公开(公告)号：US08657748B2

公开(公告)日：2014-02-25

申请号：US13377329

申请日：2009-06-09

申请人： Naotaka Nitta ,  Hiroshi Masuda

发明人： Naotaka Nitta ,  Hiroshi Masuda

IPC分类号： A61B8/00 ,  A61B5/02

CPC分类号： A61B5/145 ,  A61B5/02007 ,  A61B5/02035 ,  A61B5/14535 ,  A61B8/06 ,  A61B8/4218 ,  A61B8/5223 ,  G01N11/00

摘要： A blood vessel function inspecting apparatus including a first blood state index value calculating portion that obtains estimated hematocrit values at a plurality of points predetermined within a blood vessel, on the basis of values of a blood viscosity and values of a shear rate at said plurality of points, which are respectively extracted from a viscosity distribution and a shear rate distribution, and according to reference relationships between a hematocrit value and the blood viscosity, which reference relationships respectively correspond predetermined different values of the shear rate; and a second blood state index value calculating portion that calculates, as said blood state index value, a value relating to an amount of difference of the estimated hematocrit values at said plurality of points with respect to each other, which amount is minimized by transforming said reference relationships at the same ratio for all of the values of the shear rate.

摘要翻译： 一种血管功能检查装置，其包括：第一血液指标值计算部，其根据血液粘度的值和所述多个血压指数值的剪切速度值，求出在血管内预定的多个点处的估计的血细胞比容值 分别从粘度分布和剪切速度分布提取，并且根据血细胞比容值和血液粘度之间的参考关系，该参考关系分别对应于剪切速率的预定不同值; 以及第二血液指标值计算部，其计算与所述血液状态指标值相关的与所述多个点相对于彼此的所估计的血细胞比容值的差值相关的值，所述量通过变换所述 对于剪切速率的所有值，参考关系以相同的比例。

公开(公告)号：US08500640B2

公开(公告)日：2013-08-06

申请号：US13377357

申请日：2009-06-09

申请人： Naotaka Nitta ,  Hiroshi Masuda

发明人： Naotaka Nitta ,  Hiroshi Masuda

IPC分类号： A61B8/00 ,  A61B5/02

CPC分类号： A61B5/026 ,  A61B5/02007 ,  A61B8/08 ,  A61B8/4483

摘要： A blood vessel function inspecting apparatus including blood flow velocity distribution measuring portion for measuring a blood flow velocity distribution within a blood vessel in a non-invasion manner with ultrasonic waves before releasing of the blood vessel from a blood flow obstruction or after a blood vessel diameter measuring time period; viscosity-shear rate relationship calculating portion; and blood shear stress calculating portion for measuring a blood flow velocity within the blood vessel, concurrently with the measurement of a change ratio of the diameter of the blood vessel within the predetermined blood vessel diameter measuring time period after releasing of the blood vessel from the blood flow obstruction, and calculating a blood shear stress on the basis of a measured blood flow velocity, and according to a viscosity-shear rate relationship.

摘要翻译： 一种血管功能检查装置，包括血流速度分布测定部，用于在从血流阻塞释放血管之前以超声波测定血管内的血流速度分布，或血管直径 测量时间段; 粘度 - 剪切速率关系计算部分; 以及用于测量血管内的血流速度的血液剪切应力计算部，与血液从血液释放后的预定血管直径测量时间段内的血管直径的变化率的测量同时测量 流量阻塞，并且基于测量的血流速度计算血液剪切应力，并且根据粘度剪切速率关系。

公开(公告)号：US20120089020A1

公开(公告)日：2012-04-12

申请号：US13377329

申请日：2009-06-09

申请人： Naotaka Nitta ,  Hiroshi Masuda

发明人： Naotaka Nitta ,  Hiroshi Masuda

IPC分类号： A61B8/06 ,  A61B5/02

CPC分类号： A61B5/145 ,  A61B5/02007 ,  A61B5/02035 ,  A61B5/14535 ,  A61B8/06 ,  A61B8/4218 ,  A61B8/5223 ,  G01N11/00

摘要： A blood vessel function inspecting apparatus including a first blood state index value calculating portion that obtains estimated hematocrit values at a plurality of points predetermined within a blood vessel, on the basis of values of a blood viscosity and values of a shear rate at said plurality of points, which are respectively extracted from a viscosity distribution and a shear rate distribution, and according to reference relationships between a hematocrit value and the blood viscosity, which reference relationships respectively correspond predetermined different values of the shear rate; and a second blood state index value calculating portion that calculates, as said blood state index value, a value relating to an amount of difference of the estimated hematocrit values at said plurality of points with respect to each other, which amount is minimized by transforming said reference relationships at the same ratio for all of the values of the shear rate.

