公开(公告)号：US10231835B2

公开(公告)日：2019-03-19

申请号：US15311715

申请日：2015-03-26

申请人： Netanel Benichou

发明人： Benjamin Spenser ,  Netanel Benichou

IPC分类号： A61F2/24

摘要： A prosthesic valve for implantation in a body duct that can cover a range of target sizes by a single device. The valve comprises of three main elements:1) a support cylindrical frame structure that can be collapsed to a small diameter for insertion into the body and that can expand to a large diameter when positioned in the target implantation site, the expansion of the frame being limited by the native valve diameter, which the valve is implanted within. In some cases this may be self-expandable;2) A frustoconical leaflet support frame that has an inflow side and an outflow side. The inflow side of the leaflet support frame is attached to the cylindrical frame and can be expanded along with the cylindrical frame to a range of diameters up to the diameter of the body duct, while the outflow side is limited in its opening diameter to a smaller constant diameter;3) Flexible leaflets are attached to the leaflet support frame to create a valve that allows flow from inflow to outflow, but prevents flow in the opposite direction.A delivery catheter dilates the valve while the frustoconical leaflet support system enables the valve to function (open and close) during the deployment process. Unlike prior prosthetic valves that only allow valve expansion, the valve of the invention may be collapsed if needed in order to re position or retrieve the valve.

公开(公告)号：US08500798B2

公开(公告)日：2013-08-06

申请号：US11441406

申请日：2006-05-24

申请人： Stanton J. Rowe ,  Larry Wood ,  Henry Bourang ,  George Bakis ,  Benjamin Spenser ,  Netanel Benichou ,  Yaron Keidar ,  Assaf Bash

发明人： Stanton J. Rowe ,  Larry Wood ,  Henry Bourang ,  George Bakis ,  Benjamin Spenser ,  Netanel Benichou ,  Yaron Keidar ,  Assaf Bash

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2445 ,  A61F2/90 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/0041 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2220/0083 ,  A61F2230/0078 ,  A61F2250/006 ,  A61F2250/0098 ,  A61L27/3625

摘要： A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.

摘要翻译： 提供了一种可在外科手术过程中快速，容易地植入的两级或基于部件的瓣膜假体。 假体瓣膜包括部署在治疗部位的支撑结构。 假体瓣膜还包括构造成快速连接到支撑结构的阀构件。 支撑结构可以采取在天然瓣膜部位扩张的支架的形式。 如果需要，天然传单可以保留，并且支架可以用于保持天然瓣膜打开。 在这种情况下，支架可以是球囊可扩张的并且被配置为抵抗天然传单的强大后坐力。 支撑结构设置有用于附接到阀构件的联接装置，从而将阀构件的位置固定在主体中。 阀构件可以是不可膨胀型，或者可以从压缩状态扩展到膨胀状态。 该系统特别适用于在常规开心手术环境中快速部署心脏瓣膜。

公开(公告)号：US20120303113A1

公开(公告)日：2012-11-29

申请号：US13569028

申请日：2012-08-07

申请人： Netanel Benichou ,  Benjamin Spenser ,  Assaf Bash

发明人： Netanel Benichou ,  Benjamin Spenser ,  Assaf Bash

IPC分类号： A61F2/86 ,  A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2002/9522 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0097

摘要： An implantable prosthetic valve assembly having a support stent, or frame, having circumferential struts with multiple bends forming obtuse angles when the valve assembly is expanded to its functional size. The frame can be manufactured with one or more of the circumferential struts in a partially collapsed state and a flexible valve member can be mounted to the partially collapsed frame. The partially collapsed struts can be formed with multiple bends having angles selected to facilitate crimping of the frame to a profile suitable for percutaneous delivery. When the frame is expanded, the bends can expand to form obtuse angles, thereby enhancing the rigidity of the frame to better resist closing forces exerted on the valve assembly.

