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    Drugs comprising chymase inhibitors and ACE inhibitors as effective ingredients
    2.
    发明申请
    Drugs comprising chymase inhibitors and ACE inhibitors as effective ingredients 审中-公开
    包含胃促胰酶抑制剂和ACE抑制剂作为有效成分的药物

    公开(公告)号：US20080318961A1

    公开(公告)日：2008-12-25

    申请号：US12153897

    申请日：2008-05-27

    申请人： Hidenori Urata ,  Naoki Hase ,  Naoki Tsuchiya

    发明人： Hidenori Urata ,  Naoki Hase ,  Naoki Tsuchiya

    IPC分类号： A61K31/5025 ,  A61K31/506 ,  A61P9/00 ,  A61K31/4166

    CPC分类号： A61K45/06

    摘要： It is an object of the present invention to provide drugs which are effective for treatment of hypertension, cardiac disease (cardiac hypertrophy, cardiac failure, myocardial infarction, etc.), cerebral apoplexy, nephritis and the like. The invention also provides circulatory disease treatment agents in forms that allow combined use of chymase inhibitors and ACE inhibitors, and circulatory disease treatment methods which produce simultaneous chymase inhibition and ACE inhibition.

    摘要翻译： 本发明的目的是提供对治疗高血压，心脏病（心脏肥大，心力衰竭，心肌梗塞等），脑中风，肾炎等有效的药物。 本发明还以允许组合使用胃促胰酶抑制剂和ACE抑制剂的形式提供循环系统疾病治疗剂，以及产生同时胃促胰酶抑制和ACE抑制的循环系统疾病治疗方法。

    Acid Salt of Benzimidazole Derivative and Crystal Thereof
    4.
    发明申请
    Acid Salt of Benzimidazole Derivative and Crystal Thereof 审中-公开
    苯并咪唑衍生物及其晶体的酸性盐

    公开(公告)号：US20080015240A1

    公开(公告)日：2008-01-17

    申请号：US11667683

    申请日：2005-11-14

    申请人： Mitsuru Teramoto ,  Naoki Tsuchiya ,  Hiroshi Saitoh

    发明人： Mitsuru Teramoto ,  Naoki Tsuchiya ,  Hiroshi Saitoh

    IPC分类号： A61K31/4184 ,  A61P11/00 ,  A61P15/00 ,  A61P29/00 ,  A61P3/00 ,  C07D233/30

    CPC分类号： C07D409/06

    摘要： The present invention provides acid salts, such as sulfate, hydrochloride, and methanesulfonate, of 4-(1-((4-methylbenzothiophen-3-yl)methyl)benzimidazol-2-ylthio)butanoic acid and the crystals thereof. These benzimidazole derivatives and the crystals thereof have an in vivo chymase inhibitory activity and can be used as a preventive or therapeutic agent for inflammatory diseases, allergic diseases, respiratory diseases, circulatory diseases, or bone/cartilage metabolic diseases.

    摘要翻译： 本发明提供4-（1 - （（4-甲基苯并噻吩-3-基）甲基）苯并咪唑-2-基硫基）丁酸的酸式盐，如硫酸盐，盐酸盐和甲磺酸盐及其晶体。 这些苯并咪唑衍生物及其结晶体具有体内糜酶抑制活性，可用作炎性疾病，过敏性疾病，呼吸系统疾病，循环系统疾病或骨/软骨代谢疾病的预防或治疗剂。

    Benzimidazole derivative
    5.
    发明授权
    Benzimidazole derivative 失效
    苯并咪唑衍生物

    公开(公告)号：US07176320B2

    公开(公告)日：2007-02-13

    申请号：US10777067

    申请日：2004-02-13

    申请人： Naoki Tsuchiya ,  Yoshiyuki Matsumoto ,  Hiroshi Saitou ,  Tsuyoshi Mizuno

    发明人： Naoki Tsuchiya ,  Yoshiyuki Matsumoto ,  Hiroshi Saitou ,  Tsuyoshi Mizuno

    IPC分类号： C07D403/12 ,  C07D409/12 ,  A61K31/4184

    CPC分类号： C07D403/06 ,  C07D409/06

    摘要： A benzimidazole derivative or its medically acceptable salt, represented by the following formula (1), that is a human chymase activity inhibitor capable of being applied clinically: wherein, R1 and R2 represent a hydrogen atom, an alkyl group or an alkoxy group, etc., A represents an alkylene group or an alkenylene group, E represents —COOR3, —SO3R3, —CONHR3 or —SO2NHR3, etc., G represents an alkylene group, M represents a single bond or —S(O)m—, J represents a heterocyclic group, and X represents —CH═ or a nitrogen atom.

