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公开(公告)号：US10752606B2
公开(公告)日：2020-08-25
申请号：US16699476
申请日：2019-11-29
申请人： Neoculi Pty Ltd.
IPC分类号： A61K31/155 , A61K31/505 , C07C251/24 , C07D239/48 , C07D333/58 , A61K31/381 , C07C281/18 , C07D239/50 , C07D295/135 , A61K31/17 , A61K31/341 , A61K31/4045 , A61K31/4192 , A61K31/44 , A61K31/498 , C07C47/565 , C07C211/29 , C07D209/14 , C07D241/20 , C07D249/14 , C07D251/54 , C07D307/56 , C07D311/58 , C07D401/14 , A61K9/00 , A61K31/404 , A61K31/496 , A61K45/06 , C07C335/40 , C07D209/08
摘要： The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US10253002B2
公开(公告)日：2019-04-09
申请号：US14888306
申请日：2014-05-01
申请人： Neoculi Pty Ltd.
发明人： Stephen Page , Sanjay Garg , Martine Keenan , Adam McCluskey , Andrew Stevens
IPC分类号： C07D239/50 , C07D239/48 , C07D251/48 , C07D251/54 , C07D251/66 , C07D281/16 , C07C281/18 , C07C281/16 , C07D333/58 , A61K31/155 , A61K31/381 , C07D209/14 , C07D295/125 , C07C281/08 , A61K45/06 , A61K31/14 , A61K31/17 , A61K31/175 , A61K31/404 , A61K31/505 , C07C323/45 , C07C337/08 , C07D215/12 , C07D209/40 , C07D213/53 , C07D307/56 , A01N43/54 , A01N47/44 , C07F9/6512
摘要： The invention provides compounds of Formula I, and methods of treating or preventing a bacterial infection in a subject using a compound of Formula I. The invention also provides the use of a compound of Formula I in the manufacture of a medicament for the treatment of a bacterial infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a bacterial infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US11566012B2
公开(公告)日：2023-01-31
申请号：US17038690
申请日：2020-09-30
申请人： Neoculi Pty Ltd.
IPC分类号： A61K31/44 , C07C47/565 , C07C251/24 , C07D333/58 , A61K31/155 , A61K31/381 , C07C281/18 , C07D239/50 , C07D295/135 , A61K31/17 , A61K31/341 , A61K31/4045 , A61K31/4192 , A61K31/498 , C07C211/29 , C07D209/14 , C07D239/48 , C07D241/20 , C07D249/14 , C07D251/54 , C07D307/56 , C07D311/58 , C07D401/14 , A61K9/00 , A61K31/404 , A61K31/496 , A61K31/505 , A61K45/06 , C07C335/40 , C07D209/08
摘要： The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US20200290990A1
公开(公告)日：2020-09-17
申请号：US16892661
申请日：2020-06-04
申请人： Neoculi Pty Ltd.
IPC分类号： C07D333/58 , A61K31/155 , A61K31/381 , C07C281/18 , C07D239/50 , C07D295/135 , A61K31/17 , A61K31/341 , A61K31/4045 , A61K31/4192 , A61K31/44 , A61K31/498 , C07C47/565 , C07C211/29 , C07C251/24 , C07D209/14 , C07D239/48 , C07D241/20 , C07D249/14 , C07D251/54 , C07D307/56 , C07D311/58 , C07D401/14 , A61K9/00 , A61K31/404 , A61K31/496 , A61K31/505 , A61K45/06 , C07C335/40 , C07D209/08
摘要： The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US10562880B2
公开(公告)日：2020-02-18
申请号：US16505049
申请日：2019-07-08
申请人： Neoculi Pty Ltd.
IPC分类号： C07D333/50 , A61K9/00 , A61K31/155 , A61K31/341 , A61K31/44 , A61K31/505 , C07D333/58 , A61K45/06 , C07D209/08 , C07C335/40 , A61K31/496 , C07C47/565 , C07D209/14 , C07D239/50 , C07C211/29 , C07D401/14 , C07C251/24 , C07D241/20 , C07C281/18 , A61K31/498 , A61K31/4192 , A61K31/4045 , A61K31/381 , C07D307/56 , C07D295/135 , C07D251/54 , C07D249/14 , C07D239/48 , C07D311/58 , A61K31/404 , A61K31/17
摘要： The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US20190084941A1
公开(公告)日：2019-03-21
申请号：US16146894
申请日：2018-09-28
申请人： Neoculi Pty Ltd.
