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公开(公告)号：US20090281609A1
公开(公告)日：2009-11-12
申请号：US12392995
申请日：2009-02-25
CPC分类号： A61F2/2418 , A61F2/2427 , A61F2/2433 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2250/0059 , A61F2250/0063
摘要： A two-part implantable heart valve and procedure are disclosed that allow expansion and positioning of a first part of the implantable heart valve having a temporary or transient valvular structure. A second part of the implantable heart valve is deployed within the first part and attaches thereto. The valvular structure of the second part then acts to function as the heart valve replacement. A tool or system is provided for determining an adequate percutaneous heart valve size for a given stenotic valve. A balloon can be inflated inside the stenotic valve to a desired pressure. When this pressure is reached an angiographic image is taken and the balloon diameter is measured at a waist area created by contact between the balloon and the stenotic valve. The diameter represents the minimum percutaneous heart valve diameter to be implanted.
摘要翻译： 公开了两部分可植入心脏瓣膜和程序，其允许具有临时或暂时瓣膜结构的可植入心脏瓣膜的第一部分的膨胀和定位。 可植入心脏瓣膜的第二部分部署在第一部分内并且附接到其上。 然后，第二部分的瓣膜结构起到充当心脏瓣膜置换作用。 提供了一种用于确定给定狭窄瓣膜的足够的经皮心脏瓣膜尺寸的工具或系统。 气囊可以在狭窄的瓣膜内充气到期望的压力。 当达到该压力时，取出血管造影图像，并且在通过球囊和狭窄瓣膜之间的接触产生的腰部区域测量球囊直径。 直径代表要植入的最小经皮心脏瓣膜直径。
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公开(公告)号：US09241792B2
公开(公告)日：2016-01-26
申请号：US12392995
申请日：2009-02-25
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2427 , A61F2/2433 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2250/0059 , A61F2250/0063
摘要： A two-part implantable heart valve and procedure are disclosed that allow expansion and positioning of a first part of the implantable heart valve having a temporary or transient valvular structure. A second part of the implantable heart valve is deployed within the first part and attaches thereto. The valvular structure of the second part then acts to function as the heart valve replacement. A tool or system is provided for determining an adequate percutaneous heart valve size for a given stenotic valve. A balloon can be inflated inside the stenotic valve to a desired pressure. When this pressure is reached an angiographic image is taken and the balloon diameter is measured at a waist area created by contact between the balloon and the stenotic valve. The diameter represents the minimum percutaneous heart valve diameter to be implanted.
摘要翻译： 公开了两部分可植入心脏瓣膜和程序，其允许具有临时或暂时瓣膜结构的可植入心脏瓣膜的第一部分的膨胀和定位。 可植入心脏瓣膜的第二部分部署在第一部分内并且附接到其上。 然后，第二部分的瓣膜结构起到充当心脏瓣膜置换作用。 提供了一种用于确定给定狭窄瓣膜的足够的经皮心脏瓣膜尺寸的工具或系统。 气囊可以在狭窄的瓣膜内充气到期望的压力。 当达到该压力时，取出血管造影图像，并且在通过球囊和狭窄瓣膜之间的接触产生的腰部区域测量球囊直径。 直径代表要植入的最小经皮心脏瓣膜直径。
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公开(公告)号：US09393110B2
公开(公告)日：2016-07-19
申请号：US13253689
申请日：2011-10-05
申请人： Tamir S. Levi , Son V. Nguyen , Netanel Benichou , David Maimon , Ziv Yohanan , Nikolay Gurovich , Bella Felsen , Larisa Dadonkina , Ron Sharoni , Elena Sherman
发明人： Tamir S. Levi , Son V. Nguyen , Netanel Benichou , David Maimon , Ziv Yohanan , Nikolay Gurovich , Bella Felsen , Larisa Dadonkina , Ron Sharoni , Elena Sherman
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2220/0075 , A61F2230/0054 , A61F2250/0036 , A61F2250/0097
摘要： Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.
摘要翻译： 公开了径向可折叠和可扩张的假体心脏瓣膜的实施例。 当安装在输送轴上时，阀架可以具有锥形轮廓，流入端部的直径小于流出端部分的直径。 阀可以包括大致V形的小叶，在框架的流入端内还原材料。 外裙可以固定到框架的流入端部分的外部，当阀门膨胀时，外裙部具有纵向松弛，并且当阀门折叠时，外裙部平放在框架上。 对角编织的内裙可以与框架轴向伸长。 相邻小叶的侧翼可以延伸穿过并固定到框架的窗框部分以形成连合。 当阀被压接到输送轴上时，窗框部分可以相对于周围的框架部分径向向内按压。
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公开(公告)号：US20120123529A1
公开(公告)日：2012-05-17
申请号：US13253689
申请日：2011-10-05
申请人： Tamir Levi , Son V. Nguyen , Netanel Benichou , David Maimon , Ziv Yohanan , Nikolay Gurovich , Bella Felsen , Larisa Dadonkina
发明人： Tamir Levi , Son V. Nguyen , Netanel Benichou , David Maimon , Ziv Yohanan , Nikolay Gurovich , Bella Felsen , Larisa Dadonkina
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2220/0075 , A61F2230/0054 , A61F2250/0036 , A61F2250/0097
摘要： Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.