摘要翻译： 一种血管功能检查装置，其包括：第一血液指标值计算部，其根据血液粘度的值和所述多个血压指数值的剪切速度值，求出在血管内预定的多个点处的估计的血细胞比容值 分别从粘度分布和剪切速度分布提取，并且根据血细胞比容值和血液粘度之间的参考关系，该参考关系分别对应于剪切速率的预定不同值; 以及第二血液指标值计算部，其计算与所述血液状态指标值相关的与所述多个点相对于彼此的所估计的血细胞比容值的差值相关的值，所述量通过变换所述 对于剪切速率的所有值，参考关系以相同的比例。

公开(公告)号：US20120095332A1

公开(公告)日：2012-04-19

申请号：US13377357

申请日：2009-06-09

申请人： Naotaka Nitta ,  Hiroshi Masuda

发明人： Naotaka Nitta ,  Hiroshi Masuda

IPC分类号： A61B8/00

CPC分类号： A61B5/026 ,  A61B5/02007 ,  A61B8/08 ,  A61B8/4483

摘要： A blood vessel function inspecting apparatus including blood flow velocity distribution measuring portion for measuring a blood flow velocity distribution within a blood vessel in a non-invasion manner with ultrasonic waves before releasing of the blood vessel from a blood flow obstruction or after a blood vessel diameter measuring time period; viscosity-shear rate relationship calculating portion; and blood shear stress calculating portion for measuring a blood flow velocity within the blood vessel, concurrently with the measurement of a change ratio of the diameter of the blood vessel within the predetermined blood vessel diameter measuring time period after releasing of the blood vessel from the blood flow obstruction, and calculating a blood shear stress on the basis of a measured blood flow velocity, and according to a viscosity-shear rate relationship.

摘要翻译： 一种血管功能检查装置，包括血流速度分布测定部，用于在从血流阻塞释放血管之前以超声波测定血管内的血流速度分布，或血管直径 测量时间段; 粘度 - 剪切速率关系计算部分; 以及用于测量血管内的血流速度的血液剪切应力计算部，与血液从血液释放后的预定血管直径测量时间段内的血管直径的变化率的测量同时测量 流量阻塞，并且基于测量的血流速度计算血液剪切应力，并且根据粘度剪切速率关系。

公开(公告)号：US20060052696A1

公开(公告)日：2006-03-09

申请号：US10522807

申请日：2003-07-31

申请人： Tsuyoshi Shiina ,  Makoto Yamakawa ,  Naotaka Nitta

发明人： Tsuyoshi Shiina ,  Makoto Yamakawa ,  Naotaka Nitta

IPC分类号： A61B8/00

CPC分类号： A61B8/485 ,  A61B5/0048 ,  A61B8/08 ,  A61B8/0825 ,  A61B8/488 ,  G01S7/52042 ,  G01S15/10 ,  G01S15/88 ,  G01S15/8906

摘要： An ultrasonic diagnosis system and strain distribution display method utilizing an ultrasonic probe for performing transmission/reception of ultrasonic signals to/from a subject, a storage arrangement for storing the properties of signals detected with the ultrasonic probe, a correlation computer for calculating a correlation coefficient between the properties with and without pressure applied to the subject, and a phase difference between the received signals with and without application of pressure, based upon the properties stored in the storage arrangement with and without pressure applied to the subject, a computer for calculating a displacement of each measurement point, and a strain distribution of tissue of the subject due to application of pressure, based upon the correlation coefficient and phase difference calculated by the correlation computer, and a display for displaying the strain distribution.