发明人： Stephen Page , Sanjay Garg , Martine Keenan , Adam McCluskey , Andrew Stevens
IPC分类号： C07D239/50 , C07D251/48 , A61K45/06 , C07D251/54 , C07C281/16 , C07F9/6512 , C07C281/18 , C07C281/08 , A01N47/44 , A01N43/54 , C07D295/125 , C07D209/14 , A61K31/381 , A61K31/155 , C07D333/58 , C07D307/56 , C07D213/53 , C07D209/40 , C07D251/66 , C07D215/12 , C07C337/08 , C07C323/45 , C07D239/48 , A61K31/14 , A61K31/17 , A61K31/175 , A61K31/404 , A61K31/505
CPC分类号： C07D239/50 , A01N43/54 , A01N47/44 , A61K31/14 , A61K31/155 , A61K31/17 , A61K31/175 , A61K31/381 , A61K31/404 , A61K31/505 , A61K45/06 , C07C281/08 , C07C281/16 , C07C281/18 , C07C323/45 , C07C337/08 , C07D209/14 , C07D209/40 , C07D213/53 , C07D215/12 , C07D239/48 , C07D251/48 , C07D251/54 , C07D251/66 , C07D295/125 , C07D307/56 , C07D333/58 , C07F9/6512 , A61K2300/00
摘要： The invention provides compounds of Formula I, and methods of treating or preventing a bacterial infection in a subject using a compound of Formula I. The invention also provides the use of a compound of Formula I in the manufacture of a medicament for the treatment of a bacterial infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a bacterial infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US10392363B2
公开(公告)日：2019-08-27
申请号：US15508266
申请日：2015-08-28
申请人： Neoculi Pty Ltd.
IPC分类号： A61K31/155 , A61K31/341 , A61K31/404 , A61K31/44 , C07C211/29 , C07C281/18 , C07D333/58 , A61K31/381 , A61K31/4045 , A61K31/4192 , A61K31/498 , C07D241/20 , C07C251/24 , C07D401/14 , C07D239/50 , C07D209/14 , C07C47/565 , C07D311/58 , C07D239/48 , C07D249/14 , C07D251/54 , C07D295/135 , C07D307/56 , A61K9/00 , A61K31/496 , A61K31/505 , A61K45/06 , C07C335/40 , C07D209/08 , A61K31/17
摘要： The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US10370341B2
公开(公告)日：2019-08-06
申请号：US16146894
申请日：2018-09-28
申请人： Neoculi Pty Ltd.
发明人： Stephen Page , Sanjay Garg , Martine Keenan , Adam McCluskey , Andrew Stevens
IPC分类号： A61K31/155 , A61K31/381 , A61K31/14 , A61K31/17 , A61K31/175 , A61K31/404 , A61K31/505 , C07D239/50 , C07D251/54 , C07D239/48 , C07D251/48 , C07C281/16 , C07D333/58 , C07D209/14 , C07D295/125 , C07C281/08 , C07C281/18 , A61K45/06 , C07C323/45 , C07C337/08 , C07D215/12 , C07D251/66 , C07D209/40 , C07D213/53 , C07D307/56 , A01N43/54 , A01N47/44 , C07F9/6512
摘要： The invention provides compounds of Formula I, and methods of treating or preventing a bacterial infection in a subject using a compound of Formula I. The invention also provides the use of a compound of Formula I in the manufacture of a medicament for the treatment of a bacterial infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a bacterial infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US20210009552A1
公开(公告)日：2021-01-14
申请号：US17038690
申请日：2020-09-30
申请人： Neoculi Pty Ltd.
IPC分类号： C07D333/58 , A61K31/155 , A61K31/381 , C07C281/18 , C07D239/50 , C07D295/135 , A61K31/17 , A61K31/341 , A61K31/4045 , A61K31/4192 , A61K31/44 , A61K31/498 , C07C47/565 , C07C211/29 , C07C251/24 , C07D209/14 , C07D239/48 , C07D241/20 , C07D249/14 , C07D251/54 , C07D307/56 , C07D311/58 , C07D401/14 , A61K9/00 , A61K31/404 , A61K31/496 , A61K31/505 , A61K45/06 , C07C335/40 , C07D209/08
摘要： The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US20170291886A1
公开(公告)日：2017-10-12
申请号：US15508266
申请日：2015-08-28
申请人： Neoculi Pty Ltd.
IPC分类号： C07D333/58 , A61K45/06 , C07C281/18 , A61K31/505 , C07D239/50 , C07D295/135 , C07C335/40 , A61K31/381 , A61K31/404 , C07D209/08 , A61K31/496 , A61K31/155 , A61K9/00
CPC分类号： C07D333/58 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K31/155 , A61K31/17 , A61K31/341 , A61K31/381 , A61K31/404 , A61K31/4045 , A61K31/4192 , A61K31/44 , A61K31/496 , A61K31/498 , A61K31/505 , A61K45/06 , C07C47/565 , C07C211/29 , C07C251/24 , C07C281/18 , C07C335/40 , C07C2601/08 , C07C2601/14 , C07D209/08 , C07D209/14 , C07D239/48 , C07D239/50 , C07D241/20 , C07D249/14 , C07D251/54 , C07D295/135 , C07D307/56 , C07D311/58 , C07D401/14 , A61K2300/00
摘要： The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.
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