组合物公开(公告)号：US20050245574A1
公开(公告)日：2005-11-03
申请号：US11174575
申请日：2005-07-06
IPC分类号： C07D211/04 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61P9/10 , A61P21/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P43/00 , C07D211/58 , C07D211/96 , C07D401/06 , C07D401/12 , C07D41/02 , C07D43/02
CPC分类号： C07D401/06 , A61K31/445 , A61K31/454 , A61K31/4545 , C07D211/58 , C07D401/12
摘要： There is provided an aminophenoxyacetic acid derivative of the following formula (I): wherein, R1, R2, R3 and R4 are, independent from each other, alkoxy group, alkyl group or aryl group, etc.; E1 and E2 are oxygen atom, sulfur atom, etc.; n is 0 to 5; X and Y are alkylene group, cycloalkylen group, or alkenylen group; Q is pheny group which may be substituted or benzoyl group, etc, or a pharmaceutically acceptable salt thereof. These compounds have neuroprotective effects by inducing calbindin D28Kd, one of Ca2+-binding proteins.
摘要翻译： 提供下式（I）的氨基苯氧基乙酸衍生物：其中R 1，R 2，R 3和R 2 > 4个彼此独立地为烷氧基，烷基或芳基等; E 1和E 2是氧原子，硫原子等; n为0〜5; X和Y是亚烷基，环烷基或链烯基; Q是可以被取代的苯基或苯甲酰基等，或其药学上可接受的盐。 这些化合物通过诱导钙结合蛋白D28Kd（Ca 2+ 2+结合蛋白之一）具有神经保护作用。
-
7.发明授权公开(公告)号：US08592435B2
公开(公告)日：2013-11-26
申请号：US12596054
申请日：2008-04-25
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02
CPC分类号： C07D401/12 , C07D239/30 , C07D239/36 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D401/14 , C07D405/14
摘要： Provided is a compound that has the ability to promote axonal outgrowth in combination with the ability to promote angiogenesis and can therefore be used to reduce central nerve injuries such as head injury and spinal cord injury, cerebral infarction, ischemic heart diseases such as myocardial infarction and organic angina, peripheral arterial occlusive diseases such as critical limb ischemia, or after-effects of these diseases. Specifically, the compound is represented by the following formula (I): in which Nx group is preferably a 6-membered aromatic ring containing two nitrogen atoms; R0, R1 and R2 are each independently a hydrogen atom, an alkyl group, an amino group or the like; E is an oxygen atom or an —NR8 group (wherein R8 is an alkyl group or the like); n is an integer of 0 to 5; X and Y are each a connecting bond, a cycloalkyl group, —CO— or the like; and Q is a hydrogen atom or a phenyl group.
摘要翻译： 提供了具有促进轴突向外生长与促进血管生成的能力相结合的能力的化合物，因此可用于减少中枢神经损伤，例如头部损伤和脊髓损伤，脑梗塞，缺血性心脏病如心肌梗死和 有机心绞痛，周围动脉闭塞性疾病如关键性肢体缺血或这些疾病的后遗症。 具体地，该化合物由下式（I）表示：其中Nx基优选为含有两个氮原子的6元芳环; R 0，R 1和R 2各自独立地为氢原子，烷基，氨基等; E是氧原子或-NR8基（其中R8是烷基等）; n为0〜5的整数， X和Y各自为连接键，环烷基-CO-等; Q为氢原子或苯基。
-
8.发明授权公开(公告)号：US08685989B2
公开(公告)日：2014-04-01
申请号：US13482375
申请日：2012-05-29
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02
CPC分类号： C07D401/12 , C07D239/30 , C07D239/36 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D401/14 , C07D405/14
摘要： Compounds of Formula (I) promote axonal outgrowth angiogenesis and can therefore be used to reduce central nerve injuries such as head injury and spinal cord injury, cerebral infarction, ischemic heart diseases, peripheral arterial occlusive diseases, or after-effects of these diseases. in which Nx group is preferably a 6-membered aromatic ring containing two nitrogen atoms; R0, R1 and R2 are each independently a hydrogen atom, an alkyl group, or an amino group; E is an oxygen atom or an —NR8 group (wherein R8 is an alkyl group or the like); n is an integer of of 0 to 5; X and Y are each a connected bond, a cycloalkyl group, or —CO—; and Q is a hydrogen atom or a phenyl group.
