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公开(公告)号:US20050043348A1
公开(公告)日:2005-02-24
申请号:US10960248
申请日:2004-10-07
申请人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
发明人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
IPC分类号: A61K31/423 , A61P25/00 , C07D209/12 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号: C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
摘要: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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公开(公告)号:US20050090523A1
公开(公告)日:2005-04-28
申请号:US10960363
申请日:2004-10-07
申请人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
发明人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
IPC分类号: A61K31/423 , A61P25/00 , C07D209/12 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号: C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
摘要: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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公开(公告)号:US20050085502A1
公开(公告)日:2005-04-21
申请号:US10960342
申请日:2004-10-07
申请人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
发明人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
IPC分类号: A61K31/423 , A61P25/00 , C07D209/12 , C07D401/12 , C07D403/12 , C07D471/04 , A61K31/4745
CPC分类号: C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
摘要: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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公开(公告)号:US20050049277A1
公开(公告)日:2005-03-03
申请号:US10960885
申请日:2004-10-07
申请人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
发明人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
IPC分类号: A61K31/423 , A61P25/00 , C07D209/12 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号: C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
摘要: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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公开(公告)号:US20050085501A1
公开(公告)日:2005-04-21
申请号:US10960200
申请日:2004-10-07
申请人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
发明人: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
IPC分类号: A61K31/423 , A61P25/00 , C07D209/12 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号: C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
摘要: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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6.
公开(公告)号:US20050288323A1
公开(公告)日:2005-12-29
申请号:US11205958
申请日:2005-08-17
申请人: Richard Apodaca , Nicholas Carruthers , John Carson , Wenying Chai , Annette Kwok , Xiaobing Li , Timothy Lovenberg , Dale Rudolph , Chandravadan Shah
发明人: Richard Apodaca , Nicholas Carruthers , John Carson , Wenying Chai , Annette Kwok , Xiaobing Li , Timothy Lovenberg , Dale Rudolph , Chandravadan Shah
IPC分类号: A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K45/00 , A61K49/00 , A61K51/04 , A61P1/08 , A61P1/14 , A61P11/02 , A61P11/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , A61P37/08 , A61P43/00 , C07D455/02 , C07D455/03 , C07D471/04 , C07D487/04 , A61K31/4745
CPC分类号: C07D487/04 , A61K51/0455 , A61K51/0459 , C07D455/00 , C07D471/04
摘要: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
摘要翻译: 本发明具有取代的稠合双环化合物,含有它们的药物组合物,以及使用它们治疗或预防组胺介导的疾病和病症的方法。
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7.SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR 有权
标题翻译: 作为神经元Y2受体的调节剂的替代哌嗪和哌啶公开(公告)号:US20070100141A1
公开(公告)日:2007-05-03
申请号:US11553556
申请日:2006-10-27
申请人: Pascal Bonaventure , Nicholas Carruthers , Wenying Chai , Curt Dvorak , Jill Jablonowski , Dale Rudolph , Mark Seierstad , Chandravadan Shah , Devin Swanson , Victoria Wong
发明人: Pascal Bonaventure , Nicholas Carruthers , Wenying Chai , Curt Dvorak , Jill Jablonowski , Dale Rudolph , Mark Seierstad , Chandravadan Shah , Devin Swanson , Victoria Wong
IPC分类号: C07D413/02 , C07D403/02 , C07D401/02
CPC分类号: C07D295/15 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/27 , C07D207/34 , C07D211/14 , C07D211/16 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/58 , C07D211/70 , C07D213/55 , C07D213/56 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/14 , C07D237/20 , C07D239/28 , C07D239/48 , C07D241/04 , C07D261/08 , C07D261/14 , C07D285/01 , C07D295/135 , C07D295/155 , C07D295/185 , C07D307/24 , C07D307/52 , C07D307/68 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/08
摘要: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
摘要翻译: 本发明提供了用于治疗或预防:抗焦虑障碍或抑郁症的新型非肽性NPY Y2受体抑制剂; 受伤的哺乳动物神经组织; 通过施用神经营养因子对治疗有反应的病症; 神经系统疾病; 骨质疏松 物质相关疾病; 睡眠/觉醒障碍 心血管疾病; 肥胖; 或肥胖相关疾病。 本发明的化合物还可用于调节内分泌功能,特别是由垂体和下丘脑腺体控制的内分泌功能,因此可用于治疗或预防未排卵和不育症。
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公开(公告)号:US20050222129A1
公开(公告)日:2005-10-06
申请号:US11095225
申请日:2005-03-31
IPC分类号: A61K31/496 , A61K31/506 , A61K31/551 , C07D207/34 , C07D263/34 , C07D277/56 , C07D307/68 , C07D333/38 , C07D43/14
CPC分类号: C07D263/34 , C07D207/34 , C07D277/56 , C07D307/68 , C07D333/38
摘要: Certain non-imidazole heterocyclic compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.
摘要翻译: 某些非咪唑杂环化合物是可用于治疗组胺H 3受体介导的疾病的组胺H 3 N调节剂。
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公开(公告)号:US20050085487A1
公开(公告)日:2005-04-21
申请号:US10961247
申请日:2004-10-08
申请人: Nicholas Carruthers , Wenying Chai , Curt Dvorak , James Edwards , Cheryl Grice , Jill Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer Kreisberg , Annette Kwok , Timothy Lovenberg , Kiev Ly , Barbara Pio , Chandravadan Shah , Siquan Sun , Robin Thurmond , Jianmei Wei , Wei Xiao
发明人: Nicholas Carruthers , Wenying Chai , Curt Dvorak , James Edwards , Cheryl Grice , Jill Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer Kreisberg , Annette Kwok , Timothy Lovenberg , Kiev Ly , Barbara Pio , Chandravadan Shah , Siquan Sun , Robin Thurmond , Jianmei Wei , Wei Xiao
IPC分类号: C07D307/84 , A61K31/496 , A61P1/04 , A61P7/00 , A61P9/06 , A61P17/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07D209/42 , C07D401/12 , C07D403/06 , A61K31/454 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号: C07D401/12 , A61K31/496 , C07D209/42
摘要: Heterocyclic compounds and methods of making them and using them.
摘要翻译: 杂环化合物及其制备方法和使用方法。
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公开(公告)号:US20060235049A1
公开(公告)日:2006-10-19
申请号:US11453422
申请日:2006-06-15
申请人: Richard Apodaca , Nicholas Carruthers , Curt Dvorak , Dale Rudolph , Chandravadan Shah , Wei Xiao
发明人: Richard Apodaca , Nicholas Carruthers , Curt Dvorak , Dale Rudolph , Chandravadan Shah , Wei Xiao
IPC分类号: C07D211/20 , A61K31/445 , A61K31/40 , C07D207/04 , A61K31/138
CPC分类号: C07D207/325 , A61K31/4402 , A61K31/4465 , A61K45/06 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D231/12 , C07D233/42 , C07D233/54 , C07D233/56 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D277/36 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D471/08 , A61K2300/00
摘要: Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
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