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公开(公告)号：US5827687A
公开(公告)日：1998-10-27
申请号：US672569
申请日：1996-06-28
CPC分类号： C12N9/0069 , C12N15/85 , A01K2217/05
摘要： An isolated DNA having a promoter activity in an animal cell; a method for expressing a useful gene using the isolated DNA; and a method for producing a protein in an animal cell using the isolated DNA. The present invention provides a method for producing a desired gene product in a large quantity in an animal cell.
摘要翻译： 在动物细胞中具有启动子活性的分离的DNA; 使用分离的DNA表达有用基因的方法; 以及使用分离的DNA在动物细胞中产生蛋白质的方法。 本发明提供了在动物细胞中大量生产所需基因产物的方法。
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公开(公告)号：US08003781B2
公开(公告)日：2011-08-23
申请号：US12281601
申请日：2007-03-02
申请人： Akihiro Kondo , Wenzhe Li , Takatoshi Nakagawa , Nobuto Koyama , Naoyuki Taniguchi , Ikunoshin Kato
发明人： Akihiro Kondo , Wenzhe Li , Takatoshi Nakagawa , Nobuto Koyama , Naoyuki Taniguchi , Ikunoshin Kato
CPC分类号： C12N15/1137 , A61K48/00 , C12N2310/111 , C12N2310/14 , C12Y204/01068
摘要： Disclosed is a means for reducing the expression amount of a FUT8 gene, reducing the expression amount of a FUT8 protein, and/or reducing the expression amount of a product produced by the action of FUT8.
摘要翻译： 公开了减少FUT8基因的表达量，降低FUT8蛋白的表达量和/或降低由FUT8的作用产生的产物的表达量的方法。
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3.发明申请公开(公告)号：US20090221065A1
公开(公告)日：2009-09-03
申请号：US12281601
申请日：2007-03-02
申请人： Akihiro Kondo , Wenzhe Li , Takatoshi Nakagawa , Nobuto Koyama , Naoyuki Taniguchi , Ikunoshin Kato
发明人： Akihiro Kondo , Wenzhe Li , Takatoshi Nakagawa , Nobuto Koyama , Naoyuki Taniguchi , Ikunoshin Kato
CPC分类号： C12N15/1137 , A61K48/00 , C12N2310/111 , C12N2310/14 , C12Y204/01068
摘要： Disclosed is a means for reducing the expression amount of a FUT8 gene, reducing the expression amount of a FUT8 protein, and/or reducing the expression amount of a product produced by the action of FUT8.
摘要翻译： 公开了减少FUT8基因的表达量，降低FUT8蛋白的表达量和/或降低由FUT8的作用产生的产物的表达量的方法。
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4.发明授权Enhancement of retroviral gene transduction employing polypeptides comprising the fibronectin heparin II binding domain 失效使用包含纤连蛋白肝素II结合结构域的多肽增强逆转录病毒基因转导公开(公告)号：US07790849B2
公开(公告)日：2010-09-07
申请号：US12241581
申请日：2008-09-30
申请人： Kiyozo Asada , Takashi Uemori , Takashi Ueno , Nobuto Koyama , Kimikazu Hashino , Ikunoshin Kato
发明人： Kiyozo Asada , Takashi Uemori , Takashi Ueno , Nobuto Koyama , Kimikazu Hashino , Ikunoshin Kato
CPC分类号： C12N15/86 , A61K48/00 , C07K14/505 , C07K14/78 , C07K2319/00 , C12N9/1088 , C12N2740/13043 , C12N2740/13045
摘要： An isolated polypeptide includes the amino acid sequence shown in SEQ. ID No. 13 and an isolated nucleic acid encoding the polypeptide, such as an isolated nucleic acid including the nucleic acid sequence shown in SEQ. ID No. 17. The isolated polypeptide includes two heparin binding polypeptides connected in tandem and the isolated nucleic acid encodes these. The polypeptide and nucleic acid sequences can improve retroviral vector mediated gene transfer efficiency into target cells.