    摘要翻译： 由下式（1）表示的苯并咪唑衍生物或其医学上可接受的盐，其是能够临床应用的人胃促胰酶抑制酶抑制剂：其中R 1和R 2， SUP>表示氢原子，烷基或烷氧基等，A表示亚烷基或亚烯基，E表示-COOR 3，-SO 3 R 3，-CONHR 3或-SO 2 NHR 3等，G表示亚烷基 M表示单键或-S（O）m - ，J表示杂环基，X表示-CH-或氮原子。

    Systems, methods, and programs for updating map data
    6.
    发明申请
    Systems, methods, and programs for updating map data 审中-公开
    用于更新地图数据的系统，方法和程序

    公开(公告)号：US20060195256A1

    公开(公告)日：2006-08-31

    申请号：US11299972

    申请日：2005-12-13

    申请人： Norihiro Nakamura ,  Naoki Tsuchiya ,  Seiji Takahata

    发明人： Norihiro Nakamura ,  Naoki Tsuchiya ,  Seiji Takahata

    IPC分类号： G01C21/32

    CPC分类号： G09B29/10 ,  G01C21/32

    摘要： Systems, methods, and programs for updating map data create differential data in a server by comparing an old version of map data stored in the server with a new version of map data and transmit the differential data from the server to a relay device. The systems, methods and programs create updated map data by combining the differential data received from the server with map data previously stored in the relay device. The relay device may then be connected to an updated data storing device that disconnectably connects to both the relay device and the navigation system. The systems, methods, and programs, may then transfer the updated map data from the relay device to the updated data storing device and from the updated data storing device to the navigation system.

    摘要翻译： 用于更新地图数据的系统，方法和程序通过将存储在服务器中的旧版本的地图数据与新版本的地图数据进行比较来创建服务器中的差异数据，并将差分数据从服务器传送到中继设备。 系统，方法和程序通过将从服务器接收的差分数据与先前存储在中继设备中的地图数据组合来创建更新的地图数据。 然后，中继设备可以连接到可断开地连接到中继设备和导航系统的更新的数据存储设备。 然后，系统，方法和程序可以将更新的地图数据从中继设备传送到更新的数据存储设备，并从更新的数据存储设备传送到导航系统。

    Benzo[b]thiophene derivatives and process for preparing the same
    8.
    发明授权
    Benzo[b]thiophene derivatives and process for preparing the same 失效
    苯并[b]噻吩衍生物及其制备方法

    公开(公告)号：US06884896B2

    公开(公告)日：2005-04-26

    申请号：US10258173

    申请日：2002-02-22

    申请人： Hiroshi Saitoh ,  Naoki Tsuchiya ,  Tsuyoshi Mizuno ,  Tomohide Ida ,  Yoshiyuki Sawai

    发明人： Hiroshi Saitoh ,  Naoki Tsuchiya ,  Tsuyoshi Mizuno ,  Tomohide Ida ,  Yoshiyuki Sawai

    IPC分类号： C07D333/54 ,  C07D333/56 ,  C07D333/64 ,  C07D235/24 ,  C07D333/52

    CPC分类号： C07D333/54 ,  C07D333/56 ,  C07D333/64

    摘要： The present invention is 3,4-disubstituted-benzo[b]thiophene derivatives represented by general formula (I) and processes for preparing compounds represented by general formula (V) from compounds represented by general formula (IV), preparing a mixture of compounds represented by the following formula (II) and the following formula (III) and preparing the benzo[b]thiophene derivatives represented by the above formula (I): wherein, R1 and R2 represent each a halogen atom, a trihalomethyl group, a C1-4 alkyl group or a C1-4 alkoxy group; X represents a hydroxy group or a halogen atom; R3 and R4 represent each a hydrogen or a halogen atom, a trihalomethyl group, a C1-4 alkyl group or a C1-4 alkoxy group; and R5 represents a C1-3 alkyl group or a trifluoromethyl group.