摘要翻译： 具有支撑支架或框架的可植入假体瓣膜组件，当瓣膜组件膨胀到其功能尺寸时，具有多个弯曲的圆周支柱形成钝角。 框架可以用一个或多个周向支柱制造成部分折叠状态，并且柔性阀构件可以安装到部分折叠的框架上。 部分折叠的支柱可以形成有多个弯曲部，其具有被选择为有利于将框架卷曲到适于经皮递送的轮廓的角度。 当框架膨胀时，弯头可以膨胀以形成钝角，从而增强框架的刚性，以更好地抵抗作用在阀组件上的闭合力。

公开(公告)号：US20070056346A1

公开(公告)日：2007-03-15

申请号：US11517881

申请日：2006-09-08

申请人： Benjamin Spenser ,  Netanel Benichou

发明人： Benjamin Spenser ,  Netanel Benichou

IPC分类号： B21D41/00

CPC分类号： A61F2/2412 ,  A61F2/2433 ,  A61F2/2475 ,  A61F2002/9522 ,  B25B27/10

摘要： An improved crimping mechanism well-suited for use with stented prosthetic heart valves. The crimping mechanism includes a plurality of jaws configured for linear non-rotational movement toward a central axis. A rotational plate is formed with a plurality of spiral grooves or tracks for engaging the jaws. Rotational movement of the spiral tracks produces linear movement of the jaws. Nesting of the inner ends of the jaws permits each to be acted on along different radial lines while their inner faces move together evenly to reduce the crimping aperture in a smooth fashion. The crimping mechanism is particularly well-suited for use with stented prosthetic heart valves, such as a prosthetic aortic valve, though it can also be applied to other stented heart valves, venous valves, and even stent grafts which tend to be fairly large.

摘要翻译： 改进的压接机构非常适合用于支架假体心脏瓣膜。 压接机构包括构造成用于朝向中心轴的线性非旋转运动的多个钳口。 旋转板形成有多个用于接合夹爪的螺旋槽或轨道。 螺旋轨道的旋转运动产生夹爪的线性运动。 夹爪的内端嵌套允许每个沿着不同的径向线作用，同时其内表面均匀地移动在一起，以平滑的方式减少压接孔。 卷曲机构特别适用于支架假体心脏瓣膜，例如假体主动脉瓣，尽管它也可以应用于其他支架式心脏瓣膜，静脉瓣，甚至倾向于相当大的支架移植物。

公开(公告)号：US08632586B2

公开(公告)日：2014-01-21

申请号：US13529909

申请日：2012-06-21

申请人： Benjamin Spenser ,  Netanel Benichou ,  Assaf Bash ,  Avraham Zakai

发明人： Benjamin Spenser ,  Netanel Benichou ,  Assaf Bash ,  Avraham Zakai

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2403 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2421 ,  A61F2/2427 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2463 ,  A61F2/82 ,  A61F2002/9522 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2220/0083 ,  A61F2230/0054 ,  A61F2230/0069 ,  A61F2250/001 ,  A61F2250/0098

摘要： A method of replacing a deficient native aortic valve with a self-expandable prosthetic valve is disclosed. The method involves advancing a self-expandable prosthetic valve through a tapered tube for crimping the prosthetic valve into a crimped diameter. The prosthetic valve is then advanced into a restriction tube for maintaining the prosthetic valve in the crimped diameter. The prosthetic valve is then advanced into a body and is positioned within the deficient native aortic valve. The prosthetic valve is then released from the restriction tube such that the prosthetic valve self-expands to an expanded diameter for anchoring within the deficient native aortic valve. The prosthetic valve comprises an expandable tubular support frame and a valve assembly positioned within the support frame. The valve assembly is formed with pericardial tissue and has three leaflets for providing blockage to a reverse flow of blood.

摘要翻译： 公开了一种用自膨胀假体瓣替代缺乏天然主动脉瓣的方法。 该方法涉及通过锥形管推进自膨胀假体瓣膜，以将假体瓣膜压接成卷曲直径。 然后将人工瓣膜推进到限制管中，以将人造瓣维持在卷曲直径。 然后将人工瓣膜推进到体内并且定位在缺陷的天然主动脉瓣内。 然后将人工瓣膜从限制管释放，使得假体瓣膜自膨胀至扩张直径以锚定在缺陷的天然主动脉瓣内。 假体瓣膜包括可扩张管状支撑框架和位于支撑框架内的阀组件。 阀组件形成有心包组织，并具有三个传单，用于阻止血液逆流。