摘要翻译： 公开了径向可折叠和可扩张的假体心脏瓣膜的实施例。 当安装在输送轴上时，阀架可以具有锥形轮廓，流入端部的直径小于流出端部分的直径。 阀可以包括大致V形的小叶，在框架的流入端内还原材料。 外裙可以固定到框架的流入端部分的外部，当阀门膨胀时，外裙部具有纵向松弛，并且当阀门折叠时，外裙部平放在框架上。 对角编织的内裙可以与框架轴向伸长。 相邻小叶的侧翼可以延伸穿过并固定到框架的窗框部分以形成连合。 当阀被压接到输送轴上时，窗框部分可以相对于周围的框架部分径向向内按压。
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公开(公告)号：US20120089223A1
公开(公告)日：2012-04-12
申请号：US13253698
申请日：2011-10-05
申请人： Son V. Nguyen , Netanel Benichou
发明人： Son V. Nguyen , Netanel Benichou
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2220/0075 , A61F2220/0091 , A61F2230/0054
摘要： An implantable prosthetic valve, according to one embodiment, comprises a radially collapsible and expandable frame and a leaflet structure supported within the frame. The leaflet structure can comprise a plurality of leaflets paired together at commissures. In one embodiment, the commissures can comprise leaflet tabs rolled into spirals around non-rigid reinforcing inserts. In another embodiment, the commissures can comprise a reinforcing sheet folded around leaflet tabs.
摘要翻译： 根据一个实施例的可植入假体瓣膜包括径向可折叠和可扩张的框架以及支撑在框架内的小叶结构。 小叶结构可以包括在连合处配对在一起的多个传单。 在一个实施例中，连合件可以包括在非刚性加强插入件周围卷成螺旋形的小叶片。 在另一个实施例中，连合件可以包括折叠在叶瓣上的加强片。
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公开(公告)号：US20100036484A1
公开(公告)日：2010-02-11
申请号：US12480603
申请日：2009-06-08
申请人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhoh , Rajesh Khanna , Son V. Nguyen , Tamir Levi , Itai Pelled
发明人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhoh , Rajesh Khanna , Son V. Nguyen , Tamir Levi , Itai Pelled
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2475 , A61F2/95 , A61F2002/9522 , A61F2220/0033 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , Y10T29/49863
摘要： An implantable prosthetic valve, according to one embodiment, comprises a frame, a leaflet structure, and a skirt member. The frame can have a plurality of axial struts interconnected by a plurality of circumferential struts. The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.
摘要翻译： 根据一个实施例的可植入人造瓣膜包括框架，小叶结构和裙部构件。 框架可以具有由多个圆周支柱互连的多个轴向支柱。 小叶结构包括多个传单（例如，安排形成三尖瓣的三个小叶）。 小叶结构具有固定到框架的扇形下边缘部分。 裙部构件可以设置在小叶结构和框架之间。
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公开(公告)号：US08500798B2
公开(公告)日：2013-08-06
申请号：US11441406
申请日：2006-05-24
申请人： Stanton J. Rowe , Larry Wood , Henry Bourang , George Bakis , Benjamin Spenser , Netanel Benichou , Yaron Keidar , Assaf Bash
发明人： Stanton J. Rowe , Larry Wood , Henry Bourang , George Bakis , Benjamin Spenser , Netanel Benichou , Yaron Keidar , Assaf Bash
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2445 , A61F2/90 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075 , A61F2220/0083 , A61F2230/0078 , A61F2250/006 , A61F2250/0098 , A61L27/3625
摘要： A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.
