公开(公告)号：US10961503B2

公开(公告)日：2021-03-30

申请号：US15747103

申请日：2016-07-28

申请人： New York Stem Cell Foundation, Inc. ,  Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

发明人： Dietrich M. Egli ,  Nissim Benvenisty ,  Ido Sagi

IPC分类号： C12N5/0735 ,  C12N5/075 ,  C12N5/071

摘要： Haploid human embryonic stem cells and cell lines, haploid multipotent human cells, and haploid differentiated human cells are provided. In addition, methods of making and using the haploid human cells are provided.

公开(公告)号：US12091678B2

公开(公告)日：2024-09-17

申请号：US17122562

申请日：2020-12-15

申请人： New York Stem Cell Foundation, Inc. ,  Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

发明人： Dietrich M. Egli ,  Nissim Benvenisty ,  Ido Sagi

IPC分类号： C12N5/0735 ,  C12N5/071 ,  C12N5/075

CPC分类号： C12N5/0606 ,  C12N5/0609 ,  C12N5/0612 ,  C12N2501/115 ,  C12N2501/727 ,  C12N2501/999 ,  C12N2506/04 ,  C12N2517/04 ,  C12N2517/10

摘要： Haploid human embryonic stem cells and cell lines, haploid multipotent human cells, and haploid differentiated human cells are provided. In addition, methods of making and using the haploid human cells are provided.

公开(公告)号：US20190338313A1

公开(公告)日：2019-11-07

申请号：US16510061

申请日：2019-07-12

申请人： New York Stem Cell Foundation, Inc.

发明人： Dietrich M. Egli

IPC分类号： C12N15/873 ,  C12N5/16 ,  C12N7/00 ,  C12N5/075 ,  C12N15/877 ,  A61K35/54

摘要： The present invention provides modified oocytes having a nuclear genome derived from a first oocyte and cytoplasm derived from a second oocyte from a different subject, and methods for making and using such modified oocytes. The methods and compositions of the present invention can be useful in a variety of settings including, but not limited to, in in vitro fertilization (“IVF”) procedures.

公开(公告)号：US20180208890A1

公开(公告)日：2018-07-26

申请号：US15747103

申请日：2016-07-28

申请人： New York Stem Cell Foundation, Inc. ,  Yissu Research Development Company of the Hebrew University of Jerusalem Ltd.

发明人： Dietrich M. Egli ,  Nissim Benvenisty ,  Ido Sagi

IPC分类号： C12N5/0735 ,  C12N5/075 ,  C12N5/071

CPC分类号： C12N5/0606 ,  C12N5/0609 ,  C12N5/0612 ,  C12N2501/115 ,  C12N2501/727 ,  C12N2501/999 ,  C12N2506/04 ,  C12N2517/04 ,  C12N2517/10

摘要： Haploid human embryonic stem cells and cell lines, haploid multipotent human cells, and haploid differentiated human cells are provided. In addition, methods of making and using the haploid human cells are provided.

公开(公告)号：US10947562B2

公开(公告)日：2021-03-16

申请号：US16510061

申请日：2019-07-12

申请人： New York Stem Cell Foundation, Inc.

发明人： Dietrich M. Egli

IPC分类号： A01N65/00 ,  A61K48/00 ,  C12N15/873 ,  C12N5/075 ,  C12N5/16 ,  C12N15/877 ,  A61K35/54 ,  C12N7/00

摘要： The present invention provides modified oocytes having a nuclear genome derived from a first oocyte and cytoplasm derived from a second oocyte from a different subject, and methods for making and using such modified oocytes. The methods and compositions of the present invention can be useful in a variety of settings including, but not limited to, in in vitro fertilization (“IVF”) procedures.

公开(公告)号：US10351876B2

公开(公告)日：2019-07-16

申请号：US15253781

申请日：2016-08-31

申请人： New York Stem Cell Foundation, Inc.

