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公开(公告)号：US10752606B2
公开(公告)日：2020-08-25
申请号：US16699476
申请日：2019-11-29
申请人： Neoculi Pty Ltd.
IPC分类号： A61K31/155 , A61K31/505 , C07C251/24 , C07D239/48 , C07D333/58 , A61K31/381 , C07C281/18 , C07D239/50 , C07D295/135 , A61K31/17 , A61K31/341 , A61K31/4045 , A61K31/4192 , A61K31/44 , A61K31/498 , C07C47/565 , C07C211/29 , C07D209/14 , C07D241/20 , C07D249/14 , C07D251/54 , C07D307/56 , C07D311/58 , C07D401/14 , A61K9/00 , A61K31/404 , A61K31/496 , A61K45/06 , C07C335/40 , C07D209/08
摘要： The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US10253002B2
公开(公告)日：2019-04-09
申请号：US14888306
申请日：2014-05-01
申请人： Neoculi Pty Ltd.
发明人： Stephen Page , Sanjay Garg , Martine Keenan , Adam McCluskey , Andrew Stevens
IPC分类号： C07D239/50 , C07D239/48 , C07D251/48 , C07D251/54 , C07D251/66 , C07D281/16 , C07C281/18 , C07C281/16 , C07D333/58 , A61K31/155 , A61K31/381 , C07D209/14 , C07D295/125 , C07C281/08 , A61K45/06 , A61K31/14 , A61K31/17 , A61K31/175 , A61K31/404 , A61K31/505 , C07C323/45 , C07C337/08 , C07D215/12 , C07D209/40 , C07D213/53 , C07D307/56 , A01N43/54 , A01N47/44 , C07F9/6512
摘要： The invention provides compounds of Formula I, and methods of treating or preventing a bacterial infection in a subject using a compound of Formula I. The invention also provides the use of a compound of Formula I in the manufacture of a medicament for the treatment of a bacterial infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a bacterial infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US20210009552A1
公开(公告)日：2021-01-14
申请号：US17038690
申请日：2020-09-30
申请人： Neoculi Pty Ltd.
IPC分类号： C07D333/58 , A61K31/155 , A61K31/381 , C07C281/18 , C07D239/50 , C07D295/135 , A61K31/17 , A61K31/341 , A61K31/4045 , A61K31/4192 , A61K31/44 , A61K31/498 , C07C47/565 , C07C211/29 , C07C251/24 , C07D209/14 , C07D239/48 , C07D241/20 , C07D249/14 , C07D251/54 , C07D307/56 , C07D311/58 , C07D401/14 , A61K9/00 , A61K31/404 , A61K31/496 , A61K31/505 , A61K45/06 , C07C335/40 , C07D209/08
摘要： The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US20170291886A1
公开(公告)日：2017-10-12
申请号：US15508266
申请日：2015-08-28
申请人： Neoculi Pty Ltd.
IPC分类号： C07D333/58 , A61K45/06 , C07C281/18 , A61K31/505 , C07D239/50 , C07D295/135 , C07C335/40 , A61K31/381 , A61K31/404 , C07D209/08 , A61K31/496 , A61K31/155 , A61K9/00
CPC分类号： C07D333/58 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K31/155 , A61K31/17 , A61K31/341 , A61K31/381 , A61K31/404 , A61K31/4045 , A61K31/4192 , A61K31/44 , A61K31/496 , A61K31/498 , A61K31/505 , A61K45/06 , C07C47/565 , C07C211/29 , C07C251/24 , C07C281/18 , C07C335/40 , C07C2601/08 , C07C2601/14 , C07D209/08 , C07D209/14 , C07D239/48 , C07D239/50 , C07D241/20 , C07D249/14 , C07D251/54 , C07D295/135 , C07D307/56 , C07D311/58 , C07D401/14 , A61K2300/00
摘要： The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US20160075665A1
公开(公告)日：2016-03-17
申请号：US14888306
申请日：2014-05-01
申请人： Sanjay GARG , Martine KEENAN , Adam MCCLUSKEY , Andrew STEVENS , NEOCULI PTY LTD
发明人： Stephen Page , Sanjay Garg , Martine Keenan , Adam McCluskey , Andrew Stevens
IPC分类号： C07D239/50 , A01N47/44 , A61K45/06 , A01N43/54 , A61K31/505 , C07C281/18 , A61K31/155
CPC分类号： C07D239/50 , A01N43/54 , A01N47/44 , A61K31/14 , A61K31/155 , A61K31/17 , A61K31/175 , A61K31/381 , A61K31/404 , A61K31/505 , A61K45/06 , C07C281/08 , C07C281/16 , C07C281/18 , C07C323/45 , C07C337/08 , C07D209/14 , C07D209/40 , C07D213/53 , C07D215/12 , C07D239/48 , C07D251/48 , C07D251/54 , C07D251/66 , C07D295/125 , C07D307/56 , C07D333/58 , C07F9/6512 , A61K2300/00
摘要： The invention provides compounds of Formula (I), and methods of treating or preventing a bacterial infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a bacterial infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a bacterial infection in a subject and to a medical device comprising the composition of the invention.