摘要翻译： 式（I）的化合物促进轴突生长的血管生成，因此可用于减少中枢神经损伤，例如头部损伤和脊髓损伤，脑梗塞，缺血性心脏病，外周动脉闭塞性疾病或这些疾病的后遗症。 其中Nx基团优选为含有两个氮原子的6元芳族环; R 0，R 1和R 2各自独立地为氢原子，烷基或氨基; E是氧原子或-NR8基（其中R8是烷基等）; n为0〜5的整数， X和Y各自为连接键，环烷基或-CO-; Q为氢原子或苯基。
-
9.发明申请公开(公告)号：US20100130739A1
公开(公告)日：2010-05-27
申请号：US12596054
申请日：2008-04-25
IPC分类号： C07D239/47 , C07D239/34 , C07D239/48 , C07D239/42 , C07D211/76 , C07D241/20 , C07D241/18 , C07D237/20 , C07D401/12 , C07D239/30
CPC分类号： C07D401/12 , C07D239/30 , C07D239/36 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D401/14 , C07D405/14
摘要： Provided is a compound that has the ability to promote axonal outgrowth in combination with the ability to promote angiogenesis and can therefore be used to reduce central nerve injuries such as head injury and spinal cord injury, cerebral infarction, ischemic heart diseases such as myocardial infarction and organic angina, peripheral arterial occlusive diseases such as critical limb ischemia, or after-effects of these diseases. Specifically, the compound is represented by the following formula (I): in which Nx group is preferably a 6-membered aromatic ring containing two nitrogen atoms; R0, R1 and R2 are each independently a hydrogen atom, an alkyl group, an amino group or the like; E is an oxygen atom or an —NR8 group (wherein R8 is an alkyl group or the like); n is an integer of 0 to 5; X and Y are each a connecting bond, a cycloalkyl group, —CO— or the like; and Q is a hydrogen atom or a phenyl group.
摘要翻译： 提供了具有促进轴突向外生长与促进血管生成的能力相结合的能力的化合物，因此可用于减少中枢神经损伤，例如头部损伤和脊髓损伤，脑梗塞，缺血性心脏病如心肌梗死和 有机心绞痛，周围动脉闭塞性疾病如关键性肢体缺血或这些疾病的后遗症。 具体地，该化合物由下式（I）表示：其中Nx基优选为含有两个氮原子的6元芳环; R 0，R 1和R 2各自独立地为氢原子，烷基，氨基等; E是氧原子或-NR8基（其中R8是烷基等）; n为0〜5的整数， X和Y各自为连接键，环烷基-CO-等; Q为氢原子或苯基。
-
公开(公告)号：US20060054381A1
公开(公告)日：2006-03-16
申请号：US11221460
申请日：2005-09-08
申请人： Naohiro Takemoto , Yoshihiko Suzuki
发明人： Naohiro Takemoto , Yoshihiko Suzuki
CPC分类号： F01N1/006 , F01N1/003 , F01N1/166 , F01N5/02 , F01N2240/02 , F28D7/103 , F28D7/1669 , F28D21/0003 , F28F2265/28 , Y02T10/16
摘要： The exhaust heat recovery muffler includes a muffler unit having the outer surface thereof covered, an exhaust heat recovery unit disposed integrally with the muffler unit, and a switching valve that switches the flow of exhaust gas into the muffler unit and into the exhaust heat recovery unit. An outer pipe of the muffler unit and a cylindrical shell of the exhaust heat recovery unit, covering the outer circumference of the outer pipe, are coaxially disposed. The exhaust heat recovery unit includes a heat exchange chamber, formed by a pair of partitions provided between the inner circumference of the shell and the outer circumference of the outer pipe, and small-diameter pipes penetrating through the pair of partitions and extending through the heat exchange chamber. A heat exchange medium flows inside of the heat exchange chamber.
摘要翻译： 排气热回收消音器包括：外部表面被覆盖的消声器单元，与消声器单元一体设置的排气热回收单元，以及切换阀，其切换排气流入消声器单元并进入排气热回收单元 。 消声器单元的外管和排气热回收单元的圆筒形外壳同时设置在外管的外周。 排气热回收单元包括：热交换室，其由设置在壳体的内周与外管的外周之间的一对分隔壁形成，小直径管穿透该对隔壁并延伸穿过热量 交换室。 热交换介质在热交换室内流动。
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.026 秒)