摘要翻译： 分离的多肽包括SEQ ID NO：1所示的氨基酸序列。 ID号13和编码该多肽的分离的核酸，例如分离的核酸，包括SEQ ID NO：1所示的核酸序列。 分离的多肽包括串联连接的两个肝素结合多肽，分离的核酸编码这些。 多肽和核酸序列可以改进逆转录病毒载体介导的靶细胞的基因转移效率。
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公开(公告)号：US20060030046A1
公开(公告)日：2006-02-09
申请号：US11181091
申请日：2005-07-14
申请人： Kiyozo Asada , Takashi Uemori , Takashi Ueno , Nobuto Koyama , Kimikazu Hashino , Ikunoshin Kato
发明人： Kiyozo Asada , Takashi Uemori , Takashi Ueno , Nobuto Koyama , Kimikazu Hashino , Ikunoshin Kato
IPC分类号： C12N15/867 , C07K14/50
CPC分类号： C12N15/86 , A61K48/00 , C07K14/505 , C07K14/78 , C07K2319/00 , C12N9/1088 , C12N2740/13043 , C12N2740/13045
摘要： A polypeptide represented by SEQ. ID No. 13, a polypeptide represented by SEQ. ID No. 30 or functional equivalents thereof and a polypeptide represented by SEQ. ID No. 17.
摘要翻译： SEQ ID NO： SEQ ID NO：13，SEQ ID NO： SEQ ID No 30或其功能等同物和SEQ ID NO： ID号17。
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6.发明授权Remedies or preventives containing cyclopentenone compounds as the active ingredient 失效含环戊烯酮化合物作为活性成分的补救措施或预防措施公开(公告)号：US06548543B1
公开(公告)日：2003-04-15
申请号：US09763244
申请日：2001-02-20
申请人： Eiji Kobayashi , Hiromu Ohnogi , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
发明人： Eiji Kobayashi , Hiromu Ohnogi , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A61K31215
CPC分类号： A61K31/215 , A61K31/22 , C07C69/013 , C07C2601/10 , Y02A50/411
摘要： Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation of cell adhesion or disease with a deed for induction of heat-shock protein, which contain as the active ingredient at least one compound selected from among cyclopentenone derivatives represented by general formula [I], optically active isomers and salts thereof, wherein R1 and R2 are the same or different and each represents hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group.
摘要翻译： 需要免疫调节的疾病的治疗或预防措施，需要抑制炎症的疾病，需要调节肿瘤坏死因子产生的疾病，需要调节真菌生长的疾病，需要调节细胞的疾病 含有作为活性成分的至少一种选自通式[I]表示的环戊烯酮衍生物的化合物，其光学活性异构体和盐，其中R 1和R 2为 相同或不同，各自表示氢，脂族基，芳基或芳族脂族基。
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公开(公告)号：US6136854A
公开(公告)日：2000-10-24
申请号：US359069
申请日：1999-07-21
申请人： Nobuto Koyama , Katsushige Ikai , Eiji Kobayashi , Ikunoshin Kato
发明人： Nobuto Koyama , Katsushige Ikai , Eiji Kobayashi , Ikunoshin Kato
IPC分类号： C07C69/013 , A61K31/235 , C07C69/52 , C07C69/76
CPC分类号： C07C69/013
摘要： Cyclopentenone derivative having a structure of 5-(R.sub.1 COO--)-4-(R.sub.2 COO--)--substituted 2-cyclopenten-1-one (R.sub.1 and R.sub.2 are some or different and each is alkyl group, alkenyl group or aryl group) or an optically active substance thereof; a method for the manufacture of the cyclopentenone derivative by the reaction of 4,5-dihydroxy-2-cyclopenten-1-one with the corresponding carboxylic acid or a reactive derivative thereof; and anticancer agent, apoptosis-inducing agent and antibacterial agent containing said derivative.
