公开(公告)号：US4392976A

公开(公告)日：1983-07-12

申请号：US391590

申请日：1982-06-24

申请人： Nicholas Calderone ,  Hugh Watkins ,  Takao Yoshida

发明人： Nicholas Calderone ,  Hugh Watkins ,  Takao Yoshida

IPC分类号： C11B9/00 ,  C11D3/50

CPC分类号： C11D3/50 ,  C11B9/0034

摘要： Described is the compound, 4-methyl-3-cyclohexene-1-carboxylic acid having the structure: ##STR1## and the use thereof in augmenting or enhancing the aroma of perfume compositions, perfumed articles (e.g., solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softener compositions and fabric softener articles as well as bath preparations and hair preparations). The said 4-methyl-3-cyclohexene-1-carboxylic acid is particularly useful as a replacement for cumin oil and/or cumin aldehyde in perfume compositions, colognes and perfumed articles.

摘要翻译： 描述了具有以下结构的化合物4-甲基-3-环己烯-1-羧酸及其在增强或增强香料组合物香气的用途，加香制品（例如固体或液体阴离子，阳离子， 非离子或两性离子洗涤剂，织物柔软剂组合物和织物柔软剂制品以及浴制剂和头发制剂）。 所述4-甲基-3-环己烯-1-羧酸特别可用作香料组合物，古龙水和香料制品中孜然油和/或孜然醛的替代物。

公开(公告)号：US4442012A

公开(公告)日：1984-04-10

申请号：US391589

申请日：1982-06-24

申请人： Nicholas Calderone ,  Hugh Watkins ,  Takao Yoshida

发明人： Nicholas Calderone ,  Hugh Watkins ,  Takao Yoshida

IPC分类号： C11B9/00 ,  C11D3/50 ,  D06M13/20

CPC分类号： C11D3/50 ,  C11B9/0034

摘要： Described is the compound, 4-methyl-3-cyclohexene-1-carboxylic acid having the structure: ##STR1## and the use thereof in augmenting or enhancing the aroma of perfume compositions, perfumed articles (e.g., solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softener compositions and fabric softener articles as well as bath preparations and hair preparations). The said 4-methyl-3-cyclohexene-1-carboxylic acid is particularly useful as a replacement for cumin oil and/or cumin aldehyde in perfume compositions, colognes and perfumed articles.

摘要翻译： 描述了具有以下结构的化合物4-甲基-3-环己烯-1-羧酸及其在增强或增强香料组合物香气的用途，加香制品（例如固体或液体阴离子，阳离子， 非离子或两性离子洗涤剂，织物柔软剂组合物和织物柔软剂制品以及浴制剂和头发制剂）。 所述4-甲基-3-环己烯-1-羧酸特别可用作香料组合物，古龙水和香料制品中孜然油和/或孜然醛的替代物。

公开(公告)号：US4390434A

公开(公告)日：1983-06-28

申请号：US391592

申请日：1982-06-24

申请人： Nicholas Calderone ,  Hugh Watkins ,  Takao Yoshida

发明人： Nicholas Calderone ,  Hugh Watkins ,  Takao Yoshida

IPC分类号： C07C61/22 ,  C11B9/00 ,  C11D3/50 ,  D06M13/00 ,  D06M13/20

CPC分类号： C07C61/22 ,  C11B9/0034 ,  C11D3/50 ,  D06M13/005

摘要： Described is the compound, 4-methyl-3-cyclohexene-1-carboxylic acid having the structure: ##STR1## and the use thereof in augmenting or enhancing the aroma of perfume compositions, perfumed articles (e.g., solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softener compositions and fabric softener articles as well as bath preparations and hair preparations). The said 4-methyl-3-cyclohexene-1-carboxylic acid is particularly useful as a replacement for cumin oil and/or cumin aldehyde in perfume compositions, colognes and perfumed articles.

摘要翻译： 描述了具有以下结构的化合物4-甲基-3-环己烯-1-羧酸及其在增强或增强香料组合物香气的用途，加香制品（例如固体或液体阴离子，阳离子， 非离子或两性离子洗涤剂，织物柔软剂组合物和织物柔软剂制品以及浴制剂和头发制剂）。 所述4-甲基-3-环己烯-1-羧酸特别可用作香料组合物，古龙水和香料制品中孜然油和/或孜然醛的替代物。

公开(公告)号：US4401583A

公开(公告)日：1983-08-30

申请号：US391587

申请日：1982-06-24

申请人： Nicholas Calderone ,  Hugh Watkins ,  Takao Yoshida

发明人： Nicholas Calderone ,  Hugh Watkins ,  Takao Yoshida

IPC分类号： C07C61/22 ,  C11B9/00 ,  C11D3/50

CPC分类号： C11D3/50 ,  C07C61/22 ,  C11B9/0034

摘要： Described in the compound, 4-methyl-3-cyclohexene-1-carboxylic acid having the structure: ##STR1## and the use thereof in augmenting or enhancing the aroma of perfume compositions, perfumed articles (e.g., solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softener compositions and fabric softener articles as well as bath preparations and hair preparations). The said 4-methyl-3-cyclohexene-1-carboxylic acid is particularly useful as a replacement for cumin oil and/or cumin aldehyde in perfume compositions, colognes and perfumed articles.

