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公开(公告)号:US20050070534A1
公开(公告)日:2005-03-31
申请号:US10949055
申请日:2004-09-24
申请人: Nicholas Carruthers , Wenying Chai , Scott Dax , Jill Jablonowski , Xiaobing Li , Timothy Lovenberg , William Murray , Dale Rudolph , Mark Seierstad , Mark Youngman
发明人: Nicholas Carruthers , Wenying Chai , Scott Dax , Jill Jablonowski , Xiaobing Li , Timothy Lovenberg , William Murray , Dale Rudolph , Mark Seierstad , Mark Youngman
IPC分类号: A61K31/404 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/52 , A61K31/5377 , A61K31/541 , A61P3/04 , A61P15/08 , A61P25/22 , A61P25/24 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/02 , C07D417/02 , C07D473/02 , C07D43/02
CPC分类号: C07D401/12 , C07D401/14 , C07D409/14
摘要: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
摘要翻译: 本发明提供了用于治疗或预防:抗焦虑障碍或抑郁症的新型非肽性NPY Y2受体抑制剂; 受伤的哺乳动物神经组织; 通过施用神经营养因子治疗反应的病症; 神经系统疾病; 骨质疏松 物质相关疾病; 肥胖; 或肥胖相关疾病。 本发明的化合物还可用于调节内分泌功能,特别是由垂体和下丘脑腺体控制的内分泌功能,因此可用于治疗或预防排卵和不育症。
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公开(公告)号:US20050288323A1
公开(公告)日:2005-12-29
申请号:US11205958
申请日:2005-08-17
申请人: Richard Apodaca , Nicholas Carruthers , John Carson , Wenying Chai , Annette Kwok , Xiaobing Li , Timothy Lovenberg , Dale Rudolph , Chandravadan Shah
发明人: Richard Apodaca , Nicholas Carruthers , John Carson , Wenying Chai , Annette Kwok , Xiaobing Li , Timothy Lovenberg , Dale Rudolph , Chandravadan Shah
IPC分类号: A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K45/00 , A61K49/00 , A61K51/04 , A61P1/08 , A61P1/14 , A61P11/02 , A61P11/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , A61P37/08 , A61P43/00 , C07D455/02 , C07D455/03 , C07D471/04 , C07D487/04 , A61K31/4745
CPC分类号: C07D487/04 , A61K51/0455 , A61K51/0459 , C07D455/00 , C07D471/04
摘要: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
摘要翻译: 本发明具有取代的稠合双环化合物,含有它们的药物组合物,以及使用它们治疗或预防组胺介导的疾病和病症的方法。
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公开(公告)号:US20080132540A1
公开(公告)日:2008-06-05
申请号:US11942387
申请日:2007-11-19
申请人: Nicholas I. Carruthers , Wenying Chai , Scott L. Dax , Jill A. Jablonowski , Xiaobing Li , Timothy W. Lovenberg , William V. Murray , Dale A. Rudolph , Mark Seierstad , Mark A. Youngman
发明人: Nicholas I. Carruthers , Wenying Chai , Scott L. Dax , Jill A. Jablonowski , Xiaobing Li , Timothy W. Lovenberg , William V. Murray , Dale A. Rudolph , Mark Seierstad , Mark A. Youngman
IPC分类号: A61K31/4545 , A61K31/404 , A61P25/24 , A61P3/04 , A61P25/00 , A61K31/454
CPC分类号: C07D401/12 , C07D401/14 , C07D409/14
摘要: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
摘要翻译: 本发明提供了用于治疗或预防:抗焦虑障碍或抑郁症的新型非肽性NPY Y2受体抑制剂; 受伤的哺乳动物神经组织; 通过施用神经营养因子治疗反应的病症; 神经系统疾病; 骨质疏松 物质相关疾病; 肥胖; 或肥胖相关疾病。 本发明的化合物还可用于调节内分泌功能,特别是由垂体和下丘脑腺体控制的内分泌功能,因此可用于治疗或预防排卵和不育症。
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公开(公告)号:US07317025B2
公开(公告)日:2008-01-08
申请号:US10949055
申请日:2004-09-24
申请人: Nicholas I. Carruthers , Wenying Chai , Scott L. Dax , Jill A. Jablonowski , Xiaobing Li , Timothy W. Lovenberg , William V. Murray , Dale A. Rudolph , Mark Seierstad , Mark A. Youngman
发明人: Nicholas I. Carruthers , Wenying Chai , Scott L. Dax , Jill A. Jablonowski , Xiaobing Li , Timothy W. Lovenberg , William V. Murray , Dale A. Rudolph , Mark Seierstad , Mark A. Youngman
IPC分类号: A61K31/445 , A61K31/405 , C07D209/00 , C07D209/02 , C07D209/04 , C07D211/00
