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104 条记录 (耗时 0.031 秒)

    Use of endosialin binding proteins to isolate endosialin positive cells
    2.
    发明申请
    Use of endosialin binding proteins to isolate endosialin positive cells 审中-公开
    使用内质网蛋白结合蛋白分离内皮唾液酸阳性细胞

    公开(公告)号：US20060121541A1

    公开(公告)日：2006-06-08

    申请号：US11292634

    申请日：2005-12-02

    申请人： Luigi Grasso ,  Gaurav Deshmukh ,  Nicholas Nicolaides ,  Philip Sass

    发明人： Luigi Grasso ,  Gaurav Deshmukh ,  Nicholas Nicolaides ,  Philip Sass

    IPC分类号： G01N33/574 ,  C12N5/06 ,  C12N5/08

    CPC分类号： G01N33/574 ,  C07K16/2851 ,  G01N33/56966 ,  G01N33/57492 ,  G01N2333/515 ,  G01N2333/70596 ,  G01N2500/00 ,  G01N2800/10 ,  G01N2800/16 ,  G01N2800/24

    摘要： Monoclonal antibodies and other proteins that specifically bind to cells positive for endosialin are provided. The antibodies and proteins are useful in the isolation of endosialin-positive cells, particularly cells associated with neovascularization associated with cancer and neovascular disease. The invention is also related to cells that are isolated using monoclonal antibodies; antibody derivatives, such as chimeric and humanized monoclonal antibodies; antibody fragments; mammalian cells expressing the monoclonal antibodies, derivatives and fragments; and methods of detecting and isolating endosialin-positive cells using the antibodies, derivatives and fragments.

    摘要翻译： 提供了单克隆抗体和其他特异性结合内皮素的阳性细胞的蛋白质。 抗体和蛋白质可用于分离内皮唾液酸阳性细胞，特别是与与癌症和新血管病相关的新生血管形成相关的细胞。 本发明还涉及使用单克隆抗体分离的细胞; 抗体衍生物，例如嵌合和人源化单克隆抗体; 抗体片段; 表达单克隆抗体，衍生物和片段的哺乳动物细胞; 以及使用抗体，衍生物和片段检测和分离内皮唾液酸 - 阳性细胞的方法。

    Antibodies and methods for generating genetically altered antibodies with enhanced effector function
    5.
    发明申请
    Antibodies and methods for generating genetically altered antibodies with enhanced effector function 审中-公开
    用于产生具有增强的效应子功能的遗传改变的抗体的抗体和方法

    公开(公告)号：US20050054048A1

    公开(公告)日：2005-03-10

    申请号：US10901650

    申请日：2004-07-29

    申请人： Luigi Grasso ,  Nicholas Nicolaides ,  Howard Sands ,  Philip Sass

    发明人： Luigi Grasso ,  Nicholas Nicolaides ,  Howard Sands ,  Philip Sass

    IPC分类号： C07K16/00 ,  C07K16/42 ,  C12N15/10 ,  C07H21/04 ,  C07K16/18 ,  C12N15/87

    CPC分类号： C12N15/1024 ,  C07K16/00 ,  C07K16/4291 ,  C07K2317/732 ,  C07K2317/92

    摘要： Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. These methods are useful for generating genetic diversity within immunoglobulin genes directed against an antigen of interest to produce altered antibodies with enhanced biochemical activity. Moreover, these methods are useful for generating antibody-producing cells with increased level of antibody production. The invention also provides methods for increasing the effector function of monoclonal antibodies and monoclonal antibodies with increased effector function.

    摘要翻译： 人类错配修复基因的主要阴性等位基因可用于产生超可变细胞和生物体。 通过将这些基因引入细胞和转基因动物，可以比通过依赖于突变的自然速率更有效地制备具有新颖和有用性质的新细胞系和动物品种。 这些方法可用于在针对感兴趣的抗原的免疫球蛋白基因内产生遗传多样性，以产生具有增强的生化活性的改变的抗体。 此外，这些方法可用于产生具有增加的抗体产生水平的产生抗体的细胞。 本发明还提供了增加效应子功能增强的单克隆抗体和单克隆抗体的效应子功能的方法。

    Anti-Mesothelin Antibodies
    7.
    发明申请
    Anti-Mesothelin Antibodies 有权
    抗间皮素抗体

    公开(公告)号：US20090202559A2

    公开(公告)日：2009-08-13

    申请号：US11373546

    申请日：2006-03-09

    申请人： Wolfgang Ebel ,  Luigi Grasso ,  Nicholas Nicolaides ,  Philip Sass ,  Eric Routhier

    发明人： Wolfgang Ebel ,  Luigi Grasso ,  Nicholas Nicolaides ,  Philip Sass ,  Eric Routhier

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C07K16/30

    CPC分类号： C07K16/28 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3069 ,  C07K2317/56 ,  C07K2317/732 ,  C07K2317/77

    摘要： This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and become internalized by mesothelin-positive cells and also induce an immune effector activity such as antibody dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to mesothelin expressing cells as well as eliciting an immune-effector activity particularly on tumor cells and precursors. The invention is also related to cells expressing the monoclonal antibodies, polyclonal antibodies, antibody derivatives, such as human, humanized, and chimeric monoclonal antibodies, antibody fragments, mammalian cells expressing the monoclonal antibodies, derivatives and fragments, and methods of treating cancer using the antibodies, derivatives and fragments.

    摘要翻译： 本发明涉及单克隆和多克隆抗体的使用，其特异性结合并被间皮素阳性细胞内化，并且还诱导免疫效应子活性如抗体依赖性细胞毒性。 该抗体可用于特异性递送表达间皮素的药物学药剂，以及引发免疫效应物特异性对肿瘤细胞和前体的活性。 本发明还涉及表达单克隆抗体，多克隆抗体，抗体衍生物如人，人源化和嵌合单克隆抗体的细胞，抗体片段，表达单克隆抗体的哺乳动物细胞，衍生物和片段，以及使用 抗体，衍生物和片段。