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1.发明申请公开(公告)号：US20090291903A1
公开(公告)日：2009-11-26
申请号：US12468632
申请日：2009-05-19
申请人： Nicholas I. Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
发明人： Nicholas I. Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
IPC分类号： A61K38/05 , C07D403/06 , A61K31/551
CPC分类号： C07D403/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译： 某些取代的吡咯烷酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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2.发明授权公开(公告)号：US08236792B2
公开(公告)日：2012-08-07
申请号：US12468632
申请日：2009-05-19
申请人： Nicholas I Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
发明人： Nicholas I Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
IPC分类号： A61K31/55 , A61K31/497 , A61K31/445 , A61K31/40 , C07D243/08 , C07D403/00 , C07D401/00 , C07D205/00
CPC分类号： C07D403/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译： 某些取代的吡咯烷酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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![DISUBSTITUTED OCTAHYDROPYRROLO[3,4-c]PYRROLES AS OREXIN RECEPTOR MODULATORS](/abs-image/US/2014/06/26/US20140179697A1/abs.jpg.150x150.jpg)
3.发明申请DISUBSTITUTED OCTAHYDROPYRROLO[3,4-c]PYRROLES AS OREXIN RECEPTOR MODULATORS 有权作为OREXIN受体调节剂的分析的甲氧基吡咯并[3,4-c]吡咯公开(公告)号：US20140179697A1
公开(公告)日：2014-06-26
申请号：US14138941
申请日：2013-12-23
申请人： Wenying Chai , Michael A. Letavic , Kiev S. Ly , Daniel J. Pippel , Dale A. Rudolph , Kathleen C. Sappey , Brad M. Savall , Chandravadan R. Shah , Brock T. Shireman , Akinola Soyode Johnson , Emily M. Stocking , Devin M. Swanson
发明人： Wenying Chai , Michael A. Letavic , Kiev S. Ly , Daniel J. Pippel , Dale A. Rudolph , Kathleen C. Sappey , Brad M. Savall , Chandravadan R. Shah , Brock T. Shireman , Akinola Soyode Johnson , Emily M. Stocking , Devin M. Swanson
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/498 , A61K31/506 , A61K31/53 , A61K31/5377
摘要： Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
摘要翻译： 描述了二取代八氢吡咯并[3,4-c]吡咯化合物，其可用作食欲素受体调节剂。 这样的化合物可用于治疗由食欲素活性（例如失眠）介导的疾病状态，病症和病症的药物组合物和方法。
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![Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators](/abs-image/US/2014/02/18/US08653263B2/abs.jpg.150x150.jpg)
4.发明授权Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators 有权二取代八氢吡咯并[3,4-c]吡咯作为食欲素受体调节剂公开(公告)号：US08653263B2
公开(公告)日：2014-02-18
申请号：US13503231
申请日：2010-10-21
申请人： Wenying Chai , Michael A. Letavic , Kiev S. Ly , Daniel J. Pippel , Dale A. Rudolph , Kathleen C. Sappey , Brad M. Savall , Chandravadan R. Shah , Brock T. Shireman , Akinola Soyode-Johnson , Emily M. Stocking , Devin M. Swanson
发明人： Wenying Chai , Michael A. Letavic , Kiev S. Ly , Daniel J. Pippel , Dale A. Rudolph , Kathleen C. Sappey , Brad M. Savall , Chandravadan R. Shah , Brock T. Shireman , Akinola Soyode-Johnson , Emily M. Stocking , Devin M. Swanson
IPC分类号： C07D417/00 , C07D239/02 , C07D241/36 , C07D215/38 , A61K31/4965 , A61K31/515 , A61K31/44 , A61K31/425
CPC分类号： C07D487/04 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/498 , A61K31/506 , A61K31/53 , A61K31/5377
摘要： Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
摘要翻译： 描述了二取代八氢吡咯并[3,4-c]吡咯化合物，其可用作食欲素受体调节剂。 这样的化合物可用于治疗由食欲素活性（例如失眠）介导的疾病状态，病症和病症的药物组合物和方法。
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![DISUBSTITUTED OCTAHYDROPYRROLO[3,4-c]PYRROLES AS OREXIN RECEPTOR MODULATORS](/abs-image/US/2012/08/16/US20120208812A1/abs.jpg.150x150.jpg)
5.发明申请DISUBSTITUTED OCTAHYDROPYRROLO[3,4-c]PYRROLES AS OREXIN RECEPTOR MODULATORS 有权作为OREXIN受体调节剂的分析的甲氧基吡咯并[3,4-c]吡咯公开(公告)号：US20120208812A1
公开(公告)日：2012-08-16
申请号：US13503231
申请日：2010-10-21
申请人： Wenying Chai , Michael A. Letavic , Kiev S. Ly , Daniel J. Pippel , Dale A. Rudolph , Kathleen C. Sappey , Brad M. Savall , Chandravadan R. Shah , Brock T. Shireman , Akinola Soyode-Johnson , Emily M. Stocking , Devin M. Swanson
发明人： Wenying Chai , Michael A. Letavic , Kiev S. Ly , Daniel J. Pippel , Dale A. Rudolph , Kathleen C. Sappey , Brad M. Savall , Chandravadan R. Shah , Brock T. Shireman , Akinola Soyode-Johnson , Emily M. Stocking , Devin M. Swanson