摘要翻译： 提供了一种可在外科手术过程中快速，容易地植入的两级或基于部件的瓣膜假体。 假体瓣膜包括部署在治疗部位的支撑结构。 假体瓣膜还包括构造成快速连接到支撑结构的阀构件。 支撑结构可以采取在天然瓣膜部位扩张的支架的形式。 如果需要，天然传单可以保留，并且支架可以用于保持天然瓣膜打开。 在这种情况下，支架可以是球囊可扩张的并且被配置为抵抗天然传单的强大后坐力。 支撑结构设置有用于附接到阀构件的联接装置，从而将阀构件的位置固定在主体中。 阀构件可以是不可膨胀型，或者可以从压缩状态扩展到膨胀状态。 该系统特别适用于在常规开心手术环境中快速部署心脏瓣膜。
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公开(公告)号：US20120303113A1
公开(公告)日：2012-11-29
申请号：US13569028
申请日：2012-08-07
申请人： Netanel Benichou , Benjamin Spenser , Assaf Bash
发明人： Netanel Benichou , Benjamin Spenser , Assaf Bash
CPC分类号： A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2002/9522 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2250/0097
摘要： An implantable prosthetic valve assembly having a support stent, or frame, having circumferential struts with multiple bends forming obtuse angles when the valve assembly is expanded to its functional size. The frame can be manufactured with one or more of the circumferential struts in a partially collapsed state and a flexible valve member can be mounted to the partially collapsed frame. The partially collapsed struts can be formed with multiple bends having angles selected to facilitate crimping of the frame to a profile suitable for percutaneous delivery. When the frame is expanded, the bends can expand to form obtuse angles, thereby enhancing the rigidity of the frame to better resist closing forces exerted on the valve assembly.
摘要翻译： 具有支撑支架或框架的可植入假体瓣膜组件，当瓣膜组件膨胀到其功能尺寸时，具有多个弯曲的圆周支柱形成钝角。 框架可以用一个或多个周向支柱制造成部分折叠状态，并且柔性阀构件可以安装到部分折叠的框架上。 部分折叠的支柱可以形成有多个弯曲部，其具有被选择为有利于将框架卷曲到适于经皮递送的轮廓的角度。 当框架膨胀时，弯头可以膨胀以形成钝角，从而增强框架的刚性，以更好地抵抗作用在阀组件上的闭合力。
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公开(公告)号：US20070056346A1
公开(公告)日：2007-03-15
申请号：US11517881
申请日：2006-09-08
申请人： Benjamin Spenser , Netanel Benichou
发明人： Benjamin Spenser , Netanel Benichou
IPC分类号： B21D41/00
CPC分类号： A61F2/2412 , A61F2/2433 , A61F2/2475 , A61F2002/9522 , B25B27/10
摘要： An improved crimping mechanism well-suited for use with stented prosthetic heart valves. The crimping mechanism includes a plurality of jaws configured for linear non-rotational movement toward a central axis. A rotational plate is formed with a plurality of spiral grooves or tracks for engaging the jaws. Rotational movement of the spiral tracks produces linear movement of the jaws. Nesting of the inner ends of the jaws permits each to be acted on along different radial lines while their inner faces move together evenly to reduce the crimping aperture in a smooth fashion. The crimping mechanism is particularly well-suited for use with stented prosthetic heart valves, such as a prosthetic aortic valve, though it can also be applied to other stented heart valves, venous valves, and even stent grafts which tend to be fairly large.
摘要翻译： 改进的压接机构非常适合用于支架假体心脏瓣膜。 压接机构包括构造成用于朝向中心轴的线性非旋转运动的多个钳口。 旋转板形成有多个用于接合夹爪的螺旋槽或轨道。 螺旋轨道的旋转运动产生夹爪的线性运动。 夹爪的内端嵌套允许每个沿着不同的径向线作用，同时其内表面均匀地移动在一起，以平滑的方式减少压接孔。 卷曲机构特别适用于支架假体心脏瓣膜，例如假体主动脉瓣，尽管它也可以应用于其他支架式心脏瓣膜，静脉瓣，甚至倾向于相当大的支架移植物。
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公开(公告)号：US08568475B2
公开(公告)日：2013-10-29
申请号：US13253698
申请日：2011-10-05
申请人： Son V. Nguyen , Netanel Benichou
发明人： Son V. Nguyen , Netanel Benichou
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2220/0075 , A61F2220/0091 , A61F2230/0054
摘要： An implantable prosthetic valve, according to one embodiment, comprises a radially collapsible and expandable frame and a leaflet structure supported within the frame. The leaflet structure can comprise a plurality of leaflets paired together at commissures. In one embodiment, the commissures can comprise leaflet tabs rolled into spirals around non-rigid reinforcing inserts. In another embodiment, the commissures can comprise a reinforcing sheet folded around leaflet tabs.
摘要翻译： 根据一个实施例的可植入假体瓣膜包括径向可折叠和可扩张的框架以及支撑在框架内的小叶结构。 小叶结构可以包括在连合处配对在一起的多个传单。 在一个实施例中，连合件可以包括在非刚性加强插入件周围卷成螺旋形的小叶片。 在另一个实施例中，连合件可以包括折叠在叶瓣上的加强片。
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