公开(公告)号：US20120041551A1

公开(公告)日：2012-02-16

申请号：US13280722

申请日：2011-10-25

申请人： Benjamin Spenser ,  Netanel Benichou ,  Assaf Bash ,  Avraham Zakai

发明人： Benjamin Spenser ,  Netanel Benichou ,  Assaf Bash ,  Avraham Zakai

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2403 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2421 ,  A61F2/2427 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2463 ,  A61F2/82 ,  A61F2002/9522 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2220/0083 ,  A61F2230/0054 ,  A61F2230/0069 ,  A61F2250/001 ,  A61F2250/0098

摘要： A prosthetic valve for catheter delivery is disclosed. The prosthetic valve comprises a valve assembly having an inlet, a plurality of leaflets and commissural points. The prosthetic valve also includes a support stent comprising a web-like construction and plurality of longitudinal support beams. The support stent is configured to be collapsible for percutaneous delivery through a blood vessel and expandable to contact the the native valve. The support stent supports the inlet of the valve assembly and the commissural points of the valve assembly are secured at the longitudinal support beams. The longitudinal support beams comprise a plurality of bores and the leaflets are secured to the longitudinal support beams via threads passing through the plurality of bores.

摘要翻译： 公开了一种用于导管输送的人工瓣膜。 假体阀包括具有入口，多个传单和连合点的阀组件。 假体瓣膜还包括支撑支架，其包括网状结构和多个纵向支撑梁。 支撑支架被构造为可折叠的，用于通过血管的经皮输送并且可扩张以接触天然瓣膜。 支撑支架支撑阀组件的入口，并且阀组件的连合点固定在纵向支撑梁处。 纵向支撑梁包括多个孔，并且小叶通过穿过多个孔的螺纹固定到纵向支撑梁。

公开(公告)号：US20070293944A1

公开(公告)日：2007-12-20

申请号：US11847275

申请日：2007-08-29

申请人： Benjamin Spenser ,  Netanel Benichou ,  Assaf Bash

发明人： Benjamin Spenser ,  Netanel Benichou ,  Assaf Bash

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2/2433 ,  A61F2250/0003 ,  A61F2250/006 ,  A61F2250/0069

摘要： The present invention provides a series of new percutaneous concepts of paravalvular repairs including identifying the leak location, several repair techniques and finally built-in means for leak prevention, built on percutaneous valves. A catheter-delivered device locates cavities occurring between a prosthetic valve and the wall of the body vessel where the valve is implanted, the cavities producing paravalvular leaks during diastole, the device comprising at least one of a plurality of flexible wires, the wire having attached to it a balloon, wherein the balloon is pulled by the leak through the cavity and wherein the wire then serves to mark the cavity location.

摘要翻译： 本发明提供了一系列新颖的瓣膜修复的经皮概念，包括识别泄漏位置，几种修复技术，以及最终内置的经皮瓣置入装置。 导管输送装置定位在假体瓣膜和植入瓣膜的身体血管的壁之间发生的空腔，所述腔在舒张期间产生瓣间泄漏，所述装置包括多根柔性线中的至少一个，所述线已附接 给气球，其中气囊被泄漏通过空腔拉动，并且其中所述线然后用于标记腔体位置。

公开(公告)号：US08628569B2

公开(公告)日：2014-01-14

申请号：US13569028

申请日：2012-08-07

申请人： Netanel Benichou ,  Benjamin Spenser ,  Assaf Bash

发明人： Netanel Benichou ,  Benjamin Spenser ,  Assaf Bash

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2002/9522 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0097

摘要： An implantable prosthetic valve assembly having a support stent, or frame, having circumferential struts with multiple bends forming obtuse angles when the valve assembly is expanded to its functional size. The frame can be manufactured with one or more of the circumferential struts in a partially collapsed state and a flexible valve member can be mounted to the partially collapsed frame. The partially collapsed struts can be formed with multiple bends having angles selected to facilitate crimping of the frame to a profile suitable for percutaneous delivery. When the frame is expanded, the bends can expand to form obtuse angles, thereby enhancing the rigidity of the frame to better resist closing forces exerted on the valve assembly.