摘要翻译： 具有5-（R 1 COO - ） - 4-（R 2 COO - ） - 取代的2-环戊烯-1-酮的结构的环戊烯酮衍生物（R 1和R 2有一些或不同，各自为烷基，烯基或芳基）或 其光学活性物质; 通过4,5-二羟基-2-环戊烯-1-酮与相应的羧酸或其活性衍生物的反应制备环戊烯酮衍生物的方法; 和抗癌剂，凋亡诱导剂和含有所述衍生物的抗菌剂。
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公开(公告)号：US6133238A
公开(公告)日：2000-10-17
申请号：US347169
申请日：1999-07-02
申请人： Hiroaki Sagawa , Shinji Okuda , Nobuko Muraki , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
发明人： Hiroaki Sagawa , Shinji Okuda , Nobuko Muraki , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A61K31/34 , A61K31/341 , A61P35/00 , C07D307/24 , A61K31/70 , C07D307/00 , C07D307/02
CPC分类号： C07D307/24
摘要： 2,5-dihydroxytetrahydro-2-furancarboxylic acid represented by the following formula [I], its optically active substance or salt thereof. ##STR1##
摘要翻译： 由下式[I]表示的2,5-二羟基四氢-2-呋喃羧酸，其光学活性物质或其盐。
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9.发明授权Hyperthermostable .beta.-galactosidase gene, enzyme encoded thereby, and process for production 失效超热稳定性β-半乳糖苷酶基因，由此编码的酶，以及生产方法
公开(公告)号：US5744345A
公开(公告)日：1998-04-28
申请号：US489733
申请日：1995-06-14
申请人： Atsushi Shimada , Miki Odate , Nobuto Koyama , Kimikazu Hashino , Kiyozo Asada , Ikunoshin Kato
发明人： Atsushi Shimada , Miki Odate , Nobuto Koyama , Kimikazu Hashino , Kiyozo Asada , Ikunoshin Kato
CPC分类号： C12Y302/01023 , C12N9/2471
摘要： An isolated hyperthermostable .beta.-galactosidase gene derived from Pyrococcus furiosus is described. Examples include DNA sequences shown in SEQ ID NO. 2 and SEQ ID NO. 4 and DNAs hybridizable with these DNAs. A method of cloning the hyperthermostable .beta.-galactosidase gene in which each of the above sequences or portions thereof is used as a probe or primer is described. A process for producing a hyperthermostable .beta.-galactosidase by culturing a transformant into which a plasmid containing each of the above genes has been introduced is described. A particularly preferred gene encodes an SDS-resistant hyperthermostable .beta.-galactosidase.
摘要翻译： 描述了源自激烈热球菌的分离的超热稳定性β-半乳糖苷酶基因。 实例包括SEQ ID NO： 2和SEQ ID NO。 4和DNA可与这些DNA杂交。 描述了将上述每个上述序列或其部分用作探针或引物的克隆超热稳定性β-半乳糖苷酶基因的方法。 描述了通过培养其中已经引入了含有上述每种基因的质粒的转化体来生产超热稳定性β-半乳糖苷酶的方法。 特别优选的基因编码SDS-抗性超热稳定性β-半乳糖苷酶。
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10.发明申请Drugs, foods or drinks with the use of algae-derived physiologically active substances 审中-公开使用藻类来源的生理活性物质的药物，食品或饮料公开(公告)号：US20090099101A1
公开(公告)日：2009-04-16
申请号：US12222492
申请日：2008-08-11
申请人： Tatsuji Enoki , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Takeshi Sakai , Fu-Gong Yu , Katsushige Ikai , Ikunoshin Kato
发明人： Tatsuji Enoki , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Takeshi Sakai , Fu-Gong Yu , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A61K31/70 , A61K31/335
CPC分类号： A01N43/04 , A23L3/3472 , A23L3/3544 , A23L3/3562 , A23L33/105 , A61K31/341 , A61K31/7048
摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.
摘要翻译： 用于治疗，改善或预防对由式（1）表示的3,6-脱水吡喃半乳糖敏感的疾病的药物组合物：含有作为活性成分的至少一种选自上述组分的组分的食品，饮料，化妆品等， 所述化合物，其醛，其水合物和2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。 该化合物还显示例如细胞凋亡诱导活性，制癌活性和对活性氧，脂质过氧化物自由基和NO的产生的抑制活性，这使得它也可用作抗氧化剂和防腐剂的活性成分。
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