摘要翻译： 在化合物中描述了具有以下结构的4-甲基-3-环己烯-1-羧酸及其在增强或增强香料组合物香气中的用途，加香制品（例如固体或液体阴离子，阳离子， 非离子或两性离子洗涤剂，织物柔软剂组合物和织物柔软剂制品以及浴制剂和头发制剂）。 所述4-甲基-3-环己烯-1-羧酸特别可用作香料组合物，古龙水和香料制品中孜然油和/或孜然醛的替代物。

公开(公告)号：US08815597B2

公开(公告)日：2014-08-26

申请号：US12377234

申请日：2007-08-23

申请人： Hideto Chono ,  Junichi Mineno ,  Kazutoh Takesako ,  Takao Yoshida ,  Takashi Morimura ,  Kenji Sakai ,  Shin-ichi Yamada ,  Noritsugu Yabe ,  Yuko Taguchi

发明人： Hideto Chono ,  Junichi Mineno ,  Kazutoh Takesako ,  Takao Yoshida ,  Takashi Morimura ,  Kenji Sakai ,  Shin-ichi Yamada ,  Noritsugu Yabe ,  Yuko Taguchi

IPC分类号： C12N1/00 ,  C12M1/42 ,  C12N15/87 ,  A61J1/10 ,  C12M1/00 ,  C12M3/00 ,  C12N15/00 ,  C12P21/04 ,  C12P21/06 ,  B01L3/00

CPC分类号： A61J1/10 ,  B01L3/5021 ,  B01L3/505 ,  C12M23/14 ,  C12M35/04 ,  C12N15/87

摘要： The present invention provides a baglike container for centrifugation that is mounted in a centrifuge to thereby allow centrifugation of a dispersion liquid accommodated therein. The baglike container for centrifugation is less likely to tear or break as a result of centrifugation by disposing a container wall surface of the baglike container so as to apply centrifugal force perpendicular to the container wall surface.

摘要翻译： 本发明提供一种用于离心的袋状容器，其安装在离心机中，从而允许其中容纳的分散液的离心。 用于离心的袋状容器由于通过设置袋状容器的容器壁表面而离心而不易撕裂或破裂，从而施加垂直于容器壁表面的离心力。

公开(公告)号：US20130164294A1

公开(公告)日：2013-06-27

申请号：US13548807

申请日：2012-07-13

申请人： Tasuku Honjo ,  Shiro Shibayama ,  Kazuhiko Takeda ,  Masayoshi Matsuo ,  Takao Yoshida ,  Masakazu Miyamoto

发明人： Tasuku Honjo ,  Shiro Shibayama ,  Kazuhiko Takeda ,  Masayoshi Matsuo ,  Takao Yoshida ,  Masakazu Miyamoto

IPC分类号： A61K39/395

CPC分类号： C07K16/2818 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/2803 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/73

摘要： The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.

公开(公告)号：US20110123550A1

公开(公告)日：2011-05-26

申请号：US13001875

申请日：2009-07-03

申请人： Shiro Shibayama ,  Takao Yoshida ,  Tamon Hayashi ,  Akio Hayashi ,  Jun Murai

发明人： Shiro Shibayama ,  Takao Yoshida ,  Tamon Hayashi ,  Akio Hayashi ,  Jun Murai

IPC分类号： A61K39/395 ,  G01N33/53 ,  G01N33/50 ,  A61P35/00

CPC分类号： C07K16/2818 ,  A61K2039/505 ,  G01N2800/52

摘要： A purpose of the present invention is to provide a method capable of more effectively prescribing an anti-human PD-1 antibody for anti-cancer therapy, a method for estimating or optimizing therapeutic efficacy thereof, and further an efficacy marker that can be used in methods thereof. The present invention enables selection of the cancer patient in whom the therapeutic efficacy of the anti-human PD-1 antibody can be expected in future, by measuring the change which is more than a certain level of several kinds of efficacy markers in blood after administering the initial dose or doses of the anti-human PD-1 antibody compared to that prior to administering the initial dose, and provides a new prescription of the anti-human PD-1 antibody for anti-cancer therapy.

