-
公开(公告)号：US20090149648A1
公开(公告)日：2009-06-11
申请号：US12211745
申请日：2008-09-16
申请人： Norbert W. Bischofberger , Robert J. Jones , Murty N. Armilli , Kuei-Ying Lin , Michael S. Louie , Lawrence R. McGee , Ernest J. Prisbe , William A. Lee , Kenneth C. Cundy
发明人： Norbert W. Bischofberger , Robert J. Jones , Murty N. Armilli , Kuei-Ying Lin , Michael S. Louie , Lawrence R. McGee , Ernest J. Prisbe , William A. Lee , Kenneth C. Cundy
IPC分类号： C07F9/02
CPC分类号： C07F9/657181 , C07F9/6512 , C07F9/65616 , C07F9/65742 , C07F9/65744 , C07F9/65785 , C07H19/10 , C07H19/20
摘要： Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
摘要翻译： 公开了以与磷酸酯核苷酸类似物的磷原子结合的氨基酸连接的氨基酸或酯连接基团的存在为特征的核苷酸类似物。 类似物包含在体内水解以产生相应的膦酸酯核苷酸类似物的氨基磷酸酯或酯键。 描述了其合成和使用的方法和中间体。
-
公开(公告)号：US06225460B1
公开(公告)日：2001-05-01
申请号：US09247497
申请日：1999-02-10
申请人： Norbert W. Bischofberger , Robert J. Jones , Murty N. Arimilli , Kuei-Ying Lin , Michael S. Louie , Lawrence R. McGee , Ernest J. Prisbe , William A. Lee , Kenneth C. Cundy
发明人： Norbert W. Bischofberger , Robert J. Jones , Murty N. Arimilli , Kuei-Ying Lin , Michael S. Louie , Lawrence R. McGee , Ernest J. Prisbe , William A. Lee , Kenneth C. Cundy
IPC分类号： C07H1904
CPC分类号： C07F9/657181 , C07F9/6512 , C07F9/65616 , C07F9/65742 , C07F9/65744 , C07F9/65785 , C07H19/10 , C07H19/20
摘要： Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
摘要翻译： 公开了以与磷酸酯核苷酸类似物的磷原子结合的氨基酸连接的氨基酸或酯连接基团的存在为特征的核苷酸类似物。 类似物包含在体内水解以产生相应的膦酸酯核苷酸类似物的氨基磷酸酯或酯键。 描述了其合成和使用的方法和中间体。
-
公开(公告)号：US07439350B2
公开(公告)日：2008-10-21
申请号：US10882022
申请日：2004-06-29
申请人： Norbert W. Bischofberger , Robert J. Jones , Murty N. Arimilli , Kuei-Ying Lin , Michael S. Louie , Lawrence R. McGee , Ernest J. Prisbe , William A. Lee , Kenneth C. Cundy
发明人： Norbert W. Bischofberger , Robert J. Jones , Murty N. Arimilli , Kuei-Ying Lin , Michael S. Louie , Lawrence R. McGee , Ernest J. Prisbe , William A. Lee , Kenneth C. Cundy
IPC分类号： C07H19/04
CPC分类号： C07F9/657181 , C07F9/6512 , C07F9/65616 , C07F9/65742 , C07F9/65744 , C07F9/65785 , C07H19/10 , C07H19/20
摘要： Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
摘要翻译： 公开了以与磷酸酯核苷酸类似物的磷原子结合的氨基酸连接的氨基酸或酯连接基团的存在为特征的核苷酸类似物。 类似物包含在体内水解以产生相应的膦酸酯核苷酸类似物的氨基磷酸酯或酯键。 描述了其合成和使用的方法和中间体。
-
公开(公告)号：US08163958B2
公开(公告)日：2012-04-24
申请号：US13095101
申请日：2011-04-27
申请人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
发明人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
IPC分类号： C07C233/00 , C07C69/00
CPC分类号： C07C235/60 , C07C229/34 , C07C229/36 , C07C235/48 , C07C2601/14 , C07D213/79 , C07D213/80 , C07D213/803
摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
摘要翻译： 公开了左旋多巴的前药，制备左旋多巴的前药的方法，使用左旋多巴的前药的方法和左旋多巴的前药组合物。
-
公开(公告)号：US07601708B2
公开(公告)日：2009-10-13
申请号：US11183911
申请日：2005-07-19
申请人： Kenneth C. Cundy , Mark A. Gallop , Cindy X. Zhou
发明人： Kenneth C. Cundy , Mark A. Gallop , Cindy X. Zhou
CPC分类号： C07K5/0205 , A61K31/56 , A61K38/00 , A61K47/54 , A61K47/554 , A61K47/64 , A61K47/65 , C07C237/12 , C07C237/20 , C07C323/60 , C07C2601/14 , C07D207/16 , C07D233/64
摘要： This invention is directed to methods for providing sustained systemic concentrations of therapeutic or prophylactic agents such as GABA analogs following oral administration to animals. This invention is also directed to compounds and pharmaceutical compositions that are used in such methods.