摘要翻译： 超声波诊断系统和应变分布显示方法，利用超声波探头对被检体进行超声波信号的发送接收，存储由超声波探头检测的信号的特性的存储装置，计算相关系数的相关计算机 在施加到受试者的压力和不施加压力的属性之间以及在施加和不施加压力的情况下的接收信号之间的相位差，基于在施加和不施加压力的情况下存储在存储装置中的性质，用于计算 基于相关计算机计算出的相关系数和相位差，以及用于显示应变分布的显示器，由于施加压力而使每个测量点的位移以及受试者的组织的应变分布。

公开(公告)号：US08382670B2

公开(公告)日：2013-02-26

申请号：US12956959

申请日：2010-11-30

申请人： Tsuyoshi Shiina ,  Makoto Yamakawa ,  Naotaka Nitta

发明人： Tsuyoshi Shiina ,  Makoto Yamakawa ,  Naotaka Nitta

IPC分类号： A61B8/00 ,  A61B8/14

CPC分类号： A61B8/485 ,  A61B5/0048 ,  A61B8/08 ,  A61B8/0825 ,  A61B8/488 ,  G01S7/52042 ,  G01S15/10 ,  G01S15/88 ,  G01S15/8906

摘要： An ultrasonic diagnosis system and strain distribution display method utilizing an ultrasonic probe for performing transmission/reception of ultrasonic signals to/from a subject, a storage arrangement for storing the properties of signals detected with the ultrasonic probe, a correlation computer for calculating a correlation coefficient between the properties with and without pressure applied to the subject, and a phase difference between the received signals with and without application of pressure, based upon the properties stored in the storage arrangement with and without pressure applied to the subject, a computer for calculating a displacement of each measurement point, and a strain distribution of tissue of the subject due to application of pressure, based upon the correlation coefficient and phase difference calculated by the correlation computer, and a display for displaying the strain distribution.

摘要翻译： 超声波诊断系统和应变分布显示方法，利用超声波探头对被检体进行超声波信号的发送接收，存储由超声波探头检测的信号的特性的存储装置，计算相关系数的相关计算机 在施加到受试者的压力和不施加压力的属性之间以及在施加和不施加压力的情况下的接收信号之间的相位差，基于在施加和不施加压力的情况下存储在存储装置中的性质，用于计算 基于相关计算机计算出的相关系数和相位差，以及用于显示应变分布的显示器，由于施加压力而使每个测量点的位移以及受试者的组织的应变分布。

公开(公告)号：US08515524B2

公开(公告)日：2013-08-20

申请号：US12325678

申请日：2008-12-01

申请人： Tsutomu Furuzono ,  Miwa Masuda ,  Masahiro Okada ,  Naotaka Nitta ,  Takashi Yamane

发明人： Tsutomu Furuzono ,  Miwa Masuda ,  Masahiro Okada ,  Naotaka Nitta ,  Takashi Yamane

IPC分类号： A61B5/00

CPC分类号： A61B90/40 ,  A61N7/00

摘要： The present invention solves the issue of bacterial infection by medical devices such as intracorporeal indwelling catheters. The present invention relates to an ultrasonic medical apparatus including a medical device (titanium oxide coated medical device 10) covered with a titanium oxide material (titanium oxide alone or a titanium oxide composite material) and ultrasonic irradiation means 20. Ultrasonic irradiation of the titanium oxide material, which exists on a surface of the medical device, causes the surface of the medical device to exert beneficial effects such as antibiotic action, the stimulation of angiogenesis, and the degradation of a blood clot and a biofilm.

摘要翻译： 本发明解决了诸如体内留置导管之类的医疗装置的细菌感染问题。 超声波医疗装置技术领域本发明涉及一种超声波医疗装置，其包括被钛氧化物材料（单独的氧化钛或氧化钛复合材料）覆盖的医疗装置（氧化钛被覆医用器具10）和超声波照射手段20。 存在于医疗装置的表面上的材料导致医疗装置的表面发挥有益效果，例如抗生素作用，刺激血管生成以及血块和生物膜的降解。

公开(公告)号：US08041415B2

公开(公告)日：2011-10-18

申请号：US10522807

申请日：2003-07-31

申请人： Tsuyoshi Shiina ,  Makoto Yamakawa ,  Naotaka Nitta

发明人： Tsuyoshi Shiina ,  Makoto Yamakawa ,  Naotaka Nitta

IPC分类号： A61B8/00

CPC分类号： A61B8/485 ,  A61B5/0048 ,  A61B8/08 ,  A61B8/0825 ,  A61B8/488 ,  G01S7/52042 ,  G01S15/10 ,  G01S15/88 ,  G01S15/8906

摘要： An ultrasonic diagnosis system and strain distribution display method utilizing an ultrasonic probe for performing transmission/reception of ultrasonic signals to/from a subject, a storage arrangement for storing the properties of signals detected with the ultrasonic probe, a correlation computer for calculating a correlation coefficient between the properties with and without pressure applied to the subject, and a phase difference between the received signals with and without application of pressure, based upon the properties stored in the storage arrangement with and without pressure applied to the subject, a computer for calculating a displacement of each measurement point, and a strain distribution of tissue of the subject due to application of pressure, based upon the correlation coefficient and phase difference calculated by the correlation computer, and a display for displaying the strain distribution.

