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公开(公告)号：US09296990B2
公开(公告)日：2016-03-29
申请号：US14038001
申请日：2013-09-26
申请人： New Health Sciences, Inc. , University of Pittsburgh—Of the Commonwealth System of Higher Education
CPC分类号： C12N5/0641 , A01N1/0236 , A61M1/0272 , A61M2202/0208 , A61M2202/0429
摘要： An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are adapted to receiving and conveying red blood cells. There is another embodiment of an oxygen depletion device and method for removing oxygen from red blood cells.
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公开(公告)号：US09968718B2
公开(公告)日：2018-05-15
申请号：US14614045
申请日：2015-02-04
发明人： Tatsuro Yoshida , Paul Vernucci
CPC分类号： A61M1/0272 , A61M1/0281 , A61M1/38 , A61M2202/0208 , A61M2202/0225 , A61M2202/0439
摘要： A portable assembly for processing red blood cells RBCs including a disposable blood collection set including a blood bag, an anaerobic storage bag and an oxygen and/or oxygen and carbon dioxide depletion device disposed between the blood collection bag and anaerobic storage bag. The portable assembly further provides for a gas circulation device in fluid communication with the oxygen or oxygen and carbon dioxide depletion device, The gas circulation device includes a pressure source that is able circulate flushing gas through the depletion device as RBCs pass from the blood collection bag, through the depletion device and into the anaerobic storage bag.
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公开(公告)号：US09844615B2
公开(公告)日：2017-12-19
申请号：US14924179
申请日：2015-10-27
发明人： Tatsuro Yoshida , Paul Vernucci
CPC分类号： A61M1/0209 , A01N1/021 , A01N1/0226 , A01N1/0263 , A01N1/0294 , A61M1/0231 , A61M1/0272 , A61M2202/0208 , A61M2202/0225 , B01D19/0031
摘要： A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.
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4.发明授权Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities 有权血液储存袋系统和具有氧气和二氧化碳消耗能力的耗尽装置公开(公告)号：US09095662B2
公开(公告)日：2015-08-04
申请号：US13969095
申请日：2013-08-16
发明人： Tatsuro Yoshida , Paul J Vernucci
CPC分类号： C12N5/0641 , A01N1/0221 , A01N1/0226 , A61K35/18 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/0272 , A61M1/342 , A61M2202/0208 , A61M2202/0225 , B01D19/0031 , B01D53/22
摘要： A blood storage system. The system has a collection bag for red blood cells; an oxygen/carbon dioxide depletion device; a storage bag for red blood cells; and tubing connecting the collection bag to the depletion device and the depletion device to the storage bag. The depletion device includes a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; a plurality of hollow fibers or gas-permeable films extending within the receptacle from an entrance to an exit thereof. The hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells.
摘要翻译： 血液储存系统。 该系统具有红细胞收集袋; 氧/二氧化碳消耗装置; 红血球储存袋; 以及将收集袋连接到耗尽装置和将耗尽装置连接到存储袋的管道。 耗尽装置包括固体材料的容器，其具有适于接收和排出冲洗气体的入口和出口; 多个中空纤维或气体可渗透膜，在容器内从入口到出口延伸。 中空纤维或透气膜适于接收和输送红细胞。
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公开(公告)号：US10603417B2
公开(公告)日：2020-03-31
申请号：US15811481
申请日：2017-11-13
发明人： Tatsuro Yoshida , Paul Vernucci
摘要： A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.
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公开(公告)号：US09977037B2
公开(公告)日：2018-05-22
申请号：US14403365
申请日：2013-05-22
CPC分类号： G01N33/80 , B01L3/5027 , B01L3/502715 , B01L2300/0838 , B01L2300/0861 , B01L2300/0867
摘要： Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.
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公开(公告)号：US20150153367A1
公开(公告)日：2015-06-04
申请号：US14403365
申请日：2013-05-22
CPC分类号： G01N33/80 , B01L3/5027 , B01L3/502715 , B01L2300/0838 , B01L2300/0861 , B01L2300/0867
摘要： Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.
摘要翻译： 提供人造微血管网络（AMVN）装置，并提供相关的制造方法和使用这些装置的方法。 本公开总体上涉及一种AMVN装置，其包括基底，该基底包括毛细管网络，该毛细管网被配置为模拟在各种人类和动物模型系统的循环中实际遇到的那些毛细管网络。 在某些方面，可以使用AMVN装置，例如研究在需氧和厌氧条件下储存RBC的效果。 然而，使用这样的AMVN设备并不限于此。
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公开(公告)号：US20190167792A1
公开(公告)日：2019-06-06
申请号：US16304611
申请日：2017-05-25
摘要： A method for reducing hemolysis and microparticle formation during storage of pathogen reduced blood. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced hemolysis. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles. Oxygen and pathogen reduced blood compositions comprising CPAD and riboflavin having reduced hemolysis. Oxygen and pathogen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles.
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公开(公告)号：US10583192B2
公开(公告)日：2020-03-10
申请号：US16412084
申请日：2019-05-14
摘要： A method for reducing hemolysis and microparticle formation during storage of pathogen reduced blood. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced hemolysis. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles. Oxygen and pathogen reduced blood compositions comprising CPAD and riboflavin having reduced hemolysis. Oxygen and pathogen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles.
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公开(公告)号：US10065134B2
公开(公告)日：2018-09-04
申请号：US15363687
申请日：2016-11-29
发明人： Tatsuro Yoshida , Paul J. Vernucci
摘要： A blood filter device comprising: a housing comprising an outer wall and a first inlet, a first outlet and a second outlet; a membrane which is capable of separating plasma from the blood, wherein the membrane forms an inner chamber; a leukocyte and oxygen and/or carbon dioxide depletion media disposed wherein the inner chamber, the leukocyte and oxygen and/or carbon dioxide depletion media is capable of depleting leukocytes and oxygen and/or carbon dioxide from the blood; an outer chamber disposed between the outer wall and the membrane, wherein the plasma which permeates through the membrane enters the outer chamber and exits the filter device via the first outlet; whereby the blood which has been depleted of oxygen and/or carbon dioxide, leukocytes and plasma exists and filter device via the second outlet.
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