公开(公告)号：US11672773B2

公开(公告)日：2023-06-13

申请号：US17549227

申请日：2021-12-13

Applicant: Next Science IP Holdings Pty Ltd

Inventor： Matthew F. Myntti

IPC: A61K31/194 ,  A61K47/10 ,  A61K9/00 ,  A61P31/04 ,  A61K47/20

CPC classification number: A61K31/194 ,  A61K9/0046 ,  A61K47/10 ,  A61K47/20 ,  A61P31/04

Abstract: A composition that can be used to treat a wide spectrum of gram positive and gram negative bacteria, including but not limited to those in biofilm form, can be used in cilia-containing areas such as the sinus cavities and middle/inner ear, while resulting in no, or very minimal amounts of, deciliation and/or loss of function (e.g., ability to clear material from the sinus cavity). Where such a targeted treatment area includes or might include a biofilm, the composition often can detach and assist in removing the biofilm from affected tissue.

公开(公告)号：US11090369B2

公开(公告)日：2021-08-17

申请号：US16314168

申请日：2017-06-28

Applicant: Next Science IP Holdings Pty Ltd

Inventor： Matthew F. Myntti

IPC: A61K38/47 ,  A61P31/04 ,  A61K9/00 ,  A61K9/08 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A01N63/00 ,  A01N37/02

Abstract: A composition that can be used to treat a wide spectrum of gram positive and gram negative bacteria, including but not limited to those in biofilm form, and other microbes can be used in cilia-containing areas such as the sinus cavities and middle/inner ear, while resulting in no, or very minimal amounts of, deciliation. Where such a targeted treatment area includes a biofilm, the composition often can detach and assist in removing the biofilm from affected tissue. Many embodiments of the composition are biocompatible.

公开(公告)号：US10780037B2

公开(公告)日：2020-09-22

申请号：US16237709

申请日：2019-01-01

Applicant: Next Science IP Holdings Pty Ltd

Inventor： Matthew F. Myntti

IPC: A61K8/49 ,  A01N37/36 ,  A01N61/00 ,  A61K8/365 ,  A61K8/39 ,  A61K8/41 ,  A61K8/44 ,  A61K8/46 ,  A61K8/55 ,  A61K8/60 ,  A61Q11/00 ,  A61Q17/00 ,  A61K8/86 ,  A61K8/19 ,  A61K9/00 ,  A61K47/02 ,  A61L26/00 ,  A61K33/00 ,  A61K33/02 ,  A61K33/04 ,  A61K33/20 ,  A61K33/24 ,  A61K33/32 ,  A61K33/42 ,  A61K9/06 ,  A61K31/14 ,  A61K31/19 ,  A61K31/194 ,  A61K47/10 ,  A61K47/12 ,  A61K47/34 ,  A01N25/02 ,  A01N25/08 ,  A01N59/26 ,  A01N25/30 ,  A01N59/00 ,  A61P17/02 ,  A61P31/04 ,  A01N41/04 ,  A61K8/34 ,  A61K8/37 ,  A61K9/08

Abstract: An aqueous composition with a higher-than-neutral pH includes a significant amount of one or more surfactants and large amounts of osmotically active solutes. This composition, as well as an acidic counterpart and solid materials, can be used in a variety of applications such as wound care, oral care, medical equipment reprocessing, healthcare acquired infection and implant treatment.

公开(公告)号：US20190014777A1

公开(公告)日：2019-01-17

申请号：US15745094

申请日：2016-07-18

Applicant: Next Science IP Holdings Pty Ltd

Inventor： Matthew F. Myntti

IPC: A01N37/16 ,  A01N25/04 ,  A01N59/00 ,  A01N25/30 ,  A61L2/18

Abstract: A sporicidal composition has a moderately low pH and includes at least one oxidizing acid and the dissociation product of at least one inorganic oxidizing agent. Very high effective solute concentrations can enhance the efficacy of the composition. Embodiments of the composition can be applied to a surface and allowed to absorb into the endospore, ultimately killing at least some of those bacteria in mature endospore form. The surface being treated can be an inanimate surface, particularly a hard surface, or a medical device.