CPC分类号: C07D401/12 , C07D401/14 , C07D409/14
摘要: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
摘要翻译: 本发明提供了用于治疗或预防:抗焦虑障碍或抑郁症的新型非肽性NPY Y2受体抑制剂; 受伤的哺乳动物神经组织; 通过施用神经营养因子治疗反应的病症; 神经系统疾病; 骨质疏松 物质相关疾病; 肥胖; 或肥胖相关疾病。 本发明的化合物还可用于调节内分泌功能,特别是由垂体和下丘脑腺体控制的内分泌功能,因此可用于治疗或预防排卵和不育症。
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公开(公告)号:US20090263322A1
公开(公告)日:2009-10-22
申请号:US12494754
申请日:2009-06-30
申请人: Richard Apodaca , Nicholas I. Carruthers , John R. Carson , Wenying Chai , Annette K. Kwok , Xiaobing Li , Timothy W. Lovenberg , Dale A. Rudolph , Chandravadan R. Shah
发明人: Richard Apodaca , Nicholas I. Carruthers , John R. Carson , Wenying Chai , Annette K. Kwok , Xiaobing Li , Timothy W. Lovenberg , Dale A. Rudolph , Chandravadan R. Shah
IPC分类号: A61K31/437 , C07D221/04 , C07D401/14 , A61K31/496 , A61K51/00 , A61P11/00 , A61P25/00
CPC分类号: C07D487/04 , A61K51/0455 , A61K51/0459 , C07D455/00 , C07D471/04
摘要: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
摘要翻译: 本发明具有取代的稠合双环化合物,含有它们的药物组合物,以及使用它们治疗或预防组胺介导的疾病和病症的方法。
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公开(公告)号:US20050043348A1
公开(公告)日:2005-02-24
申请号:US10960248
申请日:2004-10-07
申请人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
发明人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
IPC分类号: A61K31/423 , A61P25/00 , C07D209/12 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号: C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
摘要: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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公开(公告)号:US20050090523A1
公开(公告)日:2005-04-28
申请号:US10960363
申请日:2004-10-07
申请人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
发明人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
IPC分类号: A61K31/423 , A61P25/00 , C07D209/12 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号: C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
摘要: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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公开(公告)号:US20050085502A1
公开(公告)日:2005-04-21
申请号:US10960342
申请日:2004-10-07
申请人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
发明人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
IPC分类号: A61K31/423 , A61P25/00 , C07D209/12 , C07D401/12 , C07D403/12 , C07D471/04 , A61K31/4745
CPC分类号: C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
摘要: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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公开(公告)号:US20050049277A1
公开(公告)日:2005-03-03
申请号:US10960885
申请日:2004-10-07
申请人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
发明人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
IPC分类号: A61K31/423 , A61P25/00 , C07D209/12 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号: C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
摘要: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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公开(公告)号:US20050085501A1
公开(公告)日:2005-04-21
申请号:US10960200
申请日:2004-10-07
申请人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
发明人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
IPC分类号: A61K31/423 , A61P25/00 , C07D209/12 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号: C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
摘要: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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