-
公开(公告)号：US20090221442A1
公开(公告)日：2009-09-03
申请号：US12172801
申请日：2008-07-14
IPC分类号： C40B30/06
CPC分类号： G01N33/5088 , A61K49/0004 , C07C271/22 , C07C2603/18 , C07D271/08 , C07D277/32 , C07D311/16 , C07K1/047 , C12N15/1034 , C12N15/1086 , C40B40/00 , G01N33/5008 , G01N33/533 , G01N33/566 , G01N33/92
摘要： A variety of methods for assaying libraries of test compounds as ligands and/or substrates of transport proteins, including both carrier-type and receptor-type transport proteins, are provided. Both in vitro and in vivo screening methods are disclosed. Also provided are methods for screening DNA libraries to identify members that encode transport proteins. Pharmaceutical compositions including compounds identified via the screening methods are also provided.
摘要翻译： 提供了用于测定测试化合物的文库作为载体蛋白质（包括载体型和受体型转运蛋白）的转运蛋白质的配体和/或底物的多种方法。 公开了体外和体内筛选方法。 还提供了筛选DNA文库以鉴定编码转运蛋白的成员的方法。 还提供了包括通过筛选方法鉴定的化合物的药物组合物。
-
公开(公告)号：US20090137834A1
公开(公告)日：2009-05-28
申请号：US12364453
申请日：2009-02-02
申请人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
发明人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
IPC分类号： C07C227/14
CPC分类号： C07C235/60 , C07C229/34 , C07C229/36 , C07C235/48 , C07C2601/14 , C07D213/79 , C07D213/80 , C07D213/803
摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
摘要翻译： 公开了左旋多巴的前药，制备左旋多巴的前药的方法，使用左旋多巴的前药的方法和左旋多巴的前药组合物。
-
8.发明授权Amino acid conjugates providing for sustained systemic concentrations of GABA analogues 失效提供持续全身浓度的GABA类似物的氨基酸缀合物公开(公告)号：US07420002B2
公开(公告)日：2008-09-02
申请号：US10480293
申请日：2002-06-11
IPC分类号： A61K31/195 , C07C229/28
CPC分类号： C07D233/64 , A61K38/00 , A61K47/64 , C07C237/12 , C07C237/20 , C07C317/50 , C07C323/59 , C07C323/60 , C07C2601/14 , C07D207/16 , C07K5/0205 , G01N33/566
摘要： Compounds that provide for sustained systemic concentrations of GABA analogs following oral administration to animals are disclosed. Pharmaceutical compositions including, and methods using, such compounds are also disclosed.
摘要翻译： 公开了在口服给予动物后提供持续的全身浓度的GABA类似物的化合物。 还公开了药物组合物，以及使用这些化合物的方法。
-
公开(公告)号：US07413536B1
公开(公告)日：2008-08-19
申请号：US09661927
申请日：2000-09-14
IPC分类号： C40B30/04
CPC分类号： G01N33/5088 , A61K49/0004 , C07C271/22 , C07C2603/18 , C07D271/08 , C07D277/32 , C07D311/16 , C07K1/047 , C12N15/1034 , C12N15/1086 , C40B40/00 , G01N33/5008 , G01N33/533 , G01N33/566 , G01N33/92
摘要： A variety of methods for assaying libraries of test compounds as ligands and/or substrates of transport proteins, including both carrier-type and receptor-type transport proteins, are provided. Both in vitro and in vivo screening methods are disclosed. Also provided are methods for screening DNA libraries to identify members that encode transport proteins. Pharmaceutical compositions including compounds identified via the screening methods are also provided.
摘要翻译： 提供了用于测定测试化合物的文库作为载体蛋白质（包括载体型和受体型转运蛋白）的转运蛋白质的配体和/或底物的多种方法。 公开了体外和体内筛选方法。 还提供了筛选DNA文库以鉴定编码转运蛋白的成员的方法。 还提供了包括通过筛选方法鉴定的化合物的药物组合物。
-
公开(公告)号：US20080161393A1
公开(公告)日：2008-07-03
申请号：US12001067
申请日：2007-12-06
CPC分类号： A61K31/195 , A61K31/197
摘要： Methods of using prodrugs of GABA analogs and pharmaceutical compositions thereof to treat migraine, fibromyalgia, amyotrophic lateral sclerosis, irritable bowel syndrome, social phobia, Parkinson's disease, asthma, cough, or chronic obstructive pulmonary disease, and pharmaceutical compositions of prodrugs of GABA analogs useful in treating migraine, fibromyalgia, amyotrophic lateral sclerosis, irritable bowel syndrome, social phobia, Parkinson's disease, asthma, cough, or chronic obstructive pulmonary disease are disclosed.
摘要翻译： 使用GABA类似物的前药及其药物组合物治疗偏头痛，纤维肌痛，肌萎缩性侧索硬化症，肠易激综合征，社交恐惧症，帕金森病，哮喘，咳嗽或慢性阻塞性肺疾病的药物组合物，以及GABA类似物的前药药物组合物 在治疗偏头痛，纤维肌痛，肌萎缩性侧索硬化症，肠易激综合征，社交恐惧症，帕金森病，哮喘，咳嗽或慢性阻塞性肺病方面。
-
-
-
-
-
-
-
-
-
搜索结果
61 条记录 (耗时 0.067 秒)