公开(公告)号：US12171220B2

公开(公告)日：2024-12-24

申请号：US17071102

申请日：2020-10-15

Applicant: Next Science IP Holdings Pty Ltd

Inventor： Matthew F. Myntti

IPC: A01N25/02 ,  A01N31/02 ,  A01N33/12 ,  A01N37/02 ,  A01N37/40 ,  A01N41/10 ,  A61K8/33 ,  A61K8/34 ,  A61K8/39 ,  A61K8/41 ,  A61K8/46 ,  A61Q17/00

Abstract: A composition that can solvate biofilms and disrupt bacterial cell walls acts to both kill the bacteria by cell lysis and remove the biofilm. This solvent-containing composition is effective against a broad spectrum of microbes and can be used on a variety of surfaces, both living and inanimate. The polarity of the solvent component of the composition is lower than that of pure water so that the composition exhibits increased efficacy in solvating the macromolecular matrix of a biofilm and in penetrating bacterial cell walls.

公开(公告)号：US11273175B2

公开(公告)日：2022-03-15

申请号：US16626194

申请日：2018-06-23

Applicant: Next Science IP Holdings Pty Ltd

Inventor： Matthew F. Myntti

IPC: A61K33/18 ,  A61K47/36

Abstract: A topical composition can be used to treat or inhibit onset of fibrillar collagenous growths, including but not limited to keloids. The composition includes elemental iodine carried in a non-migratory vehicle. Application of the composition can result in a significant reduction in the size of such a growth or, if applied to an area of skin susceptible to such a growth, inhibit the onset thereof.

公开(公告)号：US11172677B2

公开(公告)日：2021-11-16

申请号：US16846218

申请日：2020-04-10

Applicant: Next Science IP Holdings Pty Ltd

Inventor： Matthew F. Myntti

IPC: A01N25/10 ,  A01N25/08

Abstract: A solid material adapted to kill bacteria in planktonic, spore and biofilm states is lethal toward a wide spectrum of gram positive and gram negative bacteria as well as other microbes. The solid material includes a significant amount of one or more surfactants entrained in a crosslinked polymeric network.

公开(公告)号：US20200260723A1

公开(公告)日：2020-08-20

申请号：US16846218

申请日：2020-04-10

Applicant: Next Science IP Holdings Pty Ltd

Inventor： Matthew F. Myntti

IPC: A01N25/10 ,  A01N25/08

Abstract: A solid material adapted to kill bacteria in planktonic, spore and biofilm states is lethal toward a wide spectrum of gram positive and gram negative bacteria as well as other microbes. The solid material includes a significant amount of one or more surfactants entrained in a crosslinked polymeric network.

公开(公告)号：US20190191700A1

公开(公告)日：2019-06-27

申请号：US16237709

申请日：2019-01-01

Applicant: Next Science IP Holdings Pty Ltd

Inventor： Matthew F. Myntti

IPC: A01N41/04 ,  A61P31/04 ,  A61P17/02 ,  A61K33/02 ,  A61K33/04

Abstract: An aqueous composition with a higher-than-neutral pH includes a significant amount of one or more surfactants and large amounts of osmotically active solutes. This composition, as well as an acidic counterpart and solid materials, can be used in a variety of applications such as wound care, oral care, medical equipment reprocessing, healthcare acquired infection and implant treatment.

公开(公告)号：US20250064704A1

公开(公告)日：2025-02-27

申请号：US18928260

申请日：2024-10-28

Applicant: Next Science IP Holdings Pty Ltd

Inventor： Matthew F. Myntti

IPC: A61K8/49 ,  A01N25/02 ,  A01N25/08 ,  A01N25/30 ,  A01N37/36 ,  A01N41/04 ,  A01N59/00 ,  A01N59/26 ,  A01N61/00 ,  A61K8/19 ,  A61K8/34 ,  A61K8/365 ,  A61K8/37 ,  A61K8/39 ,  A61K8/41 ,  A61K8/44 ,  A61K8/46 ,  A61K8/55 ,  A61K8/60 ,  A61K8/86 ,  A61K9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K31/14 ,  A61K31/19 ,  A61K31/194 ,  A61K33/00 ,  A61K33/02 ,  A61K33/04 ,  A61K33/20 ,  A61K33/24 ,  A61K33/32 ,  A61K33/42 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/34 ,  A61L26/00 ,  A61P17/02 ,  A61P31/04 ,  A61Q11/00 ,  A61Q17/00

Abstract: A mixture of solids is provided that, when solubilized, provides an aqueous composition having a lower-than-neutral pH that includes a significant amount of one or more surfactants and large amounts of osmotically active solutes. The solids mixture can be introduced to a wound prior to solubilization.