摘要翻译： 具有支撑支架或框架的可植入假体瓣膜组件，当瓣膜组件膨胀到其功能尺寸时，具有多个弯曲的圆周支柱形成钝角。 框架可以用一个或多个周向支柱制造成部分折叠状态，并且柔性阀构件可以安装到部分折叠的框架上。 部分折叠的支柱可以形成有多个弯曲部，其具有被选择为有利于将框架卷曲到适于经皮递送的轮廓的角度。 当框架膨胀时，弯头可以膨胀以形成钝角，从而增强框架的刚性，以更好地抵抗作用在阀组件上的闭合力。

公开(公告)号：US07628805B2

公开(公告)日：2009-12-08

申请号：US11847275

申请日：2007-08-29

申请人： Benjamin Spenser ,  Netanel Benichou ,  Assaf Bash

发明人： Benjamin Spenser ,  Netanel Benichou ,  Assaf Bash

IPC分类号： A61F2/06

CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2/2433 ,  A61F2250/0003 ,  A61F2250/006 ,  A61F2250/0069

摘要： The present invention provides a series of new percutaneous concepts of paravalvular repairs including identifying the leak location, several repair techniques and finally built-in means for leak prevention, built on percutaneous valves. A catheter-delivered device locates cavities occurring between a prosthetic valve and the wall of the body vessel where the valve is implanted, the cavities producing paravalvular leaks during diastole, the device comprising at least one of a plurality of flexible wires, the wire having attached to it a balloon, wherein the balloon is pulled by the leak through the cavity and wherein the wire then serves to mark the cavity location.

摘要翻译： 本发明提供了一系列新颖的瓣膜修复的经皮概念，包括识别泄漏位置，几种修复技术，以及最终内置的经皮瓣置入装置。 导管输送装置定位在假体瓣膜和植入瓣膜的身体血管的壁之间发生的空腔，所述腔在舒张期间产生瓣间泄漏，所述装置包括多根柔性线中的至少一个，所述线已附接 给气球，其中气囊被泄漏通过空腔拉动，并且其中所述线然后用于标记腔体位置。

公开(公告)号：US20090281609A1

公开(公告)日：2009-11-12

申请号：US12392995

申请日：2009-02-25

申请人： Netanel Benichou ,  Son V. Nguyen ,  Benjamin Spenser

发明人： Netanel Benichou ,  Son V. Nguyen ,  Benjamin Spenser

IPC分类号： A61F2/06 ,  A61M29/00

CPC分类号： A61F2/2418 ,  A61F2/2427 ,  A61F2/2433 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/0054 ,  A61F2250/0059 ,  A61F2250/0063

摘要： A two-part implantable heart valve and procedure are disclosed that allow expansion and positioning of a first part of the implantable heart valve having a temporary or transient valvular structure. A second part of the implantable heart valve is deployed within the first part and attaches thereto. The valvular structure of the second part then acts to function as the heart valve replacement. A tool or system is provided for determining an adequate percutaneous heart valve size for a given stenotic valve. A balloon can be inflated inside the stenotic valve to a desired pressure. When this pressure is reached an angiographic image is taken and the balloon diameter is measured at a waist area created by contact between the balloon and the stenotic valve. The diameter represents the minimum percutaneous heart valve diameter to be implanted.

摘要翻译： 公开了两部分可植入心脏瓣膜和程序，其允许具有临时或暂时瓣膜结构的可植入心脏瓣膜的第一部分的膨胀和定位。 可植入心脏瓣膜的第二部分部署在第一部分内并且附接到其上。 然后，第二部分的瓣膜结构起到充当心脏瓣膜置换作用。 提供了一种用于确定给定狭窄瓣膜的足够的经皮心脏瓣膜尺寸的工具或系统。 气囊可以在狭窄的瓣膜内充气到期望的压力。 当达到该压力时，取出血管造影图像，并且在通过球囊和狭窄瓣膜之间的接触产生的腰部区域测量球囊直径。 直径代表要植入的最小经皮心脏瓣膜直径。