摘要翻译： 超声波诊断系统和应变分布显示方法，利用超声波探头对被检体进行超声波信号的发送接收，存储由超声波探头检测的信号的特性的存储装置，计算相关系数的相关计算机 在施加到受试者的压力和不施加压力的属性之间以及在施加和不施加压力的情况下的接收信号之间的相位差，基于在施加和不施加压力的情况下存储在存储装置中的性质，用于计算 基于相关计算机计算出的相关系数和相位差，以及用于显示应变分布的显示器，由于施加压力而使每个测量点的位移以及受试者的组织的应变分布。

公开(公告)号：US20110125019A1

公开(公告)日：2011-05-26

申请号：US12956959

申请日：2010-11-30

申请人： Tsuyoshi SHIINA ,  Makoto Yamakawa ,  Naotaka Nitta

发明人： Tsuyoshi SHIINA ,  Makoto Yamakawa ,  Naotaka Nitta

IPC分类号： A61B8/14

CPC分类号： A61B8/485 ,  A61B5/0048 ,  A61B8/08 ,  A61B8/0825 ,  A61B8/488 ,  G01S7/52042 ,  G01S15/10 ,  G01S15/88 ,  G01S15/8906

摘要： An ultrasonic diagnosis system and strain distribution display method utilizing an ultrasonic probe for performing transmission/reception of ultrasonic signals to/from a subject, a storage arrangement for storing the properties of signals detected with the ultrasonic probe, a correlation computer for calculating a correlation coefficient between the properties with and without pressure applied to the subject, and a phase difference between the received signals with and without application of pressure, based upon the properties stored in the storage arrangement with and without pressure applied to the subject, a computer for calculating a displacement of each measurement point, and a strain distribution of tissue of the subject due to application of pressure, based upon the correlation coefficient and phase difference calculated by the correlation computer, and a display for displaying the strain distribution.

摘要翻译： 超声波诊断系统和应变分布显示方法，利用超声波探头对被检体进行超声波信号的发送接收，存储由超声波探头检测的信号的特性的存储装置，计算相关系数的相关计算机 在施加到受试者的压力和不施加压力的属性之间以及在施加和不施加压力的情况下的接收信号之间的相位差，基于在施加和不施加压力的情况下存储在存储装置中的性质，用于计算 基于相关计算机计算出的相关系数和相位差，以及用于显示应变分布的显示器，由于施加压力而使每个测量点的位移以及受试者的组织的应变分布。

公开(公告)号：US07338452B2

公开(公告)日：2008-03-04

申请号：US10839205

申请日：2004-05-06

申请人： Tsuyoshi Shiina ,  Naotaka Nitta ,  Hiroyuki Yagami

发明人： Tsuyoshi Shiina ,  Naotaka Nitta ,  Hiroyuki Yagami

IPC分类号： A61B8/12

CPC分类号： A61B5/02007 ,  A61B8/08 ,  A61B8/12 ,  A61B8/485 ,  G01S7/52036

摘要： An ultrasonic diagnostic system according to the present invention has an ultrasonic transducer mounted on a catheter, an instantaneous distortion value calculator which calculates an instantaneous distortion value at the location to be evaluated in the blood vessel based on received signal representative of received reflection by the ultrasonic transducer, an analyzer which analyzes a state of the location to be evaluated using time-series data of instantaneous distortion values which are calculated at a plurality of times in a chronological sequence by the distortion value calculator, and a display which displays an analyzed result produced by the analyzer.

摘要翻译： 根据本发明的超声波诊断系统具有安装在导管上的超声波换能器，瞬时失真值计算器，其基于表示由超声波接收的反射的接收信号计算在血管中待评估的位置处的瞬时失真值 换能器，使用由失真值计算器按时间顺序计算的瞬时失真值的时间序列数据分析待评估位置的状态的分析器，以及显示分析结果的显示器 由分析仪。