发明人： Dietrich M. Egli

IPC分类号： C12N15/00 ,  C12N15/873 ,  C12N5/075 ,  C12N5/16 ,  C12N15/877 ,  A61K35/54 ,  C12N7/00

摘要： The present invention provides modified oocytes having a nuclear genome derived from a first oocyte and cytoplasm derived from a second oocyte from a different subject, and methods for making and using such modified oocytes. The methods and compositions of the present invention can be useful in a variety of settings including, but not limited to, in in vitro fertilization (“IVF”) procedures.

公开(公告)号：US10513709B2

公开(公告)日：2019-12-24

申请号：US15895976

申请日：2018-02-13

申请人： New York Stem Cell Foundation, Inc.

发明人： Dietrich M. Egli

IPC分类号： C12N15/00 ,  C12N15/877 ,  C12N5/0735 ,  C12N5/075

摘要： The present invention provides methods for making reconstructed diploid human oocytes comprising the diploid genome of a human somatic cell, and also methods for making human nuclear transfer embryos, human embryonic stem cells, and human differentiated cells therefrom. The present invention also provides reconstructed human oocytes, human nuclear transfer embryos, human embryonic stem cells, and differentiated cells made using such methods, as well as compositions and kits useful in performing such methods.

公开(公告)号：US20210198697A1

公开(公告)日：2021-07-01

申请号：US17201977

申请日：2021-03-15

申请人： New York Stem Cell Foundation, Inc.

发明人： Dietrich M. Egli

IPC分类号： C12N15/873 ,  C12N5/075 ,  C12N5/16 ,  C12N15/877 ,  A61K35/54 ,  C12N7/00

摘要： The present invention provides modified oocytes having a nuclear genome derived from a first oocyte and cytoplasm derived from a second oocyte from a different subject, and methods for making and using such modified oocytes. The methods and compositions of the present invention can be useful in a variety of settings including, but not limited to, in in vitro fertilization (“IVF”) procedures.

公开(公告)号：US20180237799A1

公开(公告)日：2018-08-23

申请号：US15895976

申请日：2018-02-13

申请人： New York Stem Cell Foundation, Inc.

发明人： Dietrich M. Egli

IPC分类号： C12N15/877 ,  C12N5/075 ,  C12N5/0735

CPC分类号： C12N15/8776 ,  C12N5/0606 ,  C12N5/0609 ,  C12N2501/065 ,  C12N2501/31 ,  C12N2501/727 ,  C12N2501/999 ,  C12N2517/04 ,  C12N2517/10 ,  C12N2760/18845

摘要： The present invention provides methods for making reconstructed diploid human oocytes comprising the diploid genome of a human somatic cell, and also methods for making human nuclear transfer embryos, human embryonic stem cells, and human differentiated cells therefrom. The present invention also provides reconstructed human oocytes, human nuclear transfer embryos, human embryonic stem cells, and differentiated cells made using such methods, as well as compositions and kits useful in performing such methods.

公开(公告)号：US20170114366A1

公开(公告)日：2017-04-27

申请号：US15253781

申请日：2016-08-31

申请人： New York Stem Cell Foundation, Inc.

发明人： Dietrich M. Egli

IPC分类号： C12N15/873 ,  C12N7/00 ,  A61K35/54 ,  C12N5/075

CPC分类号： C12N15/873 ,  A61K35/54 ,  C12N5/0609 ,  C12N5/16 ,  C12N7/00 ,  C12N15/8775 ,  C12N15/8776 ,  C12N2517/04 ,  C12N2517/10 ,  C12N2760/18832

摘要： The present invention provides modified oocytes having a nuclear genome derived from a first oocyte and cytoplasm derived from a second oocyte from a different subject, and methods for making and using such modified oocytes. The methods and compositions of the present invention can be useful in a variety of settings including, but not limited to, in in vitro fertilization (“IVF”) procedures.