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    DNAs encoding rat histamine receptors of the H4 subtype
    5.
    发明授权
    DNAs encoding rat histamine receptors of the H4 subtype 有权
    编码H4亚型大鼠组胺受体的DNA

    公开(公告)号：US07202057B2

    公开(公告)日：2007-04-10

    申请号：US10626126

    申请日：2003-07-23

    申请人： Timothy Lovenberg ,  Changlu Liu

    发明人： Timothy Lovenberg ,  Changlu Liu

    IPC分类号： C12P21/02 ,  C12N5/16 ,  C12N1/21 ,  C12N15/63 ,  C07H21/04

    CPC分类号： C07K14/723

    摘要： DNAs encoding the mammalian histamine H4 receptors have been cloned and characterized. These recombinant molecules are capable of expressing biologically active histamine H4 receptor protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The pharmacology of known histamine ligands is demonstrated. The recombinant protein may be purified from the recombinant host cells. In addition, recombinant host cells are utilized to establish methods to identify modulators of the receptor activity, and receptor modulators are identified.

    摘要翻译： 已经克隆并表征编码哺乳动物组胺H 4受体的DNA。 这些重组分子能够表达生物活性组胺H 4受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 证明了已知组胺配体的药理学。 重组蛋白可以从重组宿主细胞中纯化。 此外，利用重组宿主细胞建立识别受体活性调节剂的方法，并鉴定受体调节剂。

    DNAs encoding mammalian histamine receptor of the H4 subtype and encoded protein
    6.
    发明授权
    DNAs encoding mammalian histamine receptor of the H4 subtype and encoded protein 有权
    编码H4亚型的哺乳动物组胺受体的DNA和编码的蛋白质

    公开(公告)号：US07183078B2

    公开(公告)日：2007-02-27

    申请号：US10626445

    申请日：2003-07-23

    申请人： Timothy Lovenberg ,  Changlu Liu

    发明人： Timothy Lovenberg ,  Changlu Liu

    IPC分类号： C12N15/12 ,  C12N15/70 ,  C07H21/04 ,  C07K14/435

    CPC分类号： C07K14/723

    摘要： DNAs encoding the mammalian histamine H4 receptors have been cloned and characterized. These recombinant molecules are capable of expressing biologically active histamine H4 receptor protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The pharmacology of known histamine ligands is demonstrated. The recombinant protein may be purified from the recombinant host cells. In addition, recombinant host cells are utilized to establish methods to identify modulators of the receptor activity, and receptor modulators are identified.

    摘要翻译： 已经克隆并表征编码哺乳动物组胺H 4受体的DNA。 这些重组分子能够表达生物活性组胺H 4受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 证明了已知组胺配体的药理学。 重组蛋白可以从重组宿主细胞中纯化。 此外，利用重组宿主细胞建立识别受体活性调节剂的方法，并鉴定受体调节剂。

    DNAs encoding guinea pig histamine receptors of the H4 subtype
    9.
    发明授权
    DNAs encoding guinea pig histamine receptors of the H4 subtype 有权
    编码H4亚型豚鼠组胺受体的DNA

    公开(公告)号：US07115395B2

    公开(公告)日：2006-10-03

    申请号：US10626398

    申请日：2003-07-23

    申请人： Timothy Lovenberg ,  Changlu Liu

    发明人： Timothy Lovenberg ,  Changlu Liu

    IPC分类号： C12P21/02 ,  C12N5/16 ,  C12N1/21 ,  C12N15/63 ,  C07H21/04

    CPC分类号： C07K14/723

    摘要： DNAs encoding the mammalian histamine H4 receptors have been cloned and characterized. These recombinant molecules are capable of expressing biologically active histamine H4 receptor protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The pharmacology of known histamine ligands is demonstrated. The recombinant protein may be purified from the recombinant host cells. In addition, recombinant host cells are utilized to establish methods to identify modulators of the receptor activity, and receptor modulators are identified.

    摘要翻译： 已经克隆并表征编码哺乳动物组胺H 4受体的DNA。 这些重组分子能够表达生物活性组胺H 4受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 证明了已知组胺配体的药理学。 重组蛋白可以从重组宿主细胞中纯化。 此外，利用重组宿主细胞建立识别受体活性调节剂的方法，并鉴定受体调节剂。