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17 条记录 (耗时 0.03 秒)

    Indol acetic acid derivatives and anti-inflamatory and related uses thereof
    2.
    发明授权
    Indol acetic acid derivatives and anti-inflamatory and related uses thereof 失效
    吲哚乙酸衍生物及其抗炎和相关用途

    公开(公告)号：US4464379A

    公开(公告)日：1984-08-07

    申请号：US269515

    申请日：1981-06-01

    申请人： Hans Betzing ,  Sigurd Leyck

    发明人： Hans Betzing ,  Sigurd Leyck

    IPC分类号： C07D401/12 ,  A61K31/44

    CPC分类号： C07D401/12

    摘要： The present invention is related to new indol acetic acid derivatives having the general formula ##STR1## the salts thereof, processes for producing the same and pharmaceutical preparations comprising the same as well as their use as drugs having antithrombotic, antiarteriosclerotic and antiphlogistic activity.

    摘要翻译： 本发明涉及具有以下通式的新的吲哚乙酸衍生物：其盐，其制备方法及其制备方法及其作为具有抗血栓形成，抗动脉硬化和消炎作用的药物的用途。

    Pyrrolidinylalkylcarboxylic acid amide derivatives, their preparation and pharmaceutical compositions containing them
    8.
    发明授权
    Pyrrolidinylalkylcarboxylic acid amide derivatives, their preparation and pharmaceutical compositions containing them 失效
    吡咯烷基烷基羧酸酰胺衍生物，其制备方法和含有它们的药物组合物

    公开(公告)号：US4341790A

    公开(公告)日：1982-07-27

    申请号：US155952

    申请日：1980-06-03

    申请人： Hans Betzing ,  Jurgen Biedermann ,  Carsten Materne ,  Volker Neuser

    发明人： Hans Betzing ,  Jurgen Biedermann ,  Carsten Materne ,  Volker Neuser

    IPC分类号： C07D207/26 ,  C07D207/27 ,  C07D207/273 ,  A61K31/40 ,  A61K31/44

    CPC分类号： C07D207/27 ,  C07D207/273

    摘要： 2-Oxo-1-pyrrolidinylalkylcarboxylic acid amides of formula I ##STR1## in which R represents a hydrogen atom or hydroxy group, R.sub.1 represents a hydrogen atom or a methyl group and R.sub.2 represents a substituted or unsubstituted pyridyl group or a substituted phenyl group, the substitution being by from 1 to 3 substituents, which may be the same or different selected from halogen atoms, trifluoromethyl, nitro and acetyl groups, straight or branched-chain alkyl groups having 1-4 carbon atoms, alkoxy groups having 1-4 carbon atoms, straight or branched-chain alkylmercapto groups having 1-7 carbon atoms, substituted alkylmercapto groups of the general formula II ##STR2## in which n represents 1 or 2, R.sub.3 is a hydrogen atom or a methyl group and R.sub.4 is a hydroxy group or an amino group of the general formula V ##STR3## in which R.sub.8 represents a hydrogen atom or methyl group and R.sub.9 represents a methyl group or substituted or unsubstituted benzyl group, or R.sub.8 and R.sub.9 together with the nitrogen atom shown in formula V, form a substituted pyrrolidine ring; sulphonyl groups of the general formula III--SO.sub.2 R.sub.5 IIIin which R.sub.5 represents an --NH.sub.2 group or an alkyl group having 1-3 carbon atoms; and aminoethoxycarbonyl groups of the general formula IV ##STR4## in which each of R.sub.6 and R.sub.7, which may be the same or different, represents a hydrogen atom or methyl or ethyl group; and the pharmaceutically tolerable acid addition salts of compounds of formula I having a basic nitrogen atom are useful in treating cerebral circulatory disturbances, cerebro-atrophic crises and cerebral ageing processes.

    摘要翻译： 式I的2-氧代-1-吡咯烷基烷基羧酸酰胺其中R表示氢原子或羟基，R1表示氢原子或甲基，R2表示取代或未取代的吡啶基或取代苯基 取代基为1〜3个取代基，可以相同或不同，选自卤素原子，三氟甲基，硝基和乙酰基，具有1-4个碳原子的直链或支链烷基，烷氧基为1-4 碳原子，具有1-7个碳原子的直链或支链烷基巯基，通式II II的取代烷基巯基，其中n表示1或2，R3是氢原子或甲基，R4是 羟基或通式V“II”的氨基，其中R8表示氢原子或甲基，R9表示甲基或取代或未取代的苄基，或R8和R9与氮在一起 如式V所示，形成取代的吡咯烷环; 通式III -SO 2 R 5 III的磺酰基，其中R 5表示-NH 2基或具有1-3个碳原子的烷基; 和通式IV“IV”的氨基乙氧基羰基，其中R6和R7各自可以相同或不同，表示氢原子或甲基或乙基; 并且具有碱性氮原子的式I化合物的药学上可耐受的酸加成盐可用于治疗脑循环障碍，脑萎缩性危机和脑衰老过程。