摘要翻译： 本发明提供式（I）化合物，以及使用式（I）化合物治疗或预防受试者细菌感染的方法。 本发明还提供式（I）化合物在制备用于治疗受试者的细菌感染的药物中的用途。 本发明还提供了用于治疗或预防受试者的细菌感染的方法中的医疗装置以及包含本发明的组合物的医疗装置。
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公开(公告)号：US10392363B2
公开(公告)日：2019-08-27
申请号：US15508266
申请日：2015-08-28
申请人： Neoculi Pty Ltd.
IPC分类号： A61K31/155 , A61K31/341 , A61K31/404 , A61K31/44 , C07C211/29 , C07C281/18 , C07D333/58 , A61K31/381 , A61K31/4045 , A61K31/4192 , A61K31/498 , C07D241/20 , C07C251/24 , C07D401/14 , C07D239/50 , C07D209/14 , C07C47/565 , C07D311/58 , C07D239/48 , C07D249/14 , C07D251/54 , C07D295/135 , C07D307/56 , A61K9/00 , A61K31/496 , A61K31/505 , A61K45/06 , C07C335/40 , C07D209/08 , A61K31/17
摘要： The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US10370341B2
公开(公告)日：2019-08-06
申请号：US16146894
申请日：2018-09-28
申请人： Neoculi Pty Ltd.
发明人： Stephen Page , Sanjay Garg , Martine Keenan , Adam McCluskey , Andrew Stevens
IPC分类号： A61K31/155 , A61K31/381 , A61K31/14 , A61K31/17 , A61K31/175 , A61K31/404 , A61K31/505 , C07D239/50 , C07D251/54 , C07D239/48 , C07D251/48 , C07C281/16 , C07D333/58 , C07D209/14 , C07D295/125 , C07C281/08 , C07C281/18 , A61K45/06 , C07C323/45 , C07C337/08 , C07D215/12 , C07D251/66 , C07D209/40 , C07D213/53 , C07D307/56 , A01N43/54 , A01N47/44 , C07F9/6512
摘要： The invention provides compounds of Formula I, and methods of treating or preventing a bacterial infection in a subject using a compound of Formula I. The invention also provides the use of a compound of Formula I in the manufacture of a medicament for the treatment of a bacterial infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a bacterial infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US11566012B2
公开(公告)日：2023-01-31
申请号：US17038690
申请日：2020-09-30
申请人： Neoculi Pty Ltd.
IPC分类号： A61K31/44 , C07C47/565 , C07C251/24 , C07D333/58 , A61K31/155 , A61K31/381 , C07C281/18 , C07D239/50 , C07D295/135 , A61K31/17 , A61K31/341 , A61K31/4045 , A61K31/4192 , A61K31/498 , C07C211/29 , C07D209/14 , C07D239/48 , C07D241/20 , C07D249/14 , C07D251/54 , C07D307/56 , C07D311/58 , C07D401/14 , A61K9/00 , A61K31/404 , A61K31/496 , A61K31/505 , A61K45/06 , C07C335/40 , C07D209/08
摘要： The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US20200290990A1
公开(公告)日：2020-09-17
申请号：US16892661
申请日：2020-06-04
申请人： Neoculi Pty Ltd.
IPC分类号： C07D333/58 , A61K31/155 , A61K31/381 , C07C281/18 , C07D239/50 , C07D295/135 , A61K31/17 , A61K31/341 , A61K31/4045 , A61K31/4192 , A61K31/44 , A61K31/498 , C07C47/565 , C07C211/29 , C07C251/24 , C07D209/14 , C07D239/48 , C07D241/20 , C07D249/14 , C07D251/54 , C07D307/56 , C07D311/58 , C07D401/14 , A61K9/00 , A61K31/404 , A61K31/496 , A61K31/505 , A61K45/06 , C07C335/40 , C07D209/08
摘要： The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.
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公开(公告)号：US10562880B2
公开(公告)日：2020-02-18
申请号：US16505049
申请日：2019-07-08
申请人： Neoculi Pty Ltd.
IPC分类号： C07D333/50 , A61K9/00 , A61K31/155 , A61K31/341 , A61K31/44 , A61K31/505 , C07D333/58 , A61K45/06 , C07D209/08 , C07C335/40 , A61K31/496 , C07C47/565 , C07D209/14 , C07D239/50 , C07C211/29 , C07D401/14 , C07C251/24 , C07D241/20 , C07C281/18 , A61K31/498 , A61K31/4192 , A61K31/4045 , A61K31/381 , C07D307/56 , C07D295/135 , C07D251/54 , C07D249/14 , C07D239/48 , C07D311/58 , A61K31/404 , A61K31/17
摘要： The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.
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