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    Non-nucleoside reverse transcriptase inhibitors
    3.
    发明授权
    Non-nucleoside reverse transcriptase inhibitors 有权
    非核苷逆转录酶抑制剂

    公开(公告)号：US08404856B2

    公开(公告)日：2013-03-26

    申请号：US12742159

    申请日：2008-11-14

    申请人： Thomas J. Tucker ,  Robert Tynebor ,  John T. Sisko ,  Neville Anthony ,  Robert Gomez ,  Samson M. Jolly

    发明人： Thomas J. Tucker ,  Robert Tynebor ,  John T. Sisko ,  Neville Anthony ,  Robert Gomez ,  Samson M. Jolly

    IPC分类号： C07D403/00 ,  C07D401/00

    CPC分类号： C07D401/06 ,  C07D471/04

    摘要： Heteroaromatic compounds of Formula (I) are HIV reverse transcriptase inhibitors, wherein ring A is: (ii-a), (ii-b), (ii-c), (ii-d), or (ii-e); and wherein n, L, M, U, X, Y, Z, RE, RF, R1, R2A, R2B, R2C, R3, R8, R9 and R10 are defined herein. The compounds of Formula I and their pharmaceutically acceptable salts and prodrugs are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts and prodrugs can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

    摘要翻译： 式（I）的杂芳族化合物是HIV逆转录酶抑制剂，其中环A是：（ii-a），（ii-b），（ii-c），（ii-d）或（ii-e）; 并且其中n，L，M，U，X，Y，Z，RE，RF，R1，R2A，R2B，R2C，R3，R8，R9和R10在本文中定义。 式I化合物及其药学上可接受的盐和前药可用于抑制HIV逆转录酶，预防和治疗HIV感染以及预防，延缓发病或进展以及AIDS治疗。 化合物及其盐和前药可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

    NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
    5.
    发明申请
    NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS 有权
    非核苷酸逆转录酶抑制剂

    公开(公告)号：US20100256181A1

    公开(公告)日：2010-10-07

    申请号：US12742159

    申请日：2008-11-14

    申请人： Thomas J. Tucker ,  Robert Tynebor ,  John T. Sisko ,  Neville Anthony ,  Robert Gomez ,  Samson M. Jolly

    发明人： Thomas J. Tucker ,  Robert Tynebor ,  John T. Sisko ,  Neville Anthony ,  Robert Gomez ,  Samson M. Jolly

    IPC分类号： A61K31/444 ,  C07D471/04 ,  A61P31/18

    CPC分类号： C07D401/06 ,  C07D471/04

    摘要： Heteroaromatic compounds of Formula (I) are HIV reverse transcriptase inhibitors, wherein ring A is: (ii-a), (ii-b), (ii-c), (ii-d), or (ii-e); and wherein n, L, M, U, X, Y, Z, RE, RF, R1, R2A, R2B, R2C, R3, R8, R9 and R10 are defined herein. The compounds of Formula I and their pharmaceutically acceptable salts and prodrugs are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts and prodrugs can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

    摘要翻译： 式（I）的杂芳族化合物是HIV逆转录酶抑制剂，其中环A是：（ii-a），（ii-b），（ii-c），（ii-d）或（ii-e）; 并且其中n，L，M，U，X，Y，Z，RE，RF，R1，R2A，R2B，R2C，R3，R8，R9和R10在本文中定义。 式I化合物及其药学上可接受的盐和前药可用于抑制HIV逆转录酶，预防和治疗HIV感染以及预防，延缓发病或进展以及AIDS治疗。 化合物及其盐和前药可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

    NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
    6.
    发明申请
    NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS 审中-公开
    非核苷酸逆转录酶抑制剂

    公开(公告)号：US20100286192A1

    公开(公告)日：2010-11-11

    申请号：US12839807

    申请日：2010-07-20

    申请人： Neville J. Anthony ,  Robert Gomez

    发明人： Neville J. Anthony ,  Robert Gomez

    IPC分类号： A61K31/437 ,  A61K31/4709 ,  A61P31/18

    CPC分类号： C07D471/04 ,  C07D231/54 ,  C07D249/18

    摘要： Compounds of Formula I: are HIV reverse transcriptase inhibitors, wherein V, W, X, Y, Z, R1, R2, R4, R5, R6, ring A, ring B, j and k are defined herein. The compounds of Formula I, and the pharmaceutically acceptable salts and prodrugs thereof, are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