IPC分类号： A61K31/5377 , A61K31/498 , A61K31/517 , A61K31/506 , A61K31/444 , A61K31/428 , A61K31/423 , C07D487/04 , A61P25/20 , A61P25/00 , A61P25/24 , A61P25/18 , A61P25/16 , A61P25/22 , A61P3/00 , A61P3/04 , A61P3/10 , A61P3/06 , A61P9/12 , A61P15/00 , A61P19/02 , A61P9/00 , A61P1/04 , A61P1/00 , A61P1/12 , A61K31/53
CPC分类号： C07D487/04 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/498 , A61K31/506 , A61K31/53 , A61K31/5377
摘要： Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
摘要翻译： 描述了二取代八氢吡咯并[3,4-c]吡咯化合物，其可用作食欲素受体调节剂。 这样的化合物可用于治疗由食欲素活性（例如失眠）介导的疾病状态，病症和病症的药物组合物和方法。
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公开(公告)号：US06803362B2
公开(公告)日：2004-10-12
申请号：US10094357
申请日：2002-03-08
申请人： Nicholas I. Carruthers , Wenying Chai , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer D. Kreisberg , Annette K. Kwok , Timothy W. Lovenberg , Kiev S. Ly , Barbara Pio , Chandravadan R. Shah , Siguan Sun , Robin L. Thurmond , Jianmei Wei , Wei Xiao
发明人： Nicholas I. Carruthers , Wenying Chai , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer D. Kreisberg , Annette K. Kwok , Timothy W. Lovenberg , Kiev S. Ly , Barbara Pio , Chandravadan R. Shah , Siguan Sun , Robin L. Thurmond , Jianmei Wei , Wei Xiao
IPC分类号： A61K3133
CPC分类号： C07D401/12 , A61K31/496 , C07D209/42
摘要： Heterocyclic compounds and methods of making them and using them.
摘要翻译： 杂环化合物及其制备方法和使用方法。
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公开(公告)号：US07504426B2
公开(公告)日：2009-03-17
申请号：US10655381
申请日：2003-09-04
申请人： Nicholas I. Carruthers , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Kiev S. Ly , Barbara A. Pio , Chandravadan R. Shah , Jennifer D. Venable
发明人： Nicholas I. Carruthers , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Kiev S. Ly , Barbara A. Pio , Chandravadan R. Shah , Jennifer D. Venable
IPC分类号： C07D235/00 , A01N43/05 , A61K31/415
CPC分类号： C07D235/24 , C07D263/58 , C07D277/68 , C07D403/06 , C07D451/04 , C07D471/04
摘要： Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis.
摘要翻译： 公开了某些噻吩并吡喃基和呋喃并吡咯基化合物可用于治疗或预防由组胺H 4受体介导的病症和病症，包括过敏性鼻炎。
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8.发明申请SUBSTITUTED PYRIDYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR 有权作为组胺H3受体的调节剂的取代的吡啶酰胺化合物公开(公告)号：US20070281923A1
公开(公告)日：2007-12-06
申请号：US11753607
申请日：2007-05-25
申请人： John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
发明人： John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
IPC分类号： A61K31/551 , A61K31/496 , C07D403/02
CPC分类号： C07D213/82 , C07D213/81 , C07D213/84 , C07D401/06
摘要： Certain substituted pyridyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译： 某些取代的吡啶酰胺化合物是可用于治疗组胺H 3受体介导的疾病的组胺H 3 N 3受体调节剂。
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9.发明申请SUBSTITUTED PYRIDYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR 有权作为组胺H3受体的调节剂的取代的吡啶酰胺化合物公开(公告)号：US20100267701A1
公开(公告)日：2010-10-21
申请号：US12828883
申请日：2010-07-01
申请人： John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
发明人： John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
IPC分类号： A61K31/551 , A61K31/496 , C07D403/14 , C07D403/12 , A61P25/18 , A61P25/28 , A61P25/16 , A61P25/24 , A61P25/06 , A61P25/08 , A61P27/02 , A61P25/30 , A61P25/20 , A61P25/00
CPC分类号： C07D213/82 , C07D213/81 , C07D213/84 , C07D401/06
摘要： Certain substituted pyridyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译： 某些取代的吡啶酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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10.发明授权Substituted pyridyl amide compounds as modulators of the histamine H3 receptor 有权取代的吡啶酰胺化合物作为组胺H3受体的调节剂公开(公告)号：US08637520B2
公开(公告)日：2014-01-28
申请号：US12828883
申请日：2010-07-01
申请人： John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
发明人： John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
IPC分类号： A61K31/496 , C07D401/06
CPC分类号： C07D213/82 , C07D213/81 , C07D213/84 , C07D401/06
摘要： Certain substituted pyridyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译： 某些取代的吡啶酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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