    摘要翻译： 本发明是由通式（I）表示的3,4-二取代 - 苯并[b]噻吩衍生物和由通式（Ⅳ）表示的化合物制备由通式（Ⅴ）表示的化合物的方法，制备化合物 由下式（II）和下式（III）表示并制备由上式（I）表示的苯并[b]噻吩衍生物：其中R 1和R 2 代表卤素原子，三卤代甲基，C 1-4烷基或C 1-4烷氧基; X表示羟基或卤素原子; R 3和R 4各自表示氢或卤素原子，三卤代甲基，C 1-4烷基或C 1-4烷基， C 1-4烷氧基; R 5表示C 1-3烷基或三氟甲基。

    Feature parameter candidate generation apparatus and feature parameter candidate generation method
    9.
    发明授权
    Feature parameter candidate generation apparatus and feature parameter candidate generation method 有权
    特征参数候选生成装置和特征参数候选生成方法

    公开(公告)号：US08630823B2

    公开(公告)日：2014-01-14

    申请号：US12740336

    申请日：2008-10-31

    申请人： Mitsuhiro Yoneda ,  Hiroshi Nakajima ,  Naoki Tsuchiya ,  Hiroshi Tasaki

    发明人： Mitsuhiro Yoneda ,  Hiroshi Nakajima ,  Naoki Tsuchiya ,  Hiroshi Tasaki

    IPC分类号： G06F7/60 ,  G06F17/10

    CPC分类号： G06K9/6298 ,  G06F19/00 ,  G16H50/50

    摘要： A feature parameter candidate generation apparatus has a storage unit that stores the values of feature parameters extracted from each of samples, an index value calculation unit that calculates an index value, which is obtained by normalizing the number of the kinds of the values of feature parameters by the number of the samples, for each of the feature parameters, an evaluation object selection unit that selects combinations of feature parameters which are objects to be evaluated, an evaluation unit that evaluates whether the uniformity of a frequency distribution of index values of the individual feature parameters for combinations of feature parameters selected as the objects to be evaluated satisfies a predetermined criterion, and a candidate determination unit that determines, as feature parameter candidates to be given to the model generation device, a combination of feature parameters that is evaluated to satisfy the predetermined criterion.

    摘要翻译： 特征参数候选生成装置具有存储单元，存储从各样本提取的特征参数的值，计算索引值的索引值计算单元，该索引值计算单元通过对特征参数的值的种类的数量进行归一化而获得 通过对于每个特征参数的样本数量，评估对象选择单元，其选择作为评估对象的特征参数的组合;评估单元，其评估个体的指标值的频率分布的均匀性 作为要评估对象选择的特征参数的组合的特征参数满足预定标准，以及候选确定单元，其将作为要赋予模型生成装置的特征参数候补确定为评估满足的特征参数的组合 预定标准。

    Axial flow fluid apparatus and blade
    10.
    发明授权
    Axial flow fluid apparatus and blade 有权
    轴流式流体装置和叶片

    公开(公告)号：US08133008B2

    公开(公告)日：2012-03-13

    申请号：US12296191

    申请日：2007-03-05

    申请人： Naoki Tsuchiya

    发明人： Naoki Tsuchiya

    IPC分类号： F01D5/14 ,  F04D29/38 ,  F04D29/66

    CPC分类号： F01D5/147 ,  F01D5/145 ,  F04D29/324 ,  F04D29/384 ,  F04D29/682 ,  F04D29/684 ,  F05D2260/96 ,  Y02T50/673 ,  Y10S416/50

    摘要： An axial flow fluid apparatus axially provided with a plurality of blade rows having a plurality of blades arranged around a shaft is provided. A fluid passage for jetting a fluid to a downstream velocity defect region resulting from a blade is formed in at least one of blades constituting a blade row installed on the upstream side of the plurality of blade rows so as to lead from a positive pressure surface to a negative pressure surface or a trailing edge.

    摘要翻译： 提供轴向设置有多个叶片排的轴流式流体设备，其具有围绕轴布置的多个叶片。 用于将流体喷射到由叶片产生的下游速度缺陷区域的流体通道形成在构成安装在多个叶片排的上游侧的叶片排的叶片中的至少一个中，以便从正压表面引导到 负压表面或后缘。