    摘要翻译： 式I化合物是HIV逆转录酶抑制剂，其中V，W，X，Y，Z，R 1，R 2，R 4，R 5，R 6，环A，环B，j和k如本文所定义。 式I化合物及其药学上可接受的盐和前药可用于抑制HIV逆转录酶，预防和治疗HIV感染以及预防，延缓发病或进展以及AIDS治疗。 化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

    Non-nucleoside reverse transcriptase inhibitors
    7.
    发明授权
    Non-nucleoside reverse transcriptase inhibitors 有权
    非核苷逆转录酶抑制剂

    公开(公告)号：US07781454B2

    公开(公告)日：2010-08-24

    申请号：US11999686

    申请日：2007-12-06

    申请人： Neville J. Anthony ,  Robert Gomez

    发明人： Neville J. Anthony ,  Robert Gomez

    IPC分类号： A01N43/42 ,  A61K31/44 ,  A61K31/415 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C07D213/56

    CPC分类号： C07D471/04 ,  C07D231/54 ,  C07D249/18

    摘要： Compounds of Formula I: are HIV reverse transcriptase inhibitors, wherein V, W, X, Y, Z, R1, R2, R4, R5, R6, ring A, ring B, j and k are defined herein. The compounds of Formula I, and the pharmaceutically acceptable salts and prodrugs thereof, are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

    摘要翻译： 式I化合物是HIV逆转录酶抑制剂，其中V，W，X，Y，Z，R 1，R 2，R 4，R 5，R 6，环A，环B，j和k如本文所定义。 式I化合物及其药学上可接受的盐和前药可用于抑制HIV逆转录酶，预防和治疗HIV感染以及预防，延缓发病或进展以及AIDS治疗。 化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

    Bottle erecting device
    9.
    发明授权
    Bottle erecting device 失效
    瓶装设备

    公开(公告)号：US5029694A

    公开(公告)日：1991-07-09

    申请号：US430678

    申请日：1989-11-01

    申请人： Robert Gomez

    发明人： Robert Gomez

    IPC分类号： B65G47/52 ,  B65G47/248 ,  B65G47/252 ,  B65G47/74

    CPC分类号： B65G47/252 ,  B65G2201/0244 ,  B65G2207/14

    摘要： An erecting device for bottles transported in recumbent position by a rope conveyor rotates the bottles to an upright position and deposits them on an apron conveyor which is positioned at a lower level at the end of the rope conveyor. The erecting device includes a pulley having two outer flanges, a pair of washers between the flanges and a pair of deformable rubber disks between the washers for holding a bottle during rotation from the recumbent to the vertical position. Each outer flange is connected to the rotating pulley axle by a respective intermediate cotter. The cotters are adjustably translatable along the length of the pulley axle such that the spacing between the rubber disks is adjustable to accommodate different bottle dimensions.

    摘要翻译： 用于通过绳索传送器在卧式运输中运输的瓶子的竖立装置将瓶子旋转到直立位置，并将它们沉积在位于绳索输送机端部的较低水平的围裙输送机上。 竖立装置包括具有两个外部凸缘的滑轮，在凸缘之间的一对垫圈和垫圈之间的一对可变形的橡胶盘，用于在从卧式旋转到垂直位置时保持瓶子。 每个外凸缘通过相应的中间开口连接到旋转滑轮轴。 开口沿着皮带轮轴的长度可调节地平移，使得橡胶盘之间的间隔是可调节的，以适应不同的瓶子尺寸。

    Cutting Torch Guide Assembly
    10.
    发明申请
    Cutting Torch Guide Assembly 审中-公开

    公开(公告)号：US20180318953A1

    公开(公告)日：2018-11-08

    申请号：US15584160

    申请日：2017-05-02

    申请人： Robert Gomez ,  Richard Gomez

    发明人： Robert Gomez ,  Richard Gomez

    IPC分类号： B23K7/10 ,  B26D7/00

    CPC分类号： B23K7/10 ,  B26D7/0006

    摘要： A cutting torch guide assembly for cutting beveled openings includes a first rod that is hollow. A first sleeve is positioned around and slidably positionable on the first rod. A pin is coupled to and extends perpendicularly from the first sleeve. The pin is configured to couple to a metal substrate to define an axis of a penetration that is to be cut into the metal substrate. A second rod is positioned in and selectively extensible from the first rod. The first sleeve is positionable to select a diameter of the penetration on an opposing side of the metal substrate. The second rod is positionable relative to the first rod to select a thickness of the metal substrate. A ring coupled to the second rod is configured to insert a nozzle of a cutting torch so that the nozzle is positioned to cut a beveled penetration into the substrate.