摘要翻译： 本发明的目的是提供一种能够更有效地制备用于抗癌治疗的抗人PD-1抗体的方法，用于估计或优化其治疗功效的方法，以及可用于 方法。 本发明能够通过测量在施用后多于血液中的几种功效标记物的一定水平的变化来选择将来能够预期抗人PD-1抗体的治疗功效的癌症患者的选择 与施用初始剂量之前的抗人PD-1抗体的初始剂量或剂量相比较，并且提供了用于抗癌治疗的抗人PD-1抗体的新处方。

公开(公告)号：US07858746B2

公开(公告)日：2010-12-28

申请号：US12057637

申请日：2008-03-28

申请人： Tasuku Honjo ,  Shiro Shibayama ,  Masayoshi Matsuo ,  Takao Yoshida

发明人： Tasuku Honjo ,  Shiro Shibayama ,  Masayoshi Matsuo ,  Takao Yoshida

IPC分类号： C07K14/00

CPC分类号： C07K16/2809 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2803 ,  C07K2317/55 ,  C07K2317/626 ,  C07K2319/00

摘要： Compounds that can recognize selectively both PD-1 protein and a membrane protein co-existing with PD-1 on a cell membrane, and can transmit a suppressive signal of PD-1. The compounds are useful for medical treatment and/or prevention of diseases caused by immune abnormality.

摘要翻译： 可以选择性识别PD-1蛋白和细胞膜上与PD-1共存的膜蛋白的化合物，并且可以传递PD-1的抑制信号。 该化合物可用于治疗和/或预防由免疫异常引起的疾病。

公开(公告)号：US20100136680A1

公开(公告)日：2010-06-03

申请号：US12377234

申请日：2006-08-23

申请人： Hideto Chono ,  Junichi Mineno ,  Kazutoh Takesako ,  Takao Yoshida ,  Takashi Morimura ,  Kenji Sakai ,  Shin-ichi Yamada ,  Noritsugu Yabe ,  Yuko Taguchi

发明人： Hideto Chono ,  Junichi Mineno ,  Kazutoh Takesako ,  Takao Yoshida ,  Takashi Morimura ,  Kenji Sakai ,  Shin-ichi Yamada ,  Noritsugu Yabe ,  Yuko Taguchi

IPC分类号： C12N5/10 ,  B04B7/12

CPC分类号： A61J1/10 ,  B01L3/5021 ,  B01L3/505 ,  C12M23/14 ,  C12M35/04 ,  C12N15/87

摘要： Baglike container (1) that is fitted in a centrifuge to thereby allow centrifugation of any dispersion liquid placed therein. The baglike container for centrifugation is one comprising a main frame constituted of first container wall (3) with recess portion (6) formed so as to allow fitting in a centrifuge and with flange portion (7) provided on an open face border of the recess portion (6) and constituted of flexible second container wall (4) having its peripheral portion sealed mutually with the flange portion (7) of the first container wall (3) so as to define storing space (6′) for dispersion liquid in cooperation with the recess portion (6) and further comprising port (5) fitted to the main frame in a fashion allowing communication with the storing space (6′), wherein the recess portion (6) defining the storing space (6′) can be set in the centrifuge so that centrifugal force perpendicular to the bottom plane of the recess portion (6) applies. Moreover, there is disclosed a method of gene introduction using this baglike container.

摘要翻译： 袋状容器（1），其装配在离心机中，从而允许离心分离任何分散液体。 用于离心的袋状容器是包括由具有凹部（6）的第一容器壁（3）构成的主框架，所述第一容器壁（3）形成为能够安装在离心机中，并且具有设置在凹部的开放面边界上的凸缘部（7） 部分（6），并且由具有与第一容器壁（3）的凸缘部分（7）相互密封的周边部分的柔性第二容器壁（4）构成，以便在合作中限定用于分散液体的储存空间（6'） 与所述凹部（6）相连并且还包括以允许与所述存放空间（6'）连通的方式装配到所述主框架的端口（5），其中限定所述存储空间（6'）的所述凹部（6）可以 设置在离心机中，使得垂直于凹部（6）的底面的离心力适用。 此外，公开了使用该袋状容器的基因导入方法。

公开(公告)号：US20080247084A1

公开(公告)日：2008-10-09

申请号：US11886881

申请日：2006-03-27

申请人： Hiroyuki Matsumoto ,  Takeshi Matsumoto ,  Katsunori Tamamura ,  Takao Yoshida ,  Fumito Inaba ,  Makoto Ikehata

发明人： Hiroyuki Matsumoto ,  Takeshi Matsumoto ,  Katsunori Tamamura ,  Takao Yoshida ,  Fumito Inaba ,  Makoto Ikehata

IPC分类号： G11B17/051 ,  G11B33/02

CPC分类号： G11B17/0405 ,  G11B17/0407

摘要： To assuredly determine whether a shutter pinches a disk in a disk device including a shutter at a disk insertion slot. A shutter control device 10 includes a pinch determining unit 14 that determines whether the disk is pinched by the shutter based on a position of the shutter during a process of closing the shutter, and a sensitivity changing unit that sets sensitivity of determination to be high as ambient temperature of a shutter driving mechanism increases.

摘要翻译： 为了确定地确定快门是否在包括盘插入槽的快门的盘装置中夹住盘。 快门控制装置10包括捏合确定单元14，其确定在关闭快门的过程期间基于快门的快门的盘被盘夹住;以及灵敏度改变单元，其将确定的灵敏度设置为高，如 快门驱动机构的环境温度升高。